A new pharmacological approach based on remdesivir aerosolized administration on SARS-CoV-2 pulmonary inflammation: A possible and rational therapeutic application☆,☆☆

The new zoonotic coronavirus (SARS-CoV-2) responsible for coronavirus disease (COVID-19) is a new strain of coronavirus not previously seen in humans and which appears to come from bat species. It originated in Wuhan, Hubei Province, China, and spread rapidly throughout the world, causing over 5,569...

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Autores:
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Bogotá Jorge Tadeo Lozano
Repositorio:
Expeditio: repositorio UTadeo
Idioma:
eng
OAI Identifier:
oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12142
Acceso en línea:
https://doi.org/10.1016/j.mehy.2020.109876
http://hdl.handle.net/20.500.12010/12142
Palabra clave:
SARS-CoV-2
COVID-19
Viral pneumonia
Aerosol vaporization and nebulization
Alcoholic gargle
Povidone-iodine gargle and eye drop
Remdesivir
IL-1/IL-6
Monoclonal antibody
Cytokine storm
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
Rights
License
Acceso restringido
id UTADEO2_0af497c142c4cf2611eb58d3d4354c54
oai_identifier_str oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12142
network_acronym_str UTADEO2
network_name_str Expeditio: repositorio UTadeo
repository_id_str
dc.title.spa.fl_str_mv A new pharmacological approach based on remdesivir aerosolized administration on SARS-CoV-2 pulmonary inflammation: A possible and rational therapeutic application☆,☆☆
title A new pharmacological approach based on remdesivir aerosolized administration on SARS-CoV-2 pulmonary inflammation: A possible and rational therapeutic application☆,☆☆
spellingShingle A new pharmacological approach based on remdesivir aerosolized administration on SARS-CoV-2 pulmonary inflammation: A possible and rational therapeutic application☆,☆☆
SARS-CoV-2
COVID-19
Viral pneumonia
Aerosol vaporization and nebulization
Alcoholic gargle
Povidone-iodine gargle and eye drop
Remdesivir
IL-1/IL-6
Monoclonal antibody
Cytokine storm
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
title_short A new pharmacological approach based on remdesivir aerosolized administration on SARS-CoV-2 pulmonary inflammation: A possible and rational therapeutic application☆,☆☆
title_full A new pharmacological approach based on remdesivir aerosolized administration on SARS-CoV-2 pulmonary inflammation: A possible and rational therapeutic application☆,☆☆
title_fullStr A new pharmacological approach based on remdesivir aerosolized administration on SARS-CoV-2 pulmonary inflammation: A possible and rational therapeutic application☆,☆☆
title_full_unstemmed A new pharmacological approach based on remdesivir aerosolized administration on SARS-CoV-2 pulmonary inflammation: A possible and rational therapeutic application☆,☆☆
title_sort A new pharmacological approach based on remdesivir aerosolized administration on SARS-CoV-2 pulmonary inflammation: A possible and rational therapeutic application☆,☆☆
dc.subject.spa.fl_str_mv SARS-CoV-2
COVID-19
Viral pneumonia
Aerosol vaporization and nebulization
Alcoholic gargle
Povidone-iodine gargle and eye drop
Remdesivir
IL-1/IL-6
Monoclonal antibody
Cytokine storm
topic SARS-CoV-2
COVID-19
Viral pneumonia
Aerosol vaporization and nebulization
Alcoholic gargle
Povidone-iodine gargle and eye drop
Remdesivir
IL-1/IL-6
Monoclonal antibody
Cytokine storm
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
dc.subject.lemb.spa.fl_str_mv Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
