New insights on the role of connexins and Gap Junctions Channels in adipose tissue and Obesity
Due to the inability to curb the excessive increase in the prevalence of obesity and overweight, it is necessary to comprehend in more detail the factors involved in the pathophysiology and to appreciate more clearly the biochemical and molecular mechanisms of obesity. Thus, understanding the biolog...
- Autores:
-
González-Casanova, Jorge Enrique
Durán-Agüero, Samuel
Caro-Fuentes, Nelson Javier
Gamboa-Arancibia, Maria Elena
Tamara, Bruna
Bermúdez, Valmore
Rojas-Gómez, Diana Marcela
- Tipo de recurso:
- Fecha de publicación:
- 2021
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/13166
- Palabra clave:
- Connexins
Gap junctions channels
Adipose tissue
Obesity
Cardiovascular diseases
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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New insights on the role of connexins and Gap Junctions Channels in adipose tissue and Obesity |
| title |
New insights on the role of connexins and Gap Junctions Channels in adipose tissue and Obesity |
| spellingShingle |
New insights on the role of connexins and Gap Junctions Channels in adipose tissue and Obesity Connexins Gap junctions channels Adipose tissue Obesity Cardiovascular diseases |
| title_short |
New insights on the role of connexins and Gap Junctions Channels in adipose tissue and Obesity |
| title_full |
New insights on the role of connexins and Gap Junctions Channels in adipose tissue and Obesity |
| title_fullStr |
New insights on the role of connexins and Gap Junctions Channels in adipose tissue and Obesity |
| title_full_unstemmed |
New insights on the role of connexins and Gap Junctions Channels in adipose tissue and Obesity |
| title_sort |
New insights on the role of connexins and Gap Junctions Channels in adipose tissue and Obesity |
| dc.creator.fl_str_mv |
González-Casanova, Jorge Enrique Durán-Agüero, Samuel Caro-Fuentes, Nelson Javier Gamboa-Arancibia, Maria Elena Tamara, Bruna Bermúdez, Valmore Rojas-Gómez, Diana Marcela |
| dc.contributor.author.none.fl_str_mv |
González-Casanova, Jorge Enrique Durán-Agüero, Samuel Caro-Fuentes, Nelson Javier Gamboa-Arancibia, Maria Elena Tamara, Bruna Bermúdez, Valmore Rojas-Gómez, Diana Marcela |
| dc.subject.eng.fl_str_mv |
Connexins Gap junctions channels Adipose tissue Obesity Cardiovascular diseases |
| topic |
Connexins Gap junctions channels Adipose tissue Obesity Cardiovascular diseases |
| description |
Due to the inability to curb the excessive increase in the prevalence of obesity and overweight, it is necessary to comprehend in more detail the factors involved in the pathophysiology and to appreciate more clearly the biochemical and molecular mechanisms of obesity. Thus, understanding the biological regulation of adipose tissue is of fundamental relevance. Connexin, a protein that forms intercellular membrane channels of gap junctions and unopposed hemichannels, plays a key role in adipogenesis and in the maintenance of adipose tissue homeostasis. The expression and function of Connexin 43 (Cx43) during the different stages of the adipogenesis are differentially regulated. Moreover, it has been shown that cell–cell communication decreases dramatically upon differentiation into adipocytes. Furthermore, inhibition of Cx43 degradation or constitutive overexpression of Cx43 blocks adipocyte differentiation. In the first events of adipogenesis, the connexin is highly phosphorylated, which is likely associated with enhanced Gap Junction (GJ) communication. In an intermediate state of adipocyte differentiation, Cx43 phosphorylation decreases, as it is displaced from the membrane and degraded through the proteasome; thus, Cx43 total protein is reduced. Cx is involved in cardiac disease as well as in obesity-related cardiovascular diseases. Different studies suggest that obesity together with a high-fat diet are related to the production of remodeling factors associated with expression and distribution of Cx43 in the atrium. |
| publishDate |
2021 |
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2021 |
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2023-08-19T20:13:30Z |
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2023-08-19T20:13:30Z |
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info:eu-repo/semantics/article |
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Artículo científico |
| dc.identifier.citation.eng.fl_str_mv |
González-Casanova, J.E.; Durán-Agüero, S.; Caro-Fuentes, N.J.; Gamboa-Arancibia, M.E.; Bruna, T.; Bermúdez, V.; Rojas-Gómez, D.M. New Insights on the Role of Connexins and Gap Junctions Channels in Adipose Tissue and Obesity. Int. J. Mol. Sci. 2021, 22, 12145. https://doi.org/10.3390/ijms222212145 |
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14220067 |
