Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure
Cell cycle alterations are among the principle hallmarks of cancer. Consequently, the study of cell cycle regulators has emerged as an important topic in cancer research, particularly in relation to environmental exposure. Particulate matter and coal dust around coal mines have the potential to indu...
- Autores:
-
Torres-Ávila, Jose F.
Espitia-Pérez, Lyda
Bonatto, Diego
Rabaioli da Silva, Fernanda
Marques de Oliveira, Iuri
Silva, Luís F.O.
Silva Corrêa, Dione
Ferraz Dias, Johnny
da Silva, Juliana
Pêgas Henriques, João Antonio
- Tipo de recurso:
- Fecha de publicación:
- 2020
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/6152
- Acceso en línea:
- https://hdl.handle.net/20.500.12442/6152
http://dx.doi.org/10.1590/1678-4685-gmb-2019-0134
- Palabra clave:
- Coal
Cell cycle
Systems chemo-biology
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
| title |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
| spellingShingle |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure Coal Cell cycle Systems chemo-biology |
| title_short |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
| title_full |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
| title_fullStr |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
| title_full_unstemmed |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
| title_sort |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
| dc.creator.fl_str_mv |
Torres-Ávila, Jose F. Espitia-Pérez, Lyda Bonatto, Diego Rabaioli da Silva, Fernanda Marques de Oliveira, Iuri Silva, Luís F.O. Silva Corrêa, Dione Ferraz Dias, Johnny da Silva, Juliana Pêgas Henriques, João Antonio |
| dc.contributor.author.none.fl_str_mv |
Torres-Ávila, Jose F. Espitia-Pérez, Lyda Bonatto, Diego Rabaioli da Silva, Fernanda Marques de Oliveira, Iuri Silva, Luís F.O. Silva Corrêa, Dione Ferraz Dias, Johnny da Silva, Juliana Pêgas Henriques, João Antonio |
| dc.subject.eng.fl_str_mv |
Coal Cell cycle Systems chemo-biology |
| topic |
Coal Cell cycle Systems chemo-biology |
| description |
Cell cycle alterations are among the principle hallmarks of cancer. Consequently, the study of cell cycle regulators has emerged as an important topic in cancer research, particularly in relation to environmental exposure. Particulate matter and coal dust around coal mines have the potential to induce cell cycle alterations. Therefore, in the present study, we performed chemical analyses to identify the main compounds present in two mineral coal samples from Colombian mines and performed systems chemo-biology analysis to elucidate the interactions between these chemical compounds and proteins associated with the cell cycle. Our results highlight the role of oxidative stress generated by the exposure to the residues of coal extraction, such as major inorganic oxides (MIOs), inorganic elements (IEs) and polycyclic aromatic hydrocarbons (PAH) on DNA damage and alterations in the progression of the cell cycle (blockage and/or delay), as well as structural dysfunction in several proteins. In particular, IEs such as Cr, Ni, and S and PAHs such as benzo[a]pyrene may have influential roles in the regulation of the cell cycle through DNA damage and oxidative stress. In this process, cyclins, cyclin-dependent kinases, zinc finger proteins such as TP53, and protein kinases may play a central role. |
| publishDate |
2020 |
| dc.date.accessioned.none.fl_str_mv |
2020-07-05T14:20:33Z |
| dc.date.available.none.fl_str_mv |
2020-07-05T14:20:33Z |
| dc.date.issued.none.fl_str_mv |
2020 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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info:eu-repo/semantics/article |
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Artículo científico |
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16784685 |
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https://hdl.handle.net/20.500.12442/6152 |
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http://dx.doi.org/10.1590/1678-4685-gmb-2019-0134 |
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16784685 |
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https://hdl.handle.net/20.500.12442/6152 http://dx.doi.org/10.1590/1678-4685-gmb-2019-0134 |
