Intrinsic and environmental basis of aging: A narrative review

Longevity has been a topic of interest since the beginnings of humanity, yet its aetiology and precise mechanisms remain to be elucidated. Aging is currently viewed as a physiological phenomenon characterized by the gradual degeneration of organic physiology and morphology due to the passage of time...

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Autores:: Navarro, Carla
Salazar, Juan
Díaz, María P.
Chacin, Maricarmen
Santeliz, Raquel
Vera, Ivana
D'Marco, Luis
Parra, Heliana
Bernal, Mary Carlota
Castro, Ana
Escalona, Daniel
García-Pacheco, Henry
Bermúdez, Valmore

Tipo de recurso:

Fecha de publicación:: 2023

Institución:: Universidad Simón Bolívar

Repositorio:: Repositorio Digital USB

Idioma:: eng

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dc.title.eng.fl_str_mv	Intrinsic and environmental basis of aging: A narrative review
title	Intrinsic and environmental basis of aging: A narrative review
spellingShingle	Intrinsic and environmental basis of aging: A narrative review Aging Telomeres Telomerase Obesity Chronic diseases Age-related genes
title_short	Intrinsic and environmental basis of aging: A narrative review
title_full	Intrinsic and environmental basis of aging: A narrative review
title_fullStr	Intrinsic and environmental basis of aging: A narrative review
title_full_unstemmed	Intrinsic and environmental basis of aging: A narrative review
title_sort	Intrinsic and environmental basis of aging: A narrative review
dc.creator.fl_str_mv	Navarro, Carla Salazar, Juan Díaz, María P. Chacin, Maricarmen Santeliz, Raquel Vera, Ivana D'Marco, Luis Parra, Heliana Bernal, Mary Carlota Castro, Ana Escalona, Daniel García-Pacheco, Henry Bermúdez, Valmore
dc.contributor.author.none.fl_str_mv	Navarro, Carla Salazar, Juan Díaz, María P. Chacin, Maricarmen Santeliz, Raquel Vera, Ivana D'Marco, Luis Parra, Heliana Bernal, Mary Carlota Castro, Ana Escalona, Daniel García-Pacheco, Henry Bermúdez, Valmore
dc.subject.eng.fl_str_mv	Aging Telomeres Telomerase Obesity Chronic diseases Age-related genes
topic	Aging Telomeres Telomerase Obesity Chronic diseases Age-related genes
description	Longevity has been a topic of interest since the beginnings of humanity, yet its aetiology and precise mechanisms remain to be elucidated. Aging is currently viewed as a physiological phenomenon characterized by the gradual degeneration of organic physiology and morphology due to the passage of time where both external and internal stimuli intervene. The influence of intrinsic factors, such as progressive telomere shortening, genome instability due to mutation buildup, the direct or indirect actions of age-related genes, and marked changes in epigenetic, metabolic, and mitochondrial patterns constitute a big part of its underlying endogenous mechanisms. On the other hand, several psychosocial and demographic factors, such as diet, physical activity, smoking, and drinking habits, may have an even more significant impact on shaping the aging process. Consequentially, implementing dietary and exercise patterns has been proposed as the most viable alternative strategy for attenuating the most typical degenerative aging changes, thus increasing the likelihood of prolonging lifespan and achieving successful aging.
publishDate	2023
dc.date.accessioned.none.fl_str_mv	2023-09-07T19:54:17Z
dc.date.available.none.fl_str_mv	2023-09-07T19:54:17Z
dc.date.issued.none.fl_str_mv	2023
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dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12442/13249
dc.identifier.doi.none.fl_str_mv	https://doi.org/10.1016/j.heliyon.2023.e18239
identifier_str_mv	24058440
url	https://hdl.handle.net/20.500.12442/13249 https://doi.org/10.1016/j.heliyon.2023.e18239
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language	eng
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dc.publisher.eng.fl_str_mv	Elsevier Ltd.
dc.source.eng.fl_str_mv	Heliyon
dc.source.none.fl_str_mv	Volume 9, Issue 8 (2023)
institution	Universidad Simón Bolívar
