Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis
Cardiovascular disease (CVD) is a global public health issue due to its high morbidity, mortality, and economic impact. The implementation of innovative therapeutic alternatives for CVD is urgently required. Specialized proresolving lipid mediators (SPMs) are bioactive compounds derived from ω-3 and...
- Autores:
-
Salazar, Juan
Pirela, Daniela
Nava, Manuel
Castro, Ana
Angarita, Lissé
Parra, Heliana
Durán-Agüero, Samuel
Rojas-Gómez, Diana Marcela
Galbán, Néstor
Añez, Roberto
Chacín, Maricarmen
Diaz, Andrea
Villasmil, Nelson
Bautista De Sanctis, Juan
Bermúdez, Valmore
- Tipo de recurso:
- Fecha de publicación:
- 2022
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/11286
- Palabra clave:
- specialized proresolving mediators
inflammation
resolution
Atherosclerosis
Intimal hyperplasia
Reperfusion injury
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis |
| title |
Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis |
| spellingShingle |
Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis specialized proresolving mediators inflammation resolution Atherosclerosis Intimal hyperplasia Reperfusion injury |
| title_short |
Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis |
| title_full |
Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis |
| title_fullStr |
Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis |
| title_full_unstemmed |
Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis |
| title_sort |
Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis |
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Salazar, Juan Pirela, Daniela Nava, Manuel Castro, Ana Angarita, Lissé Parra, Heliana Durán-Agüero, Samuel Rojas-Gómez, Diana Marcela Galbán, Néstor Añez, Roberto Chacín, Maricarmen Diaz, Andrea Villasmil, Nelson Bautista De Sanctis, Juan Bermúdez, Valmore |
| dc.contributor.author.none.fl_str_mv |
Salazar, Juan Pirela, Daniela Nava, Manuel Castro, Ana Angarita, Lissé Parra, Heliana Durán-Agüero, Samuel Rojas-Gómez, Diana Marcela Galbán, Néstor Añez, Roberto Chacín, Maricarmen Diaz, Andrea Villasmil, Nelson Bautista De Sanctis, Juan Bermúdez, Valmore |
| dc.subject.eng.fl_str_mv |
specialized proresolving mediators inflammation resolution Atherosclerosis Intimal hyperplasia Reperfusion injury |
| topic |
specialized proresolving mediators inflammation resolution Atherosclerosis Intimal hyperplasia Reperfusion injury |
| description |
Cardiovascular disease (CVD) is a global public health issue due to its high morbidity, mortality, and economic impact. The implementation of innovative therapeutic alternatives for CVD is urgently required. Specialized proresolving lipid mediators (SPMs) are bioactive compounds derived from ω-3 and ω-6 fatty acids, integrated into four families: Lipoxins, Resolvins, Protectins, and Maresins. SPMs have generated interest in recent years due to their ability to promote the resolution of inflammation associated with the pathogeneses of numerous illnesses, particularly CVD. Several preclinical studies in animal models have evidenced their ability to decrease the progression of atherosclerosis, intimal hyperplasia, and reperfusion injury via diverse mechanisms. Large-scale clinical trials are required to determine the effects of SPMs in humans. This review integrates the currently available knowledge of the therapeutic impact of SPMs in CVD from preclinical and clinical studies, along with the implicated molecular pathways. In vitro results have been promising, and as such, SPMs could soon represent a new therapeutic alternative for CVD. |
| publishDate |
2022 |
| dc.date.accessioned.none.fl_str_mv |
2022-11-10T13:31:14Z |
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2022-11-10T13:31:14Z |
| dc.date.issued.none.fl_str_mv |
