Probiotics and Gut Microbiota in Obesity: Myths and realities of a New Health Revolution
Obesity and its comorbidities are humans’ most prevalent cardio-metabolic diseases worldwide. Recent evidence has shown that chronic low-grade inflammation is a common feature in all highly prevalent chronic degenerative diseases. In this sense, the gut microbiota is a complete ecosystem involved in...
- Autores:
-
León Aguilera, Xavier Eugenio
Manzano, Alexander
Pirela, Daniela
Bermúdez, Valmore
- Tipo de recurso:
- Fecha de publicación:
- 2022
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/11428
- Palabra clave:
- obesity
Gut microbiota
short chain fatty acids
Probiotics
Prebiotics
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Probiotics and Gut Microbiota in Obesity: Myths and realities of a New Health Revolution |
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Probiotics and Gut Microbiota in Obesity: Myths and realities of a New Health Revolution |
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Probiotics and Gut Microbiota in Obesity: Myths and realities of a New Health Revolution obesity Gut microbiota short chain fatty acids Probiotics Prebiotics |
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Probiotics and Gut Microbiota in Obesity: Myths and realities of a New Health Revolution |
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Probiotics and Gut Microbiota in Obesity: Myths and realities of a New Health Revolution |
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Probiotics and Gut Microbiota in Obesity: Myths and realities of a New Health Revolution |
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Probiotics and Gut Microbiota in Obesity: Myths and realities of a New Health Revolution |
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Probiotics and Gut Microbiota in Obesity: Myths and realities of a New Health Revolution |
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León Aguilera, Xavier Eugenio Manzano, Alexander Pirela, Daniela Bermúdez, Valmore |
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León Aguilera, Xavier Eugenio Manzano, Alexander Pirela, Daniela Bermúdez, Valmore |
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obesity Gut microbiota short chain fatty acids Probiotics Prebiotics |
| topic |
obesity Gut microbiota short chain fatty acids Probiotics Prebiotics |
| description |
Obesity and its comorbidities are humans’ most prevalent cardio-metabolic diseases worldwide. Recent evidence has shown that chronic low-grade inflammation is a common feature in all highly prevalent chronic degenerative diseases. In this sense, the gut microbiota is a complete ecosystem involved in different processes like vitamin synthesis, metabolism regulation, and both appetite and immune system control. Thus, dysbiosis has been recognised as one of the many factors associated with obesity due to a predominance of Firmicutes, a decrease in Bifidobacterium in the gut, and a consequent short-chain fatty acids (SCFA) synthesis reduction leading to a reduction in incretins action and intestinal permeability increase. In this context, bacteria, bacterial endotoxins, and toxic bacterial by-products are translocated to the bloodstream, leading to systemic inflammation. This review focuses on gut microbiota composition and its role in obesity, as well as probiotics and prebiotics benefits in obesity. |
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2022 |
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2022-11-21T18:03:06Z |
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2022-11-21T18:03:06Z |
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2022 |
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León Aguilera, X. E., Manzano, A., Pirela, D., & Bermúdez, V. (2022). Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health Revolution. Journal of Personalized Medicine, 12(8), 1282. https://doi.org/10.3390/jpm12081282 |
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https://hdl.handle.net/20.500.12442/11428 |
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https://doi.org/10.3390/jpm12081282 |
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León Aguilera, X. E., Manzano, A., Pirela, D., & Bermúdez, V. (2022). Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health Revolution. Journal of Personalized Medicine, 12(8), 1282. https://doi.org/10.3390/jpm12081282 |
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https://hdl.handle.net/20.500.12442/11428 https://doi.org/10.3390/jpm12081282 |
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eng |
