Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study

Oral diabetes-specific nutritional supplements (ONS-D) induce favourable postprandial responses in subjects with type 2 diabetes (DM2), but they have not been correlated yet with incretin release and subjective appetite (SA). This randomised, double-blind, cross-over study compared postprandial effe...

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Autores:: Angarita Dávila, Lisse
Bermúdez, Valmore
Aparicio, Daniel
Céspedes, Virginia
Escobar, Ma. Cristina
Durán-Agüero, Samuel
Cisternas, Silvana
Costa, Jorge de Assis
Rojas-Gómez, Diana
Reyna, Nadia
López-Miranda, Jose

Tipo de recurso:

Fecha de publicación:: 2019

Institución:: Universidad Simón Bolívar

Repositorio:: Repositorio Digital USB

Idioma:: eng

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dc.title.eng.fl_str_mv	Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study
title	Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study
spellingShingle	Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study Glycaemic index Incretins Subjective appetite Isomaltulose Sucromalt Nutritional supplement
title_short	Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study
title_full	Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study
title_fullStr	Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study
title_full_unstemmed	Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study
title_sort	Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study
dc.creator.fl_str_mv	Angarita Dávila, Lisse Bermúdez, Valmore Aparicio, Daniel Céspedes, Virginia Escobar, Ma. Cristina Durán-Agüero, Samuel Cisternas, Silvana Costa, Jorge de Assis Rojas-Gómez, Diana Reyna, Nadia López-Miranda, Jose
dc.contributor.author.spa.fl_str_mv	Angarita Dávila, Lisse Bermúdez, Valmore Aparicio, Daniel Céspedes, Virginia Escobar, Ma. Cristina Durán-Agüero, Samuel Cisternas, Silvana Costa, Jorge de Assis Rojas-Gómez, Diana Reyna, Nadia López-Miranda, Jose
dc.subject.eng.fl_str_mv	Glycaemic index Incretins Subjective appetite Isomaltulose Sucromalt Nutritional supplement
topic	Glycaemic index Incretins Subjective appetite Isomaltulose Sucromalt Nutritional supplement
description	Oral diabetes-specific nutritional supplements (ONS-D) induce favourable postprandial responses in subjects with type 2 diabetes (DM2), but they have not been correlated yet with incretin release and subjective appetite (SA). This randomised, double-blind, cross-over study compared postprandial effects of ONS-D with isomaltulose and sucromalt versus standard formula (ET) on glycaemic index (GI), insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and SA in 16 individuals with DM2. After overnight fasting, subjects consumed a portion of supplements containing 25 g of carbohydrates or reference food. Blood samples were collected at baseline and at 30, 60, 90, 120, 150 and 180 min; and SA sensations were assessed by a visual analogue scale on separate days. Glycaemic index values were low for ONS-D and intermediate for ET (p < 0.001). The insulin area under the curve (AUC0–180 min) (p < 0.02) and GIP AUC (p < 0.02) were lower after ONS-D and higher GLP-1 AUC when compared with ET (p < 0.05). Subjective appetite AUC was greater after ET than ONS-D (p < 0.05). Interactions between hormones, hunger, fullness and GI were found, but not within the ratings of SA; isomaltulose and sucromalt may have influenced these factors.
