Sepsis neonatal

La sepsis neonatal es la causa más común de muertes neonatales con alta mortalidad a pesar del tratamiento, actualmente causan alrededor de 1,6 millones de muertes al año en los países en desarrollo. Esta patología se puede clasificar en dos subtipos dependiendo de la aparición de los síntomas. Hay...

Full description

Autores:
Agudelo Chalarca, Kely Vanessa
Tipo de recurso:
Fecha de publicación:
2014
Institución:
Universidad Simón Bolívar
Repositorio:
Repositorio Digital USB
Idioma:
spa
OAI Identifier:
oai:bonga.unisimon.edu.co:20.500.12442/14316
Acceso en línea:
https://hdl.handle.net/20.500.12442/14316
Palabra clave:
Sepsis neonatal (NS)
Infección bacteriana sistémica
Epidemiologia
Factores de riesgo neonatales
Rights
restrictedAccess
License
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
id USIMONBOL2_ec225ae45cebf63a9d99644cd153b2ff
oai_identifier_str oai:bonga.unisimon.edu.co:20.500.12442/14316
network_acronym_str USIMONBOL2
network_name_str Repositorio Digital USB
repository_id_str
dc.title.spa.fl_str_mv Sepsis neonatal
title Sepsis neonatal
spellingShingle Sepsis neonatal
Sepsis neonatal (NS)
Infección bacteriana sistémica
Epidemiologia
Factores de riesgo neonatales
title_short Sepsis neonatal
title_full Sepsis neonatal
title_fullStr Sepsis neonatal
title_full_unstemmed Sepsis neonatal
title_sort Sepsis neonatal
dc.creator.fl_str_mv Agudelo Chalarca, Kely Vanessa
dc.contributor.advisor.none.fl_str_mv González Torres, Henry J.
dc.contributor.author.none.fl_str_mv Agudelo Chalarca, Kely Vanessa
dc.subject.spa.fl_str_mv Sepsis neonatal (NS)
Infección bacteriana sistémica
Epidemiologia
Factores de riesgo neonatales
topic Sepsis neonatal (NS)
Infección bacteriana sistémica
Epidemiologia
Factores de riesgo neonatales
description La sepsis neonatal es la causa más común de muertes neonatales con alta mortalidad a pesar del tratamiento, actualmente causan alrededor de 1,6 millones de muertes al año en los países en desarrollo. Esta patología se puede clasificar en dos subtipos dependiendo de la aparición de los síntomas. Hay muchos factores que hacen que los recién nacidos más susceptible a la infección. Los signos de la sepsis en recién nacidos a menudo son inespecíficos y se necesita alto grado de sospecha para el diagnóstico precoz. Algunos parámetros de laboratorio pueden ser útiles para el tamizaje de sepsis neonatal, pero nada de esto es específico y lo suficientemente sensible como para ser utilizados por separado. El enfoque diagnóstico se centra principalmente en la historia y el examen de los signos y síntomas no específicos. La terapia con antibióticos es la base del tratamiento y la atención de apoyo es igualmente importante. El presente trabajo tiene como propósito identificar aspectos relevantes de la sepsis neonatal y su patogénesis. Para ello, se hizo búsquedas en Pubmed entre el año (2001-2014), el uso de palabras clave como sepsis, sepsis neonatal, shock séptico, patogénesis, incidencia. Ampliamos nuestra búsqueda siguiendo las referencias de los artículos identificados, se revisaron de forma individual los títulos de 120 artículos para identificar los temas principales, también hicimos búsquedas adicionales en base a palabras clave o conceptos que habían sido identificados en la búsqueda inicial. Los datos presentados se derivan directamente de los trabajos seleccionados y no han sido objeto de un mayor análisis estadístico Finalmente se organizaron las ideas con el conocimiento y la experiencia de nuestros propios campos, para preparar una breve revisión de las secciones con los temas de nuestro interés.
