Use of biomarkers as prognostic indicators in dogs with natural heartworm
Heartworm disease is a parasitic illness caused by the Dirofilaria immitis nematode. In its developed form, remains in the pulmonary artery and right side of the heart, resulting in pulmonary thromboembolism, myocarditis, and inflammation. A retrospective study was made in which was evaluated the us...
- Autores:
-
de la Puente, Mario
De Lavalle Galvis, Rodrigo
Rodríguez, Jorge G.
Duarte, Ariel M.
Riquett, Amanda R.
de la Puente, María
Viloria, Maria B.
- Tipo de recurso:
- Fecha de publicación:
- 2018
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/2194
- Acceso en línea:
- http://hdl.handle.net/20.500.12442/2194
- Palabra clave:
- pulmonary hypertension
Acute phase proteins
Troponins
- Rights
- License
- licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional
| id |
USIMONBOL2_e233063824726b6abde6b4c9538e1afa |
|---|---|
| oai_identifier_str |
oai:bonga.unisimon.edu.co:20.500.12442/2194 |
| network_acronym_str |
USIMONBOL2 |
| network_name_str |
Repositorio Digital USB |
| repository_id_str |
|
| dc.title.eng.fl_str_mv |
Use of biomarkers as prognostic indicators in dogs with natural heartworm |
| title |
Use of biomarkers as prognostic indicators in dogs with natural heartworm |
| spellingShingle |
Use of biomarkers as prognostic indicators in dogs with natural heartworm pulmonary hypertension Acute phase proteins Troponins |
| title_short |
Use of biomarkers as prognostic indicators in dogs with natural heartworm |
| title_full |
Use of biomarkers as prognostic indicators in dogs with natural heartworm |
| title_fullStr |
Use of biomarkers as prognostic indicators in dogs with natural heartworm |
| title_full_unstemmed |
Use of biomarkers as prognostic indicators in dogs with natural heartworm |
| title_sort |
Use of biomarkers as prognostic indicators in dogs with natural heartworm |
| dc.creator.fl_str_mv |
de la Puente, Mario De Lavalle Galvis, Rodrigo Rodríguez, Jorge G. Duarte, Ariel M. Riquett, Amanda R. de la Puente, María Viloria, Maria B. |
| dc.contributor.author.none.fl_str_mv |
de la Puente, Mario De Lavalle Galvis, Rodrigo Rodríguez, Jorge G. Duarte, Ariel M. Riquett, Amanda R. de la Puente, María Viloria, Maria B. |
| dc.subject.eng.fl_str_mv |
pulmonary hypertension Acute phase proteins Troponins |
| topic |
pulmonary hypertension Acute phase proteins Troponins |
| description |
Heartworm disease is a parasitic illness caused by the Dirofilaria immitis nematode. In its developed form, remains in the pulmonary artery and right side of the heart, resulting in pulmonary thromboembolism, myocarditis, and inflammation. A retrospective study was made in which was evaluated the usefulness of the Dimer-D, troponin I and C-reactive protein in sick dogs naturally infected with heartworm. There were evaluated the concentrations of D-Dimer, troponin I and C-reactive protein in 23 dogs, analyzed hematological variables, the presence or absence of microfilariae, the pulmonary hypertension and clinical signs. The respiratory problems were the most frequent clinical signs including dyspnea (74%), cough (30%), pulmonary hypertension (57%), and other signs of inflammation or pulmonary thromboembolism. Hematological changes were not found. Elevations of the Dimer-D were found in 73.9% of cases, where the patients with microfilariae (69.6%) showed higher values compared to amicrofilaremics (30.4%); males had a higher average (3,857.83 ng ml-1) compared to females (1,714.0 ng ml-1). Troponin I and C-reactive protein had elevations in 21.7 - 39.1% of cases without significant changes compared to sex or microfilariae. The measurement of Dimer-D, troponin I and C-reactive protein complements for the diagnosis, prognosis and therapeutic control in patients with D. immitis indicated inflammation, pulmonary thromboembolism and/or myocarditis. |