2022 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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Artículo científico |
| dc.identifier.citation.eng.fl_str_mv |
Salazar, J., Pirela, D., Nava, M., Castro, A., Angarita, L., Parra, H., Durán-Agüero, S., Rojas-Gómez, D. M., Galbán, N., Añez, R., Chacín, M., Diaz, A., Villasmil, N., De Sanctis, J. B., & Bermúdez, V. (2022). Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis. International Journal of Molecular Sciences, 23(6), 3133. https://doi.org/10.3390/ijms23063133 |
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14220067 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12442/11286 |
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https://doi.org/10.3390/ijms23063133 |
| identifier_str_mv |
Salazar, J., Pirela, D., Nava, M., Castro, A., Angarita, L., Parra, H., Durán-Agüero, S., Rojas-Gómez, D. M., Galbán, N., Añez, R., Chacín, M., Diaz, A., Villasmil, N., De Sanctis, J. B., & Bermúdez, V. (2022). Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis. International Journal of Molecular Sciences, 23(6), 3133. https://doi.org/10.3390/ijms23063133 14220067 |
| url |
https://hdl.handle.net/20.500.12442/11286 https://doi.org/10.3390/ijms23063133 |
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eng |
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eng |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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pdf |
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MDPI |
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International Journal of Molecular Sciences |
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Vol. 23, No.6 (2022) |
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Salazar, Juanfbd053e7-5aea-424c-812f-92153ecb9181Pirela, Danielaf7d00476-6884-4e9b-b972-aa1b154fcf02Nava, Manuelcf0ca570-5fc3-4ec7-9913-90be952261e2Castro, Ana542840db-6b79-4654-9321-1e0b9737ea93Angarita, Lissécd37d36e-0d41-457f-9dc8-1ed5b9201b16Parra, Heliana13603b25-99ce-42ac-a469-5b65a89ce794Durán-Agüero, Samuel9b230002-fae1-415b-800f-28692bd535a4Rojas-Gómez, Diana Marcelab1ebdaef-8f66-435e-a42c-cb80d01925e9Galbán, Néstore4c75ab2-e804-4874-a08d-3c96cebb9bd6Añez, Roberto233a8885-3f6a-4c67-ab42-f44cd09e3b3fChacín, Maricarmenfdb0f1d1-c963-4360-8d3b-f21d402ee436Diaz, Andrea2ce7bf2a-d262-43bc-82b6-ff67cc910778Villasmil, Nelson50e458e5-5ecc-452c-9129-64ed50705088Bautista De Sanctis, Juanbb02f2a8-71af-4f6f-89de-a7740d8107e0Bermúdez, Valmore29f9aa18-16a4-4fd3-8ce5-ed94a0b8663a2022-11-10T13:31:14Z2022-11-10T13:31:14Z2022Salazar, J., Pirela, D., Nava, M., Castro, A., Angarita, L., Parra, H., Durán-Agüero, S., Rojas-Gómez, D. M., Galbán, N., Añez, R., Chacín, M., Diaz, A., Villasmil, N., De Sanctis, J. B., & Bermúdez, V. (2022). Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis. International Journal of Molecular Sciences, 23(6), 3133. https://doi.org/10.3390/ijms2306313314220067https://hdl.handle.net/20.500.12442/11286https://doi.org/10.3390/ijms23063133Cardiovascular disease (CVD) is a global public health issue due to its high morbidity, mortality, and economic impact. The implementation of innovative therapeutic alternatives for CVD is urgently required. Specialized proresolving lipid mediators (SPMs) are bioactive compounds derived from ω-3 and ω-6 fatty acids, integrated into four families: Lipoxins, Resolvins, Protectins, and Maresins. SPMs have generated interest in recent years due to their ability to promote the resolution of inflammation associated with the pathogeneses of numerous illnesses, particularly CVD. Several preclinical studies in animal models have evidenced their ability to decrease the progression of atherosclerosis, intimal hyperplasia, and reperfusion injury via diverse mechanisms. Large-scale clinical trials are required to determine the effects of SPMs in humans. This review integrates the currently available knowledge of the therapeutic impact of SPMs in CVD from preclinical and clinical studies, along with the implicated molecular pathways. In vitro results have been promising, and as such, SPMs could soon represent a new therapeutic alternative for CVD.pdfengMDPIAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2International Journal of Molecular SciencesVol. 