Age, gender, and percentage of circulating osteoprogenitor (COP) cells: The COP Study

Circulating osteoprogenitor (COP) cells are blood-borne cellswhich express a variety of osteoblasticmarkers and are able to formbone nodules in vivo.Whereas a high percentage of COP cells (%COP) is associatedwith vascular calcification, low %COP has been associated with disability and frailty. However, the reference range of %COP in age- and gender-matching populations, and the age-related changes in %COP remain unknown. A cross-sectional studywas undertaken in 144 healthy volunteers inWestern Sydney (20–90 year-old, 10male and 10 female subjects per decade). %COP was quantified by flow cytometry. A high inter-and intra-rater reliability was found. In average, in this healthy population average of %COP was 0.42. There was no significant difference in %COP among the age groups. Similarly, no significant difference was found in %COP with gender, weight, height or BMI. In addition, we identified a normal reference range of %COP of 0.1–3.8%. In conclusion, in addition to the identification of steady levels of COP cells with age, we also identified a normal reference range of %COP, which could be used in future studies looking at musculoskeletal diseases in older populations.

• Autores: Gunawardene, Piumali; Al Saedi, Ahmed; Singh, Lakshman; Bermeo, Sandra; Vogrin, Sara; Phu, Steven; Suriyaarachchi, Pushpa; Pignolo, Robert J.; Duque, Gustavo
• Fecha de publicación: 2017
• Institución: Universidad Simón Bolívar
• Repositorio: Repositorio Digital USB
• Idioma: eng
• OAI Identifier: oai:bonga.unisimon.edu.co:20.500.12442/1933
• Acceso en línea: http://hdl.handle.net/20.500.12442/1933
• Palabra clave: Osteosarcopenia; Stem cells; Musculoskeletal; Circulating osteoprogenitors
• License: licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional