Efecto genotóxico y susceptibilidad genética asociada a la exposición crónica a partículas emitidas de la minería de carbón en la Loma-Cesar
La exposición al polvo de la minería del carbón representa un riesgo sustancial para la salud de las personas debido a la compleja mezcla de componentes liberados durante el proceso de extracción entre los que se emiten a la atmósfera grandes cantidades de cenizas, metales, óxidos y de hidrocarburos...
- Autores:
-
Fiorillo Moreno, Ornella del Rosario
- Tipo de recurso:
- Fecha de publicación:
- 2024
- Institución:
- Universidad Simón Bolívar
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- Repositorio Digital USB
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- spa
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/14543
- Acceso en línea:
- https://hdl.handle.net/20.500.12442/14543
- Palabra clave:
- Carbón
Emisiones de partículas de minas
Daño oxidativo
Telómeros
Polimorfismos
Material particulado
Coal
Mine particulate emissions
Oxidative damage
Telomeres
Polymorphisms
Particulate matter
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- restrictedAccess
- License
- http://purl.org/coar/access_right/c_16ec
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Efecto genotóxico y susceptibilidad genética asociada a la exposición crónica a partículas emitidas de la minería de carbón en la Loma-Cesar |
| title |
Efecto genotóxico y susceptibilidad genética asociada a la exposición crónica a partículas emitidas de la minería de carbón en la Loma-Cesar |
| spellingShingle |
Efecto genotóxico y susceptibilidad genética asociada a la exposición crónica a partículas emitidas de la minería de carbón en la Loma-Cesar Carbón Emisiones de partículas de minas Daño oxidativo Telómeros Polimorfismos Material particulado Coal Mine particulate emissions Oxidative damage Telomeres Polymorphisms Particulate matter |
| title_short |
Efecto genotóxico y susceptibilidad genética asociada a la exposición crónica a partículas emitidas de la minería de carbón en la Loma-Cesar |
| title_full |
Efecto genotóxico y susceptibilidad genética asociada a la exposición crónica a partículas emitidas de la minería de carbón en la Loma-Cesar |
| title_fullStr |
Efecto genotóxico y susceptibilidad genética asociada a la exposición crónica a partículas emitidas de la minería de carbón en la Loma-Cesar |
| title_full_unstemmed |
Efecto genotóxico y susceptibilidad genética asociada a la exposición crónica a partículas emitidas de la minería de carbón en la Loma-Cesar |
| title_sort |
Efecto genotóxico y susceptibilidad genética asociada a la exposición crónica a partículas emitidas de la minería de carbón en la Loma-Cesar |
| dc.creator.fl_str_mv |
Fiorillo Moreno, Ornella del Rosario |
| dc.contributor.advisor.none.fl_str_mv |
León Mejía, Grethel Quintana Sosa, Milton |
| dc.contributor.author.none.fl_str_mv |
Fiorillo Moreno, Ornella del Rosario |
| dc.subject.spa.fl_str_mv |
Carbón Emisiones de partículas de minas Daño oxidativo Telómeros Polimorfismos Material particulado |
| topic |
Carbón Emisiones de partículas de minas Daño oxidativo Telómeros Polimorfismos Material particulado Coal Mine particulate emissions Oxidative damage Telomeres Polymorphisms Particulate matter |
| dc.subject.eng.fl_str_mv |
Coal Mine particulate emissions Oxidative damage Telomeres Polymorphisms Particulate matter |
| description |