publishDate 2014
dc.date.issued.none.fl_str_mv 2014
dc.date.accessioned.none.fl_str_mv 2024-03-11T15:41:20Z
dc.date.available.none.fl_str_mv 2024-03-11T15:41:20Z
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/bachelorThesis
dc.type.spa.spa.fl_str_mv Trabajo de grado - pregrado
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12442/14316
url https://hdl.handle.net/20.500.12442/14316
dc.language.iso.spa.fl_str_mv spa
language spa
dc.rights.*.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/restrictedAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
http://purl.org/coar/access_right/c_16ec
eu_rights_str_mv restrictedAccess
dc.format.mimetype.spa.fl_str_mv pdf
dc.publisher.spa.fl_str_mv Ediciones Universidad Simón Bolívar
Facultad de Ciencias de la Salud
institution Universidad Simón Bolívar
bitstream.url.fl_str_mv https://bonga.unisimon.edu.co/bitstreams/fffa1a30-3cad-45e9-878b-d1236ac84a10/download
https://bonga.unisimon.edu.co/bitstreams/5d44a603-ea3c-47a1-87ce-d389bf845ead/download
https://bonga.unisimon.edu.co/bitstreams/d306e356-81a4-4692-a47d-91cb28c7a6c2/download
https://bonga.unisimon.edu.co/bitstreams/7931ddd0-cf48-4d7d-9baa-c98d5b39ee2b/download
https://bonga.unisimon.edu.co/bitstreams/6bab5b7b-5d90-4d99-86e8-3c1dab2368a5/download
https://bonga.unisimon.edu.co/bitstreams/99d74461-c705-44a8-95bc-9e5cddd2c04e/download
https://bonga.unisimon.edu.co/bitstreams/35f36049-360b-4d51-84a5-d57315c765a8/download
https://bonga.unisimon.edu.co/bitstreams/7f1059a9-ea7c-4783-b4c0-f43d0da1929d/download
https://bonga.unisimon.edu.co/bitstreams/96b1bc39-1403-4309-ab41-f223497d4da3/download
bitstream.checksum.fl_str_mv eddfba48ebf3f4974f4a890d8c49824f
4460e5956bc1d1639be9ae6146a50347
2a1661e5960a7bab4fd8dda692fb677c
1b93e55d938ab41073b02058cca4e9a2
1b93e55d938ab41073b02058cca4e9a2
1b93e55d938ab41073b02058cca4e9a2
c1baec0f21f3a63ff982bad7775a54ed
c1baec0f21f3a63ff982bad7775a54ed
c1baec0f21f3a63ff982bad7775a54ed
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
MD5
MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositorio Digital Universidad Simón Bolívar
repository.mail.fl_str_mv repositorio.digital@unisimon.edu.co
_version_ 1812100483602448384
spelling González Torres, Henry J.Agudelo Chalarca, Kely Vanessa44e86f3e-7397-46d4-a7b7-47c77d3626292024-03-11T15:41:20Z2024-03-11T15:41:20Z2014https://hdl.handle.net/20.500.12442/14316La sepsis neonatal es la causa más común de muertes neonatales con alta mortalidad a pesar del tratamiento, actualmente causan alrededor de 1,6 millones de muertes al año en los países en desarrollo. Esta patología se puede clasificar en dos subtipos dependiendo de la aparición de los síntomas. Hay muchos factores que hacen que los recién nacidos más susceptible a la infección. Los signos de la sepsis en recién nacidos a menudo son inespecíficos y se necesita alto grado de sospecha para el diagnóstico precoz. Algunos parámetros de laboratorio pueden ser útiles para el tamizaje de sepsis neonatal, pero nada de esto es específico y lo suficientemente sensible como para ser utilizados por separado. El enfoque diagnóstico se centra principalmente en la historia y el examen de los signos y síntomas no específicos. La terapia con antibióticos es la base del tratamiento y la atención de apoyo es igualmente importante. El presente trabajo tiene como propósito identificar aspectos relevantes de la sepsis neonatal y su patogénesis. Para ello, se hizo búsquedas en Pubmed entre el año (2001-2014), el uso de palabras clave como sepsis, sepsis neonatal, shock séptico, patogénesis, incidencia. Ampliamos nuestra búsqueda siguiendo las referencias de los artículos identificados, se revisaron de forma individual los títulos de 120 artículos para identificar los temas principales, también hicimos búsquedas