publishDate	2019
dc.date.accessioned.*.fl_str_mv	2019-07-19T19:03:14Z
dc.date.available.*.fl_str_mv	2019-07-19T19:03:14Z
dc.date.issued.*.fl_str_mv	2019
dc.type.eng.fl_str_mv	article
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dc.identifier.issn.none.fl_str_mv	20726643
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12442/3598
identifier_str_mv	20726643
url	https://hdl.handle.net/20.500.12442/3598
dc.language.iso.eng.fl_str_mv	eng
language	eng
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dc.rights.uri.*.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
dc.publisher.eng.fl_str_mv	MDPI
dc.source.eng.fl_str_mv	Nutrients Vol. 11, Núm. 7, 2019
institution	Universidad Simón Bolívar
dc.source.uri.*.fl_str_mv	https://doi.org/10.3390/nu11071477
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spelling	Angarita Dávila, Lisse47f242a1-258b-48db-840d-5ed5ea603992Bermúdez, Valmore29f9aa18-16a4-4fd3-8ce5-ed94a0b8663aAparicio, Daniel9bcc5baa-584e-4ffc-bed7-b51ee408da2aCéspedes, Virginia95f96603-96a6-4f28-8b9b-c9c973e248eaEscobar, Ma. Cristina24e319ab-c656-41be-b53b-479034dad486Durán-Agüero, Samuel9b230002-fae1-415b-800f-28692bd535a4Cisternas, Silvanadb0a3a68-2bad-41c3-967d-3dbdb60d0509Costa, Jorge de Assisfc8552b8-e6cb-467e-bdf7-53b36fc5c045Rojas-Gómez, Diana9f480c1f-339b-41b0-a3c3-55707ca24258Reyna, Nadia7c783057-2fc8-4d09-9fbf-1bd064634f9bLópez-Miranda, Josef69a2988-4177-4853-863c-b7579c6a5d822019-07-19T19:03:14Z2019-07-19T19:03:14Z201920726643https://hdl.handle.net/20.500.12442/3598Oral diabetes-specific nutritional supplements (ONS-D) induce favourable postprandial responses in subjects with type 2 diabetes (DM2), but they have not been correlated yet with incretin release and subjective appetite (SA). This randomised, double-blind, cross-over study compared postprandial effects of ONS-D with isomaltulose and sucromalt versus standard formula (ET) on glycaemic index (GI), insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and SA in 16 individuals with DM2. After overnight fasting, subjects consumed a portion of supplements containing 25 g of carbohydrates or reference food. Blood samples were collected at baseline and at 30, 60, 90, 120, 150 and 180 min; and SA sensations were assessed by a visual analogue scale on separate days. Glycaemic index values were low for ONS-D and intermediate for ET (p < 0.001). The insulin area under the curve (AUC0–180 min) (p < 0.02) and GIP AUC (p < 0.02) were lower after ONS-D and higher GLP-1 AUC when compared with ET (p < 0.05). Subjective appetite AUC was greater after ET than ONS-D (p < 0.05). Interactions between hormones, hunger, fullness and GI were found, but not within the ratings of SA; isomaltulose and sucromalt may have influenced these factors.engMDPIAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2NutrientsVol. 11, Núm. 7, 2019https://doi.org/10.3390/nu11071477Glycaemic indexIncretinsSubjective appetiteIsomaltuloseSucromaltNutritional supplementEffect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Studyarticlehttp://purl.org/coar/resource_type/c_6501Rosen, E.D.; Kaestner, K.H.; Natarajan, R.; Patti, M.