Computational and Experimental Approaches in Multi-Target Pharmacology
The next frontier in pharmacology is the development of multi-target strategies in which pathological processes are controlled by pharmacologically manipulating them at many different points at once. Designing multi-target strategies will require deep understanding of the complex physiology that und...
- Autores:
- Tipo de recurso:
- Book
- Fecha de publicación:
- 2017
- Institución:
- Universidad de Bogotá Jorge Tadeo Lozano
- Repositorio:
- Expeditio: repositorio UTadeo
- Idioma:
- eng
- OAI Identifier:
- oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/14207
- Acceso en línea:
- https://www.frontiersin.org/research topics/3524/computational-and-experimental-approaches-in-multi-target-pharmacology
http://hdl.handle.net/20.500.12010/14207
- Palabra clave:
- Science (General)
Therapeutics
Polypharmacy
Synergy
Systems biology
Drug combination
Drug repurposing
Multidrug therapeutics
Multifactorial process
Drug discovery
Computer modeling
High throughput screening
- Rights
- License
- Abierto (Texto Completo)
| Summary: | The next frontier in pharmacology is the development of multi-target strategies in which pathological processes are controlled by pharmacologically manipulating them at many different points at once. Designing multi-target strategies will require deep understanding of the complex physiology that underlies pathological processes. It will also require the development of single drugs with multiple targets, or combinations of drugs with compatible pharmacokinetics that work synergistically to maximize desirable effects while minimizing unwanted side effects. This e-Book contains ten original articles, each addressing a different aspect of this challenge. Together they open new perspectives and show the way forward in the development of multi-target therapeutics. |
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