Clinical and immunological factors associated with the progression of Lupus Nephritis in a population from the Colombian Caribbean
Lupus nephritis represents a significant immune-mediated glomerulonephritis, constituting the most important organ involvement induced by systemic lupus erythematosus (SLE), with variable epidemiology and clinical presentation among populations. Objective: to identify clinical and immunological fact...
- Autores:
-
Vélez-Verbel, María
Aroca-Martinez, Gustavo
Vélez-Verbel, David
Domínguez-Vargas, Alex
Vallejo-Patiño, Manuela
Sarmiento-Gutiérrez, Joanny
Gómez-Escorcia, Lorena
Musso, Carlos G.
González-Torres, Henry J.
- Tipo de recurso:
- Fecha de publicación:
- 2024
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- spa
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/15551
- Acceso en línea:
- https://hdl.handle.net/20.500.12442/15551
https://doi.org/10.3390/biomedicines12092047
https://www.mdpi.com/2227-9059/12/9/2047
- Palabra clave:
- Lupus nephritis
Immunological factors
Disease progression
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivs 3.0 United States
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Clinical and immunological factors associated with the progression of Lupus Nephritis in a population from the Colombian Caribbean |
| title |
Clinical and immunological factors associated with the progression of Lupus Nephritis in a population from the Colombian Caribbean |
| spellingShingle |
Clinical and immunological factors associated with the progression of Lupus Nephritis in a population from the Colombian Caribbean Lupus nephritis Immunological factors Disease progression |
| title_short |
Clinical and immunological factors associated with the progression of Lupus Nephritis in a population from the Colombian Caribbean |
| title_full |
Clinical and immunological factors associated with the progression of Lupus Nephritis in a population from the Colombian Caribbean |
| title_fullStr |
Clinical and immunological factors associated with the progression of Lupus Nephritis in a population from the Colombian Caribbean |
| title_full_unstemmed |
Clinical and immunological factors associated with the progression of Lupus Nephritis in a population from the Colombian Caribbean |
| title_sort |
Clinical and immunological factors associated with the progression of Lupus Nephritis in a population from the Colombian Caribbean |
| dc.creator.fl_str_mv |
Vélez-Verbel, María Aroca-Martinez, Gustavo Vélez-Verbel, David Domínguez-Vargas, Alex Vallejo-Patiño, Manuela Sarmiento-Gutiérrez, Joanny Gómez-Escorcia, Lorena Musso, Carlos G. González-Torres, Henry J. |
| dc.contributor.author.none.fl_str_mv |
Vélez-Verbel, María Aroca-Martinez, Gustavo Vélez-Verbel, David Domínguez-Vargas, Alex Vallejo-Patiño, Manuela Sarmiento-Gutiérrez, Joanny Gómez-Escorcia, Lorena Musso, Carlos G. González-Torres, Henry J. |
| dc.subject.keywords.eng.fl_str_mv |
Lupus nephritis Immunological factors Disease progression |
| topic |
Lupus nephritis Immunological factors Disease progression |
| description |
Lupus nephritis represents a significant immune-mediated glomerulonephritis, constituting the most important organ involvement induced by systemic lupus erythematosus (SLE), with variable epidemiology and clinical presentation among populations. Objective: to identify clinical and immunological factors associated with the progression of lupus nephritis in a population from the Colombian Caribbean. Methods: we evaluated 401 patients diagnosed with SLE and lupus nephritis, treated at a reference center in the Colombian Caribbean, gathering data recorded in medical records. Results: A proportion of 87% were female, with a median age of 42 years. Most patients presented with proliferative classes (90%), with class IV being the most common (70%). A proportion of 52% of patients did not respond to treatment, which is described as the lack of complete or partial response, while 28% had a complete response. A significant decrease in hemoglobin, glomerular filtration rate, and proteinuria