-E.; Sallari, R.; Sander, M.; Susztak, K. Epigenetics and Epigenomics: Implications for Diabetes and Obesity. Diabetes 2018, 67, 1923–1931. [Google Scholar] [CrossRef]World Health Organization. The Top 10 Causes of Death. 2018. Available online: https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death (accessed on 31 March 2019).World Health Organization. Diabetes. 2018. Available online: https://www.who.int/en/news-room/fact-sheets/detail/diabetes (accessed on 31 March 2019).Unnikrishnan, R.; Pradeepa, R.; Joshi, S.R.; Mohan, V. Type 2 Diabetes: Demystifying the Global Epidemic. Diabetes 2017, 66, 1432–1442.International Diabetes Federation (IDF). The 8th Edition of the Diabetes Atlas. 2017. Available online: http://diabetesatlas.org/resources/2017-atlas.html (accessed on 31 March 2019).International Diabetes Federation Guideline Development Group. Guideline for management of postmeal glucose in diabetes. Diabetes Res. Clin. Pract. 2014, 103, 256–268.American Diabetes Association. 15. Diabetes Advocacy: Standards of Medical Care in Diabetes—2018. Diabetes Care 2018, 41, S152–S153.Diabetes and Nutrition Study Group of the European Association for the Study of Diabetes Recommendations for the nutritional management of patients with diabetes mellitus. Eur. J. Clin. Nutr. 2000, 54, 353–355.Willett, W.; Manson, J.; Liu, S. Glycemic index, glycemic load, and risk of type 2 diabetes. Am. J. Clin. Nutr. 2002, 76, 274S–280S.Augustin, L.S.A.; Kendall, C.W.C.; Jenkins, D.J.A.; Willett, W.C.; Astrup, A.; Barclay, A.W.; Björck, I.; Brand-Miller, J.C.; Brighenti, F.; Buyken, A.E.; et al. Glycemic index, glycemic load and glycemic response: An International Scientific Consensus Summit from the International Carbohydrate Quality Consortium (ICQC). Nutr. Metab. Cardiovasc. Dis. 2015, 25, 795–815.Ojo, O.; Ojo, O.O.; Adebowale, F.; Wang, X.-H. The Effect of Dietary Glycaemic Index on Glycaemia in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients 2018, 10, 373.Niwano, Y.; Adachi, T.; Kashimura, J.; Sakata, T.; Sasaki, H.; Sekine, K.; Yamamoto, S.; Yonekubo, A.; Kimura, S. Is glycemic index of food a feasible predictor of appetite, hunger, and satiety? J. Nutr. Sci. Vitaminol. (Tokyo) 2009, 55, 201–207.Sun, F.-H.; Li, C.; Zhang, Y.-J.; Wong, S.; Wang, L. Effect of Glycemic Index of Breakfast on Energy Intake at Subsequent Meal among Healthy People: A Meta-Analysis. Nutrients 2016, 8, 37.Flint, A.; Møller, B.K.; Raben, A.; Sloth, B.; Pedersen, D.; Tetens, I.; Holst, J.J.; Astrup, A. Glycemic and insulinemic responses as determinants of appetite in humans. Am. J. Clin. Nutr. 2006, 84, 1365–1373.Elia, M.; Ceriello, A.; Laube, H.; Sinclair, A.J.; Engfer, M.; Stratton, R.J. Enteral nutritional support and use of diabetes-specific formulas for patients with diabetes: A systematic review and meta-analysis. Diabetes Care 2005, 28, 2267–2279.Ojo, O.; Brooke, J. Evaluation of the Role of Enteral Nutrition in Managing Patients with Diabetes: A Systematic Review. Nutrients 2014, 6, 5142–5152.De Luis DA, D.M. A randomized clinical trial with two enteral diabetes-specific supplements in patients with diabetes mellitus type 2: Metabolic effects. Eur. Rev. Med. Pharmacol. Sci. 2008, 12, 