adicionales en base a palabras clave o conceptos que habían sido identificados en la búsqueda inicial. Los datos presentados se derivan directamente de los trabajos seleccionados y no han sido objeto de un mayor análisis estadístico Finalmente se organizaron las ideas con el conocimiento y la experiencia de nuestros propios campos, para preparar una breve revisión de las secciones con los temas de nuestro interés.Neonatal sepsis is the most common cause of neonatal deaths with high mortality despite treatment, currently cause about 1.6 million deaths per year in developing countries. This condition can be classified into two subtypes depending on the onset of symptoms. There are many factors that make infants more susceptible to infection. Signs of sepsis in newborns are often nonspecific and high index of suspicion for early diagnosis is needed. Some laboratory parameters may be useful for screening for neonatal sepsis, but none of this is specific and sensitive enough to be used separately. The diagnostic approach focuses primarily on the history and examination of nonspecific signs and symptoms. Antibiotic therapy is the mainstay of treatment and supportive care is equally important. This paper aims to identify important aspects of neonatal sepsis and its pathogenesis. To do this, we searched PubMed between the year (2001-2014), using keywords such as sepsis, neonatal sepsis, septic shock, pathogenesis, incidence was. We extended our search following the references of identified articles were reviewed individually titles 120 articles to identify key issues, we also made additional searches based on key words or concepts that had been identified in the initial search. The data presented are derived directly from the selected works and have not been further statistical analysis. Finally ideas were organized with the knowledge and experience of our own fields, to prepare a brief review of the sections with topics of interest.pdfspaEdiciones Universidad Simón BolívarFacultad de Ciencias de la SaludAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/restrictedAccesshttp://purl.org/coar/access_right/c_16ecSepsis neonatal (NS)Infección bacteriana sistémicaEpidemiologiaFactores de riesgo neonatalesSepsis neonatalinfo:eu-repo/semantics/bachelorThesisTrabajo de grado - pregradohttp://purl.org/coar/resource_type/c_7a1fEsper AM, Martin GS: Extending international sepsis epidemiology: the impact of organ dysfunction. Crit Care 2009, 13(1):120Levy MM, Dellinger RP, Townsend SR, et al. The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med.Wong HR, Nowak JE, Standage S, de Oliveira CF. Sepsis and Septic Shock. In: Fuhrman BP, Zimmerman JJ, editors. Pediatric Critical Care Medicine. 4. St. Louis: Mosby; 2011. pp. 1413-1429.Vergnano S, Sharland M, Kazembe P, Mwansambo C, Heath PT. Neonatal sepsis: an international perspective. Arch Dis Child Fetal Neonatal Ed 2005; 90: 220-224.Thaver D, Zaidi AK. Burden of neonatal infections in developing countries: a review of evidence from community-based studies. Pediatr Infect Dis J 2009; 28(Suppl): S3-9.Puopolo KM, Eichenwald EC. No change in the incidence of ampicillinresistant, neonatal, early-onset sepsis over 18 years. Pediatrics. 2010; 125:e1031-1038. [PubMed: 20385650]Verani JR, McGee L, Schrag SJ. Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention. Prevention of perinatal group B streptococcal disease - revised guidelines from CDC, 2010. MMWR Recomm Rep. [PubMed: 21088663]Stoll BJ, Hansen NI, Sånchez PJ, et al. Early onset neonatal sepsis: the burden of Group B Streptococcal and E. colicontinues. Pediatrics. 