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https://hdl.handle.net/20.500.12442/13166 |
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https://doi.org/10.3390/ijms222212145 |
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González-Casanova, J.E.; Durán-Agüero, S.; Caro-Fuentes, N.J.; Gamboa-Arancibia, M.E.; Bruna, T.; Bermúdez, V.; Rojas-Gómez, D.M. New Insights on the Role of Connexins and Gap Junctions Channels in Adipose Tissue and Obesity. Int. J. Mol. Sci. 2021, 22, 12145. https://doi.org/10.3390/ijms222212145 14220067 |
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https://hdl.handle.net/20.500.12442/13166 https://doi.org/10.3390/ijms222212145 |
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eng |
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openAccess |
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González-Casanova, Jorge Enrique7def9f01-d2eb-4070-8780-d0a6364210e0Durán-Agüero, Samuel9b230002-fae1-415b-800f-28692bd535a4Caro-Fuentes, Nelson Javierd6f6cd74-5397-48e2-9be4-d067a2ec84e9Gamboa-Arancibia, Maria Elena9fa75bf2-6ed2-4d38-b238-c5de16efc803Tamara, Brunae164aae4-c74d-44ce-8214-fb7b6fcb67a6Bermúdez, Valmore29f9aa18-16a4-4fd3-8ce5-ed94a0b8663aRojas-Gómez, Diana Marcelab1ebdaef-8f66-435e-a42c-cb80d01925e92023-08-19T20:13:30Z2023-08-19T20:13:30Z2021González-Casanova, J.E.; Durán-Agüero, S.; Caro-Fuentes, N.J.; Gamboa-Arancibia, M.E.; Bruna, T.; Bermúdez, V.; Rojas-Gómez, D.M. New Insights on the Role of Connexins and Gap Junctions Channels in Adipose Tissue and Obesity. Int. J. Mol. Sci. 2021, 22, 12145. https://doi.org/10.3390/ijms22221214514220067https://hdl.handle.net/20.500.12442/13166https://doi.org/10.3390/ijms222212145Due to the inability to curb the excessive increase in the prevalence of obesity and overweight, it is necessary to comprehend in more detail the factors involved in the pathophysiology and to appreciate more clearly the biochemical and molecular mechanisms of obesity. Thus, understanding the biological regulation of adipose tissue is of fundamental relevance. Connexin, a protein that forms intercellular membrane channels of gap junctions and unopposed hemichannels, plays a key role in adipogenesis and in the maintenance of adipose tissue homeostasis. The expression and function of Connexin 43 (Cx43) during the different stages of the adipogenesis are differentially regulated. Moreover, it has been shown that cell–cell communication decreases dramatically upon differentiation into adipocytes. Furthermore, inhibition of Cx43 degradation or constitutive overexpression of Cx43 blocks adipocyte differentiation. In the first events of adipogenesis, the connexin is highly phosphorylated, which is likely associated with enhanced Gap Junction (GJ) communication. In an intermediate state of adipocyte differentiation, Cx43 phosphorylation decreases, as it is displaced from the membrane and degraded through the proteasome; thus, Cx43 total protein is reduced. Cx is involved in cardiac disease as well as in obesity-related cardiovascular diseases. Different studies suggest that obesity together with a high-fat diet are related to the production of remodeling factors associated with expression and distribution of Cx43 in the atrium.pdfengMDPIAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2International Journal of Molecular SciencesVol. 20 Issue 22 (2021)ConnexinsGap junctions channelsAdipose tissueObesityCardiovascular diseasesNew insights on the role of connexins and Gap Junctions Channels in adipose tissue and Obesityinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Arroyo-Johnson, C.; Mincey, K.D. Obesity epidemiology worldwide. Gastroenterol. Clin. N. Am. 2017, 45, 571–579. [Google ScholarMello, M.M. Obesity—Personal choice or public health issue? Nat. Clin. Pract. Endocrinol. Metab. 2008, 4, 2–3. 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Cell Sci. 2014, 127, 455–464.Sorgen, P.L.; Trease, A.J.; Spagnol, G.; Delmar, M.; Nielsen, M.S. Protein-protein interactions with connexin 43: Regulation and function. Int. J. Mol. Sci. 2018, 19, 1428.Sáez, J.C.; Nairn, A.C.; Czernik, A.J.; Spray, D.C.; Hertzberg, E.L.; Greengard, P.; Bennett, M.V. Phosphorylation of connexin 32, a hepatocyte gap-junction protein, by cAMP-dependent protein kinase, protein kinase C and Ca2+/calmodulin-dependent protein kinase II. Eur. J. Biochem. 1990, 192, 263–273Peracchia, C. Calmodulin-mediated regulation of gap junction channels. Int. J. Mol. Sci. 2020, 21, 485. [Zou, J.; Salarian, M.; Chen, Y.; Veenstra, R.; Louis, C.F.; Yang, J.J. Gap junction regulation by calmodulin. FEBS Lett. 2014, 588, 1430–1438.Johnstone, S.R.; Kroncke, B.M.; Straub, A.C.; Best, A.K.; Dunn, C.A.; Mitchell, L.A.; Peskova, Y.; Nakamoto, R.K.; Koval, M.; Lo, C.W.; et al. MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation. 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