261–266.Voss, A.C.; Maki, K.C.; Garvey, W.T.; Hustead, D.S.; Alish, C.; Fix, B.; Mustad, V.A. Effect of two carbohydrate-modified tube-feeding formulas on metabolic responses in patients with type 2 diabetes. Nutrition 2008, 24, 990–997.Sanz-Paris, A.; Boj-Carceller, D.; Lardies-Sanchez, B.; Perez-Fernandez, L.; Cruz-Jentoft, A. Health-Care Costs, Glycemic Control and Nutritional Status in Malnourished Older Diabetics Treated with a Hypercaloric Diabetes-Specific Enteral Nutritional Formula. Nutrients 2016, 8, 153.Tan, S.Y.; Siow, P.C.; Peh, E.; Henry, C.J. Influence of rice, pea and oat proteins in attenuating glycemic response of sugar sweetened beverages. Eur. J. Nutr. 2018, 57, 2795–2803.Yabe, D.; Seino, Y.; Seino, Y. Incretin concept revised: The origin of the insulinotropic function of glucagon-like peptide-1 -the gut, the islets or both? J. Diabetes Investig. 2018, 9, 21–24.Rojas, J.; Bermudez, V.; Palmar, J.; Martínez, M.S.; Olivar, L.C.; Nava, M.; Tomey, D.; Rojas, M.; Salazar, J.; Garicano, C.; et al. Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy. J. Diabetes Res. 2018, 2018, 1–19.Prinz, P. The role of dietary sugars in health: Molecular composition or just calories? Eur. J. Clin. Nutr. 2019.Giezenaar, C.; Trahair, L.G.; Luscombe-Marsh, N.D.; Hausken, T.; Standfield, S.; Jones, K.L.; Lange, K.; Horowitz, M.; Chapman, I.; Soenen, S. Effects of randomized whey-protein loads on energy intake, appetite, gastric emptying, and plasma gut-hormone concentrations in older men and women. Am. J. Clin. Nutr. 2017, 106, 865–877.Steinert, R.E.; Feinle-Bisset, C.; Asarian, L.; Horowitz, M.; Beglinger, C.; Geary, N. Ghrelin, CCK, GLP-1, and PYY(3-36): Secretory controls and physiological roles in eating and glycemia in health, obesity, and after RYGB. Physiol. Rev. 2017, 97, 411–463.Behall, K.M.; Scholfield, D.J.; Canary, J. Effect of starch structure on glucose and insulin responses in adults. Am. J. Clin. Nutr. 1988, 47, 428–432.McMahon, M.M.; Nystrom, E.; Braunschweig, C.; Miles, J.; Compher, C.; the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors. A.S.P.E.N. Clinical Guidelines: Nutrition Support of Adult Patients with Hyperglycemia. J. Parenter. Enter. Nutr. 2013, 37, 23–36.Doola, R.; Todd, A.S.; Forbes, J.M.; Deane, A.M.; Presneill, J.J.; Sturgess, D.J. Diabetes-Specific Formulae Versus Standard Formulae as Enteral Nutrition to Treat Hyperglycemia in Critically Ill Patients: Protocol for a Randomized Controlled Feasibility Trial. JMIR Res. Protoc. 2018, 7, e90.Devitt, A.A.; Williams, J.A.; Choe, Y.S.; Hustead, D.S.; Mustad, V.A. Glycemic responses to glycemia-targeted specialized-nutrition beverages with varying carbohydrates compared to a standard nutritional beverage in adults with type 2 diabetes. Adv. Biosci. Biotechnol. 2013, 4, 1–10.Grysman, A.; Carlson, T.; Wolever, T.M.S. Effects of sucromalt on postprandial responses in human subjects. Eur. J. Clin. Nutr. 2008, 62, 1364–1371.Maresch, C.C.; Petry, S.F.; Theis, S.; Bosy-Westphal, A.; Linn, T. Low Glycemic Index Prototype Isomaltulose-Update of Clinical Trials. Nutrients 2017, 9, 381.Pfeiffer, A.F.H.; Keyhani-Nejad, F. High Glycemic Index Metabolic Damage—A Pivotal Role of GIP and GLP-1. Trends Endocrinol. Metab. 