2011; 127:817-826. [PubMed: 21518717]Anas AA, Wiersinga WJ, de Vos AF, van der Poll T. Recent insights into the pathogenesis of bacterial sepsis. Neth J Med. 2010 Apr;Lever, A. , Mackenzie, I. , Sepsis: definition, epidemiology, and diagnosis. Br. Med. J. 2007, 335, 879-883Nguyen, H. B. , Rivers, E. P. , Abrahamian, F. M. , Moran, G. J. et al., Severe sepsis and septic shock: review of the literatura and emergency department management guidelines. Ann. Emerg. Med. 2006, 48, 2854.Riedemann NC, Guo RF, Ward PA. The enigma of sepsis. J. Clin. Invest. 2003; [PubMed: 12925683]Levy MM, Fink MP, Marshall 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit. Care Med. 2003; [PubMed: 12682500]Howell MD, Talmor D, Schuetz P, Hunziker S, Jones AE, Shapiro NI. Proof of principle: the predisposition, infection, response, organ failure sepsis staging system. Crit. Care Med. 2011; 39(2):322-327. [PubMed: 21099424]Vincent JL, Sakr Y, Sprung CL, et al. Sepsis in European intensive care units: results of the SOAP study. Crit. Care Med. 2006; 34(2):344353. [PubMed: 16424713]Vincent JL, Rello J, Marshall J, et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA. 2009; [PubMed: 19952319]Danai P, Martin GS. Epidemiology of sepsis: recent advances. Curr. Infect. Dis. Rep. 2005; [PubMed:16107228]Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospitalization andmortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit.Care Med. 2007; 35(5):12441250. [PubMed:17414736]Finfer S, Bellomo R, Lipman J, French C, Dobb G, Myburgh J. Adultpopulation incidence of severe sepsis in Australian and New Zealand intensive care units. Intensive Care Med. [PubMed: 14963646]Adhikari NK, Fowler RA, Bhagwanjee S, Rubenfeld GD. Critical care and the global burden of critical illness in adults. Lancet. 2010; [PubMed: 20934212]Berkley JA, Maitland K, Mwangi I, et al. Use of clinical syndromes to target antibiotic prescribing in seriously ill children in malaria endemic area: observational study. BMJ. 2005; 15797893]Danai PA, Moss M, Mannino DM, Martin GS. The epidemiology of sepsis in patients with malignancy. Chest. 2006; 129(6):1432-1440. [PubMed: 16778259]Mayr FB, Yende S, Linde-Zwirble WT, et al. Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis. JAMA. 2010; [PubMed:20571016]Esper AM, Moss M, Lewis CA, Nisbet R, Mannino DM, Martin GS. The role of infection and comorbidity: factors that influence disparities in sepsis. Crit. Care Med. 2006; 16915108]Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Occurrence and outcomes of sepsis:influence of race. Crit. Care Med. 2007; 35(3):763768. [PubMed: 17255870]Danai PA, Sinha S, Moss M, Haber MJ, Martin GS. Seasonal variation in the epidemiology of sepsis. Crit. Care Med. 2007; 35(2):410-415. [PubMed: 17167351Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit. Care Med. 2006; 34(6):15891596. [PubMed: 16625125]Harbarth S, Garbino J, Pugin J, Romand JA, Lew D, Pittet D. Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis. Am. J. Med. 2003; [PubMed: 14599631]Garnacho-Montero J, Garcia-Garmendia JL, Barrero-Almodovar A, Jimenez-Jimenez FJ, Perez- Paredes C, Ortiz-Leyba C. Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis. Crit. Care Med. 2003; 14668610]Kumar A, Zarychanski R, Light B, et al. Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis. Crit. Care Med. 2010; [PubMed: 20639750]Dellinger RP, Carlet JM, Masur H, et al. Surviving sepsis campaign guidelines for management of severe sepsis and septic shock. Crit. Care Med. 2004; [PubMed: 15090974]Department at Children's Hospital Orange County Orange, California, USA, A Guide for the Caregiver of the Hospitalized Child. January 2004International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-IO). V012. Geneva, Switzerland: World Health Organization;2006Rodriguez F, Barrera L, De La Rosa G, Dennis R, Duenas C, Granados M, Londono D, Molina F, Ortiz G, Jaimes F: The epidemiology of sepsis in Colombia: a