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eng |
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eng |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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http://purl.org/coar/access_right/c_abf2 |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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pdf |
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Sociedade Brasileira de Genética |
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Genetics and Molecular Biology |
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Vol. 43 N° 3, (2020) |
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Universidad Simón Bolívar |
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Torres-Ávila, Jose F.49fdb30f-f869-4241-ab59-aa6cb8764e32Espitia-Pérez, Lyda8c646a69-2fd1-499d-9691-d31053b5bd0bBonatto, Diegoce824757-67db-4198-9820-40a856fd7a40Rabaioli da Silva, Fernandaf0305db6-c1ed-49bb-bf85-3442c0303e14Marques de Oliveira, Iuri7c384480-9878-46d1-91bc-c46f48ce98a4Silva, Luís F.O.1f9cc6e9-1769-4a8b-9123-dc2a6a069c27Silva Corrêa, Dione2989216c-3987-4a0e-9985-f51f56af923fFerraz Dias, Johnny50c20315-c564-4e3a-9605-0d47ba0cf353da Silva, Juliana9f32768b-932a-4f04-a9bd-41306619a841Pêgas Henriques, João Antonio2ac2cde7-854d-4e14-a6aa-c7a95bc7c1c52020-07-05T14:20:33Z2020-07-05T14:20:33Z202016784685https://hdl.handle.net/20.500.12442/6152http://dx.doi.org/10.1590/1678-4685-gmb-2019-0134Cell cycle alterations are among the principle hallmarks of cancer. Consequently, the study of cell cycle regulators has emerged as an important topic in cancer research, particularly in relation to environmental exposure. Particulate matter and coal dust around coal mines have the potential to induce cell cycle alterations. Therefore, in the present study, we performed chemical analyses to identify the main compounds present in two mineral coal samples from Colombian mines and performed systems chemo-biology analysis to elucidate the interactions between these chemical compounds and proteins associated with the cell cycle. Our results highlight the role of oxidative stress generated by the exposure to the residues of coal extraction, such as major inorganic oxides (MIOs), inorganic elements (IEs) and polycyclic aromatic hydrocarbons (PAH) on DNA damage and alterations in the progression of the cell cycle (blockage and/or delay), as well as structural dysfunction in several proteins. In particular, IEs such as Cr, Ni, and S and PAHs such as benzo[a]pyrene may have influential roles in the regulation of the cell cycle through DNA damage and oxidative stress. In this process, cyclins, cyclin-dependent kinases, zinc finger proteins such as TP53, and protein kinases may play a central role.pdfengSociedade Brasileira de GenéticaAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Genetics and Molecular BiologyVol. 43 N° 3, (2020)CoalCell cycleSystems chemo-biologySystems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposureinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Alfaro-Moreno E, Martínez L, García-Cuellar C, Bonner JC, Murray JC, Rosas I, Rosales SP and Osornio-Vargas AR (2002) Biologic effects induced in vitro by PM10 from three different zones of Mexico City. Environ Health Persp 110:715-720.Asweto CO, Wu J, Hu H, Feng L, Yang X, Duan J and Sun Z (2017) Combined Effect of Silica Nanoparticles and Benzo[a]pyrene on Cell Cycle Arrest Induction and Apoptosis in Human Umbilical Vein Endothelial Cells. Int J Environ Res Public Health 14:289.Azevedo H and Moreira-Filho CA (2015) Topological robustness analysis of protein interaction networks reveals key targets for overcoming chemotherapy resistance in glioma. Sci Rep-UK 5:16830.Bader GD and HogueCW(2003) An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics 4:2.Benjamini Y and Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc B Met 57:289-300.Bianchi M, Giacomini E, Crinelli R, Radici L, Carloni E and Magnani M (2015) Dynamic transcription of ubiquitin genes under basal and stressful conditions and new insights into the multiple UBC transcript variants. Gene 573:100-109.Billet