La exposición al polvo de la minería del carbón representa un riesgo sustancial para la salud de las personas debido a la compleja mezcla de componentes liberados durante el proceso de extracción entre los que se emiten a la atmósfera grandes cantidades de cenizas, metales, óxidos y de hidrocarburos aromáticos policíclicos (HAP) lo que tiene diversos efectos a los ecosistemas naturales y las poblaciones humanas circundantes. Este estudio evalúo los efectos genotóxicos, longitud de telómeros y susceptibilidad genética asociada a la exposición crónica a partículas emitidas de minería de carbón en la Loma-Cesar. En esta investigación se incluyeron 150 personas expuestas al área de influencia a las minas de carbón de la Loma-Cesar y 120 personas que, por su tipo de trabajo, no están expuestas a fuentes industriales relacionadas con actividades de minería de carbón de la Ciudad de Barranquilla. Los resultados obtenidos en el ensayo cometa demuestran un mayor daño oxidativo en la población expuesta de la Loma-Cesar comparado con el grupo control; en el análisis de micronúcleos en linfocitos de sangre periférica fue encontrada una mayor formación de micronúcleos en el grupo expuesto, además, se evidenció telómeros significativamente más cortos en el grupo expuesto de la Loma-Cesar comparado con el grupo control. Se analizó mediante genotipificación por espectrometría de masas Maldi Tof, el polimorfismo ERCC2 Asp711Asp (rs1052555) de la vía de reparación de escisión de nucleótidos (NER), el polimorfismo del metabolismo AHR Arg554Lys (rs2066853), y los proinflamatorios IFNɣ G>A (rs2069705), Il12B T>G (rs3212227), CXCL8 A>T (rs4073). Así mismo, fue encontrado en el grupo expuesto una significativa correlación entre la presencia del polimorfismo del gen ERCC2 Asp711Asp y el daño oxidativo detectado con el ensayo cometa; los genes IL1-β-31T>C y ERCC2 Asp711Asp con la frecuencia de micronúcleos en linfocitos; y los genes IL1-B-31T>C, INFɣ G>A, CXCL8 A>T y AHR Arg554Lys en la longitud de telómeros. En los resultados del grupo control solo hubo una correlación significativa entre la presencia del polimorfismo del gen ERCC2 Asp711Asp y CXCL8 A>T y los niveles de daño oxidativo detectados con el ensayo cometa. Estos hallazgos pueden contribuir significativamente a la comprensión de los impactos de la minería del carbón en la salud humana y subrayan la importancia de estrategias preventivas y de intervención, lo cual a su vez tendría un impacto significativo en la salud pública y la calidad de vida de las personas expuestas. |
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2024 |
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2024-04-25T16:45:42Z |
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2024-04-25T16:45:42Z |
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2024 |
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2050-25-04 |
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info:eu-repo/semantics/doctoralThesis |
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Tesis de doctorado |
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Ediciones Universidad Simón Bolívar Facultad de Ciencias Básicas y Biomédicas |
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Universidad Simón Bolívar |
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León Mejía, GrethelQuintana Sosa, MiltonFiorillo Moreno, Ornella del Rosario3137b9b9-3fce-4ee0-bcd3-25dc29a42338-12050-25-042024-04-25T16:45:42Z2024-04-25T16:45:42Z2024https://hdl.handle.net/20.500.12442/14543La exposición al polvo de la minería del carbón representa un riesgo sustancial para la salud de las personas debido a la compleja mezcla de componentes liberados durante el proceso de extracción entre los que se emiten a la atmósfera grandes cantidades de cenizas, metales, óxidos y de hidrocarburos aromáticos policíclicos (HAP) lo que tiene diversos efectos a los ecosistemas naturales y las poblaciones humanas circundantes. Este estudio evalúo los efectos genotóxicos, longitud de telómeros y susceptibilidad genética asociada