| publishDate |
2018 |
| dc.date.accessioned.none.fl_str_mv |
2018-07-23T19:56:09Z |
| dc.date.available.none.fl_str_mv |
2018-07-23T19:56:09Z |
| dc.date.issued.none.fl_str_mv |
2018-07-19 |
| dc.type.eng.fl_str_mv |
article |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
| dc.identifier.issn.none.fl_str_mv |
20667663 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12442/2194 |
| identifier_str_mv |
20667663 |
| url |
http://hdl.handle.net/20.500.12442/2194 |
| dc.language.iso.eng.fl_str_mv |
eng |
| language |
eng |
| dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| dc.rights.license.eng.fl_str_mv |
licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional |
| rights_invalid_str_mv |
licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional http://purl.org/coar/access_right/c_abf2 |
| dc.publisher.eng.fl_str_mv |
HVM Bioflux |
| dc.source.eng.fl_str_mv |
Human & Veterinary Medicine |
| dc.source.none.fl_str_mv |
Vol. 10, No.3 (2018) |
| institution |
Universidad Simón Bolívar |
| dc.source.uri.none.fl_str_mv |
http://www.hvm.bioflux.com.ro/docs/2018.99-103a.pdf |
| bitstream.url.fl_str_mv |
https://bonga.unisimon.edu.co/bitstreams/41645c12-6e62-42b8-bbdf-2ea4ad2c808f/download |
| bitstream.checksum.fl_str_mv |
3fdc7b41651299350522650338f5754d |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 |
| repository.name.fl_str_mv |
DSpace UniSimon |
| repository.mail.fl_str_mv |
bibliotecas@biteca.com |
| _version_ |
1812100506959478784 |
| spelling |
licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacionalhttp://purl.org/coar/access_right/c_abf2de la Puente, Marioe717dfa4-a5d3-48f1-9249-c0902f03cb00-1De Lavalle Galvis, Rodrigo1a70e6cc-d977-484d-8724-71f0ed2fedd4-1Rodríguez, Jorge G.50f17229-b66c-44e7-aecc-a4bb6103d2f2-1Duarte, Ariel M.413167be-5112-4086-9aa6-cb4ed1555405-1Riquett, Amanda R.4a7226e4-1c72-4fd5-80c4-364d9da5d55d-1de la Puente, María5093892a-c701-4ba0-8374-4dde18e88fc1-1Viloria, Maria B.de66393f-6d9d-4d84-a97e-bb1896fb1091-12018-07-23T19:56:09Z2018-07-23T19:56:09Z2018-07-1920667663http://hdl.handle.net/20.500.12442/2194Heartworm disease is a parasitic illness caused by the Dirofilaria immitis nematode. In its developed form, remains in the pulmonary artery and right side of the heart, resulting in pulmonary thromboembolism, myocarditis, and inflammation. A retrospective study was made in which was evaluated the usefulness of the Dimer-D, troponin I and C-reactive protein in sick dogs naturally infected with heartworm. There were evaluated the concentrations of D-Dimer, troponin I and C-reactive protein in 23 dogs, analyzed hematological variables, the presence or absence of microfilariae, the pulmonary hypertension and clinical signs. The respiratory problems were the most frequent clinical signs including dyspnea (74%), cough (30%), pulmonary hypertension (57%), and other signs of inflammation or pulmonary thromboembolism. Hematological changes were not found. Elevations of the Dimer-D were found in 73.9% of cases, where the patients with microfilariae (69.6%) showed higher values compared to amicrofilaremics (30.4%); males had a higher average (3,857.83 ng ml-1) compared to females (1,714.0 ng ml-1). Troponin I and C-reactive protein had elevations in 21.7 - 39.1% of cases without significant changes compared to sex or microfilariae. The measurement of Dimer-D, troponin I and C-reactive protein complements for the diagnosis, prognosis and therapeutic control in patients with D. immitis indicated inflammation, pulmonary thromboembolism and/or myocarditis.engHVM BiofluxHuman & Veterinary MedicineVol. 