From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID

Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection triggers var-ious events from the molecular to the tissue level, which in turn is given by the intrinsic character-istics of each patient. Given the molecular diversity characteristic of each cellular phenotype, the possible cyto...

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Autores:
Gonzalez-Garcia, Pablo
Fiorillo Moreno, Ornella
Pacheco Lugo, Lisandro
Acosta Hoyos, Antonio
Villarreal Camacho, José Luis
Navarro Quiroz, Roberto
Pacheco Londoño, Leonardo
Aroca Martínez, Gustavo
Moares, Noelia
Gabucio, Antonio
Fernández-Ponce, Cecilia
Garcia-Cozar, Francisco
Navarro Quiroz, Elkin
Tipo de recurso:
Fecha de publicación:
2023
Institución:
Universidad Simón Bolívar
Repositorio:
Repositorio Digital USB
Idioma:
eng
OAI Identifier:
oai:bonga.unisimon.edu.co:20.500.12442/12310
Acceso en línea:
https://hdl.handle.net/20.500.12442/12310
http://dx.doi.org/10.3390/xxxxx
https://www.mdpi.com/journal/ijms
Palabra clave:
COVID-19
SARS-CoV-2
Long COVID
Cytopathy
Cytokine storm
Sequelae
PASC
Coronavirus
Angiotensin-converting enzyme 2
Cell dysfunction
Rights
openAccess
License
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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oai_identifier_str oai:bonga.unisimon.edu.co:20.500.12442/12310
network_acronym_str USIMONBOL2
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dc.title.eng.fl_str_mv From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID
title From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID
spellingShingle From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID
COVID-19
SARS-CoV-2
Long COVID
Cytopathy
Cytokine storm
Sequelae
PASC
Coronavirus
Angiotensin-converting enzyme 2
Cell dysfunction
title_short From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID
title_full From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID
title_fullStr From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID
title_full_unstemmed From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID
title_sort From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID
dc.creator.fl_str_mv Gonzalez-Garcia, Pablo
Fiorillo Moreno, Ornella
Pacheco Lugo, Lisandro
Acosta Hoyos, Antonio
Villarreal Camacho, José Luis
Navarro Quiroz, Roberto
Pacheco Londoño, Leonardo
Aroca Martínez, Gustavo
Moares, Noelia
Gabucio, Antonio
Fernández-Ponce, Cecilia
Garcia-Cozar, Francisco
Navarro Quiroz, Elkin
dc.contributor.author.none.fl_str_mv Gonzalez-Garcia, Pablo
Fiorillo Moreno, Ornella
Pacheco Lugo, Lisandro
Acosta Hoyos, Antonio
Villarreal Camacho, José Luis
Navarro Quiroz, Roberto
Pacheco Londoño, Leonardo
Aroca Martínez, Gustavo
Moares, Noelia
Gabucio, Antonio
Fernández-Ponce, Cecilia
Garcia-Cozar, Francisco
Navarro Quiroz, Elkin
dc.subject.spa.fl_str_mv COVID-19
topic COVID-19
SARS-CoV-2
Long COVID
Cytopathy
Cytokine storm
Sequelae
PASC
Coronavirus
Angiotensin-converting enzyme 2
Cell dysfunction
dc.subject.eng.fl_str_mv SARS-CoV-2
Long COVID
Cytopathy
Cytokine storm
Sequelae
PASC
Coronavirus
Angiotensin-converting enzyme 2
Cell dysfunction
description Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection triggers var-ious events from the molecular to the tissue level, which in turn is given by the intrinsic character-istics of each patient. Given the molecular diversity characteristic of each cellular phenotype, the possible cytopathic, tissue, and clinical effects are difficult to predict, which determines the hetero-geneity of COVID-19 symptoms. The purpose of this article is to provide a comprehensive review of the cytopathic effects of SARS-CoV-2 on various cell types, focusing on the development of COVID-19, which in turn may lead, in some patients, to the persistence of symptoms after recovery from the disease, a condition known as long COVID. We describe the molecular mechanisms un-derlying virus–host interactions, including alterations in protein expression, intracellular signaling pathways, and immune responses. In particular, the article highlights the potential impact of these cytopathies on cellular function and clinical outcomes, such as immune dysregulation, neuropsy-chiatric disorders, and organ damage. The article concludes by discussing future directions for re-search and implications for the management and treatment of COVID-19 and long COVID.
