Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review
Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disorder, affecting around 25% of the population worldwide. It is a complex disease spectrum, closely linked with other conditions such as obesity, insulin resistance, type 2 diabetes mellitus, and metabolic syndrome, whic...
- Autores:
-
Cano, Raquel
Pérez, José L.
Angarita Dávila, Lissé
Ortega, Ángel
Gómez, Yosselin
Valero-Cedeño, Nereida Josefina
Parra, Heliana
Manzano, Alexander
Díaz Albornoz, María P
Cano, Gabriel
Rojas-Quintero, Joselyn
Chacín, Maricarmen
Bermúdez, Valmore
Véliz Castro, Teresa Isabel
- Tipo de recurso:
- Fecha de publicación:
- 2021
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/8361
- Palabra clave:
- Non-alcoholic fatty liver disease
Endocrine-disrupting chemicals
Liver disorder
Environmental pollutants
Exposure
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review |
| title |
Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review |
| spellingShingle |
Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review Non-alcoholic fatty liver disease Endocrine-disrupting chemicals Liver disorder Environmental pollutants Exposure |
| title_short |
Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review |
| title_full |
Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review |
| title_fullStr |
Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review |
| title_full_unstemmed |
Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review |
| title_sort |
Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review |
| dc.creator.fl_str_mv |
Cano, Raquel Pérez, José L. Angarita Dávila, Lissé Ortega, Ángel Gómez, Yosselin Valero-Cedeño, Nereida Josefina Parra, Heliana Manzano, Alexander Díaz Albornoz, María P Cano, Gabriel Rojas-Quintero, Joselyn Chacín, Maricarmen Bermúdez, Valmore Véliz Castro, Teresa Isabel |
| dc.contributor.author.none.fl_str_mv |
Cano, Raquel Pérez, José L. Angarita Dávila, Lissé Ortega, Ángel Gómez, Yosselin Valero-Cedeño, Nereida Josefina Parra, Heliana Manzano, Alexander Díaz Albornoz, María P Cano, Gabriel Rojas-Quintero, Joselyn Chacín, Maricarmen Bermúdez, Valmore |
| dc.contributor.author.spa.fl_str_mv |
Véliz Castro, Teresa Isabel |
| dc.subject.eng.fl_str_mv |
Non-alcoholic fatty liver disease Endocrine-disrupting chemicals Liver disorder Environmental pollutants Exposure |
| topic |
Non-alcoholic fatty liver disease Endocrine-disrupting chemicals Liver disorder Environmental pollutants Exposure |
| description |
Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disorder, affecting around 25% of the population worldwide. It is a complex disease spectrum, closely linked with other conditions such as obesity, insulin resistance, type 2 diabetes mellitus, and metabolic syndrome, which may increase liver-related mortality. In light of this, numerous efforts have been carried out in recent years in order to clarify its pathogenesis and create new prevention strategies. Currently, the essential role of environmental pollutants in NAFLD development is recognized. Particularly, endocrine-disrupting chemicals (EDCs) have a notable influence. EDCs can be classified as natural (phytoestrogens, genistein, and coumestrol) or synthetic, and the latter ones can be further subdivided into industrial (dioxins, polychlorinated biphenyls, and alkylphenols), agricultural (pesticides, insecticides, herbicides, and fungicides), residential (phthalates, polybrominated biphenyls, and bisphenol A), and pharmaceutical (parabens). Several experimental models have proposed a mechanism involving this group of substances with the disruption of hepatic metabolism, which promotes NAFLD. These include an imbalance between lipid influx/efflux in the liver, mitochondrial dysfunction, liver inflammation, and epigenetic reprogramming. It can be concluded that exposure to EDCs might play a crucial role in NAFLD initiation and evolution. However, further investigations supporting these effects in humans are required. |
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2021 |
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2021-09-13T23:36:01Z |
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2021-09-13T23:36:01Z |
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2021 |
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Artículo científico |
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Cano, R., Pérez, J., Dávila, L., Ortega, Á., Gómez, Y., Valero-Cedeño, N., Parra, H., et al. (2021). Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review. International Journal of Molecular Sciences, 22(9), 4807. MDPI AG. Retrieved from http://dx.doi.org/10.3390/ijms22094807 |
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14220067 |
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https://hdl.handle.net/20.500.12442/8361 |
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https://doi.org/10.3390/ijms22094807 |
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Cano, R., Pérez, J., Dávila, L., Ortega, Á., Gómez, Y., Valero-Cedeño, N., Parra, H., et al. (2021). Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review. International Journal of Molecular Sciences, 22(9), 4807. MDPI AG. Retrieved from http://dx.doi.org/10.3390/ijms22094807 14220067 |
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https://hdl.handle.net/20.500.12442/8361 https://doi.org/10.3390/ijms22094807 |
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eng |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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pdf |