prospective multicenter cohort study in ten university hospitals. Crit Care Med 1675-1682Phares CR, Lynfield R, Farley MM, et al. Epidemiology of Invasive Group B Streptococcal Disease in the United States, 1999-2005. JAMA. 2008; 299:2056-2065. [PubMed: 18460666]Centers for Disease Control and Prevention. Prevention of perinatal group B streptococcal disease. MMWR. 2010;59:1-32.Weston EJ, Pondo T, Lewis MM, et al. The Burden of invasive earlyonset neonatal sepsis in the United States, 2005-2008. . Pediatr Infect Dis J.Vergnano S, Menson E, Kennea N, et al. Neonatal infections in England: the Neon IN surveillance network. Arch Dis Child Fetal Neonatal Ed.Clinical report of the American Academy of Pediatrics. Management of neonates with suspected of proven early-onset bacterial sepsis. Pediatrics. 2012; 129:1006-15Shankar MJ, Aggarwal R, Deorari AK, Paul VK. Symposium on AllMS protocol in Neonatology- Ill. Indian J Paediatr 2008;75:261-6.Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, et al. Late- onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. PediatricsKlinger G, Levy I, Sirota L, Boyko V, Reichman B, Lerner-Geva L. Epidemiology and risk factors for early onset sepsis among very-lowbirthweight infants. Am J Obstet Gynecol 2009;201:38.e1-6.Stroll BJ, Hansen NI, Sanchez PJ, Faix RG, Poindexter BB, Van Meurs KP, et al. Early onset neonatal sepsis: the burden of group B Streptococcal and E.coli diseasecontinues. Pediatics 2011;127:817-26.Salem SY, Sheiner E, Zmora E, Vardi H, Shoham-Vardi I, Mazor M. Risk factors for early neonatal sepsis. Arch Gynecol Obstet 274: 198-202. 2006Shin YJ, Ki M, Foxman B. Epidemiology of neonatal sepsis in South Korea. Pediatr Int 51: 225-232. 2009Wynn JL, Levy O. Role of innate host defenses in susceptibility to early-onset neonatal sepsis. Clin Perinatol 2010; 37: 307-337Shah GS, Budhathoki S, Das BK, Mandal RN. Risk factors in early neonatal sepsis. Kathmandu Univ Med J (KUMJ) 2006 Apr-Jun;4(2):187191. [PubMed: 18603896]Sharma R, Tepas JJ 3rd, Hudak ML, et al. Neonatal gut barrier and multiple organ failure: role of endotoxin and proinflammatory cytokines in sepsis and necrotizing enterocolitis. J Pediatr surg 2007 [PubMed: 17336180]Verboon-Maciolek MA, Krediet TG, Gerards LJ, Fleer A, van Loon TM. Clinical and epidemiologic characteristics of viral infections in a neonatal intensive care unit during a 12-year period. Pediatr Infect Dis J 2005 [PubMed: 16220089]Kawada J, Kimura H, Ito Y, et al. Evaluation of systemic inflammatory responses in neonates with herpes simplex virus infection. J Infect Dis 2004 Aug [PubMed:15243922C]Kermorvant-Duchemin E, Laborie S, Rabilloud M, Lapillonne A, Claris O. Outcome and prognostic factors in neonates with septic shock. Pediatr Crit Care Med 2008 [PubMed:18477932]Hyde TB, Hilger TM, Reingold A, Farley MM, O'Brien KL, Schuchat A. Trends in incidence and antimicrobial resistance of early-onset sepsis: population-based surveillance in San Francisco and Atlanta. pediatrics 2002 [PubMed: 12359781]Benjamin DK, DeLong E, Cotten CM, Garges HP, Steinbach WJ, Clark RH. Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia. J Perinatol 2004 [PubMed: 14985775]Benitz WE. Adjunct laboratory tests in the diagnosis of early-onset neonatal sepsis. Clin Perinatol 2010;37:421-38.M. T. Brady, "Health care-associated infections in the neonatal intensive care unit," American Journal of Infection Control, vol. 33, no. 5, pp. 268-275, 2005.P. L. Graham, M. D. Begg, E. Larson, P. Della-Latta, A. Allen, and L. Saiman, "Risk factors for late onset gram-negative sepsis in lowbirthweight infants hospitalized in the neonatal intensive care unit," The Pediatric Infectious Disease Journal, vol. 25, no. 2, pp. 113—117, 2006.J. S. Remington, J. O. Klein, C. B.Wilson, V. Nizet, and