Genetic variation underpinning ADHD risk in a caribbean community
Attention Deficit Hyperactivity Disorder (ADHD) is a highly heritable and prevalent neurodevelopmental disorder that frequently persists into adulthood. Strong evidence from genetic studies indicates that single nucleotide polymorphisms (SNPs) harboured in the ADGRL3 (LPHN3), SNAP25, FGF1, DRD4, and...
- Autores:
-
Puentes-Rozo, Pedro J.
Acosta-López, Johan E.
Cervantes-Henríquez, Martha L.
Martínez-Banfi, Martha L.
Mejia-Segura, Elsy
Sánchez-Rojas, Manuel
Anaya-Romero, Marco E.
Acosta-Hoyos, Antonio
García-Llinás, Guisselle A.
Mastronardi, Claudio A.
Pineda, David A.
Castellanos, F. Xavier
Arcos-Burgos, Mauricio
Vélez, Jorge I.
- Tipo de recurso:
- Fecha de publicación:
- 2019
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/3886
- Acceso en línea:
- https://hdl.handle.net/20.500.12442/3886
- Palabra clave:
- ADHD
ADGRL3
LPHN3
SNAP25
FGF1
Genetics
Caribbean community
FBAT
Predictive genomics
- Rights
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Genetic variation underpinning ADHD risk in a caribbean community |
| title |
Genetic variation underpinning ADHD risk in a caribbean community |
| spellingShingle |
Genetic variation underpinning ADHD risk in a caribbean community ADHD ADGRL3 LPHN3 SNAP25 FGF1 Genetics Caribbean community FBAT Predictive genomics |
| title_short |
Genetic variation underpinning ADHD risk in a caribbean community |
| title_full |
Genetic variation underpinning ADHD risk in a caribbean community |
| title_fullStr |
Genetic variation underpinning ADHD risk in a caribbean community |
| title_full_unstemmed |
Genetic variation underpinning ADHD risk in a caribbean community |
| title_sort |
Genetic variation underpinning ADHD risk in a caribbean community |
| dc.creator.fl_str_mv |
Puentes-Rozo, Pedro J. Acosta-López, Johan E. Cervantes-Henríquez, Martha L. Martínez-Banfi, Martha L. Mejia-Segura, Elsy Sánchez-Rojas, Manuel Anaya-Romero, Marco E. Acosta-Hoyos, Antonio García-Llinás, Guisselle A. Mastronardi, Claudio A. Pineda, David A. Castellanos, F. Xavier Arcos-Burgos, Mauricio Vélez, Jorge I. |
| dc.contributor.author.none.fl_str_mv |
Puentes-Rozo, Pedro J. Acosta-López, Johan E. Cervantes-Henríquez, Martha L. Martínez-Banfi, Martha L. Mejia-Segura, Elsy Sánchez-Rojas, Manuel Anaya-Romero, Marco E. Acosta-Hoyos, Antonio García-Llinás, Guisselle A. Mastronardi, Claudio A. Pineda, David A. Castellanos, F. Xavier Arcos-Burgos, Mauricio Vélez, Jorge I. |
| dc.subject.eng.fl_str_mv |
ADHD ADGRL3 LPHN3 SNAP25 FGF1 Genetics Caribbean community FBAT Predictive genomics |
| topic |
ADHD ADGRL3 LPHN3 SNAP25 FGF1 Genetics Caribbean community FBAT Predictive genomics |
| description |
Attention Deficit Hyperactivity Disorder (ADHD) is a highly heritable and prevalent neurodevelopmental disorder that frequently persists into adulthood. Strong evidence from genetic studies indicates that single nucleotide polymorphisms (SNPs) harboured in the ADGRL3 (LPHN3), SNAP25, FGF1, DRD4, and SLC6A2 genes are associated with ADHD. We genotyped 26 SNPs harboured in genes previously reported to be associated with ADHD and evaluated their potential association in 386 individuals belonging to 113 nuclear families from a Caribbean community in Barranquilla, Colombia, using family-based association tests. SNPs rs362990-SNAP25 (T allele; p = 2.46 10x-4), rs2282794-FGF1 (A allele; p = 1.33 10x-2), rs2122642-ADGRL3 (C allele, p = 3.5 10x-2), and ADGRL3 haplotype CCC (markers rs1565902-rs10001410-rs2122642, OR = 1.74, Ppermuted = 0.021) were significantly associated with ADHD. Our results confirm the susceptibility to ADHD conferred by SNAP25, FGF1, and ADGRL3 variants in a community with a significant African American component, and provide evidence supporting the existence of specific patterns of genetic stratification underpinning the susceptibility to ADHD. Knowledge of population genetics is crucial to define risk and predict susceptibility to disease. |
| publishDate |
2019 |
| dc.date.accessioned.none.fl_str_mv |
2019-09-03T15:34:39Z |
| dc.date.available.none.fl_str_mv |
2019-09-03T15:34:39Z |
| dc.date.issued.none.fl_str_mv |
2019 |
| dc.type.eng.fl_str_mv |
article |
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http://purl.org/coar/resource_type/c_6501 |
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20734409 |
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https://hdl.handle.net/20.500.12442/3886 |
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20734409 |
