Hyponatremia and malnutrition: a comprehensive review

Background Hyponatremia (serum sodium lower than 135 mmol/L) is the most frequent electrolyte alteration diagnosed in medical practice. It has deleterious clinical effects, being an independent predictor of mortality. Malnutrition encompasses pathological states caused by both nutrients excess and d...

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Autores:: Baez, German
Chirio, Martin
Pisula, Pedro
Seminario, Enrique
Carasa, Natalia
Philippi, Romina
Aroca-Martinez, Gustavo
Musso, Carlos

Tipo de recurso:

Fecha de publicación:: 2024

Institución:: Universidad Simón Bolívar

Repositorio:: Repositorio Digital USB

Idioma:: eng

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dc.title.eng.fl_str_mv	Hyponatremia and malnutrition: a comprehensive review
title	Hyponatremia and malnutrition: a comprehensive review
spellingShingle	Hyponatremia and malnutrition: a comprehensive review Hyponatremia Malnutrition Pathophysiology
title_short	Hyponatremia and malnutrition: a comprehensive review
title_full	Hyponatremia and malnutrition: a comprehensive review
title_fullStr	Hyponatremia and malnutrition: a comprehensive review
title_full_unstemmed	Hyponatremia and malnutrition: a comprehensive review
title_sort	Hyponatremia and malnutrition: a comprehensive review
dc.creator.fl_str_mv	Baez, German Chirio, Martin Pisula, Pedro Seminario, Enrique Carasa, Natalia Philippi, Romina Aroca-Martinez, Gustavo Musso, Carlos
dc.contributor.author.none.fl_str_mv	Baez, German Chirio, Martin Pisula, Pedro Seminario, Enrique Carasa, Natalia Philippi, Romina Aroca-Martinez, Gustavo Musso, Carlos
dc.subject.eng.fl_str_mv	Hyponatremia Malnutrition Pathophysiology
topic	Hyponatremia Malnutrition Pathophysiology
description	Background Hyponatremia (serum sodium lower than 135 mmol/L) is the most frequent electrolyte alteration diagnosed in medical practice. It has deleterious clinical effects, being an independent predictor of mortality. Malnutrition encompasses pathological states caused by both nutrients excess and deficiency, being frequently documented in chronic kidney disease patients. In addition, chronic hyponatremia promotes adiposity loss and sarcopenia, while malnutrition can induce hyponatremia. This pathological interaction is mediated by four main mechanisms: altered electrolyte body composition (low sodium, low potassium, low phosphorus, or high-water body content), systemic inflammation (cytokines increase), hormonal mechanisms (renin–angiotensin–aldosterone system activation, vasopressin release), and anorexia (primary or secondary). Conclusion Malnutrition can induce hyponatremia through hydro-electrolytic, hormonal, inflammatory, or nutritional behavior changes; while hyponatremia per se can induce malnutrition, so there is a pathophysiological feedback between both conditions.
publishDate	2024
dc.date.accessioned.none.fl_str_mv	2024-10-24T15:08:21Z
dc.date.available.none.fl_str_mv	2024-10-24T15:08:21Z
dc.date.issued.none.fl_str_mv	2024
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dc.type.spa.none.fl_str_mv	Artículo científico
dc.identifier.citation.eng.fl_str_mv	Baez, G., Chirio, M., Pisula, P. et al. Hyponatremia and malnutrition: a comprehensive review. Ir J Med Sci 193, 1043–1046 (2024). https://doi.org/10.1007/s11845-023-03490-8
dc.identifier.issn.none.fl_str_mv	00211265 (Impreso) 18634362 (Electrónico)
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12442/15890
dc.identifier.doi.none.fl_str_mv	https://doi.org/10.1007/s11845-023-03490-8
dc.identifier.url.none.fl_str_mv	https://link.springer.com/article/10.1007/s11845-023-03490-8#citeas
identifier_str_mv	Baez, G., Chirio, M., Pisula, P. et al. Hyponatremia and malnutrition: a comprehensive review. Ir J Med Sci 193, 1043–1046 (2024). https://doi.org/10.1007/s11845-023-03490-8 00211265 (Impreso) 18634362 (Electrónico)
url	https://hdl.handle.net/20.500.12442/15890 https://doi.org/10.1007/s11845-023-03490-8 https://link.springer.com/article/10.1007/s11845-023-03490-8#citeas
dc.language.iso.none.fl_str_mv	eng
language	eng
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eu_rights_str_mv	openAccess
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dc.publisher.eng.fl_str_mv	Springer
dc.source.eng.fl_str_mv	Irish Journal of Medical Science Ir J Med Sci
dc.source.spa.fl_str_mv	Vol.193 No.2 Año 2024