S, Abbas I, Le Goff J, Verdin A, Andre V, Lafargue PE, Hachimi A, Cazier F, Sichel F, Shirali P and Garcon G (2008) Genotoxic potential of Polycyclic Aromatic Hydrocarbonscoated onto airborne Particulate Matter (PM 2.5) in human lung epithelial A549 cells. Cancer Lett 270:144-155.Blissett RS and Rowson NA (2012) A review of the multicomponent utilisation of coal fly ash. Fuel 97:1-23.Borm PJ (1997) Toxicity and occupational health hazards of coal fly ash (CFA). A review of data and comparison to coal mine dust. Ann Occup Hyg 41:659-676British Petroleum (2014) BP Statistical Review of World Energy. British Petroleum, London.Branzei D and FoianiM(2008) Regulation of DNA repair throughout the cell cycle. Nat Rev Mol Cell Bio 9:297-308.Bridges CC and Zalups RK (2005) Molecular and ionic mimicry and the transport of toxic metals. Toxicol Appl Pharmacol 204:274-308.Brook RD, Rajagopalan S, Pope CA 3rd, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA et al. (2010) Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation 121:2331-2378.Burch PM and Heintz NH (2005) Redox regulation of cell-cycle re-entry: cyclin D1 as a primary target for the mitogenic effects of reactive oxygen and nitrogen species. Antioxid Redox Signal 7:741-751.Callen MS, de la Cruz MT, Lopez JM, Navarro MV and Mastral AM (2009) Comparison of receptor models for source apportionment of the PM10 in Zaragoza (Spain). Chemosphere 76:1120-1129.Campbell JL, Boyd NI, Grassi N, Bonnick P and Maxwell JA (2010) The Guelph PIXE software package IV. Nucl Instrum Meth B 268:3356-3363.Cavalcante RM, de Lima DM, Correia LM, Nascimento RF, Silveira ER, Freire GS and Viana RB (2008) Técnicas de extrações e procedimentos de clean-up para a determinação de hidrocarbonetos policílicos aromáticos (HPA) em sedimentos da costa do Ceará. Quím Nova 31:1371-1377.Celik M, Donbak L, Unal F, Yuzbasioglu D, Aksoy H and Yilmaz S (2007) Cytogenetic damage in workers from a coal-fired power plant. Mutat Res 627:158-163.Chaulya S (2004) Assessment and management of air quality for an opencast coal mining area. J Environ Manage 70:1-14.Chiang HC and Tsou TC (2009) Arsenite enhances the benzo[a]pyrene diol epoxide (BPDE)-induced mutagenesis with no marked effect on repair of BPDE-DNA adducts in human lung cells. Toxicol In Vitro 23:897-905.Chiba S, Okayasu K, Tsuchiya K, Tamaoka M, Miyazaki Y, Inase N and Sumi Y (2017) The C-jun N-terminal kinase signaling pathway regulates cyclin D1 and cell cycle progression in airway smooth muscle cell proliferation. Int J Clin Exp Med 10:2252-2262.Choi WJ, Banerjee J, Falcone T, Bena J, Agarwal A and Sharma RK (2007) Oxidative stress and tumor necrosis factor-alphainduced alterations in metaphase II mouse oocyte spindle structure. Fertil Steril 88:1220-1231.Collins AR (2009) Investigating oxidative DNA damage and its repair using the comet assay. Mut Res 681:24–32.D’Angiolella V, Santarpia C and Grieco D (2007) Oxidative stress overrides the spindle checkpoint. Cell Cycle 6:576-579.da Silva J (2016) DNA damage induced by occupational and environmental exposure to miscellaneous chemicals. Mutat Res 770:170-182.Dasika GK, Lin SCJ, Zhao S, Sung P, Tomkinson A and Lee EY (1999) DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis. Oncog 18:7883-7899.de Kok TM, Hogervorst JG, Briede JJ, van Herwijnen MH, Maas LM, Moonen EJ, Driece HA and Kleinjans JC (2005) Genotoxicity and physicochemical characteristics of traffic-related ambient particulate matter. Environ Mol Mutagen 46:71-80.Espitia-Pérez L, da Silva J, Espitia-Pérez P, Brango H, Salcedo- Arteaga S, Hoyos-Giraldo LS, de Souza CT, Dias JF, Agudelo- Castañeda D, Valdés Toscano A et al. (2018) Cytogenetic instability in populations with residential proximity to open-pit coal mine in Northern Colombia in relation to PM10 and PM2.5 levels. Ecotox and Environ Saf 148:453-466.Feltes BC, de Faria Poloni J, Notari DL and Bonatto D (2013) Toxicological Effects of the Different Substances in Tobacco Smoke on Human Embryonic Development by a Systems Chemo-Biology Approach. PLoS ONE 8:e61743.Feng B, Jensen A, Bhatia SK and Dam-Johansen K (2003) Activation energy distribution of thermal annealing of a bituminous coal. Energ Fuel 17:399-404.Fischer JM, Robbins SB, Al-Zoughool M, Kannamkumarath SS, Stringer SL, Larson JS, Caruso JA, Talaska G, Stambrook PJ and Stringer JR (2005) Co-mutagenic activity of arsenic and benzo[a]pyrene in mouse skin. Mutat Res 588:35-46.Gauthier PT, Norwood WP, Prepas EE and Pyle GG (2015) Metal–polycyclic aromatic hydrocarbon mixture toxicity in Hyalella azteca. 