description The new zoonotic coronavirus (SARS-CoV-2) responsible for coronavirus disease (COVID-19) is a new strain of coronavirus not previously seen in humans and which appears to come from bat species. It originated in Wuhan, Hubei Province, China, and spread rapidly throughout the world, causing over 5,569,679 global cases and 351,866 deaths in almost every country in the world, including Europe, particularly Italy. In general, based on existing data published to date, 80.9% of patients infected with the virus develop mild infection; 13.8% severe pneumonia; 4.7% respiratory failure, septic shock or multi-organ failure; 3% of these cases are fatal. Critical patients have been shown to develop acute respiratory distress syndrome (ARDS) and hospitalization in intensive care units. The average age of patients admitted to hospital is 57–79 years, with one third half with an underlying disease. Asymptomatic infections have also been described, but their frequency is not known. SARSCoV-2 transmission is mainly airborne from one person to another via droplets. The data available so far seem to indicate that SARS-CoV-2 is capable of producing an excessive immune reaction in the host. The virus attacks type II pneumocytes in the lower bronchi through the binding of the Spike protein (S protein) to viral receptors, of which the angiotensin 2 conversion enzyme (ACE2) receptor is the most important. ACE2 receptor is widely expressed in numerous tissues, including the oropharynx and conjunctiva, but mostly distributed in ciliated bronchial epithelial cells and type II pneumocytes in the lower bronchi. The arrival of SARS-CoV-2 in the lungs causes severe primary interstitial viral pneumonia that can lead to the “cytokine storm syndrome”, a deadly uncontrolled systemic inflammatory response triggered by the activation of interleukin 6 (IL-6), whose effect is extensive lung tissue damage and disseminated intravascular coagulation (DIC), that are life-threatening for patients with COVID-19. In the absence of a therapy of proven efficacy, current management consists of off-label or compassionate use therapies based on antivirals, antiparasitic agents in both oral and parenteral formulation, anti-inflammatory drugs, oxygen therapy and heparin support and convalescent plasma. Like most respiratory viruses can function and replicate at low temperatures (i.e. 34–35 °C) and assuming viral thermolability of SARSCoV-2, local instillation or aerosol of antiviral (i.e. remdesivir) in humid heat vaporization (40°–41 °C) in the first phase of infection (phenotype I, before admission), both in asymptomatic but nasopharyngeal swab positive patients, together with antiseptic-antiviral oral gargles and povidone-iodine eye drops for conjunctiva (0,8–5% conjunctival congestion), would attack the virus directly through the receptors to which it binds, significantly decreasing viral replication, risk of evolution to phenotypes IV and V, reducing hospitalization and therefore death.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-08-24T15:21:25Z
dc.date.available.none.fl_str_mv 2020-08-24T15:21:25Z
dc.date.created.none.fl_str_mv 2020
dc.type.local.spa.fl_str_mv Artículo
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format http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.issn.spa.fl_str_mv 0306-9877
dc.identifier.other.spa.fl_str_mv https://doi.org/10.1016/j.mehy.2020.109876
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12010/12142
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1016/j.mehy.2020.109876
identifier_str_mv 0306-9877
url https://doi.org/10.1016/j.mehy.2020.109876
http://hdl.handle.net/20.500.12010/12142
dc.language.iso.spa.fl_str_mv eng
language eng
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dc.rights.local.spa.fl_str_mv Acceso restringido
rights_invalid_str_mv Acceso restringido
http://purl.org/coar/access_right/c_f1cf
dc.format.extent.spa.fl_str_mv 8 páginas
dc.format.mimetype.spa.fl_str_mv image/jepg
dc.publisher.spa.fl_str_mv Medical Hypotheses
dc.source.spa.fl_str_mv reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
instname_str Universidad de Bogotá Jorge Tadeo Lozano
institution Universidad de Bogotá Jorge Tadeo Lozano
reponame_str Expeditio Repositorio Institucional UJTL
collection Expeditio Repositorio Institucional UJTL