institution	Universidad Simón Bolívar
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spelling	Baez, Germana4c8b574-0023-4415-89b3-86b2f3a8b3f0-1Chirio, Martin991549c3-66b4-4327-b9fb-e66d6ccf65ff-1Pisula, Pedro4dbc6c8a-b40d-4b55-9d8e-b9e1bd32d875600Seminario, Enrique15e55f4b-7cbc-4513-ba61-3112861aa84f-1Carasa, Nataliab5c96d00-b75b-4a7f-97d7-741d32125ed0-1Philippi, Romina776658e1-bcf8-41fc-a743-df1b710a1e74600Aroca-Martinez, Gustavo7fc5e0d9-66b3-4e58-815c-3574c28418a6600Musso, Carlos92bc9d9e-0454-4202-af3b-500f0a116d7e6002024-10-24T15:08:21Z2024-10-24T15:08:21Z2024Baez, G., Chirio, M., Pisula, P. et al. Hyponatremia and malnutrition: a comprehensive review. Ir J Med Sci 193, 1043–1046 (2024). https://doi.org/10.1007/s11845-023-03490-800211265 (Impreso)18634362 (Electrónico)https://hdl.handle.net/20.500.12442/15890https://doi.org/10.1007/s11845-023-03490-8https://link.springer.com/article/10.1007/s11845-023-03490-8#citeasBackground Hyponatremia (serum sodium lower than 135 mmol/L) is the most frequent electrolyte alteration diagnosed in medical practice. It has deleterious clinical effects, being an independent predictor of mortality. Malnutrition encompasses pathological states caused by both nutrients excess and deficiency, being frequently documented in chronic kidney disease patients. In addition, chronic hyponatremia promotes adiposity loss and sarcopenia, while malnutrition can induce hyponatremia. This pathological interaction is mediated by four main mechanisms: altered electrolyte body composition (low sodium, low potassium, low phosphorus, or high-water body content), systemic inflammation (cytokines increase), hormonal mechanisms (renin–angiotensin–aldosterone system activation, vasopressin release), and anorexia (primary or secondary). Conclusion Malnutrition can induce hyponatremia through hydro-electrolytic, hormonal, inflammatory, or nutritional behavior changes; while hyponatremia per se can induce malnutrition, so there is a pathophysiological feedback between both conditions.pdfengSpringerAttribution-NonCommercial-NoDerivs 3.0 United Stateshttp://creativecommons.org/licenses/by-nc-nd/3.0/us/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Irish Journal of Medical ScienceIr J Med SciVol.193 No.2 Año 2024HyponatremiaMalnutritionPathophysiologyHyponatremia and malnutrition: a comprehensive reviewinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Musso CG, Vilas M (2019) Water, electrolyte, and acid-base disorders in the elderly. In: Nephrogeriatrics Clinical (ed) Clinical Nephrogeriatrics. An Evidence-Based Guide. Springer, Cham, pp 43–62Kovesdy CP, Kopple JD, Kalantar-Zadeh K (2013) Management of protein-energy wasting in non-dialysis-dependent chronic kidney disease: reconciling low protein intake with nutritional therapy. Am J Clin Nutr 97(6):1163–1177Hanna RM, Ghobry L, Wassef O et al (2020) A practical approach to nutrition, protein-energy wasting, sarcopenia, and cachexia in patients with chronic kidney disease. Blood Purif 49(1–2):202–211Fouque D, Kalantar-Zadeh K, Kopple J et al (2008) A proposed nomenclature and diagnostic criteria for protein–energy wasting in acute and chronic kidney disease. Kidney Int 73(4):391–398Carrero JJ, Thomas F, Nagy K et al (2018) Global prevalence of protein-energy wasting in kidney disease: a meta-analysis of contemporary observational studies from the International Society of Renal Nutrition and Metabolism. J Ren Nutr 28(6):380–392. https://doi.org/10.1053/j.jrn.2018.08.006. (PMID: 30348259)Gracia-Iguacel C et al (2014) Defining protein-energy wasting syndrome in chronic kidney disease: prevalence and clinical implications. Nefrologia 34:507–519Gómez-Hoyos E, Buigues AO, Ballesteros Pomar MD et al (2019) Development of hyponatremia in non-critical patients receiving total parenteral nutrition: a prospective, multicenter study. Clin Nutr 38(6):2639–2644. https://doi.org/10.1016/j.clnu.2018.11.014Dekker MJE, Marcelli D, Canaud B et al (2019) Unraveling the relationship between mortality, hyponatremia, inflammation and malnutrition in hemodialysis patients: results from the international MONDO initiative. Eur J Clin Nutr 70(7):779–784. https://doi.org/10.1038/ejcn.2016.49Rhee CM, Ayus JC, Kalantar-Zadeh K (2019) Hyponatremia in the dialysis population. Kidney Int 4(6):769–780Bertini V, Nicoletti C, Beker BM, Musso CG (2019) Sarcopenia as a potential cause