10, No.3 (2018)http://www.hvm.bioflux.com.ro/docs/2018.99-103a.pdfpulmonary hypertensionAcute phase proteinsTroponinsUse of biomarkers as prognostic indicators in dogs with natural heartwormarticlehttp://purl.org/coar/resource_type/c_6501Becattini C, Vedovati MC, Agnelli G. Prognostic value of troponins in acute pulmonary embolism:a meta-analysis. Circulation 2007;116:427- 433. DOI:10.1161/CIRCULATIONAHA.106.680421Ben SQ, Ni SS, Shen HH, Shi YX, Huang SB, Xu JH, Huang JF. The dynamic changes of LDH isoenzyme 3 and D-dimer following pulmonary thromboembolism in canine. Thromb Res 2007;120:575- 583. DOI:10.1016/j.thromres.2006.12.015.Boswood A. Biomarkers in cardiovascular disease:beyond natriuretic peptides. J Vet cardiol 2009;1:23-32. DOI:10.1016/j.jvc.2009.01.003Bowman DD, Atkins CE. Heartworm biology, treatment, and control. Vet clin North Am small anim Pract 2009;39:1127-1158. DOI:10.1016/j. cvsm.2009.06.003.Buxhofer-Ausch V, Gisslinger H, Thiele J, Gisslinger B, Kvasnicka HM, Müllauer L, et al. Leukocytosis as an important risk factor for arterial thrombosis in WHO-defined early/prefibrotic myelofibrosis:an international study of 264 patients. Am J Hematol 2012;87:669-672. DOI:10.1002/ajh.23217.Carretón E, Corbera JA, Justea MC, Morchón R, Simón F, Montoya A. Dirofilaria immitis infection in dogs:Cardiopulmonary biomarker levels. Vet Parasitol 2011;176:313-316. DOI:10.1016/j. vetpar.2011.01.015.Carretón E, González-Miguel J, Montoya-Alonso JA, Morchón R, Simón F, Passeri B, Cantoni AM, Kramer L. D-dimer deposits in lungs and kidneys suggest its use as a marker in the clinical workup of dogs with heartworm (Dirofilaria immitis) disease. Vet Parasitol 2013a;191:182-186. DOI:10.1016/j.vetpar.2012.08.008.Carretón E, Grandi G, Morchón R, Simón F, Passeri B, Cantoni M, et al. Myocardial damage in dogs affected by heartworm disease (Dirofilaria immitis):immunohistochemical study of cardiac myoglobin and troponin I in naturally infected dogs. Vet Parasitol.2012;189:390-393. DOI:10.1016/j.vetpar.2012.04.013.Carretón E, Morchón R, González-Miguel J, Simón F, Juste M C, Montoya-Alonso J A. Variation of D-dimer values as assessment of pulmonary thromboembolism during adulticide treatment of heartworm disease in dogs. Vet Parasitol 2013b;195:106-111.Darcy BA, Rowan JM, Kate DB, Cathy E, Marc S. Cardiac troponin I concentrations in normal dogs and cats using a bedside analyzer. J Vet Cardiol 2005; 7:27-32. DOI:10.1016/j.vetpar.2013.01.005Eckersall PD, Bell R. Acute phase proteins:Biomarkers of infection and inflammation in veterinary medicine. Vet J 2010;185:23-27. DOI:10.1016/j.tvjl.2010.04.009.Epstein SE, Hopper K, Mellema MS, Johnson LR. Diagnostic Utility of D-Dimer Concentrations in Dogs with Pulmonary Embolism. J Vet Interm Med 2013;27:1646-1649. DOI:10.1111/jvim.12177.Goggs, R, Letendre, JA. Measurement of plasma cell‐free DNA concentrations in dogs with sepsis, trauma neoplasia. Journal of Veterinary Emergency and Critical Care 2017;27:307-314. DOI:https://doi. org/10.1111/vec.12592.Gorton HJ, Warren ER, Simpson NA, Lyons GR, Columb MO. Thromboelastography identifies sex-related differences in coagulation. Anesth Anal 2000;91:1279-1281.Janata K, Holzer M, Laggner AN, Müllner M. Cardiac troponin T in the severity assessment of patients with pulmonary embolism:cohort study. BMJ 2003;8:312-313.Klein MK, Dow SW, Rosychuk RA. Pulmonary thromboembolism associated with immune-mediated hemolytic anemia in dogs:ten cases (1982-1987). J Am Vet Med Assoc 1989;195:246-250.Kumar SA, Vardhan SH, Arun RA, Kumar SS. C-reactive protein, inflammation and coronary heart disease. EHJ 2015;67:89-97.Lennon EM, Hanel RM, Walker JM, Vaden SL. Hypercoagulability in dogs with protein-losing nephropathy as assessed by thromboelastography. J Vet Interm Med 2013;27:462-468. DOI:10.1111/jvim.12067.Lowe GD, Rumley A, Woodward M, Morrison CE, Philippou H, Lane DA, Tunstall-Pedoe H. Epidemiology of coagulation