publishDate 2023
dc.date.accessioned.none.fl_str_mv 2023-04-27T22:07:52Z
dc.date.available.none.fl_str_mv 2023-04-27T22:07:52Z
dc.date.issued.none.fl_str_mv 2023
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/article
dc.type.spa.spa.fl_str_mv Artículo científico
dc.identifier.citation.spa.fl_str_mv Gonzalez-Garcia, P.; Fiorillo Moreno, O.; Peñate, E.Z.; Calderon-Villalba, A.; Pacheco Lugo, L.; Hoyos, A.A.; Camacho, J.L.V.; Quiroz, R.N.; Londoño, L.P.; Aroca Martinez, G.; et al. From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID. Int. J. Mol. Sci. 2023, 24, x. https://doi.org/10.3390/xxxxx
dc.identifier.issn.none.fl_str_mv 14220067
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12442/12310
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.3390/xxxxx
dc.identifier.url.none.fl_str_mv https://www.mdpi.com/journal/ijms
identifier_str_mv Gonzalez-Garcia, P.; Fiorillo Moreno, O.; Peñate, E.Z.; Calderon-Villalba, A.; Pacheco Lugo, L.; Hoyos, A.A.; Camacho, J.L.V.; Quiroz, R.N.; Londoño, L.P.; Aroca Martinez, G.; et al. From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID. Int. J. Mol. Sci. 2023, 24, x. https://doi.org/10.3390/xxxxx
14220067
url https://hdl.handle.net/20.500.12442/12310
http://dx.doi.org/10.3390/xxxxx
https://www.mdpi.com/journal/ijms
dc.language.iso.eng.fl_str_mv eng
language eng
dc.rights.*.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
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eu_rights_str_mv openAccess
dc.format.mimetype.spa.fl_str_mv pdf
dc.publisher.spa.fl_str_mv MDPI
dc.source.eng.fl_str_mv International Journal of Molecular Sciences
int. J. Mol. Sci.
dc.source.none.fl_str_mv Vol 24, No X, (2023)
institution Universidad Simón Bolívar
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spelling Gonzalez-Garcia, Pablo597209c9-0625-47df-a759-a4ac5385b28aFiorillo Moreno, Ornella19bf58ee-ad93-4604-b018-8bf23736caebPacheco Lugo, Lisandro51b70dab-9baa-4f8f-afc1-f2b44b87c346Acosta Hoyos, Antonioe6dc1476-342c-4c42-a546-918f46b52df5Villarreal Camacho, José Luisd0fa1187-a6da-4a14-8f22-99338200eb54Navarro Quiroz, Roberto1246844f-5707-438a-808b-1f8c2761977ePacheco Londoño, Leonardo25b7d488-7f13-48ec-aca8-af95ac2b0420Aroca Martínez, Gustavod6bf7d66-bf9b-492a-be14-677f6ecdad05Moares, Noelia1c5a7e29-4678-4074-924d-fd6017b5da81Gabucio, Antoniof135b74f-8bd8-464b-b093-7020e18dff92Fernández-Ponce, Cecilia3ea042ce-c868-4666-918b-baddf44673f4Garcia-Cozar, Francisco014b186c-a8f0-4ae9-8bda-a4255f413931Navarro Quiroz, Elkind586f4e1-e86b-4364-8aa2-1b1dc7c1bb5e2023-04-27T22:07:52Z2023-04-27T22:07:52Z2023Gonzalez-Garcia, P.; Fiorillo Moreno, O.; Peñate, E.Z.; Calderon-Villalba, A.; Pacheco Lugo, L.; Hoyos, A.A.; Camacho, J.L.V.; Quiroz, R.N.; Londoño, L.P.; Aroca Martinez, G.; et al. From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID. Int. J. Mol. Sci. 2023, 24, x. https://doi.org/10.3390/xxxxx14220067https://hdl.handle.net/20.500.12442/12310http://dx.doi.org/10.3390/xxxxxhttps://www.mdpi.com/journal/ijmsSevere Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection triggers var-ious events from the molecular to the tissue level, which in turn is given by the intrinsic character-istics of each patient. Given the molecular diversity characteristic of each cellular phenotype, the possible cytopathic, tissue, and clinical effects are difficult to predict, which determines the hetero-geneity of COVID-19 symptoms. The purpose of this article is to provide a comprehensive review of the cytopathic effects of SARS-CoV-2 on various cell types, focusing on the development of COVID-19, which in turn may lead, in some patients, to the persistence of symptoms after recovery from the disease, a condition known as long COVID. We describe the molecular mechanisms un-derlying virus–host interactions, including alterations in protein expression, intracellular signaling pathways, and immune responses. In particular, the article highlights the potential impact of these cytopathies on cellular function and clinical outcomes, such as immune dysregulation, neuropsy-chiatric disorders, and organ damage. The article concludes by discussing future directions for re-search and implications for the management and treatment of COVID-19 and long COVID.pdfengMDPIAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2International Journal of Molecular Sciencesint. J. Mol. Sci.Vol 24, No X, (2023)COVID-19SARS-CoV-2Long COVIDCytopathyCytokine stormSequelaePASCCoronavirusAngiotensin-converting enzyme 2Cell dysfunctionFrom Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVIDinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/resource_type/c_2df8fbb1Lu, R.; Zhao, X.; Li, J.; Niu, P.; Yang, B.; Wu, H.; Wang, W.; Song, H.; Huang, B.; Zhu, N.; et al. Genomic Characterisation and Epidemiology of 2019 Novel Coronavirus: Implications for Virus Origins and Receptor Binding. 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