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León Aguilera, Xavier Eugenio28a6b2a3-37a6-4c2a-8fe2-db9797ce4ea3Manzano, Alexander0dd1f5fe-19cd-42e0-b698-34b17a178629Pirela, Danielaf7d00476-6884-4e9b-b972-aa1b154fcf02Bermúdez, Valmore29f9aa18-16a4-4fd3-8ce5-ed94a0b8663a2022-11-21T18:03:06Z2022-11-21T18:03:06Z2022León Aguilera, X. E., Manzano, A., Pirela, D., & Bermúdez, V. (2022). Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health Revolution. Journal of Personalized Medicine, 12(8), 1282. https://doi.org/10.3390/jpm12081282https://hdl.handle.net/20.500.12442/11428https://doi.org/10.3390/jpm12081282Obesity and its comorbidities are humans’ most prevalent cardio-metabolic diseases worldwide. Recent evidence has shown that chronic low-grade inflammation is a common feature in all highly prevalent chronic degenerative diseases. In this sense, the gut microbiota is a complete ecosystem involved in different processes like vitamin synthesis, metabolism regulation, and both appetite and immune system control. Thus, dysbiosis has been recognised as one of the many factors associated with obesity due to a predominance of Firmicutes, a decrease in Bifidobacterium in the gut, and a consequent short-chain fatty acids (SCFA) synthesis reduction leading to a reduction in incretins action and intestinal permeability increase. In this context, bacteria, bacterial endotoxins, and toxic bacterial by-products are translocated to the bloodstream, leading to systemic inflammation. This review focuses on gut microbiota composition and its role in obesity, as well as probiotics and prebiotics benefits in obesity.pdfengMDPIAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Journal of Personalized MedicineVol. 12 Issue 8 (2022)obesityGut microbiotashort chain fatty acidsProbioticsPrebioticsProbiotics and Gut Microbiota in Obesity: Myths and realities of a New Health Revolutioninfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1CarrGómez, J.C.; Ena, J.; Lorido, J.A.; Ripoll, J.S.; Carrasco-Sánchez, F.J.; Gómez-Huelgas, R.; Soto, M.P.; Lista, J.D.; Martínez, P.P. Obesity Is a Chronic Disease. Positioning Statement of the Diabetes, Obesity and Nutrition Workgroup of the Spanish Society of internal Medicine (SEMI) for An Approach Centred on individuals with Obesity. Rev. Clín. Esp. 2021, 221, 509–516.Hales, C.M.; Carroll, M.D.; Fryar, C.D.; Ogden, C.L. Prevalence of Obesity and Severe Obesity Among Adults: United States, 2017–2018. NCHS Data Brief. 2020, 360, 1–8.Safaei, M.; Sundararajan, E.A.; Driss, M.; Boulila, W.; Shapi’I, A. A Systematic Literature Review on Obesity: Understanding the Causes & Consequences of Obesity and Reviewing Various Machine Learning Approaches Used to Predict obesity. Comput. Biol. Med. 2021, 136, 104754.Zhang, X.; Zhang, M.; Zhao, Z.; Huang, Z.; Deng, Q.; Li, Y. Obesogenic Environmental Factors of Adult Obesity in China: A Nationally Representative Cross-Sectional Study. Environ. Res. Lett. 2020, 15, 4.Prakash, K.; Munyanyi, M.E. Energy Poverty and Obesity. 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Gastroenterology 2019, 157, 97–108.Nielsen, S.D.; Pearson, N.M.; Seidler, K. The Link between the Gut Microbiota and Parkinson’s Disease: A Systematic Mechanism Review with Focus on α-Synuclein Transport. Brain Res. 2021, 1769, 147609.Lukacs, N.W.; Huang, Y.J. Microbiota–Immune interactions in Asthma Pathogenesis and Phenotype. Curr. Opin. Immunol. 2020, 66, 22–26.Guo, L.; Yang, K.; Zhou, P.; Yong, W. Gut Microbiota in Obesity and Nonalcoholic Fatty Liver. Disease. Surg. Pract. Sci. 2021, 5, 100030.Mills, S.; Stanton, C.; Lane, J.; Smith, G.; Ross, R. Precision Nutrition and the Microbiome, Part I: Current State of the Science. Nutrients 2019, 11, 923.Gomaa, E.Z. Human Gut Microbiota/Microbiome in Health and Diseases: A Review. Antonie Van Leeuwenhoek 2020, 113, 2019–2040.Crovesy, L.; Masterson, D.; Rosado, E.L. Profile of the Gut Microbiota of Adults with Obesity: A Systematic Review. Eur. J. Clin. Nutr. 2020, 74, 1251–1262.Lilly, D.M.; Stillwell, R.H. Probiotics: Growth-Promoting Factors Produced by Microorganisms. Science 1965, 147, 747–748.Afrc, R.F. Probiotics in Man and Animals. J. Appl. Bacteriol. 1989, 66, 365–378.Gilliland, S.E. Health and Nutritional Benefits from Lactic Acid Bacteria. FEMS Microbiol. Lett. 1990, 87, 175–1788.Goldin, B.R.; Gorbach, S.L. The Effect of Milk and Lactobacillus Feeding on Human intestinal Bacterial Enzyme Activity. Am. J. Clin. Nutr. 1984, 39, 756–761.Perdigón, G.; Fuller, R.; Raya, R. Lactic Acid Bacteria and their Effect-on the Immune System. Curr. Issues Intest. Microbiol. 2001, 2, 27–42.Vedamuthu, E.R. Starter Cultures for Yogurt and Fer-mented Milks. In RC Chandan Manufacturing Yogurt and Fermented Milks; Blackwell Publishing: Ames, IA, USA, 2006; pp. 88–115.Siciliano, R.A.; Mazzeo, M.F. Molecular Mechanisms of Probiotic Action: A Perspective. Curr. Opin. Microbiol. 2012, 15, 390–396.Abdoli, M.; Mohammadi, G.; Mansouri, K.; Khaledian, S.; Taran, M.; Martinez, F. 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