2018, 29, 289–299.Holub, I.; Gostner, A.; Theis, S.; Nosek, L.; Kudlich, T.; Melcher, R.; Scheppach, W. Novel findings on the metabolic effects of the low glycaemic carbohydrate isomaltulose (Palatinose). Br. J. Nutr. 2010, 103, 1730–1737.Kendall, F.E.; Marchand, O.; Haszard, J.J.; Venn, B.J. The Comparative Effect on Satiety and Subsequent Energy Intake of Ingesting Sucrose or Isomaltulose Sweetened Trifle: A Randomized Crossover Trial. Nutrients 2018, 10, 1504.Hofman, Z.; De Van Drunen, J.; Kuipers, H. The Glycemic Index of standard and diabetes-specific enteral formulas. Asia Pac. J. Clin. Nutr. 2006, 15, 412–417.Atkinson, F.S.; Foster-Powell, K.; Brand-Miller, J.C. International Tables of Glycemic Index and Glycemic Load Values: 2008. Diabetes Care 2008, 31, 2281–2283.World Medical Association. Ethical Principles for Medical Research Involving Human Subjects. 64ª General Assembly. 2013. Available online: https://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects/ (accessed on 24 March 2019).Brouns, F.; Bjorck, I.; Frayn, K.N.; Gibbs, A.L.; Lang, V.; Slama, G.; Wolever, T.M. Glycaemic index methodology. Nutr. Res. Rev. 2005, 18, 145–171.Parker, B.A.; Sturm, K.; Macintosh, C.G.; Feinle, C.; Horowitz, M.; Chapman, I.M. Relation between food intake and visual analogue scale ratings of appetite and other sensations in healthy older and young subjects. Eur. J. Clin. Nutr. 2004, 58, 212–218.World Health Organization. Energy and Protein Requirements: Report of a Joint FAO/WHO/UNU Expert Consultation. 1981. Available online: https://apps.who.int/iris/handle/10665/39527 (accessed on 24 March 2019).Akilen, R.; Deljoomanesh, N.; Hunschede, S.; Smith, C.E.; Arshad, M.U.; Kubant, R.; Anderson, G.H. The effects of potatoes and other carbohydrate side dishes consumed with meat on food intake, glycemia and satiety response in children. Nutr. Diabetes 2016, 6, e195.Mottalib, A.; Mohd-Yusof, B.-N.; Shehabeldin, M.; Pober, D.; Mitri, J.; Hamdy, O. Impact of Diabetes-Specific Nutritional Formulas versus Oatmeal on Postprandial Glucose, Insulin, GLP-1 and Postprandial Lipidemia. Nutrients 2016, 8, 443.Alish, C.J.; Garvey, W.T.; Maki, K.C.; Sacks, G.S.; Hustead, D.S.; Hegazi, R.A.; Mustad, V.A. A Diabetes-Specific Enteral Formula Improves Glycemic Variability in Patients with Type 2 Diabetes. Diabetes Technol. Ther. 2010, 12, 419–425.Ceriello, A.; Davidson, J.; Hanefeld, M.; Leiter, L.; Monnier, L.; Owens, D.; Tajima, N.; Tuomilehto, J. Postprandial hyperglycaemia and cardiovascular complications of diabetes: An update. Nutr. Metab. Cardiovasc. Dis. 2006, 16, 453–456.Yoshizane, C.; Mizote, A.; Yamada, M.; Arai, N.; Arai, S.; Maruta, K.; Mitsuzumi, H.; Ariyasu, T.; Ushio, S.; Fukuda, S. Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects. Nutr. J. 2017, 16.Kawaguchi, T.; Nakano, D.; Oriishi, T.; Torimura, T. Effects of isomaltulose on insulin resistance and metabolites in patients with non-alcoholic fatty liver disease: A metabolomic analysis. Mol. Med. Rep. 2018.Nauck, M.A.; Meier, J.J. The incretin effect in healthy individuals and those with type 2 diabetes: Physiology, pathophysiology, and response to therapeutic interventions. Lancet Diabetes Endocrinol. 