Computational and Experimental Approaches in Multi-Target Pharmacology

The next frontier in pharmacology is the development of multi-target strategies in which pathological processes are controlled by pharmacologically manipulating them at many different points at once. Designing multi-target strategies will require deep understanding of the complex physiology that und...

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Autores:
Tipo de recurso:
Book
Fecha de publicación:
2017
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/14207
Acceso en línea:
https://www.frontiersin.org/research topics/3524/computational-and-experimental-approaches-in-multi-target-pharmacology
http://hdl.handle.net/20.500.12010/14207
Palabra clave:
Science (General)
Therapeutics
Polypharmacy
Synergy
Systems biology
Drug combination
Drug repurposing
Multidrug therapeutics
Multifactorial process
Drug discovery
Computer modeling
High throughput screening
Rights
License
Abierto (Texto Completo)
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dc.title.spa.fl_str_mv Computational and Experimental Approaches in Multi-Target Pharmacology
title Computational and Experimental Approaches in Multi-Target Pharmacology
spellingShingle Computational and Experimental Approaches in Multi-Target Pharmacology
Science (General)
Therapeutics
Polypharmacy
Synergy
Systems biology
Drug combination
Drug repurposing
Multidrug therapeutics
Multifactorial process
Drug discovery
Computer modeling
High throughput screening
title_short Computational and Experimental Approaches in Multi-Target Pharmacology
title_full Computational and Experimental Approaches in Multi-Target Pharmacology
title_fullStr Computational and Experimental Approaches in Multi-Target Pharmacology
title_full_unstemmed Computational and Experimental Approaches in Multi-Target Pharmacology
title_sort Computational and Experimental Approaches in Multi-Target Pharmacology
dc.subject.spa.fl_str_mv Science (General)
Therapeutics
Polypharmacy
Synergy
Systems biology
topic Science (General)
Therapeutics
Polypharmacy
Synergy
Systems biology
Drug combination
Drug repurposing
Multidrug therapeutics
Multifactorial process
Drug discovery
Computer modeling
High throughput screening
dc.subject.lemb.spa.fl_str_mv Drug combination
Drug repurposing
Multidrug therapeutics
Multifactorial process
dc.subject.keyword.spa.fl_str_mv Drug discovery
Computer modeling
High throughput screening
description The next frontier in pharmacology is the development of multi-target strategies in which pathological processes are controlled by pharmacologically manipulating them at many different points at once. Designing multi-target strategies will require deep understanding of the complex physiology that underlies pathological processes. It will also require the development of single drugs with multiple targets, or combinations of drugs with compatible pharmacokinetics that work synergistically to maximize desirable effects while minimizing unwanted side effects. This e-Book contains ten original articles, each addressing a different aspect of this challenge. Together they open new perspectives and show the way forward in the development of multi-target therapeutics.
publishDate 2017
dc.date.created.none.fl_str_mv 2017
dc.date.accessioned.none.fl_str_mv 2020-10-05T19:19:57Z
dc.date.available.none.fl_str_mv 2020-10-05T19:19:57Z
dc.type.local.spa.fl_str_mv Libro
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2f33
format http://purl.org/coar/resource_type/c_2f33
dc.identifier.isbn.none.fl_str_mv 978-2-88945-252-1
dc.identifier.issn.none.fl_str_mv 1664-8714
dc.identifier.other.none.fl_str_mv https://www.frontiersin.org/research topics/3524/computational-and-experimental-approaches-in-multi-target-pharmacology
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/14207
dc.identifier.doi.none.fl_str_mv 10.3389/978-2-88945-252-1
identifier_str_mv 978-2-88945-252-1
1664-8714
10.3389/978-2-88945-252-1
url https://www.frontiersin.org/research topics/3524/computational-and-experimental-approaches-in-multi-target-pharmacology
http://hdl.handle.net/20.500.12010/14207
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.references.spa.fl_str_mv Anastasio, T. J., ed. (2017). Computational and Experimental Approaches in Multi-target Pharmacology. Lausanne: Frontiers Media. doi: 10.3389/978-2-88945-252-1
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Abierto (Texto Completo)
dc.rights.creativecommons.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv Abierto (Texto Completo)
https://creativecommons.org/licenses/by/4.0/
http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 124 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Frontiers Media SA
institution Universidad de Bogotá Jorge Tadeo Lozano
bitstream.url.fl_str_mv https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14207/1/2521_COMPUTATIONAL%20AND%20EXPERIMENTAL.PDF
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repository.name.fl_str_mv Repositorio Institucional - Universidad Jorge Tadeo Lozano
repository.mail.fl_str_mv expeditio@utadeo.edu.co
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spelling 2020-10-05T19:19:57Z2020-10-05T19:19:57Z2017978-2-88945-252-11664-8714https://www.frontiersin.org/research topics/3524/computational-and-experimental-approaches-in-multi-target-pharmacologyhttp://hdl.handle.net/20.500.12010/1420710.3389/978-2-88945-252-1124 páginasapplication/pdfengFrontiers Media SAScience (General)TherapeuticsPolypharmacySynergySystems biologyDrug combinationDrug repurposingMultidrug therapeuticsMultifactorial processDrug discoveryComputer modelingHigh throughput screeningComputational and Experimental Approaches in Multi-Target PharmacologyLibrohttp://purl.org/coar/resource_type/c_2f33Abierto (Texto Completo)https://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2Anastasio, T. J., ed. (2017). Computational and Experimental Approaches in Multi-target Pharmacology. Lausanne: Frontiers Media. doi: 10.3389/978-2-88945-252-1The next frontier in pharmacology is the development of multi-target strategies in which pathological processes are controlled by pharmacologically manipulating them at many different points at once. Designing multi-target strategies will require deep understanding of the complex physiology that underlies pathological processes. It will also require the development of single drugs with multiple targets, or combinations of drugs with compatible pharmacokinetics that work synergistically to maximize desirable effects while minimizing unwanted side effects. This e-Book contains ten original articles, each addressing a different aspect of this challenge. Together they open new perspectives and show the way forward in the development of multi-target therapeutics.Anastasio, Thomas J.ORIGINAL2521_COMPUTATIONAL AND EXPERIMENTAL.PDF2521_COMPUTATIONAL AND EXPERIMENTAL.PDFVer documentoapplication/pdf21915410https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14207/1/2521_COMPUTATIONAL%20AND%20EXPERIMENTAL.PDFe6ded265f5212ffee995d1346e007539MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82938https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14207/2/license.txtabceeb1c943c50d3343516f9dbfc110fMD52open accessTHUMBNAIL2521_COMPUTATIONAL AND EXPERIMENTAL.PDF.jpg2521_COMPUTATIONAL AND EXPERIMENTAL.PDF.jpgIM Thumbnailimage/jpeg24750https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/14207/3/2521_COMPUTATIONAL%20AND%20EXPERIMENTAL.PDF.jpgf7132709b1e56c0008a46f34d9156c71MD53open access20.500.12010/14207oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/142072021-02-23 15:26:03.928open accessRepositorio Institucional - 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