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https://hdl.handle.net/20.500.12442/3886 |
| dc.language.iso.eng.fl_str_mv |
eng |
| language |
eng |
| dc.rights.*.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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http://purl.org/coar/access_right/c_abf2 |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
| dc.publisher.eng.fl_str_mv |
Published by MDP |
| dc.source.spa.fl_str_mv |
Revista Cell Vol. 8 No. 8 (2019) |
| institution |
Universidad Simón Bolívar |
| dc.source.uri.spa.fl_str_mv |
https://doi.org/10.3390/cells8080907 |
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Puentes-Rozo, Pedro J.f5776586-b6b2-4086-8bed-3e4972516196Acosta-López, Johan E.b7a16ff4-ce8a-419c-a6ba-597013d207edCervantes-Henríquez, Martha L.fb444be3-6d82-40aa-8a3c-75f422f8ec66Martínez-Banfi, Martha L.1b81e373-3714-45ae-880d-823a74a8c415Mejia-Segura, Elsy93d20bbf-dfbf-45b5-8c91-f33f3b2764ccSánchez-Rojas, Manuel6fb45b46-3064-4222-9dbc-4c9687eea18fAnaya-Romero, Marco E.2570c3a6-1f6c-4501-ac81-5740e09a3213Acosta-Hoyos, Antonio09a6d3fe-f531-42c9-adfe-e782d15f43f6García-Llinás, Guisselle A.def109fc-2946-4278-b37e-b4cecbf804baMastronardi, Claudio A.55aa2248-59ef-49ea-9101-21682e3932a0Pineda, David A.7fa7af6f-d0cb-4f00-b3bf-d0b4188e1ffaCastellanos, F. Xavierfd693e91-0459-48e6-814f-030688b23568Arcos-Burgos, Mauriciob0eeb625-a6f6-4508-8925-309b5f765a14Vélez, Jorge I.83044e45-79cc-4eec-a9cc-72bf4514e76b2019-09-03T15:34:39Z2019-09-03T15:34:39Z201920734409https://hdl.handle.net/20.500.12442/3886Attention Deficit Hyperactivity Disorder (ADHD) is a highly heritable and prevalent neurodevelopmental disorder that frequently persists into adulthood. Strong evidence from genetic studies indicates that single nucleotide polymorphisms (SNPs) harboured in the ADGRL3 (LPHN3), SNAP25, FGF1, DRD4, and SLC6A2 genes are associated with ADHD. We genotyped 26 SNPs harboured in genes previously reported to be associated with ADHD and evaluated their potential association in 386 individuals belonging to 113 nuclear families from a Caribbean community in Barranquilla, Colombia, using family-based association tests. SNPs rs362990-SNAP25 (T allele; p = 2.46 10x-4), rs2282794-FGF1 (A allele; p = 1.33 10x-2), rs2122642-ADGRL3 (C allele, p = 3.5 10x-2), and ADGRL3 haplotype CCC (markers rs1565902-rs10001410-rs2122642, OR = 1.74, Ppermuted = 0.021) were significantly associated with ADHD. Our results confirm the susceptibility to ADHD conferred by SNAP25, FGF1, and ADGRL3 variants in a community with a significant African American component, and provide evidence supporting the existence of specific patterns of genetic stratification underpinning the susceptibility to ADHD. Knowledge of population genetics is crucial to define risk and predict susceptibility to disease.engPublished by MDPAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Revista CellVol. 8 No. 8 (2019)https://doi.org/10.3390/cells8080907ADHDADGRL3LPHN3SNAP25FGF1GeneticsCaribbean communityFBATPredictive genomicsGenetic variation underpinning ADHD risk in a caribbean communityarticlehttp://purl.org/coar/resource_type/c_6501Visser, S.; Bitsko, R.; Danielson, M.; Perou, R. Increasing prevalence of parent-reported attention-deficit/hyperactivity disorder among children—United States, 2003 and 2007. Mortal. Morb. Wkly. Rep. 2010, 59, 1439–1443.Jain, M.; Velez, J.I.; Acosta, M.T.; Palacio, L.G.; Balog, J.; Roessler, E.; Pineda, D.; Londono, A.C.; Palacio, J.D.; Arbelaez, A.; et al. A cooperative interaction between lphn3 and 11q doubles the risk for adhd. Mol. Psychiatry 2011, 17, 741–747Acosta, M.T.; Velez, J.I.; Bustamante, M.L.; Balog, J.Z.; Arco-Burgos, M.; Muenke, M. A two-locus genetic interaction between lphn3 and 11q predicts adhd severity and long-term outcome. Transl. Psychiatry 2011, 1, e17.Bukstein, O.G. Attention deficit hyperactivity disorder and substance use disorders. Curr. Top. Behav. Neurosci. 2012, 9, 145–172.Pelham,W.E., Jr.; Fabiano, G.A. Evidence-based psychosocial treatments for attention-deficit/hyperactivity disorder. J. Clin. Child. Adolesc. Psychol. 2008, 37, 184–214.Arcos-Burgos, M.; Jain, M.; Acosta, M.T.; Shively, S.; Stanescu, H.; Wallis, D.; Domene, S.; Velez, J.I.; Karkera, J.D.; Balog, J.; et al. A common variant of the latrophilin 3 gene, lphn3, confers susceptibility to adhd and predicts e ectiveness of stimulant medication. Mol. Psychiatry 2010, 15, 1053–1066.Sibley, M.H.; Pelham,W.E., Jr.; Molina, B.S.; Gnagy, E.M.;Waschbusch, D.A.; Garefino, A.C.; Kuriyan, A.B.; Babinski, D.E.; Karch, K.M. 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