2016, 4, 525–536.Holst, J.J. On the Physiology of GIP and GLP-1. Horm. Metab. Res. 2004, 36, 747–754.Nasteska, D.; Harada, N.; Suzuki, K.; Yamane, S.; Hamasaki, A.; Joo, E.; Iwasaki, K.; Shibue, K.; Harada, T.; Inagaki, N. Chronic Reduction of GIP Secretion Alleviates Obesity and Insulin Resistance Under High-Fat Diet Conditions. Diabetes 2014, 63, 2332.Bray, G.A. Potential health risks from beverages containing fructose found in sugar or high-fructose corn syrup. Diabetes Care 2013, 36, 11–12.Herman, M.A.; Samuel, V.T. The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis. Trends Endocrinol. Metab. 2016, 27, 719–730.Donner, T.W.; Wilber, J.F.; Ostrowski, D. D-tagatose, a novel hexose: Acute effects on carbohydrate tolerance in subjects with and without type 2 diabetes. Diabetes Obes. Metab. 1999, 1, 285–291.Guerrero-Wyss, M.; Durán Agüero, S.; Angarita Dávila, L. D-Tagatose Is a Promising Sweetener to Control Glycaemia: A New Functional Food. BioMed Res. Int. 2018, 2018, 8718053.Maeda, A.; Miyagawa, J.-I.; Miuchi, M.; Nagai, E.; Konishi, K.; Matsuo, T.; Tokuda, M.; Kusunoki, Y.; Ochi, H.; Murai, K.; et al. Effects of the naturally-occurring disaccharides, palatinose and sucrose, on incretin secretion in healthy non-obese subjects. J. Diabetes Investig. 2013, 4, 281–286.Ruiz-Ojeda, F.J.; Plaza-Díaz, J.; Sáez-Lara, M.J.; Gil, A. Effects of Sweeteners on the Gut Microbiota: A Review of Experimental Studies and Clinical Trials. Adv. Nutr. (Bethesda Md.) 2019, 10, S31–S48.Zeevi, D.; Korem, T.; Zmora, N.; Israeli, D.; Rothschild, D.; Weinberger, A.; Ben-Yacov, O.; Lador, D.; Avnit-Sagi, T.; Lotan-Pompan, M.; et al. Personalized Nutrition by Prediction of Glycemic Responses. Cell 2015, 163, 1079–1094.Angarita, L.; Bermudez, V.; Reina, N.; Cisternas, S.; Díaz, W.; Escobar, M.C.; Carrasco, P.; Durán, S.; Buhring, K.; Buhring, R.; et al. New Insights into Alleviating Diabetes Mellitus: Role of Gut Microbiota and a Nutrigenomic Approach. In Diabetes Food Plan; Waisundara, V., Ed.; InTech: London, UK, 2018; ISBN 978-1-78923-274-5.Ang, M.; Linn, T. Comparison of the effects of slowly and rapidly absorbed carbohydrates on postprandial glucose metabolism in type 2 diabetes mellitus patients: A randomized trial. Am. J. Clin. Nutr. 2014, 100, 1059–1068.König, D.; Theis, S.; Kozianowski, G.; Berg, A. Postprandial substrate use in overweight subjects with the metabolic syndrome after isomaltulose (Palatinose TM) ingestion. Nutrition 2012, 28, 651–656.Van Can, J.G.P.; van Loon, L.J.C.; Brouns, F.; Blaak, E.E. Reduced glycaemic and insulinaemic responses following trehalose and isomaltulose ingestion: Implications for postprandial substrate use in impaired glucose-tolerant subjects. Br. J. Nutr. 2012, 108, 1210–1217.Sloth, B.; Due, A.; Larsen, T.M.; Holst, J.J.; Heding, A.; Astrup, A. The effect of a high-MUFA, low-glycaemic index diet and a low-fat diet on appetite and glucose metabolism during a 6-month weight maintenance period. Br. J. Nutr. 2008, 101, 1846–1858.Drucker, D.J. The biology of incretin hormones. Cell Metab. 