a la exposición crónica a partículas emitidas de minería de carbón en la Loma-Cesar. En esta investigación se incluyeron 150 personas expuestas al área de influencia a las minas de carbón de la Loma-Cesar y 120 personas que, por su tipo de trabajo, no están expuestas a fuentes industriales relacionadas con actividades de minería de carbón de la Ciudad de Barranquilla. Los resultados obtenidos en el ensayo cometa demuestran un mayor daño oxidativo en la población expuesta de la Loma-Cesar comparado con el grupo control; en el análisis de micronúcleos en linfocitos de sangre periférica fue encontrada una mayor formación de micronúcleos en el grupo expuesto, además, se evidenció telómeros significativamente más cortos en el grupo expuesto de la Loma-Cesar comparado con el grupo control. Se analizó mediante genotipificación por espectrometría de masas Maldi Tof, el polimorfismo ERCC2 Asp711Asp (rs1052555) de la vía de reparación de escisión de nucleótidos (NER), el polimorfismo del metabolismo AHR Arg554Lys (rs2066853), y los proinflamatorios IFNɣ G>A (rs2069705), Il12B T>G (rs3212227), CXCL8 A>T (rs4073). Así mismo, fue encontrado en el grupo expuesto una significativa correlación entre la presencia del polimorfismo del gen ERCC2 Asp711Asp y el daño oxidativo detectado con el ensayo cometa; los genes IL1-β-31T>C y ERCC2 Asp711Asp con la frecuencia de micronúcleos en linfocitos; y los genes IL1-B-31T>C, INFɣ G>A, CXCL8 A>T y AHR Arg554Lys en la longitud de telómeros. En los resultados del grupo control solo hubo una correlación significativa entre la presencia del polimorfismo del gen ERCC2 Asp711Asp y CXCL8 A>T y los niveles de daño oxidativo detectados con el ensayo cometa. Estos hallazgos pueden contribuir significativamente a la comprensión de los impactos de la minería del carbón en la salud humana y subrayan la importancia de estrategias preventivas y de intervención, lo cual a su vez tendría un impacto significativo en la salud pública y la calidad de vida de las personas expuestas.Exposure to coal mining dust represents a substantial risk to human health due to the complex mixture of components released during the extraction process among which large amounts of ash, metals, oxides and polycyclic aromatic hydrocarbons (PAHs) are emitted into the atmosphere with diverse effects on natural ecosystems and surrounding human populations. This study evaluated the genotoxic effects, telomere length and genetic susceptibility associated with chronic exposure to particulate matter emitted from coal mining in Loma-Cesar. This research included 150 people exposed to the area of influence of the coal mines of La Loma-Cesar and 120 people who, due to their type of work, are not exposed to industrial sources of coal mining activity in the city of Barranquilla. The results obtained in the comet assay show a greater oxidative damage in the exposed population of Loma-Cesar compared to the control group; in the analysis of micronuclei in peripheral blood lymphocytes, a greater formation of micronuclei was found in the exposed group; in addition, significantly shorter telomeres were evidenced in the exposed group of Loma-Cesar compared to the control group. The ERCC2 Asp711Asp (rs1052555) polymorphism of the nucleotide excision repair (NER) pathway was analyzed by Maldi Tof mass spectrometry genotyping, the AHR metabolism polymorphism Arg554Lys (rs2066853), and the proinflammatory IFNɣ G>A (rs2069705), Il-12B T>G (rs3212227), CXCL8 A>T (rs4073). Likewise, a significant correlation was found in the exposed group between the presence of the ERCC2 Asp711Asp gene polymorphism and oxidative damage detected with the comet assay; the IL1-β-31T>C and ERCC2 Asp711Asp genes with the