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MDPI |
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International Journal of Molecular Sciences |
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Vol. 22 N° 9 (2021) |
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Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review. International Journal of Molecular Sciences, 22(9), 4807. MDPI AG. Retrieved from http://dx.doi.org/10.3390/ijms2209480714220067https://hdl.handle.net/20.500.12442/8361https://doi.org/10.3390/ijms22094807Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disorder, affecting around 25% of the population worldwide. It is a complex disease spectrum, closely linked with other conditions such as obesity, insulin resistance, type 2 diabetes mellitus, and metabolic syndrome, which may increase liver-related mortality. In light of this, numerous efforts have been carried out in recent years in order to clarify its pathogenesis and create new prevention strategies. Currently, the essential role of environmental pollutants in NAFLD development is recognized. Particularly, endocrine-disrupting chemicals (EDCs) have a notable influence. EDCs can be classified as natural (phytoestrogens, genistein, and coumestrol) or synthetic, and the latter ones can be further subdivided into industrial (dioxins, polychlorinated biphenyls, and alkylphenols), agricultural (pesticides, insecticides, herbicides, and fungicides), residential (phthalates, polybrominated biphenyls, and bisphenol A), and pharmaceutical (parabens). Several experimental models have proposed a mechanism involving this group of substances with the disruption of hepatic metabolism, which promotes NAFLD. These include an imbalance between lipid influx/efflux in the liver, mitochondrial dysfunction, liver inflammation, and epigenetic reprogramming. It can be concluded that exposure to EDCs might play a crucial role in NAFLD initiation and evolution. However, further investigations supporting these effects in humans are required.pdfengMDPIAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2International Journal of Molecular SciencesVol. 22 N° 9 (2021)Non-alcoholic fatty liver diseaseEndocrine-disrupting chemicalsLiver disorderEnvironmental pollutantsExposureRole of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Reviewinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Chalasani, N.; Younossi, Z.; Lavine, J.E.; Charlton, M.; Cusi, K.; Rinella, M.; Harrison, S.A.; Brunt, E.M.; Sanyal, A.J. The Diagnosis and Management of Nonalcoholic Fatty Liver Disease: Practice Guidance from the American Association for the Study of Liver Diseases. Hepatology 2018, 67, 328–357. [CrossRef]Amini, M.; Ansari, I.; Yekesadat, S.; Vaseie, M.; Malekhoseyni, M. Response rate to the vaccination with hepatitis b vaccine among cardiovascular health staff in Tehran. Latinoam. Hipertens. 2020, 14, 562–567.Younossi, Z.; Tacke, F.; Arrese, M.; Chander Sharma, B.; Mostafa, I.; Bugianesi, E.; Wai-Sun Wong, V.; Yilmaz, Y.; George, J.; Fan, J.; et al. Global Perspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis: Hepatology. Hepatology 2019, 69, 2672–2682. [CrossRef] [PubMed]Bermudez, V.; Moisés, R.; Lisney, V.; Yettana, L.; Ana, C.; ali, U.; Guerra-Torres, X.; Colmenares, C.A.; Chacín, M.; Rojas Quintero, J.; et al. Pharmacologic Treatment of Obesity: Pitfalls and New Promises. Rev. Latinoam. Hipertens. 2008, 5, 137–147Younossi, Z.; Anstee, Q.M.; Marietti, M.; Hardy, T.; Henry, L.; Eslam, M.; George, J.; Bugianesi, E. Global Burden of NAFLD and NASH: Trends, Predictions, Risk Factors and Prevention. Nat. Rev. Gastroenterol. Hepatol. 2018, 15, 11–20. [CrossRef]Younossi, Z.M.; Koenig, A.B.; Abdelatif, D.; Fazel, Y.; Henry, L.; Wymer, M. Global Epidemiology of Nonalcoholic Fatty Liver Disease-Meta-Analytic Assessment of Prevalence, Incidence, and Outcomes. Hepatology 2016, 64, 73–84. [CrossRef] [PubMed]Fang, Y.-L.; Chen, H.; Wang, C.-L.; Liang, L. Pathogenesis of Non-Alcoholic Fatty Liver Disease in Children and Adolescence: From “Two Hit Theory” to “Multiple Hit Model”. World J. Gastroenterol. 2018, 24, 2974–2983. [CrossRef]Carr, R.M.; Oranu, A.; Khungar, V. Nonalcoholic Fatty Liver Disease. Gastroenterol. Clin. N. Am. 2016, 45, 639–652. [CrossRef]Souki-Rincón, A.; Sandoval, M.; Sánchez, G.; Andrade, U.; García-Rondón, D.; Cano-Ponce, C.; Medina, M.; Almarza, J.; Urdaneta, Y.; González, C. Intake of saturated fatty acids and insulin sensitivity in obese young adults from Maracaibo. Rev. Latinoam. 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[CrossRef]Bergman, Å.; Heindel, J.J.; Kasten, T.; Kidd, K.A.; Jobling, S.; Neira, M.; Zoeller, R.T.; Becher, G.; Bjerregaard, P.; Bornman, R.; et al. The Impact of Endocrine Disruption: A Consensus Statement on the State of the Science. Environ. Health Perspect. 2013, 121, A104–A106. [CrossRef]VoPham, T. Environmental Risk Factors for Liver Cancer and Nonalcoholic Fatty Liver Disease. Curr. Epidemiol. Rep. 2019, 6, 50–66. [CrossRef] [PubMed]Klaunig, J.E.; Li, X.; Wang, Z. Role of Xenobiotics in the Induction and Progression of Fatty Liver Disease. Toxicol. Res. 2018, 7, 664–680. [CrossRef] [PubMed]Wei, J.; Sun, X.; Chen, Y.; Li, Y.; Song, L.; Zhou, Z.; Xu, B.; Lin, Y.; Xu, S. Perinatal Exposure to Bisphenol A Exacerbates Nonalcoholic Steatohepatitis-like Phenotype in Male Rat Offspring Fed on a High-Fat Diet. J. Endocrinol. 2014, 222, 313–325. [CrossRef] [PubMed]Marty, M.S.; Carney, E.W.; Rowlands, J.C. 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