2006, 3, 153–165.Rocca, A.S.; LaGreca, J.; Kalitsky, J.; Brubaker, P.L. Monounsaturated Fatty Acid Diets Improve Glycemic Tolerance through Increased Secretion of Glucagon-Like Peptide-1*. Endocrinology 2001, 142, 1148–1155.Storm, H.; Holst, J.J.; Hermansen, K.; Thomsen, C. Differential effects of saturated and monounsaturated fats on postprandial lipemia and glucagon-like peptide 1 responses in patients with type 2 diabetes. Am. J. Clin. Nutr. 2003, 77, 605–611.Printz, H.; Recke, B.; Fehmann, H.C.; Göke, B. No apparent benefit of liquid formula diet in NIDDM. Exp. Clin. Endocrinol. Diabetes 2009, 105, 134–139.Noreberg, C.; Indar-Brown, K.; Madar, Z. Glycemic and insulinemic responses after ingestion of ethnic foods by NIDDM and healthy subjects. Am. J. Clin. Nutr. 1992, 55, 89–95.Aguirre, P.C.; Galgani, F.J.; Díaz, B.E. Determinación del índice glicémico del alimento nutridiabetic® destinado a diabéticos tipo 2. Rev. Chil. Nutr. 2006, 33, 14–21.Rizkalla, S.W.; Laromiguiere, M.; Champ, M.; Bruzzo, F.; Boillot, J.; Slama, G. Effect of baking process on postprandial metabolic consequences: Randomized trials in normal and type 2 diabetic subjects. Eur. J. Clin. Nutr. 2006, 61, 175.Ye, Z.; Arumugam, V.; Haugabrooks, E.; Williamson, P.; Hendrich, S. Soluble dietary fibre (Fibersol-2) decreased hunger and increased satiety hormones in humans when ingested with a meal. Nutr. Res. 2015, 35, 393–400.Delzenne, N.M.; Cani, P.D.; Daubioul, C.; Neyrinck, A.M. Impact of inulin and oligofructose on gastrointestinal peptides. Br. J. Nutr. 2005, 93, S157–S161.Kirkmeyer, S.V.; Mattes, R.D. Effects of food attributes on hunger and food intake. Int. J. Obes. 2000, 24, 1167–1175.Stafleu, A.; Hendriks, H.F.; Smeets, P.A.; Blom, W.A.; de Graaf, C. Biomarkers of satiation and satiety. Am. J. Clin. Nutr. 2004, 79, 946–961.Thomas, D.; Elliott, E.; Baur, L. Low glycaemic index or low glycaemic load diets for overweight and obesity. Cochrane Database Syst. Rev. 2007.Bornet, F.R.J.; Jardy-Gennetier, A.-E.; Jacquet, N.; Stowell, J. Glycaemic response to foods: Impact on satiety and long-term weight regulation. Appetite 2007, 49, 535–553.Van Dam, R.M.; Seidell, J.C. Carbohydrate intake and obesity. Eur. J. Clin. Nutr. 2007, 61, S75.Flint, A.; Gregersen, N.T.; Gluud, L.L.; Møller, B.K.; Raben, A.; Tetens, I.; Verdich, C.; Astrup, A. Associations between postprandial insulin and blood glucose responses, appetite sensations and energy intake in normal weight and overweight individuals: A meta-analysis of test meal studies. Br. J. Nutr. 2007, 98, 17–25.Giezenaar, C.; van der Burgh, Y.; Lange, K.; Hatzinikolas, S.; Hausken, T.; Jones, K.; Horowitz, M.; Chapman, I.; Soenen, S. Effects of Substitution, and Adding of Carbohydrate and Fat to Whey-Protein on Energy Intake, Appetite, Gastric Emptying, Glucose, Insulin, Ghrelin, CCK and GLP-1 in Healthy Older Men—A Randomized Controlled Trial. Nutrients 2018, 10, 113.Peters, H.P.F.; Ravestein, P.; van der Hijden, H.T.W.M.; Boers, H.M.; Mela, D.J. Effect of carbohydrate digestibility on appetite and its relationship to postprandial blood glucose and insulin levels. Eur. J. Clin. 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Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study

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