23, No.6 (2022)specialized proresolving mediatorsinflammationresolutionAtherosclerosisIntimal hyperplasiaReperfusion injurySpecialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosisinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Capó, X.; Martorell, M.; Busquets-Cortés, C.; Tejada, S.; Tur, J.A.; Pons, A.; Sureda, A. Resolvins as proresolving inflammatory mediators in cardiovascular disease. Eur. J. Med. Chem. 2018, 153, 123–130. [CrossRef] [PubMed]World Health Organization. Cardiovascular Diseases (CVDs). Available online: https://www.who.int/news-room/fact-sheets/ detail/cardiovascular-diseases-(cvds) (accessed on 18 August 2021).Recchiuti, A.; Serhan, C.N. Pro-Resolving Lipid Mediators (SPMs) and Their Actions in Regulating miRNA in Novel Resolution Circuits in Inflammation. Front. Immunol. 2012, 3, 298. [CrossRef] [PubMed]Sugimoto, M.A.; Sousa, L.P.; Pinho, V.; Perretti, M.; Teixeira, M.M. Resolution of Inflammation: What Controls Its Onset? Front. Immunol. 2016, 7, 160. [CrossRef]Nathan, C.; Ding, A. Nonresolving Inflammation. Cell 2010, 140, 871–882. [CrossRef]Headland, S.E.; Norling, L.V. The resolution of inflammation: Principles and challenges. Semin. Immunol. 2015, 27, 149–160. [CrossRef]Serhan, C.N.; Chiang, N.; Van Dyke, T.E. Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators. Nat. Rev. Immunol. 2008, 8, 349–361. [CrossRef]Buckley, C.D.; Gilroy, D.W.; Serhan, C.N. Pro-Resolving lipid mediators and Mechanisms in the resolution of acute inflammation. Immunity 2014, 40, 315–327. [CrossRef]Basil, M.C.; Levy, B.D. Specialized pro-resolving mediators: Endogenous regulators of infection and inflammation. Nat. Rev. Immunol. 2016, 16, 51–67. [CrossRef]Park, J.; Langmead, C.J.; Riddy, D.M. New Advances in Targeting the Resolution of Inflammation: Implications for Specialized Pro-Resolving Mediator GPCR Drug Discovery. ACS Pharmacol. Transl. Sci. 2020, 3, 88–106. [CrossRef]Doran, A.C. Inflammation Resolution: Implications for Atherosclerosis. Circ. Res. 2022, 130, 130–148. [CrossRef]de Gaetano, M.; McEvoy, C.; Andrews, D.; Cacace, A.; Hunter, J.; Brennan, E.; Godson, C. Specialized Pro-resolving Lipid Mediators: Modulation of Diabetes-Associated Cardio-, Reno-, and Retino-Vascular Complications. Front. Pharmacol. 2018, 9, 1488. [CrossRef] [PubMed]Doyle, R.; Sadlier, D.M.; Godson, C. Pro-resolving lipid mediators: Agents of anti-ageing? Semin. Immunol. 2018, 40, 36–48. [CrossRef] [PubMed]Viola, J.R.; Lemnitzer, P.; Jansen, Y.; Csaba, G.; Winter, C.; Neideck, C.; Silvestre-Roig, C.; Dittmar, G.; Döring, Y.; Drechsler, M.; et al. Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice. Circ. Res. 2016, 119, 1030–1038. [CrossRef] [PubMed]Fredman, G.; Spite, M. Specialized pro-resolving mediators in cardiovascular diseases. Mol. Asp. Med. 2017, 58, 65–71. [CrossRef]Kasikara, C.; Doran, A.C.; Cai, B.; Tabas, I. The role of non-resolving inflammation in atherosclerosis. J. Clin. Investig. 2018, 128, 2713–2723. [CrossRef]Satish, M.; Agrawal, D.K. Pro-resolving lipid mediators in the resolution of neointimal hyperplasia pathogenesis in atherosclerotic diseases. Expert Rev. Cardiovasc. Ther. 2019, 17, 177–184. [CrossRef]Halade, G.V.; Black, L.M.; Verma, M. Paradigm shift—Metabolic transformation of docosahexaenoic and eicosapentaenoic acids to bioactives exemplify the promise of fatty acid drug discovery. Biotechnol. Adv. 2018, 36, 935–953. [CrossRef]Halade, G.V.; Kain, V.; Ingle, K.A.; Prabhu, S.D. Interaction of 12/15-lipoxygenase with fatty acids alters the leukocyte kinetics leading to improved postmyocardial infarction healing. Am. J. Physiol. Heart Circ. Physiol. 