2. Metal accumulation and oxidative stress as interactive co-toxic mechanisms. Environ Sci Technol 49:11780-11788.Gloscow EJ (2007) New Research on Genomic Instability. Nova Science Publishers, Nova York.Gualtieri M, Øvrevik J, Mollerup S, Asare N, Longhin E, Dahlman HJ, Camatini M and Holme JA (2011) Airborne urban particles (Milan winter-PM 2.5) cause mitotic arrest and cell death: effects on DNA, mitochondria, AhR binding and spindle organization. Mutat Res 713:18-31.Gutzkow KB, Langleite TM, Meier S, Graupner A, Collins AR and Brunborg G (2013) High-throughput comet assay using 96 minigels. Mutagen 28:333–40.Hartwig A, Asmuss M, Ehleben I, Herzer U, Kostelac D, Pelzer A, Schwerdtle T and BürkleA(2002) Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms. Environ Health Perspect 110 Suppl 5:797-799.Hartwig A and Schwerdtle T (2002) Interactions by carcinogenic metal compounds with DNA repair processes: toxicological implications. Toxicol Lett 127:47-54.Hsiao WL, Mo ZY, Fang M, ShiXMand Wang F (2000) Cytotoxicity of PM(2.5) and PM(2.5—10) ambient air pollutants assessed by the MTT and the Comet assays. Mutat Res 471:45-55.Huang YC, Rappold AG, Graff DW, Ghio AJ and Devlin RB (2012) Synergistic effects of exposure to concentrated ambient fine pollution particles and nitrogen dioxide in humans. Inhal Toxicol 24:790-797.Huertas JI, Huertas ME, Izquierdo S and González ED (2012a) Air quality impact assessment of multiple open pit coal mines in northern Colombia. J Environ Manage 93:121-129.Huertas JI, Huertas ME and Solis DA (2012b) Characterization of airborne particles in an open pit mining region. Sci Total Environ 423:39-46.Jensen LJ, Kuhn M, Stark M, Chaffron S, Creevey C, Muller J, Doerks T, Julien P, Roth A, Simonovic M et al. (2009) STRING 8—a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res 37:D412-416.Johansson SAE, Campbell JL and Malmqvist KG (1995) Particle- Induced X-Ray Emission Spectrometry (PIXE). Wiley-Blackwell, Hoboken.Kim SM, Lee HM, Hwang KA and Choi KC (2017) Benzo(a)pyrene induced cell cycle arrest and apoptosis in human choriocarcinoma cancer cells through reactive oxygen speciesinduced endoplasmic reticulum-stress pathway. Food Chem Toxicol 107:339-348.Kiskinis E, Suter W and Hartmann A (2002) High throughput comet assay using 96-well plates. Mutagen 17:37–43.Klein JA and Ackerman SL (2003) Oxidative stress, cell cycle, and neurodegeneration. J Clin Invest 111:785-793.Kocbach A, Herseth JI, Låg M, RefsnesMand Schwarze PE (2008) Particles from wood smoke and traffic induce differential pro-inflammatory response patterns in co-cultures. Toxicol Appl Pharmacol 232:317-326.Kothai P, Prathibha P, Saradhi I, Pandit G and Puranik V (2009) Characterization of atmospheric particulate matter using pixe technique. Int J Environ Sci Eng 3:39-42.Ku T, Chen M, Li B, Yun Y, LiGand SangN(2017) Synergistic effects of particulate matter (PM 2.5) and sulfur dioxide (SO 2) on neurodegeneration via the microRNA-mediated regulation of tau phosphorylation. Toxicol Res (Camb) 6:7-16.Kushwaha S, Vikram A, Trivedi PP and Jena GB (2011) Alkaline, Endo III and FPG modified comet assay as biomarkers for the detection of oxidative DNA damage in rats with experimentally induced diabetes. Mutat Res 726:242–250.Labranche N, El Khattabi C, Dewachter L, Dreyfuss C, Fontaine J, Van De Borne P, Berkenboom G and Pochet S (2012) Vascular oxidative stress induced by diesel exhaust microparticles: synergism with hypertension. J Cardiovasc Pharmacol 60:530-537.Lee D and Ryu KY (2017) Effect of cellular ubiquitin levels on the regulation of oxidative stress response and proteasome function via Nrf1. Biochem Biophys Res Commun 485:234-240.Leon-Mejia G, Espitia-Perez L, Hoyos-Giraldo LS, da Silva J, Hartmann A, Henriques JA and Quintana M (2011) Assessment of DNA damage in coal open-cast