was identified by the third follow-up (p < 0.001), along with an increase in creatinine, urea, and hematuria (p < 0.001). Patients with initial proteinuria > 2 g/day were found to be 27 times more likely to be non-responders (p < 0.001). Mortality was associated with the presence of serum creatinine >1.5 mg/dL (p = 0.01) (OR: 1.61 CI 95% 0.75–3.75) and thrombocytopenia (p = 0.01) (OR: 0.36; CI 95% 0.12–0.81). Conclusions: identifying factors of progression, non-response, and mortality provides an opportunity for more targeted and personalized intervention, thereby improving care and outcomes for patients with lupus nephritis. |
| publishDate |
2024 |
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2024-09-09T21:48:12Z |
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2024-09-09T21:48:12Z |
| dc.date.issued.none.fl_str_mv |
2024 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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Artículo científico |
| dc.identifier.citation.eng.fl_str_mv |
Vélez-Verbel, M.; Aroca-Martínez, G.; Vélez-Verbel, D.; Domínguez-Vargas, A.; Vallejo-Patiño, M.; Sarmiento-Gutierrez, J.; Gomez-Escorcia, L.; Musso, C.G.; González-Torres, H.J. Clinical and Immunological Factors Associated with the Progression of Lupus Nephritis in a Population from the Colombian Caribbean. Biomedicines 2024, 12, 2047. https://doi.org/10.3390/biomedicines12092047 |
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22279059 (Electrónico) |
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https://hdl.handle.net/20.500.12442/15551 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.3390/biomedicines12092047 |
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https://www.mdpi.com/2227-9059/12/9/2047 |
| identifier_str_mv |
Vélez-Verbel, M.; Aroca-Martínez, G.; Vélez-Verbel, D.; Domínguez-Vargas, A.; Vallejo-Patiño, M.; Sarmiento-Gutierrez, J.; Gomez-Escorcia, L.; Musso, C.G.; González-Torres, H.J. Clinical and Immunological Factors Associated with the Progression of Lupus Nephritis in a Population from the Colombian Caribbean. Biomedicines 2024, 12, 2047. https://doi.org/10.3390/biomedicines12092047 22279059 (Electrónico) |
| url |
https://hdl.handle.net/20.500.12442/15551 https://doi.org/10.3390/biomedicines12092047 https://www.mdpi.com/2227-9059/12/9/2047 |
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spa |
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spa |
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Attribution-NonCommercial-NoDerivs 3.0 United States |
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http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-NoDerivs 3.0 United States http://creativecommons.org/licenses/by-nc-nd/3.0/us/ http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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pdf |
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MDPI |
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Biomedicines |
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Vol.12 No.9 Año 2024 |
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Universidad Simón Bolívar |
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Vélez-Verbel, María8cbb1ae1-ca05-406f-81fc-86ff55fb6f20-1Aroca-Martinez, Gustavo1b37f037-7cd9-4e5c-87a6-a66351104938600Vélez-Verbel, David20a81ad4-458a-4f98-8b8d-0c734d552dc4-1Domínguez-Vargas, Alex5565ade7-9f42-474d-924c-3dd522dd6e66600Vallejo-Patiño, Manuela5f40861d-7b8f-44a3-b6b9-26b41f289d93-1Sarmiento-Gutiérrez, Joanny6bd807ac-4135-40b1-a11a-cddb26340ec3-1Gómez-Escorcia, Lorena0f8da4a7-1326-4e31-9e08-4432548de4e7-1Musso, Carlos G.b310094b-baeb-4838-bde5-206ff4744824-1González-Torres, Henry J.647be977-823a-432b-a0a3-166d8b4751c4-12024-09-09T21:48:12Z2024-09-09T21:48:12Z2024Vélez-Verbel, M.; Aroca-Martínez, G.; Vélez-Verbel, D.; Domínguez-Vargas, A.; Vallejo-Patiño, M.; Sarmiento-Gutierrez, J.; Gomez-Escorcia, L.; Musso, C.G.; González-Torres, H.J. Clinical and Immunological Factors Associated with the Progression of Lupus Nephritis in a Population from the Colombian