Y. A. Maldonado, "Staphylococcal infections," in Infectious Diseases of the Fetus and Newborn, pp. 489-505, Saunders (Elsevier), Philadelphia, Pa, USA,2011.V. Milisavljevic, F. Wu, J. Cimmotti et al., "Genetic relatedness of Staphylococcus epidermidis frominfected infants and staff in the neonatal intensive care unit," American Journal of Infection Control, vol. 33, no. 6, pp. 341-347, 2005.M. Liljedahl, J. Zimmermann, J. Schollin, and B. Soderquist, "Colonization pattern of coagulase-negative staphylococci in preterm neonates and the relation to bacteremia," European Journal of ClinicalMicrobiology & Infectious Diseases, vol. 29, no. 9, pp. 10851093, 2010V.Hira, R. F. Kornelisse, M. Sluijter et al., "Colonization dynamics of antibiotic-resistant coagulase-negative Staphylococci in neonates," Journal of Clinical Microbiology, vol. 51, no. 2, pp.595-597, 2013.T. Strunk, P. Richmond, K. Simmer, A. Currie, O. Levy, and D. Burgner, "Neonatal immune responses to coagulase-negative staphylococci," Current Opinion in Infectious Diseases, vol. 20,no. 4, pp. 370-375, 2007.A. A. Sharma, R. Jen, A. Butler, and P. M. Lavoie, "The developing human preterm neonatal immune system: a case for more research in this area," Clinical Immunology, vol. 145, no. l,pp. 61-68, 2012.O. Levy, "Innate immunity of the newborn: basic mechanisms and clinical correlates," Nature Reviews. Immunology, vol. 7, no.5, pp. 379390, 2007.A. A. Larson and J. G. H. Dinulos, "Cutaneous bacterial infections in the newborn," Current Opinion in Pediatrics, vol. 17, no. 4, pp. 481485, 2005S. J.McElroy and J. H.Weitkamp, "Innate immunity in the small intestine of the preterm infant," NeoReviews, vol. 12, no. 9, pp. e517e526, 2011.M. P. Sherman, S. H. Bennett, F. F. Y. Hwang, J. Sherman, and C. L. Bevins, "Paneth cells and antibacterial host defense in neonatal small intestine," Infection and Immunity, vol. 73, no. 9, pp. 6143-6146, 2005.H. J. L. Brooks, M. A. Mcconnell, and R. S. Broadbent, "Microbes and the inflammatory response in necrotising enterocolitis,"in Preterm Birth, O. Erez, Ed., pp. 137-174, lnTech, 2013.K. L. Schnabl, J. E. van Aerde, A. B. R. Thomson, and M. T.Clandinin, "Necrotizing enterocolitis: a multifactorial disease with no cure,"World Journal of Gastroenterology, vol. 14, no. 14, pp. 21422161, 2008.S. F.Wu, M. Caplan, and H. C. Lin, "Necrotizing enterocolitis: old problem with new hope," Pediatrics and Neonatology, vol. 53, no. 3, pp. 158-163, 2012J.M. Voyich, K. R. Braughton, D. E. Sturdevant et al., "Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils," Journal of Immunology, vol. 175, no. 6, pp. 39073919,2005.M. Bj"orkqvist, M. Jurstrand, L. Bodin, H. Fredlund, and J. Schollin, "Defective neutrophil oxidative burst in preterm newborns on exposure to coagulase-negative staphylococci," Pediatric Research, vol. 55, no. 6, pp. 966-971, 2004.C. C. Yost, M. J. Cody, E. S. Harris et al., "Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates," Blood, vol. 113, no. 25, pp. 6419-6427, 2009O. Takeuchi and S. Akira, "Pattern recognition receptors and inflammation," cell, vol. 140, no. 6, pp. 805-820, 2010.T. Kawai and S. Akira, "Toll-like receptors and their crosstalk with other innate receptors in infection and immunity," Immunity, vol. 34, no. 5, pp. 637-650, 2011.K. D. Kronforst, C. J. Mancuso, M. Pettengill et al., "A neonatal model of intravenous Staphylococcus epidermidis infection in mice <24 h old enables characterization of early innate immune responses," Plos one, vol. 7, no. 9,Article ID e43897, 2012.L. S. Miller and J. S. Cho, "Immunity against Staphylococcus aureus cutaneous infections," Nature Reviews Immunology, vol. 11, no. 8, pp. 505-518, 2011.Y. Lai, A. L. Cogen, K. A. Radek et al., "Activation of TLR2 by a small molecule