Genetic variation underpinning ADHD risk in a caribbean community

Attention Deficit Hyperactivity Disorder (ADHD) is a highly heritable and prevalent neurodevelopmental disorder that frequently persists into adulthood. Strong evidence from genetic studies indicates that single nucleotide polymorphisms (SNPs) harboured in the ADGRL3 (LPHN3), SNAP25, FGF1, DRD4, and...

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Autores:
Puentes-Rozo, Pedro J.
Acosta-López, Johan E.
Cervantes-Henríquez, Martha L.
Martínez-Banfi, Martha L.
Mejia-Segura, Elsy
Sánchez-Rojas, Manuel
Anaya-Romero, Marco E.
Acosta-Hoyos, Antonio
García-Llinás, Guisselle A.
Mastronardi, Claudio A.
Pineda, David A.
Castellanos, F. Xavier
Arcos-Burgos, Mauricio
Vélez, Jorge I.
Tipo de recurso:
Fecha de publicación:
2019
Institución:
Universidad Simón Bolívar
Repositorio:
Repositorio Digital USB
Idioma:
eng
OAI Identifier:
oai:bonga.unisimon.edu.co:20.500.12442/3886
Acceso en línea:
https://hdl.handle.net/20.500.12442/3886
Palabra clave:
ADHD
ADGRL3
LPHN3
SNAP25
FGF1
Genetics
Caribbean community
FBAT
Predictive genomics
Rights
License
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Description
Summary:Attention Deficit Hyperactivity Disorder (ADHD) is a highly heritable and prevalent neurodevelopmental disorder that frequently persists into adulthood. Strong evidence from genetic studies indicates that single nucleotide polymorphisms (SNPs) harboured in the ADGRL3 (LPHN3), SNAP25, FGF1, DRD4, and SLC6A2 genes are associated with ADHD. We genotyped 26 SNPs harboured in genes previously reported to be associated with ADHD and evaluated their potential association in 386 individuals belonging to 113 nuclear families from a Caribbean community in Barranquilla, Colombia, using family-based association tests. SNPs rs362990-SNAP25 (T allele; p = 2.46 10x-4), rs2282794-FGF1 (A allele; p = 1.33 10x-2), rs2122642-ADGRL3 (C allele, p = 3.5 10x-2), and ADGRL3 haplotype CCC (markers rs1565902-rs10001410-rs2122642, OR = 1.74, Ppermuted = 0.021) were significantly associated with ADHD. Our results confirm the susceptibility to ADHD conferred by SNAP25, FGF1, and ADGRL3 variants in a community with a significant African American component, and provide evidence supporting the existence of specific patterns of genetic stratification underpinning the susceptibility to ADHD. Knowledge of population genetics is crucial to define risk and predict susceptibility to disease.

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