Caribbean. Biomedicines 2024, 12, 2047. https://doi.org/10.3390/biomedicines1209204722279059 (Electrónico)https://hdl.handle.net/20.500.12442/15551https://doi.org/10.3390/biomedicines12092047https://www.mdpi.com/2227-9059/12/9/2047Lupus nephritis represents a significant immune-mediated glomerulonephritis, constituting the most important organ involvement induced by systemic lupus erythematosus (SLE), with variable epidemiology and clinical presentation among populations. Objective: to identify clinical and immunological factors associated with the progression of lupus nephritis in a population from the Colombian Caribbean. Methods: we evaluated 401 patients diagnosed with SLE and lupus nephritis, treated at a reference center in the Colombian Caribbean, gathering data recorded in medical records. Results: A proportion of 87% were female, with a median age of 42 years. Most patients presented with proliferative classes (90%), with class IV being the most common (70%). A proportion of 52% of patients did not respond to treatment, which is described as the lack of complete or partial response, while 28% had a complete response. A significant decrease in hemoglobin, glomerular filtration rate, and proteinuria was identified by the third follow-up (p < 0.001), along with an increase in creatinine, urea, and hematuria (p < 0.001). Patients with initial proteinuria > 2 g/day were found to be 27 times more likely to be non-responders (p < 0.001). Mortality was associated with the presence of serum creatinine >1.5 mg/dL (p = 0.01) (OR: 1.61 CI 95% 0.75–3.75) and thrombocytopenia (p = 0.01) (OR: 0.36; CI 95% 0.12–0.81). Conclusions: identifying factors of progression, non-response, and mortality provides an opportunity for more targeted and personalized intervention, thereby improving care and outcomes for patients with lupus nephritis.pdfspaMDPIAttribution-NonCommercial-NoDerivs 3.0 United Stateshttp://creativecommons.org/licenses/by-nc-nd/3.0/us/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2BiomedicinesVol.12 No.9 Año 2024Clinical and immunological factors associated with the progression of Lupus Nephritis in a population from the Colombian Caribbeaninfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Lupus nephritisImmunological factorsDisease progressionAringer, M.; Costenbader, K.; Daikh, D.; Brinks, R.; Mosca, M.; Ramsey-Goldman, R.; Smolen, J.S.; Wofsy, D.; Boumpas, D.T.; Kamen, D.L.; et al. 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus. Ann. Rheum. Dis. 2019, 78, 1151–1159.Jesus, D.; Rodrigues, M.; Matos, A.; Henriques, C.; Pereira da Silva, J.A.; Inês, L.S. Performance of SLEDAI-2K to Detect a Clinically Meaningful Change in SLE Disease Activity: A 36-Month Prospective Cohort Study of 334 Patients. Lupus 2019, 28, 607–612.Student, M.T.; Kumar, R.R.; Omments, R.E.C.; Prajapati, A.; Blockchain, T.-A.; Ml, A.I.; Randive, P.S.N.; Chaudhari, S.; Barde, S.; Devices, E.; et al. Lupus Nephritis. En Comprehensive Clinical. Front. Neurosci. 2021, 14, 726–729.Saxena, R.; Mahajan, T.; Mohan, C. Lupus Nephritis: Current Update. Arthritis Res. Ther. 2011, 13, 240.Zahab, M.; Fouda, M.A.; Elhendy, Y.; Elokely, A.; Abdul Rahim, M.; Refaie, A.F.; Alobaidi, S.; Akl, A. Treatment Outcomes of Proliferative vs. Non-Proliferative Adult Lupus Nephritis: A 10-Year Follow-Up. Cureus 2021, 13, e16955.Duran, E.; Yıldırım, T.; Taghiyeva, A.; Bilgin, E.; Arıcı, M.; Sa˘glam, E.A.; Özen, S.; Üner, M.; Erdem, Y.; Kalyoncu, U.; et al. Differences and Similarities of Proliferative and Non-Proliferative Forms of Biopsy-Proven Lupus Nephritis: Single Centre, Cross-Disciplinary Experience. Lupus 2022, 31, 1147–1156.McDonald, S.; Yiu, S.; Su, L.; Gordon, C.; Truman, M.; Lisk, L.; Solomons, N.; Bruce, I.N. MASTERPLANS Consortium Predictors of Treatment Response in a Lupus Nephritis Population: Lessons from the Aspreva Lupus Management Study (ALMS) Trial. Lupus Sci. Med. 2022, 9, e000584.Pacheco-Lugo, L.; Sáenz-García, J.; Navarro Quiroz, E.; González Torres, H.J.; Fang, L.; Díaz-Olmos, Y.; Garavito de Egea, G.; Egea Bermejo, E.; Aroca Martínez, G. Plasma Cytokines as Potential Biomarkers of Kidney Damage in Patients with Systemic Lupus Erythematosus. Lupus 2019, 28, 34–43.Choi, S.