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spelling	Navarro, Carla9892bf34-10a9-479a-8b3a-6769d4804207Salazar, Juanfbd053e7-5aea-424c-812f-92153ecb9181Díaz, María P.e5017bb2-15b8-412f-a151-05cba49ffa99Chacin, Maricarmen79f4c63d-7d90-4e40-a735-6f58ce5c8f0bSanteliz, Raquel5e2f7a44-1208-4164-83cb-743abf6a557dVera, Ivana89ef899e-d9fb-4348-b1ff-f1b3543f4019D'Marco, Luis4f289143-892b-43a3-ac1f-6f462224f314Parra, Heliana13603b25-99ce-42ac-a469-5b65a89ce794Bernal, Mary Carlotaa4a05de6-132a-41ef-b763-ddbdb1776814Castro, Ana542840db-6b79-4654-9321-1e0b9737ea93Escalona, Daniel0d731e82-c39a-40b3-b682-16c02e731a2aGarcía-Pacheco, Henry784e8766-d84b-4be0-8e05-ed7c7b86b393Bermúdez, Valmore29f9aa18-16a4-4fd3-8ce5-ed94a0b8663a2023-09-07T19:54:17Z2023-09-07T19:54:17Z202324058440https://hdl.handle.net/20.500.12442/13249https://doi.org/10.1016/j.heliyon.2023.e18239Longevity has been a topic of interest since the beginnings of humanity, yet its aetiology and precise mechanisms remain to be elucidated. Aging is currently viewed as a physiological phenomenon characterized by the gradual degeneration of organic physiology and morphology due to the passage of time where both external and internal stimuli intervene. The influence of intrinsic factors, such as progressive telomere shortening, genome instability due to mutation buildup, the direct or indirect actions of age-related genes, and marked changes in epigenetic, metabolic, and mitochondrial patterns constitute a big part of its underlying endogenous mechanisms. On the other hand, several psychosocial and demographic factors, such as diet, physical activity, smoking, and drinking habits, may have an even more significant impact on shaping the aging process. Consequentially, implementing dietary and exercise patterns has been proposed as the most viable alternative strategy for attenuating the most typical degenerative aging changes, thus increasing the likelihood of prolonging lifespan and achieving successful aging.pdfengElsevier Ltd.Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2HeliyonVolume 9, Issue 8 (2023)AgingTelomeresTelomeraseObesityChronic diseasesAge-related genesIntrinsic and environmental basis of aging: A narrative reviewinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1A. Poças, E. Soukiazis, M. Antunes, Factors explaining life expectancy at age 65: a panel data approach applied to European union countries, Soc. Indic. Res. 150 (1) (2020) 265–288, el 1 de julio de.H. Beltran-Sánchez, E.M. Crimmins, C.E. Finch, Early cohort mortality predicts the rate of aging in the cohort: a historical analysis, J. Develop. Orig. Heal. Dis. 3 (5) (2012) 380–386, octubre de.G.A. Mensah, G.S. Wei, P.D. Sorlie, L.J. Fine, Y. Rosenberg, P.G. Kaufmann, et al., Decline in cardiovascular mortality: possible causes and implications, Circ. Res. 120 (2) (2017) 366–380, el 20 de enero deR. Guthold, G.A. Stevens, L.M. Riley, F.C. Bull, Worldwide trends in insufficient physical activity from 2001 to 2016: a pooled analysis of 358 population-based surveys with 1⋅9 million participants, Lancet Glob. Heal. 6 (10) (2018) e1077–e1086, el 1 de octubre de.S. Stenholm, J. Head, M. Kivimaki, I. Kawachi, V. Aalto, M. Zins, et al., Smoking, physical inactivity and obesity as predictors of healthy and disease-free life expectancy between ages 50 and 75: a multicohort study, Int. J. Epidem. 45 (4) (2016) 1260–1270, el 1 de agosto de.M. Abdelaal, C.W. le Roux, N.G. 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Muench, et al., Epigenetic ageing is accelerated in alcohol use disorder and regulated by genetic variation in APOL2, Neuropsychopharmacol 45 (2) (2020) 327–336, enero de.ORIGINALPDF.pdfPDF.pdfPDFapplication/pdf1628189https://bonga.unisimon.edu.co/bitstreams/d2344c19-bc84-4f25-936e-a8856249ff2b/downloadca412a9ac1d83e9bf7591aab90850270MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://bonga.unisimon.edu.co/bitstreams/f1b29f6b-d397-49c5-a378-387da5903dd3/download4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8381https://bonga.unisimon.edu.co/bitstreams/81d78218-52a3-4641-94fc-bb32df0d41a3/download733bec43a0bf5ade4d97db708e29b185MD53TEXT26_2023_GC_ART_Intrinsic-and-environmental.pdf.txt26_2023_GC_ART_Intrinsic-and-environmental.pdf.txtExtracted texttext/plain100359https://bonga.unisimon.edu.co/bitstreams/0a246b82-0324-4712-8f9e-b7ef2b731491/download554844cc94133a23a378fd98a5a61264MD54PDF.pdf.txtPDF.pdf.txtExtracted texttext/plain100359https://bonga.unisimon.edu.co/bitstreams/d1856a57-ce05-4027-a905-c2b473520683/download554844cc94133a23a378fd98a5a61264MD56THUMBNAIL26_2023_GC_ART_Intrinsic-and-environmental.pdf.jpg26_2023_GC_ART_Intrinsic-and-environmental.pdf.jpgGenerated Thumbnailimage/jpeg5447https://bonga.unisimon.edu.co/bitstreams/827bc767-0e38-46ad-a853-c6a25efc66c7/downloadcb5fce4e58db5fde736355fc70d94ec3MD55PDF.pdf.jpgPDF.pdf.jpgGenerated Thumbnailimage/jpeg5447https://bonga.unisimon.edu.co/bitstreams/9ce723ab-5ae4-485f-b90b-d246d71f62e7/downloadcb5fce4e58db5fde736355fc70d94ec3MD5720.500.12442/13249oai:bonga.unisimon.edu.co:20.500.12442/132492024-08-14 21:54:08.487http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internacionalopen.accesshttps://bonga.unisimon.edu.coRepositorio Digital Universidad Simón Bolívarrepositorio.digital@unisimon.edu.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