frequency of micronuclei in lymphocytes; and the IL1- B-31T>C, INFɣ G>A, CXCL8 A>T and AHR Arg554Lys genes in telomere length. In the control group results there was only a significant correlation between the presence of the ERCC2 Asp711Asp and CXCL8 A>T gene polymorphism and the levels of oxidative damage detected with the comet assay. These findings may contribute significantly to the understanding of the impacts of coal mining on human health and underline the importance of preventive and intervention strategies, which in turn would have a significant impact on public health and the quality of life of exposed individualspdfspaEdiciones Universidad Simón BolívarFacultad de Ciencias Básicas y BiomédicasCarbónEmisiones de partículas de minasDaño oxidativoTelómerosPolimorfismosMaterial particuladoCoalMine particulate emissionsOxidative damageTelomeresPolymorphismsParticulate matterEfecto genotóxico y susceptibilidad genética asociada a la exposición crónica a partículas emitidas de la minería de carbón en la Loma-Cesarinfo:eu-repo/semantics/restrictedAccesshttp://purl.org/coar/access_right/c_16ecinfo:eu-repo/semantics/doctoralThesisTesis de doctoradohttp://purl.org/coar/resource_type/c_db06Maya Muñoz G. Cambio climático: ¿la humanidad culpable? Ens Econ. 2020 Jun;30(56):7–10. https://doi.org/10.15446/ede.v30n56.87109Martínez Medina MA, López Monroy J, Díaz Godoy RV, Moreno Alcántara J, Martínez Medina MA, López Monroy J, et al. ESTUDIO ESPACIAL DEL CARBONO ELEMENTAL PRESENTE EN LA FRACCIÓN RESPIRABLE DE LAS PM2.5 MEDIANTE ESPECTROMETRÍA DE RETRODISPERSIÓN DE RUTHERFORD EN LA ZONA METROPOLITANA DEL VALLE DE TOLUCA. Rev Int Contam Ambient. 2020;36(4):893–905. https://doi.org/10.20937/RICA.53521Ruiz-Bautista C. El impacto del carbón mineral en la salud humana - Carlota Ruiz-Bautista [Internet]. IIDMA. 2022 [cited 2023 Dec 17]. Available from: https://iidma.org/impacto-del-carbon-mineral-en-la-salud-humana/Paz M, Magdaleno A, Tornello C, Balbis N, Moretton J. Genotoxicidad y determinación de compuestos tóxicos en un residuo líquido hospitalario de Buenos Aires, Argentina. Rev Int Contam Ambient. 2008 May;24(2):79 –87. http://www.scielo.org.mx/scielo.php?script=sci_abstract&pid=S0188 - 49992008000200004&lng=es&nrm=iso&tlng=esRodríguez-Rey A, Noris-García E, Fundora Torres MT. Principios y relevancia del ensayo cometa. Rev Cuba Investig Bioméd. 2016 Jun;35(2):184– 94. http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S0864 - 03002016000200007&lng=es&nrm=iso&tlng=esZalacain M, Sierrasesúmaga L, Patiño A. El ensayo de micronúcleos como medida de inestabilidad genética inducida por agentes genotóxicos. An Sist Sanit Navar. 2005 Aug;28(2):227–36. https://scielo.isciii.es/scielo.php?script=sci_abstract&pid=S11376627200500030 0007&lng=es&nrm=iso&tlng=esTorrades S. Diversidad del genoma humano: los polimorfismos. Offarm. 2002 May 1;21(5):122–5. https://www.elsevier.es/es-revista-offarm-4-articulodiversidad-del-genoma-humano-polimorfismos-13031745Agencia Nacional de Minería ANM | Administración, Fomento, Promoción y Fiscalización de la Minería Nacional [Internet]. [cited 2023 Dec 16]. Available from: https://www.anm.gov.co/M OUG, V RGM, G DFP. Condiciones de Seguridad y Salud en el Trabajo, una revisión teórica desde la minería colombiana. Rev Venez Gerenc [Internet]. 2019 [cited 2023 Dec 16];24(85). Available from: https://www.redalyc.org/articulo.oa?id=29058864013Torres-Sandoval FA, Murcia-Hurtado DA. Riesgo por exposición a agentes químicos y atmósferas explosivas en minas de carbón de Tópaga, Colombia *. Entramado. 2021 Dec;17(2):292–304.Arteaga SS, Pérez LE, Sosa MQ. Efecto modulador del polimorfismo hOGG1Ser326Cys sobre la frecuencia de micronúcleos en poblaciones ocupacionalmente expuestas a residuos de minería de carbón. Salud UIS [Internet]. 