2017, 313, H89–H102. [CrossRef]Halade, G.V.; Kain, V.; Tourki, B.; Jadapalli, J.K. Lipoxygenase drives lipidomic and metabolic reprogramming in ischemic heart failure. Metabolism 2019, 96, 22–32. [CrossRef]Chiang, N.; Serhan, C.N. Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors. Mol. Asp. Med. 2017, 58, 114–129. [CrossRef] [PubMed]Bang, S.; Xie, Y.-K.; Zhang, Z.-J.; Wang, Z.; Xu, Z.-Z.; Ji, R.-R. GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain. J. Clin. Investig. 2018, 128, 3568–3582. 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Prostaglandins Other Lipid Mediat. 2013, 107, 64–76.McCrary, M.R.; Jiang, M.Q.; Giddens, M.M.; Zhang, J.Y.; Owino, S.; Wei, Z.Z.; Zhong, W.; Gu, X.; Xin, H.; Hall, R.A.; et al. Protective effects of GPR37 via regulation of inflammation and multiple cell death pathways after ischemic stroke in mice. FASEB J. 2019, 33, 10680–10691.McCrary, M.R.; Jiang, M.Q.; Giddens, M.M.; Zhang, J.Y.; Owino, S.; Wei, Z.Z.; Zhong, W.; Gu, X.; Xin, H.; Hall, R.A.; et al. Protective effects of GPR37 via regulation of inflammation and multiple cell death pathways after ischemic stroke in mice. FASEB J. 2019, 33, 10680–10691.Dalli, J.; Serhan, C.N. Pro-Resolving Mediators in Regulating and Conferring Macrophage Function. Front. Immunol. 2017, 8, 1400.Dalli, J.; Serhan, C.N. Pro-Resolving Mediators in Regulating and Conferring Macrophage Function. Front. Immunol. 2017, 8, 1400. [CrossRef]Yokomizo, T. Two distinct leukotriene B4 receptors, BLT1 and BLT2. J. Biochem. 2015, 157, 65–71. 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[CrossRef]Lopez, E.F.; Kabarowski, J.H.; Ingle, K.A.; Kain, V.; Barnes, S.; Crossman, D.; Lindsey, M.; Halade, G.V. Obesity superimposed on aging magnifies inflammation and delays the resolving response after myocardial infarction. Am. J. Physiol. Circ. Physiol. 2015, 308, H269–H280. [CrossRef]Halade, G.V.; Kain, V.; Black, L.M.; Prabhu, S.D.; Ingle, K.A. Aging dysregulates D- and E-series resolvins to modulate cardios- plenic and cardiorenal network following myocardial infarction. Aging 2016, 8, 2611–2634. [CrossRef]Jadapalli, J.K.; Wright, G.W.; Kain, V.; Sherwani, M.A.; Sonkar, R.; Yusuf, N.; Halade, G.V. Doxorubicin triggers splenic contraction and irreversible dysregulation of COX and LOX that alters the inflammation-resolution program in the myocardium. Am. J. Physiol. Circ. Physiol. 2018, 315, H1091–H1100. [CrossRef]Halade, G.V.; Kain, V.; Wright, G.M.; Jadapalli, J.K. Subacute treatment of carprofen facilitate splenocardiac resolution deficit in cardiac injury. J. Leukoc. Biol. 2018, 104, 1173–1186. [CrossRef] [PubMed]Kain, V.; Jadapalli, J.K.; Tourki, B.; Halade, G.V. Inhibition of FPR2 impaired leukocytes recruitment and elicited non-resolving inflammation in acute heart failure. Pharmacol. Res. 2019, 146, 104295. [CrossRef] [PubMed]Brennan, E.; Kantharidis, P.; Cooper, M.E.; Godson, C. Pro-resolving lipid mediators: Regulators of inflammation, metabolism and kidney function. Nat. Rev. Nephrol. 2021, 17, 725–739. [CrossRef] [PubMed]Jadapalli, J.K.; Halade, G.V. Unified nexus of macrophages and maresins in cardiac reparative mechanisms. FASEB J. 2018, 32, 5227–5237. [CrossRef] [PubMed]Chandrasekharan, J.A.; Sharma-Walia, N. Lipoxins: Nature’s way to resolve inflammation. J. Inflamm. Res. 2015, 8, 181–192.Ho, K.J.; Spite, M.; Owens, C.D.; Lancero, H.; Kroemer, A.H.; Pande, R.; Creager, M.A.; Serhan, C.N.; Conte, M.S. Aspirin- Triggered Lipoxin and Resolvin E1 Modulate Vascular Smooth Muscle Phenotype and Correlate with Peripheral Atherosclerosis. Am. 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