factors, inhibitors and activation markers:the Third Glasgow MONICA Survey. I. Illustrative reference ranges by age, sex and hormone use. Br J Haematol 1997;97:775-784.Lynelle RJ, Michael RL, Dale CB. Pulmonary Thromboembolism in 29 Dogs:1985–1995. J Vet Interm Med 1999;13:338-345.McCall JW, Genchi C, Kramer LH, Guerrero J, Venco L. Heartworm disease in animal and humans. Adv Parasitol 2008;66:193-285. DOI:10.1016/S0065-308X(08)00204-2Méndez JC, Carretón E, Martínez S, Tvarijonaviciute A, Cerón JJ, MontoyaAlonso JA. Acute phase response in dogs with Dirofilaria immitis. Vet Parasitol 2014;204:420-425. DOI:10.1016/j.vetpar.2014.05.016.Montoya JA, carretón EG. Dirofilariosis pautas de manejo clínico (Dirofilariosis clinical management guidelines). Barcelona:Multimedica;2012. ISBN:9788496344440.Murata H, Shimada N, Yoshioka M. Current Research on Acute Phase Proteins in Veterinary Diagnosis:An Overview. Vet J 2004;168:28- 40. DOI:10.1016/S1090-0233(03)00119-9.Nelson OL, Andreasen C. The utility of plasma D-dimer to identify thromboembolic disease in dogs. J Vet Intern Med 2003;17:830-834.Oyama MA, Sisson DD. Cardiac troponin-I concentration in dogs with cardiac disease. J Vet Intern Med 2004;18:831-839.Respess M, O’Toole TE, Taeymans O, Rogers CL, Johnston A, Webster CR. Portal vein thrombosis in 33 dogs:1998-2011. J Vet Intern Med 2012;26:230-237. DOI:10.1111/j.1939-1676.2012.00893.xSchreiber MA, Differding J, Thorborg P, Mayberry JC, Mullins R. Hypercoagulability is most prevalent early after injury and in female patients. J Trauma 2005;58:475-480.Serrano-Parreño B, Carretón E, Caro-Vadillo A, Falcón-Cordón S, Falcón-Cordón Y, Montoya-Alonso J A. Pulmonary hypertension in dogs with heartworm before and after the adulticide protocol recommended by the American Heartworm Society. Vet Parasitol 2017a;236:34-37. DOI:10.1016/j.vetpar.2017.02.001.Serrano-Parreño B, Carretón E, Caro-Vadillo A, Falcón-Cordón Y, FalcónCordón S, Montoya-Alonso JA. Evaluation of pulmonary hypertension and clinical status in dogs with heartworm by Right Pulmonary Artery Distensibility Index and other echocardiographic parameters. Parasit Vectors 2017b;10:2-6. DOI:10.1186/s13071-017-2047-2Simón F, Mar Siles L, Morchón R, González MJ, Mellado I, Carretón E, Montoya JA. Human and Animal Dirofilariasis:the Emergence of a Zoonotic Mosaic. Clin Microbiol Rev 2012;25:507-544. DOI:10.1128/CMR.00012-12.Stokol T. Plasma D-dimer for the diagnosis of thromboembolic disorders in dogs. Vet Clin North Am Small Anim Pract 2003;33:1419-1435.Thawley VJ, Sánchez MD, Drobatz KJ, King LG. Retrospective comparison of thromboelastography results to postmortem evidence of thrombosis in critically ill dogs:39 cases (2005-2010). J Vet Emerg Crit Care 2016;26:428-436. DOI:10.1111/vec.12441.Tracy RP. Inflammation in Cardiovascular Disease:Cart, Horse or Both− Revisited. Journal of the American Heath Association. 2002;22:1514- 1515. DOI:10.1161/01.ATV.0000035403.39442.DBLICENSElicense.txtlicense.txttext/plain; charset=utf-8368https://bonga.unisimon.edu.co/bitstreams/41645c12-6e62-42b8-bbdf-2ea4ad2c808f/download3fdc7b41651299350522650338f5754dMD5220.500.12442/2194oai:bonga.unisimon.edu.co:20.500.12442/21942019-04-11 21:51:37.93metadata.onlyhttps://bonga.unisimon.edu.coDSpace UniSimonbibliotecas@biteca.comPGEgcmVsPSJsaWNlbnNlIiBocmVmPSJodHRwOi8vY3JlYXRpdmVjb21tb25zLm9yZy9saWNlbnNlcy9ieS1uYy80LjAvIj48aW1nIGFsdD0iTGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyIgc3R5bGU9ImJvcmRlci13aWR0aDowIiBzcmM9Imh0dHBzOi8vaS5jcmVhdGl2ZWNvbW1vbnMub3JnL2wvYnktbmMvNC4wLzg4eDMxLnBuZyIgLz48L2E+PGJyLz5Fc3RhIG9icmEgZXN0w6EgYmFqbyB1bmEgPGEgcmVsPSJsaWNlbnNlIiBocmVmPSJodHRwOi8vY3JlYXRpdmVjb21tb25zLm9yZy9saWNlbnNlcy9ieS1uYy80LjAvIj5MaWNlbmNpYSBDcmVhdGl2ZSBDb21tb25zIEF0cmlidWNpw7NuLU5vQ29tZXJjaWFsIDQuMCBJbnRlcm5hY2lvbmFsPC9hPi4= |