2017 Mar 20 [cited 2023 Dec 15];49(1). Available from: https://revistas.uis.edu.co/index.php/revistasaluduis/article/view/6190Sustancias químicas en la carne cocinada a altas temperaturas y el riesgo de cáncer - NCI [Internet]. 2018 [cited 2023 Dec 15]. Available from: https://www.cancer.gov/espanol/cancer/causasprevencion/riesgo/dieta/hoja-informativa-carne-cocinadaRodríguez Suárez MM. Cáncer de pulmón por hidrocarburos aromáticos policíclicos en la población del estudio CAPUA [Internet] [http://purl.org/dc/dcmitype/Text]. Universidad de Oviedo; 2011 [cited 2023 Dec 15]. Available from: https://dialnet.unirioja.es/servlet/tesis?codigo=98684González X, Melo D. Historizar el lugar para resistir el desplazamiento por minería de carbón: una aproximación teórica al caso de la comunidad de Boquerón en el Cesar. Mem Soc. 2015 Sep 15;19(39):107–26.Rodríguez Aparicio J, Vergara Buitrago PA. Análisis ambiental de la minería de carbón en el ecosistema estratégico de páramo (Boyacá, Colombia). Sci Tech. 2021;26(3):398–405.Efectos tóxicos asociados con la exposición a contaminantes derivados de la minería de carbón [Internet]. [cited 2023 Dec 15]. Available from: https://repositorio.unicartagena.edu.co/handle/11227/4538León J de C y. Naturaleza y origen del carbón [Internet]. Junta de Castilla y León; [cited 2023 Dec 15]. Available from: https://energia.jcyl.es/web/es/biblioteca/naturaleza-origen-carbon.htmlAreaCiencias. El Carbón [Internet]. Areaciencias. 2017 [cited 2023 Dec 15]. Available from: https://www.areaciencias.com/geologia/carbon/Zapata RB, Bayer JFP, Jiménez CS. Carbones colombianos: clasificación y caracterización termoquímica para aplicaciones energéticas. Rev ION [Internet]. 2015 Jan 20 [cited 2023 Dec 15];27(2). Available from: https://revistas.uis.edu.co/index.php/revistaion/article/view/4589Gallego Carmona E. Poder calorífico de carbones colombianos a partir de análisis próximo. 2015 [cited 2023 Dec 15]; Available from: https://bibliotecadigital.univalle.edu.co/entities/publication/b3ca69f5-9355- 4b37-879e-75b2ed7484f3Acevedo S, Galicia L, Plaza E, Atencio R, Rodríguez A, González E. Carbón activado preparado a partir de carbón mineral bituminoso activado con hidróxido de potasio. Rev Téc Fac Ing Univ Zulia. 2016 Aug;39(2):064–70.Arzadún G, Cisternas ME, Cesaretti NN, Tomezzoli RN. Análisis de materia orgánica en niveles de carbón identificados en el pozo PANG0001, en la Formación Tunas (Pérmico de Gondwana), Cuenca de Claromecó, provincia de Buenos Aires. Rev Asoc Geológica Argent. 2016 Dec 30;73(4):538–51.Toro Cataño DA, Ramírez García J, Sepúlveda Mejía DL. Riesgos ambientales y de seguridad en calderas a carbón de las pequeñas y medianas empresas «PYME», ubicadas en el municipio de Itagüí, Antioquia. 2017 Jul 1 [cited 2023 Dec 15]; Available from: https://repositorio.unal.edu.co/handle/unal/65491Somoza A, Vázquez P, Somoza A, Vázquez P. Variación espacio temporal del stock de carbono orgánico y su relación con los cambios en el uso del suelo. Partido de Tandil, Región Pampeana Austral, Argentina. Rev Geográfica América Cent. 2023 Jun;(70):476–513Cely-Andrade JL, García-Ubaque JC, Manrique-Abril F. Calidad de vida relacionada con la salud en población minera de Boyacá. Rev Salud Pública. 2017 Jun;19:362–7.Shimada M. A. Nutrición animal.Rodríguez Heredia D. Intoxicación ocupacional por metales pesados. MEDISAN. 2017 Dec;21(12):3372–85.León Regal M, Alvarado Borges A, de Armas García J, Miranda Alvarado L, Varens Cedeño J, Cuesta del Sol J. Respuesta inflamatoria aguda. Consideraciones bioquímicas y celulares: cifras alarmantes. 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