mining workers using the cytokinesis-blocked micronucleus test and the comet assay. Sci Total Environ 409:686-691.Leon-Mejia G, Silva LF, Civeira MS, Oliveira ML, Machado M, Villela IV, Hartmann A, Premoli S, Correa DS, da Silva J et al. (2016) Cytotoxicity and genotoxicity induced by coal and coal fly ash particles samples in V79 cells. Environ Sci Pollut Res Int 23:24019-24031.Lin MT and Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443:787-795.Lima M, Bouzid H, Soares DG, Selle F, Morel C, Galmarini CM, Henriques JAP, Larsen AK and Escargueil AE (2016) Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing theDNAdamage response and homologous recombination repair. Oncotarget 7:25885–25901.Liu G, Niu Z, Van Niekerk D, Xue J and Zheng L (2008) Polycyclic aromatic hydrocarbons (PAHs) from coal combustion: emissions, analysis, and toxicology. Rev Environ Contam Toxicol 192:1-28.Longhin E, Holme JA, Gutzkow KB, Arlt VM, Kucab JE, Camatini M and Gualtieri M (2013) Cell cycle alterations induced by urban PM2.5 in bronchial epithelial cells: characterization of the process and possible mechanisms involved. Part Fibre Toxicol 10:63.McNamee J (2000) Comet assay: rapid processing of multiple samples. Mutat Res Toxicol Environ Mutagen 466:63–9.Maere S, Heymans K and Kuiper M (2005) BiNGO: a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks. Bioinformatics 21:3448-3449.Meixner A, Karreth F, Kenner L, Penninger JM and Wagner EF (2010) Jun and JunD-dependent functions in cell proliferation and stress response. Cell Death Differ 17:1409-1419.Meng Z, Qin G and Zhang B (2005) DNA damage in mice treated with sulfur dioxide by inhalation. Environ Mol Mutagen 46:150-155.Meplan C, MannKand Hainaut P (1999) Cadmium induces conformational modifications of wild-type p53 and suppresses p53 response to DNA damage in cultured cells. J Biol Chem 274:31663-31670.Mouton-Liger F, Paquet C, Dumurgier J, Bouras C, Pradier L, Gray F and Hugon J (2012) Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2alpha pathway. Biochim Biophys Acta 1822:885-896.Muche A, Arendt T and Schliebs R (2017) Oxidative stress affects processing of amyloid precursor protein in vascular endothelial cells. PloS One 12:e0178127.Muthusamy S, Peng C and Ng JC (2018) Genotoxicity evaluation of multi-component mixtures of polyaromatic hydrocarbons (PAHs), arsenic, cadmium, and lead using flow cytometry based micronucleus test in HepG2 cells. Mutat Res Genet Toxicol Environ Mutagen 827:9-18.Nathan C and Cunningham-Bussel A (2013) Beyond oxidative stress: an immunologist’s guide to reactive oxygen species. Nat Rev Immunol 13:349-361.Nathan Y, Dvorachek M, Pelly I and Mimran U (1999) Characterization of coal fly ash from Israel. Fuel 78:205-213.Norrish K and Hutton JT (1969) An accurate X-ray spectrographic method for the analysis of a wide range of geological samples. Geochim Cosmochim Ac 33:431-453.Otto T and Sicinski P (2017) Cell cycle proteins as promising targets in cancer therapy. Nat Rev Cancer 17:93-115.Pandey B, AgrawalMand Singh S (2014) Assessment of air pollution around coal mining area: Emphasizing on spatial distributions, seasonal variations and heavy metals, using cluster and principal component analysis. Atmospheric Pollution Research 5:79-86Parker AL, Kavallaris M and McCarroll JA (2014) Microtubules and their role in cellular stress in cancer. Front Oncol 4:153.PearceAKand Humphrey TC (2001) Integrating stress-response and cell-cycle checkpoint pathways. Trends Cell Biol 11:426-433.Peng C, Muthusamy S, Xia Q, Lal V, Denison MS and Ng JC (2015) Micronucleus formation by single and mixed heavy metals/loids and PAH compounds in HepG2 cells. Mutagen 30:593-602.Poma A, Limongi T, Pisani C, Granato V and Picozzi P (2006) Genotoxicity induced by fine urban air particulate matter in the macrophages cell line RAW 264.7. Toxicol In Vitro 20:1023-1029.Pope CA 3rd, Burnett RT, Thun MJ, Calle EE, Krewski D, Ito K and Thurston GD (2002) Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. Jama 287:1132-1141.Pope CA 3rd, Burnett RT, Turner MC, Cohen A, Krewski D, Jerrett M, Gapstur SM and Thun MJ (2011) Lung cancer and cardiovascular disease mortality associated with ambient air