produced by staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections," Journal of Investigative Dermatology, vol. 130, no. 9, pp. 2211-2221, 2010T. Strunk, A. Currie, P. Richmond, K. Simmer, andD. Burgner, "Innate immunity in human newborn infants: prematurity means more than immaturity," Journal of Maternal-Fetal and Neonatal Medicine, vol. 24, no. 1, pp. 25-31, 2011.P. M. Lavoie, Q. Huang, E. Jolette et al., "Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis," The Journal of Infectious Diseases, vol. 202, no. 11, pp. 1754-1763, 2010T. Strunk, A. Prosser, O. Levy et al., "Responsiveness of human monocytes to the commensal bacterium Staphylococcus epidermidis develops late in gestation," Pediatric Research, vol. 72, no. 1, pp. 1018, 2012.G. Y. C. Cheung, K. Rigby, R. Wang et al., "Staphylococcus epidermidis strategies to avoid killing by human neutrophils," PLOS Pathogens, vol. 6, no. 10, Article ID e1001133, 2010.T. J. Foster, "Immune evasion by staphylococci," Nature Reviews. Microbiology, vol. 3, no. 12, pp. 948-958, 2005.D.Mack, A. P. Davies, L. G.Harris, H. Rohde, M. A.Horstkotte, and J. K. M. Knobloch, "Microbial interactions in Staphylococcus epidermidis biofilms," Analytical and Bioanalytical Chemistry, vol. 387, no. 2, pp. 399-408, 2007.F. Guenther, P. Stroh, C. Wagner, U. Obst, and G. M. H" anch, "Phagocytosis of staphylococci biofilms by polymorphonuclear neutrophils: S. aureus and S. epidermidis differ with regard to their susceptibility towards the host defense," International Journal of Artificial Organs, vol. 32, no. 9, pp. 565-573, 2009.C. Klingenberg, E. Aarag, A. Rønnestad et al., "Coagulasenegative staphylococcal sepsis in neonates: association between antibiotic resistance, biofilm formation and the host inflammatory response," The Pediatric Infectious Disease Journal, vol. 24, no. 9, pp. 817-822, 2005.H. Rohde, S. Frankenberger, U. Z"ahringer, and D.Mack, "Structure, function and contribution of polysaccharide intercelular adhesin (PIA) to Staphylococcus epidermidis biofilm formation and pathogenesis of biomaterial-associated infections," European Journal of Cell Biology, vol. 89, no. 1, pp. 103-111, 2010.S. Kocianova, C. Vuong, Y. Yao et al., "Key role of poly-Y-DLglutamic acid in immune evasion and virulence of Staphylococcus epidermidis," Journal of Clinical Investigation, vol. 115, no. 3,pp. 688-694, 2005.M. Otto, "Staphylococcus colonization of the skin and antimicrobial peptides," Expert Review of Dermatology, vol. 5, no. 2,pp. 183-195, 2010.W. Ziebuhr, S. Hennig, M. Eckart, H. C. Batzilla, and S. Kozitskaya, "Nosocomial infections by Staphylococcus epidermidis: how a commensal bacterium turns into a pathogen," International Journal ofAntimicrobialAgents, vol. 28, supplement 1, pp. S14-S20, 2006.Mazzoni A, Young HA, Spitzer JH, Visintin A, Segal DM. Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization. J Clin Invest 2001 Dec; 108(12): 1865-1873. [PubMed: 11748270]Nguyen HB, Rivers EP, Abrahamian FM, Moran GJ, Abraham E, Trzeciak S, Huang DT, Osborn T, Stevens D, Talan DA; Severe sepsis and septic shock: review of the literature and emergency department management guidelines.; Ann Emerg Med. 2006 Jul;48(1):28-54Cribbs SK, Martin GS, Rojas M. Monitoring of endothelial dysfunction in critically ill patients: the role of endothelial progenitor cells. Curr Opin Crit Care 2008 Jun; [PubMed:18467899]James L. Wynn, MDa and Hector R. Wong, MDb. Pathophysiology and Treatment of Septic Shock in Neonates. Clin Perinatol. 