of chronic hyponatremia in the elderly Med Hypotheses 127:46–48. https://doi.org/10.1016/j.mehy.2019.03.029Feder J, Gomez JM, Serra-Aguirre F, Musso CG (2019) Reset osmostat: facts and controversies. Indian J Nephrol 29(4):232–234Musso CG, Jauregui JR (2016) Hyponatremia secondary to reset osmostat in a very old individual: a case report and pathophysiologic proposal. Electron J Biomed 3:49–51Poulikakos D, Marks V, Lelos N, Banerjee D (2014) Low serum sodium is associated with protein energy wasting and increased interdialytic weight gain in haemodialysis patients. Clin Kidney J 7(2):156–160. https://doi.org/10.1093/ckj/sft170Caksen H, Odabaş D, Sar S et al (2001) Hyponatremic dehydration: an analysis of 78 cases. Int Urol Nephrol 33(3):445–448. https://doi.org/10.1023/a:1019563222488Barsony J, Manigrasso MB, Xu Q et al (2013) Chronic hyponatremia exacerbates multiple manifestations of senescence in male rats. Age (Dordr) 35(2):271–288. https://doi.org/10.1007/s11357-011-9347-9Musso CG, Juarez R, Glassock RJ (2018) Water, electrolyte, acid-base, and trace elements alterations in cirrhotic patients. Int Urol Nephrol 50(1):81–89. https://doi.org/10.1007/s11255-017-1614-yMusso CG, Belloso WH, Glassock RJ (2016) Water, electrolytes, and acid-base alterations in human immunodeficiency virus infected patients. World J Nephrol 5(1):33–42. https://doi.org/10.5527/wjn.v5.i1.33Fujisawa C, Umegaki H, Sugimoto T et al (2021) Mild hyponatremia is associated with low skeletal muscle mass, physical function impairment, and depressive mood in the elderly. BMC Geriatr 21(1):15. https://doi.org/10.1186/s12877-020-01955-4Zevallos G, Oreopoulos DG, Halperin ML (2001) Hyponatremia in patients undergoing CAPD: role of water gain and/or malnutrition. Perit Dial Int 21(1):72–6De Arteaga J (2019) Hyponatremia in peritoneal dialysis: free water overload hyperosmolarity or malnutrition? Bull Dial Domic 2(4):201–206. https://doi.org/10.25796/bdd.v2i4.21303Kashiji A, Tajiri M, Chikugo M et al (2021) Hyponatremia is a prognostic factor in patients receiving nutrition support. Am J Med Sci 361(6):744–50. https://doi.org/10.1016/j.amjms.2020.11.025Dekker MJE, van der Sande FM, van den Berghe F et al (2018) Fluid overload and inflammation axis. Blood Purif 45(1–3):159–165. https://doi.org/10.1159/000485153Caregaro L, Di Pascoli L, Favaro A et al (2005) Sodium depletion and hemoconcentration: overlooked complications in patients with anorexia nervosa? Nutrition 21(4):438–445. https://doi.org/10.1016/j.nut.2004.08.022Sede BarranquillaORIGINALPDF.pdfPDF.pdfapplication/pdf602772https://bonga.unisimon.edu.co/bitstreams/bf48af7a-d87e-43e9-8dd5-0e8e283281dc/download1c0e35d5180e685d34e4d71decf44626MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8905https://bonga.unisimon.edu.co/bitstreams/fc98bb90-4937-437e-9ece-961033b482cb/download2f656a26de8af8c32aaacd5e2a33538cMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8381https://bonga.unisimon.edu.co/bitstreams/cbcd1508-8670-4c23-b522-1d96dba5ad9f/download733bec43a0bf5ade4d97db708e29b185MD53TEXTPDF.pdf.txtPDF.pdf.txtExtracted texttext/plain21043https://bonga.unisimon.edu.co/bitstreams/3a32cec9-5fbc-4004-a8e8-09cc5778c17c/download6142983174d918fa0b8f07b939026e97MD54THUMBNAILPDF.pdf.jpgPDF.pdf.jpgGenerated Thumbnailimage/jpeg5808https://bonga.unisimon.edu.co/bitstreams/5101667e-32f7-4ceb-b617-d266b48331d4/downloadc3db7ac079b5d085b0368351c6610530MD5520.500.12442/15890oai:bonga.unisimon.edu.co:20.500.12442/158902024-10-25 03:04:08.775http://creativecommons.org/licenses/by-nc-nd/3.0/us/Attribution-NonCommercial-NoDerivs 3.0 United Statesopen.accesshttps://bonga.unisimon.edu.coRepositorio Digital Universidad Simón Bolívarrepositorio.digital@unisimon.edu.coPGEgcmVsPSJsaWNlbnNlIiBocmVmPSJodHRwOi8vY3JlYXRpdmVjb21tb25zLm9yZy9saWNlbnNlcy9ieS1uYy80LjAvIj48aW1nIGFsdD0iTGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyIgc3R5bGU9ImJvcmRlci13aWR0aDowO3dpZHRoOjEwMHB4OyIgc3JjPSJodHRwczovL2kuY3JlYXRpdmVjb21tb25zLm9yZy9sL2J5LW5jLzQuMC84OHgzMS5wbmciIC8+PC9hPjxici8+RXN0YSBvYnJhIGVzdMOhIGJham8gdW5hIDxhIHJlbD0ibGljZW5zZSIgaHJlZj0iaHR0cDovL2NyZWF0aXZlY29tbW9ucy5vcmcvbGljZW5zZXMvYnktbmMvNC4wLyI+TGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyBBdHJpYnVjacOzbi1Ob0NvbWVyY2lhbCA0LjAgSW50ZXJuYWNpb25hbDwvYT4u

Hyponatremia and malnutrition: a comprehensive review

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