pollution pollution and cigarette smoke: shape of the exposure-response relationships. Environ Health Perspect 119:1616-1621.Pope CA and DockeryDW(2006) Health effects of fine particulate air pollution: lines that connect. J Air Waste Manag Assoc 56:709-742.Prada-Fonseca M, Caicedo-Pineda G and Márquez-Godoy M (2016) Comparación del potencial oxidativo de Acidithiobacillus ferrooxidans, en un proceso de biodesulfurización de carbón. Rev Colomb Biotecnol 18:57-64.Prada-Fonseca M, Caicedo-Pineda G and Márquez-Godoy M (2016) Comparación del potencial oxidativo de Acidithiobacillus ferrooxidans, en un proceso de biodesulfurización de carbón. Rev Colomb Biotecnol 18:57-64.Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA et al. (2014) The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell 157:565-579.Pyo CW, Choi JH, Oh SM and Choi SY (2013) Oxidative stressinduced cyclin D1 depletion and its role in cell cycle processing. Biochim Biophys Acta 1830:5316-5325.Rebhan M, Chalifa-Caspi V, Prilusky J and Lancet D (1997) GeneCards: integrating information about genes, proteins and diseases. Trends Genet 13:163.Rieder CL (2011) Mitosis in vertebrates: the G2/M and M/A transitions and their associated checkpoints. Chromosome Res 19:291-306.Safran M, Dalah I, Alexander J, Rosen N, Iny Stein T, Shmoish M, Nativ N, Bahir I, Doniger T, Krug H et al. (2010) GeneCards Version 3: the human gene integrator. Database (Oxford) 2010:baq020.Sambandam B, Devasena T, Islam VI and Prakhya BM (2015) Characterization of coal fly ash nanoparticles and their induced in vitro cellular toxicity and oxidative DNA damage in different cell lines. Indian J Exp Biol 53:585-593.Savitsky PA and Finkel T (2002) Redox regulation of Cdc25C. Int J Biol Chem 277:20535-20540.Scardoni G, PetterliniMand Laudanna C (2009) Analyzing biological network parameters with CentiScaPe. Bioinformatics 25:2857-2859.Schins RP and Borm PJ (1999) Mechanisms and mediators in coal dust induced toxicity: a review. Ann Occup Hyg 43:7-33Schreiber M, Kolbus A, Piu F, Szabowski A, Möhle-Steinlein U, Tian J, Karin M, Angel P and Wagner EF (1999) Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev 13:607-619.Schweinsberg F and von Karsa L (1990) Heavy metal concentrations in humans. Comp Biochem Physiol C 95:117-123.Scott J (2017) Social Network Analysis. SAGE Publications, Nova York.Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13:2498-2504.Singh NP, McCoy MT, Tice R and Schneider EL (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184–91.Snel B, Lehmann G, Bork P and Huynen MA (2000) STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene. Nucleic Acids Res 28:3442-3444.Sun F, Littlejohn D and Gibson MD (1998) Ultrasonication extraction and solid phase extraction clean-up for determination of US EPA 16 priority pollutant polycyclic aromatic hydrocarbons in soils by reversed-phase liquid chromatography with ultraviolet absorption detection. Anal Chim Acta 364:1-11.Tice R, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae Y, Rojas E, Ryu JC and Sasaki YF (2000) Single-cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Env Mol Mutagen 35:206–21.Tran HP, Prakash AS, Barnard R, Chiswell B and Ng JC (2002) Arsenic inhibits the repair of DNA damage induced by benzo(a)pyrene. Toxicol Lett 133:59-67.Tucker JD and Ong TM (1985) Induction of sister chromatid exchanges by coal dust and tobacco snuff extracts in human peripheral lymphocytes. Environ Mutagen 7:313-324.Uren N, Yuksel S and Onal Y (2014) Genotoxic effects of sulfur dioxide in human lymphocytes. Toxicol Ind Health 30:311-315.Valko M, Rhodes CJ, Moncol J, Izakovic M and Mazur M (2006) Free radicals, metals and antioxidants in oxidative stressinduced cancer. Chem Biol Interact 160:1-40.Vasylkiv OY, Kubrak OI, Storey KB and Lushchak VI (2010) Cytotoxicity of chromium ions may be connected with induction of oxidative stress. Chemosphere 80:1044-1049.Wang X, McCullough KD, Franke TF and Holbrook NJ (2000) Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival. J Biol Chem 275:14624-14631.Wise SS and Wise JP (2010) Aneuploidy as an early mechanistic event in metal carcinogenesis. 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