Profiling and characterization of SARS-CoV-2 mutants’ infectivity and antigenicity
Using high-throughput pseudovirus assay in conjunction with neutralizing antibodies, Wang et al. investigated 80 natural variants and 26 glycosylation-spike (S) mutants of SARS-CoV-2 in terms of infectivity and antigenicity.1 They identified several mutations that can critically affect the virus inf...
- Autores:
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Bogotá Jorge Tadeo Lozano
- Repositorio:
- Expeditio: repositorio UTadeo
- Idioma:
- eng
- OAI Identifier:
- oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/14038
- Acceso en línea:
- https://doi.org/10.1038/s41392-020-00302-8
http://hdl.handle.net/20.500.12010/14038
- Palabra clave:
- SARS-CoV-2
SARS-CoV-2 mutants
Infectivity and antigenicity
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
- Rights
- License
- Abierto (Texto Completo)
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| dc.title.spa.fl_str_mv |
Profiling and characterization of SARS-CoV-2 mutants’ infectivity and antigenicity |
| title |
Profiling and characterization of SARS-CoV-2 mutants’ infectivity and antigenicity |
| spellingShingle |
Profiling and characterization of SARS-CoV-2 mutants’ infectivity and antigenicity SARS-CoV-2 SARS-CoV-2 mutants Infectivity and antigenicity Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
| title_short |
Profiling and characterization of SARS-CoV-2 mutants’ infectivity and antigenicity |
| title_full |
Profiling and characterization of SARS-CoV-2 mutants’ infectivity and antigenicity |
| title_fullStr |
Profiling and characterization of SARS-CoV-2 mutants’ infectivity and antigenicity |
| title_full_unstemmed |
Profiling and characterization of SARS-CoV-2 mutants’ infectivity and antigenicity |
| title_sort |
Profiling and characterization of SARS-CoV-2 mutants’ infectivity and antigenicity |
| dc.subject.spa.fl_str_mv |
SARS-CoV-2 SARS-CoV-2 mutants Infectivity and antigenicity |
| topic |
SARS-CoV-2 SARS-CoV-2 mutants Infectivity and antigenicity Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
| dc.subject.lemb.spa.fl_str_mv |
Síndrome respiratorio agudo grave COVID-19 SARS-CoV-2 Coronavirus |
| description |
Using high-throughput pseudovirus assay in conjunction with neutralizing antibodies, Wang et al. investigated 80 natural variants and 26 glycosylation-spike (S) mutants of SARS-CoV-2 in terms of infectivity and antigenicity.1 They identified several mutations that can critically affect the virus infectivity and reactivity to neutralizing antibodies (Fig. 1). This study provides abundant and comprehensive data that will help us better understand the impact of mutations in S protein, and may contribute to future design of potent vaccine candidate and monoclonal antibodies (mAbs). |
| publishDate |
2020 |
| dc.date.accessioned.none.fl_str_mv |
2020-09-30T20:09:50Z |
| dc.date.available.none.fl_str_mv |
2020-09-30T20:09:50Z |
| dc.date.created.none.fl_str_mv |
2020 |
| dc.type.local.spa.fl_str_mv |
Artículo |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.identifier.issn.spa.fl_str_mv |
2059-3635 |
| dc.identifier.other.spa.fl_str_mv |
https://doi.org/10.1038/s41392-020-00302-8 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12010/14038 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1038/s41392-020-00302-8 |
| identifier_str_mv |
2059-3635 |
| url |
https://doi.org/10.1038/s41392-020-00302-8 http://hdl.handle.net/20.500.12010/14038 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
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http://purl.org/coar/access_right/c_abf2 |
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Abierto (Texto Completo) |
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Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
| dc.format.extent.spa.fl_str_mv |
2 páginas |
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application/pdf |
| dc.publisher.spa.fl_str_mv |
Signal Transduction and Targeted Therapy |
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reponame:Expeditio Repositorio Institucional UJTL instname:Universidad de Bogotá Jorge Tadeo Lozano |
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Universidad de Bogotá Jorge Tadeo Lozano |
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Expeditio Repositorio Institucional UJTL |
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2020-09-30T20:09:50Z2020-09-30T20:09:50Z20202059-3635https://doi.org/10.1038/s41392-020-00302-8http://hdl.handle.net/20.500.12010/14038https://doi.org/10.1038/s41392-020-00302-8Using high-throughput pseudovirus assay in conjunction with neutralizing antibodies, Wang et al. investigated 80 natural variants and 26 glycosylation-spike (S) mutants of SARS-CoV-2 in terms of infectivity and antigenicity.1 They identified several mutations that can critically affect the virus infectivity and reactivity to neutralizing antibodies (Fig. 1). This study provides abundant and comprehensive data that will help us better understand the impact of mutations in S protein, and may contribute to future design of potent vaccine candidate and monoclonal antibodies (mAbs).2 páginasapplication/pdfengSignal Transduction and Targeted Therapyreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoSARS-CoV-2SARS-CoV-2 mutantsInfectivity and antigenicitySíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusProfiling and characterization of SARS-CoV-2 mutants’ infectivity and antigenicityArtículohttp://purl.org/coar/resource_type/c_2df8fbb1Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Wang, LinWang, LingZhuang, HuiTHUMBNAILs41392-020-00302-8.pdf.jpgs41392-020-00302-8.pdf.jpgIM Thumbnailimage/jpeg24510https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14038/3/s41392-020-00302-8.pdf.jpgb610166a2b34f8604ead171d7d39503dMD53open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14038/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open access20.500.12010/14038oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/140382021-03-17 19:51:23.963metadata only accessRepositorio Institucional - Universidad Jorge Tadeo Lozanoexpeditio@utadeo.edu.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 |