Biology and Pathogenesis of Legionella

Legionella pneumophila was first isolated as the causative agent of a deadly infectious pneumonia at a convention of the American Legion forty years ago. Since then, Legionnaires’ disease continues to be a significant public health concern. Today, our understanding of the Legionella genus, comprisin...

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Autores:
Tipo de recurso:
Book
Fecha de publicación:
2018
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/14227
Acceso en línea:
https://www.frontiersin.org/research-topics/4989/biology-and-pathogenesis-of-legionella
http://hdl.handle.net/20.500.12010/14227
Palabra clave:
Internal medicine
Science (General)
Legionnaires' Disease
Intravacuolar pathogen
Host-Pathogen Interactions
Dot/Icm effector
Legionella
Rights
License
Abierto (Texto Completo)
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dc.title.spa.fl_str_mv Biology and Pathogenesis of Legionella
title Biology and Pathogenesis of Legionella
spellingShingle Biology and Pathogenesis of Legionella
Internal medicine
Science (General)
Legionnaires' Disease
Intravacuolar pathogen
Host-Pathogen Interactions
Dot/Icm effector
Legionella
title_short Biology and Pathogenesis of Legionella
title_full Biology and Pathogenesis of Legionella
title_fullStr Biology and Pathogenesis of Legionella
title_full_unstemmed Biology and Pathogenesis of Legionella
title_sort Biology and Pathogenesis of Legionella
dc.subject.spa.fl_str_mv Internal medicine
Science (General)
topic Internal medicine
Science (General)
Legionnaires' Disease
Intravacuolar pathogen
Host-Pathogen Interactions
Dot/Icm effector
Legionella
dc.subject.lemb.spa.fl_str_mv Legionnaires' Disease
Intravacuolar pathogen
Host-Pathogen Interactions
dc.subject.keyword.spa.fl_str_mv Dot/Icm effector
Legionella
description Legionella pneumophila was first isolated as the causative agent of a deadly infectious pneumonia at a convention of the American Legion forty years ago. Since then, Legionnaires’ disease continues to be a significant public health concern. Today, our understanding of the Legionella genus, comprising environmental bacteria and opportunistic human pathogens, has dramatically increased. The study of how pathogenic Legionella interact with host cells, both protozoan and mammalian, has not only taught us about host-pathogen interactions but has revealed novel and unexpected insights into human cell biology and immunology. The capacity of pathogenic Legionella to commandeer cellular processes such as eukaryotic vesicular trafficking to establish an ER-like replicative niche, reflects the exquisite ability of this pathogen to manipulate eukaryotic cell biology in order to replicate in an intracellular compartment. This requires the specific and targeted action of a cohort of translocated bacterial effector proteins. In addition, we have learnt much about cell autonomous innate immune sensing of intracellular bacteria through the inability of L. pneumophila to avoid intracellular mammalian defense mechanisms.Now, in the age of large-scale comparative “omics”, it is clear that different Legionella species utilize different cohorts of effectors to replicate inside eukaryotic cells. While we understand some of the strategies employed by L. pneumophila and L. longbeachae to replicate within eukaryotic cells, there is still much to learn about many aspects of the Legionella life cycle.This Research Topic highlights the latest findings regarding the biology of Legionella species, their interactions with eukaryotic host cells, and how the application of various technologies has increased our understanding of this important pathogen.