2010 June; 37(2): 439-479.Plebani M, Piva E. Quality in laboratory diagnostics: from theory to practice. Biochem Med 2010;20:173-8.Mussap M, Degrandi R, Cataldi L, Fanos V, Plebani M. Biochemical markers for the early assessment of neonatal sepsis: the role of procalcitonin. J Chemother 2007;19:35-8.Yu Z, Liu J, Sun Q, Qiu J, Han S, Guo X. The accuracy of the procalcitonin test for the diagnosis of neonatal sepsis: a meta-analysis. Scand J Infect DisBhandari V, Wang C, Rinder C, Rinder H. Hematologic profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker. PediatricsWynn J, Cornell TT, Wong HR, Shaniey TP, Wheeler DS. The host response to sepsis and developmental impact. Pediatrics 2010; 125: 1031-1041.Nizet V, Klein JO. Bacterial sepsis and meningitis. In: Remington JS, Klein JO, Wilson CB, Nizet V, Maldonada YA (eds). Infectious Diseases of the Fetus and Newborn Infant (7th ed). Philadelphia: Elsevier; 2011: 222-275.Stoll BJ, Hansen NI, Higgins RD, et al. Very low birth weight preterm infants with early onset neonatal sepsis: the predominance of gram-negative infections continues in the National Institute of Child Health and Human Development Neonatal Research Network, 20022003. Pediatr Infect Dis J 2005 [PubMed: 15999007]Parker MM, Hazelzet JA, Carcillo JA. Pediatric considerations. Crit Care Med 2004 [PubMed: 15542968]Dempsey EM, Al Hazzani F, Barrington KJ. Permissive hypotension in the extremely low birthweight infant with signs of good perfusion. Arch Dis Child Fetal Neonatal Ed 2009 Jul;94 [PubMed: 19174413]Shankar MJ, Aggarwal R, Deorari AK, Paul VK. Symposium on AllMS protocol in Neonatology- Ill. Indian J Paediatr 2008;75:261-6.Alberto Dougnac L. Sepsis y Shock Séptico. Apuntes de Medicina Intensiva. Pontificia Universidad Catålica de Chile.2000;1-9Philip AGS (2003) Neonatal Meningitis in the New Millennium. NeoReviews 4:73-80Weber MW, Carlin JB, Gatchalian S, Lehmann D, Muhe L, Mulholland EK, et al. Predictors of neonatal sepsis in developing countries. Pediatr Infect Dis JM. O. Visscher, V. Narendran, W. L. Pickens et al., "Vernix caseosa in neonatal adaptation," Journal of Perinatology, vol. 25, no. 7, pp. 440446, 2005.Sede BarranquillaMedicinaORIGINALPDF.pdfPDF.pdfapplication/pdf18381646https://bonga.unisimon.edu.co/bitstreams/fffa1a30-3cad-45e9-878b-d1236ac84a10/downloadeddfba48ebf3f4974f4a890d8c49824fMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://bonga.unisimon.edu.co/bitstreams/5d44a603-ea3c-47a1-87ce-d389bf845ead/download4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-83000https://bonga.unisimon.edu.co/bitstreams/d306e356-81a4-4692-a47d-91cb28c7a6c2/download2a1661e5960a7bab4fd8dda692fb677cMD53TEXTSepsis_Neonatal.pdf.txtSepsis_Neonatal.pdf.txtExtracted texttext/plain120https://bonga.unisimon.edu.co/bitstreams/7931ddd0-cf48-4d7d-9baa-c98d5b39ee2b/download1b93e55d938ab41073b02058cca4e9a2MD54PDF.txtPDF.txtExtracted texttext/plain120https://bonga.unisimon.edu.co/bitstreams/6bab5b7b-5d90-4d99-86e8-3c1dab2368a5/download1b93e55d938ab41073b02058cca4e9a2MD56PDF.pdf.txtPDF.pdf.txtExtracted texttext/plain120https://bonga.unisimon.edu.co/bitstreams/99d74461-c705-44a8-95bc-9e5cddd2c04e/download1b93e55d938ab41073b02058cca4e9a2MD58THUMBNAILSepsis_Neonatal.pdf.jpgSepsis_Neonatal.pdf.jpgGenerated Thumbnailimage/jpeg2827https://bonga.unisimon.edu.co/bitstreams/35f36049-360b-4d51-84a5-d57315c765a8/downloadc1baec0f21f3a63ff982bad7775a54edMD55PDF.jpgPDF.jpgGenerated Thumbnailimage/jpeg2827https://bonga.unisimon.edu.co/bitstreams/7f1059a9-ea7c-4783-b4c0-f43d0da1929d/downloadc1baec0f21f3a63ff982bad7775a54edMD57PDF.pdf.jpgPDF.pdf.jpgGenerated Thumbnailimage/jpeg2827https://bonga.unisimon.edu.co/bitstreams/96b1bc39-1403-4309-ab41-f223497d4da3/downloadc1baec0f21f3a63ff982bad7775a54edMD5920.500.12442/14316oai:bonga.unisimon.edu.co:20.500.12442/143162024-08-14 21:52:50.497http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internacionalrestrictedhttps://bonga.unisimon.edu.coRepositorio Digital Universidad Simón Bolívarrepositorio.digital@unisimon.edu.co

Publicaciones similares