-E.; Park, D.-J.; Kang, J.-H.; Lee, K.-E.; Xu, H.; Lee, J.S.; Choi, Y.-D.; Lee, S.-S. Comparison of Renal Responses to Cyclophosphamide and Mycophenolate Mofetil Used as Induction Therapies in Korean Patients with Lupus Nephritis. J. Rheum. Dis. 2019, 26, 57.Park, D.J.; Bin Joo, Y.; Bang, S.-Y.; Lee, J.; Lee, H.-S.; Bae, S.-C. Predictive Factors for Renal Response in Lupus Nephritis: A Single-Center Prospective Cohort Study. J. Rheum. Dis. 2022, 29, 223–231.Gasparotto, M.; Gatto, M.; Binda, V.; Doria, A.; Moroni, G. Lupus Nephritis: Clinical Presentations and Outcomes in the 21st Century. Rheumatology 2020, 59, v39–v51.Du, K.; Zhang, X.; Feng, J.; Zhong, S.; Qi, J.; Lin, Z. Renal Response and Its Predictive Factors of Lupus Nephritis: A 2-Year Real-World Study of 56 Hospital-Based Patients. Clin. Rheumatol. 2022, 41, 3363–3371.Seligman, V.A.; Lum, R.F.; Olson, J.L.; Li, H.; Criswell, L.A. Demographic Differences in the Development of Lupus Nephritis: A Retrospective Analysis. Am. J. Med. 2002, 112, 726–729.Afifi, R.; Elkhayat, S.S.; Medkouri, G.; Mtioui, N.; Zamd, M.; Ramdani, B.; Benghanem, M. MO119: Lupus Nephritis in Males: About 34 Cases. Nephrol. Dial. Transplant. 2022, 37, S43–S44.Resende, A.; Titan, S.; Barros, R.; Woronik, V. Worse Renal Outcome of Lupus Nephritis in Male Patients: A Case–Control Study. Lupus 2011, 20, 561–567.Farah, R.I.; Dannoun, E.; Abu Shahin, N.; AlRyalat, S.A. Characteristics and Histological Types of Lupus Nephritis in a Jordanian Tertiary Medical Center. Biomed Res. Int. 2019, 2019, 7087461.Ichinose, K.; Kitamura, M.; Sato, S.; Eguchi, M.; Okamoto, M.; Endo, Y.; Tsuji, S.; Takatani, A.; Shimizu, T.; Umeda, M.; et al. Complete Renal Response at 12 Months after Induction Therapy Is Associated with Renal Relapse-Free Rate in Lupus Nephritis: A Single-Center, Retrospective Cohort Study. Lupus 2019, 28, 501–509.Luís, M.S.F.; Bultink, I.E.M.; da Silva, J.A.P.; Voskuyl, A.E.; Inês, L.S. Early Predictors of Renal Outcome in Patients with Proliferative Lupus Nephritis: A 36-Month Cohort Study. Rheumatology 2021, 60, 5134–5141.Delfino, J.; dos Santos, T.A.F.G.; Skare, T.L. Comparison of Lupus Patients with Early and Late Onset Nephritis: A Study in 71 Patients from a Single Referral Center. Adv. Rheumatol. 2020, 60, 5.Bobirca, A.; Bobira, F.; Florescui, A.; Iorgusi, C.; Tinta, R.; Musetescu, A.; Bojica, M.; Ancata, I. Evaluation of Treatment Response in Lupus Nephritis. Mod. Med. 2021, 28, 389–395.Rossi, G.M.; Maggiore, U.; Peyronel, F.; Fenaroli, P.; Delsante, M.; Benigno, G.D.; Gianfreda, D.; Urban, M.L.; Manna, Z.; Arend, L.J.; et al. Persistent Isolated C3 Hypocomplementemia as a Strong Predictor of End-Stage Kidney Disease in Lupus Nephritis. Kidney Int. Rep. 2022, 7, 2647–2656.Miranda-Hernández, D.; Cruz-Reyes, C.; Angeles, U.; Jara, L.J.; Saavedra, M.A. Prognostic Factors for Treatment Response in Patients with Lupus Nephritis. Reumatol. Clin. 2014, 10, 164–169.Dall’Era, M.; Stone, D.; Levesque, V.; Cisternas, M.;Wofsy, D. Identification of Biomarkers That Predict Response to Treatment of Lupus Nephritis with Mycophenolate Mofetil or Pulse Cyclophosphamide. Arthritis Care Res. 2011, 63, 351–357.Yap, D.Y.H.; Tang, C.S.O.; Ma, M.K.M.; Lam, M.F.; Chan, T.M. Survival Analysis and Causes of Mortality in Patients with Lupus Nephritis. Nephrol. Dial. Transplant. 2012, 27, 3248–3254.Luo, W.; Farinha, F.; Isenberg, D.A.; Rahman, A. Survival Analysis of Mortality and Development of Lupus Nephritis in Patients with Systemic Lupus Erythematosus up to 40 Years of Follow-Up. Rheumatology 2022, 62, 200–208.Teh, C.L.; Phui, V.E.; Ling, G.R.; Ngu, L.-S.; Wan, S.A.; Tan, C.H.-H. Causes and Predictors of Mortality in Biopsy-Proven Lupus Nephritis: The Sarawak Experience. Clin. Kidney J. 2018, 11, 56–61.Almaani, S.; Meara, A.; Rovin, B.H. Update on Lupus Nephritis. Clin. J. Am. Soc. 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