publishDate 2018
dc.date.created.none.fl_str_mv 2018
dc.date.accessioned.none.fl_str_mv 2020-10-06T03:30:06Z
dc.date.available.none.fl_str_mv 2020-10-06T03:30:06Z
dc.type.local.spa.fl_str_mv Libro
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2f33
format http://purl.org/coar/resource_type/c_2f33
dc.identifier.isbn.none.fl_str_mv 978-2-88945-661-1
dc.identifier.issn.none.fl_str_mv 1664-8714
dc.identifier.other.none.fl_str_mv https://www.frontiersin.org/research-topics/4989/biology-and-pathogenesis-of-legionella
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/14227
dc.identifier.doi.none.fl_str_mv 10.3389/978-2-88945-661-1
identifier_str_mv 978-2-88945-661-1
1664-8714
10.3389/978-2-88945-661-1
url https://www.frontiersin.org/research-topics/4989/biology-and-pathogenesis-of-legionella
http://hdl.handle.net/20.500.12010/14227
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.references.none.fl_str_mv Newton, H., Hartland, E., Machner, M., eds. (2018). Biology and Pathogenesis of Legionella. Lausanne: Frontiers Media. doi: 10.3389/978-2-88945-661-1
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Abierto (Texto Completo)
dc.rights.creativecommons.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv Abierto (Texto Completo)
https://creativecommons.org/licenses/by/4.0/
http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 181 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Frontiers Media SA
institution Universidad de Bogotá Jorge Tadeo Lozano
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spelling 2020-10-06T03:30:06Z2020-10-06T03:30:06Z2018978-2-88945-661-11664-8714https://www.frontiersin.org/research-topics/4989/biology-and-pathogenesis-of-legionellahttp://hdl.handle.net/20.500.12010/1422710.3389/978-2-88945-661-1181 páginasapplication/pdfengFrontiers Media SAInternal medicineScience (General)Legionnaires' DiseaseIntravacuolar pathogenHost-Pathogen InteractionsDot/Icm effectorLegionellaBiology and Pathogenesis of LegionellaLibrohttp://purl.org/coar/resource_type/c_2f33Abierto (Texto Completo)https://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2Newton, H., Hartland, E., Machner, M., eds. (2018). Biology and Pathogenesis of Legionella. Lausanne: Frontiers Media. doi: 10.3389/978-2-88945-661-1Legionella pneumophila was first isolated as the causative agent of a deadly infectious pneumonia at a convention of the American Legion forty years ago. Since then, Legionnaires’ disease continues to be a significant public health concern. Today, our understanding of the Legionella genus, comprising environmental bacteria and opportunistic human pathogens, has dramatically increased. The study of how pathogenic Legionella interact with host cells, both protozoan and mammalian, has not only taught us about host-pathogen interactions but has revealed novel and unexpected insights into human cell biology and immunology. The capacity of pathogenic Legionella to commandeer cellular processes such as eukaryotic vesicular trafficking to establish an ER-like replicative niche, reflects the exquisite ability of this pathogen to manipulate eukaryotic cell biology in order to replicate in an intracellular compartment. This requires the specific and targeted action of a cohort of translocated bacterial effector proteins. In addition, we have learnt much about cell autonomous innate immune sensing of intracellular bacteria through the inability of L. pneumophila to avoid intracellular mammalian defense mechanisms.Now, in the age of large-scale comparative “omics”, it is clear that different Legionella species utilize different cohorts of effectors to replicate inside eukaryotic cells. While we understand some of the strategies employed by L. pneumophila and L. longbeachae to replicate within eukaryotic cells, there is still much to learn about many aspects of the Legionella life cycle.This Research Topic highlights the latest findings regarding the biology of Legionella species, their interactions with eukaryotic host cells, and how the application of various technologies has increased our understanding of this important pathogen.Newton, HayleyHartland, ElizabethMachner, MatthiasORIGINAL6611_BIOLOGY AND PATHOGENESIS.PDF6611_BIOLOGY AND PATHOGENESIS.PDFVer documentoapplication/pdf24803373https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14227/1/6611_BIOLOGY%20AND%20PATHOGENESIS.PDFffeeb0470a40a5782b6dd448838e985eMD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14227/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open accessTHUMBNAIL6611_BIOLOGY AND PATHOGENESIS.PDF.jpg6611_BIOLOGY AND PATHOGENESIS.PDF.jpgIM Thumbnailimage/jpeg27897https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14227/3/6611_BIOLOGY%20AND%20PATHOGENESIS.PDF.jpgf683eae3b9687993e025f54e508ad1feMD53open access20.500.12010/14227oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/142272021-02-22 22:19:39.354open accessRepositorio Institucional - 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