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spelling 2020-08-24T15:21:25Z2020-08-24T15:21:25Z20200306-9877https://doi.org/10.1016/j.mehy.2020.109876http://hdl.handle.net/20.500.12010/12142https://doi.org/10.1016/j.mehy.2020.109876The new zoonotic coronavirus (SARS-CoV-2) responsible for coronavirus disease (COVID-19) is a new strain of coronavirus not previously seen in humans and which appears to come from bat species. It originated in Wuhan, Hubei Province, China, and spread rapidly throughout the world, causing over 5,569,679 global cases and 351,866 deaths in almost every country in the world, including Europe, particularly Italy. In general, based on existing data published to date, 80.9% of patients infected with the virus develop mild infection; 13.8% severe pneumonia; 4.7% respiratory failure, septic shock or multi-organ failure; 3% of these cases are fatal. Critical patients have been shown to develop acute respiratory distress syndrome (ARDS) and hospitalization in intensive care units. The average age of patients admitted to hospital is 57–79 years, with one third half with an underlying disease. Asymptomatic infections have also been described, but their frequency is not known. SARSCoV-2 transmission is mainly airborne from one person to another via droplets. The data available so far seem to indicate that SARS-CoV-2 is capable of producing an excessive immune reaction in the host. The virus attacks type II pneumocytes in the lower bronchi through the binding of the Spike protein (S protein) to viral receptors, of which the angiotensin 2 conversion enzyme (ACE2) receptor is the most important. ACE2 receptor is widely expressed in numerous tissues, including the oropharynx and conjunctiva, but mostly distributed in ciliated bronchial epithelial cells and type II pneumocytes in the lower bronchi. The arrival of SARS-CoV-2 in the lungs causes severe primary interstitial viral pneumonia that can lead to the “cytokine storm syndrome”, a deadly uncontrolled systemic inflammatory response triggered by the activation of interleukin 6 (IL-6), whose effect is extensive lung tissue damage and disseminated intravascular coagulation (DIC), that are life-threatening for patients with COVID-19. In the absence of a therapy of proven efficacy, current management consists of off-label or compassionate use therapies based on antivirals, antiparasitic agents in both oral and parenteral formulation, anti-inflammatory drugs, oxygen therapy and heparin support and convalescent plasma. Like most respiratory viruses can function and replicate at low temperatures (i.e. 34–35 °C) and assuming viral thermolability of SARSCoV-2, local instillation or aerosol of antiviral (i.e. remdesivir) in humid heat vaporization (40°–41 °C) in the first phase of infection (phenotype I, before admission), both in asymptomatic but nasopharyngeal swab positive patients, together with antiseptic-antiviral oral gargles and povidone-iodine eye drops for conjunctiva (0,8–5% conjunctival congestion), would attack the virus directly through the receptors to which it binds, significantly decreasing viral replication, risk of evolution to phenotypes IV and V, reducing hospitalization and therefore death.8 páginasimage/jepgengMedical Hypothesesreponame:Expeditio Repositorio Institucional UJTLinstname:Universidad de Bogotá Jorge Tadeo LozanoSARS-CoV-2COVID-19Viral pneumoniaAerosol vaporization and nebulizationAlcoholic garglePovidone-iodine gargle and eye dropRemdesivirIL-1/IL-6Monoclonal antibodyCytokine stormSíndrome respiratorio agudo graveCOVID-19SARS-CoV-2CoronavirusA new pharmacological approach based on remdesivir aerosolized administration on SARS-CoV-2 pulmonary inflammation: A possible and rational therapeutic application☆,☆☆Artículohttp://purl.org/coar/resource_type/c_2df8fbb1Acceso restringidohttp://purl.org/coar/access_right/c_f1cfContini, CarloEnrica Gallenga, CarlaNeri, GiampieroMaritati, MartinaConti, PioORIGINALCaptura.PNGCaptura.PNGVer portadaimage/png197597https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12142/1/Captura.PNGca6ec9d5315b4297a930b1608ee3afe2MD51open accessA-new-pharmacological-approach-based-on-remdesivir-aerosolized-a_2020_Medica.pdfA-new-pharmacological-approach-based-on-remdesivir-aerosolized-a_2020_Medica.pdfArtículo reservadoapplication/pdf683583https://expeditiorepositorio.utadeo.edu.co/bitstream/20.500.12010/12142/3/A-new-pharmacological-approach-based-on-remdesivir-aerosolized-a_2020_Medica.pdf89ed7f093cefe8957df99d66d132a82aMD53embargoed access|||2200-08-24LICENSElicense.txtlicense.txttext/plain; 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