Characterization of patients with diabetic kidney disease nonalbuminuric phenotype. A single-center observational study

Introduction: The phenotypes with albuminuria and the nonalbuminuric phenotype in diabetic kidney disease (DKD) are known. The nonalbuminuric phenotype is defined with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 associated with km il.;p.albuminuria- creatinuria ratio (ACR)...

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Autores:: Salas Carmona, Yerina Hortensia
Serpa Diaz, Dagoberto
Salas Carmona, Yuris C
Ramos Clason, Enrique C
Raad Sarabia, María
Daza Arnedo, Rodrigo
Cardona Blanco, María Ximena
Parra Sánchez, Paula
Rico Fontalvo, Jorge

Tipo de recurso:

Fecha de publicación:: 2024

Institución:: Universidad Simón Bolívar

Repositorio:: Repositorio Digital USB

Idioma:: eng

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dc.title.eng.fl_str_mv	Characterization of patients with diabetic kidney disease nonalbuminuric phenotype. A single-center observational study
title	Characterization of patients with diabetic kidney disease nonalbuminuric phenotype. A single-center observational study
spellingShingle	Characterization of patients with diabetic kidney disease nonalbuminuric phenotype. A single-center observational study Chronic kidney disease Diabetic kidney disease Mellitus diabetes Albuminuria Creatinuria Glomerular filtration rate
title_short	Characterization of patients with diabetic kidney disease nonalbuminuric phenotype. A single-center observational study
title_full	Characterization of patients with diabetic kidney disease nonalbuminuric phenotype. A single-center observational study
title_fullStr	Characterization of patients with diabetic kidney disease nonalbuminuric phenotype. A single-center observational study
title_full_unstemmed	Characterization of patients with diabetic kidney disease nonalbuminuric phenotype. A single-center observational study
title_sort	Characterization of patients with diabetic kidney disease nonalbuminuric phenotype. A single-center observational study
dc.creator.fl_str_mv	Salas Carmona, Yerina Hortensia Serpa Diaz, Dagoberto Salas Carmona, Yuris C Ramos Clason, Enrique C Raad Sarabia, María Daza Arnedo, Rodrigo Cardona Blanco, María Ximena Parra Sánchez, Paula Rico Fontalvo, Jorge
dc.contributor.author.none.fl_str_mv	Salas Carmona, Yerina Hortensia Serpa Diaz, Dagoberto Salas Carmona, Yuris C Ramos Clason, Enrique C Raad Sarabia, María Daza Arnedo, Rodrigo Cardona Blanco, María Ximena Parra Sánchez, Paula Rico Fontalvo, Jorge
dc.subject.keywords.eng.fl_str_mv	Chronic kidney disease Diabetic kidney disease Mellitus diabetes Albuminuria Creatinuria Glomerular filtration rate
topic	Chronic kidney disease Diabetic kidney disease Mellitus diabetes Albuminuria Creatinuria Glomerular filtration rate
description	Introduction: The phenotypes with albuminuria and the nonalbuminuric phenotype in diabetic kidney disease (DKD) are known. The nonalbuminuric phenotype is defined with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 associated with km il.;p.albuminuria- creatinuria ratio (ACR) less than 30 mg/gr. The objective of the present study was to describe the clinical characteristics of patients with DKD nonalbuminuric phenotype (nADKD). Methods: This is an observational, descriptive study of patients treated at an IPS in Cartagena, Colombia, from 2021 to 2022. Results: Of a total of 7698 patients with DKD criteria, 1714 patients (22.3%) had nA-DKD criteria, with a median age of 69 years (IQR 62-76), and women (75.73%). A total of 85% had hypertension, (22.3%) dyslipidemia, and the average BMI was in the overweight range. 9.5% had a history of smoking. Little presence of diabetic retinopathy was found. Conclusion: Nonalbuminuric phenotype diabetic kidney disease is not uncommon in our environment. In general, the characteristics of our patients are very similar to those reported in other series.
publishDate	2024
dc.date.accessioned.none.fl_str_mv	2024-07-18T15:14:35Z
dc.date.available.none.fl_str_mv	2024-07-18T15:14:35Z
dc.date.issued.none.fl_str_mv	2024
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dc.type.spa.none.fl_str_mv	Artículo científico
dc.identifier.citation.spa.fl_str_mv	Salas Carmona YH, Serpa Diaz D, Salas Carmona YC, Ramos Clason E, Raad Sarabia M, Daza Arnedo R, Cardona Blanco M, Parra Sánchez P, Rico Fontalvo J. Characterization of patients with diabetic kidney disease nonalbuminuric phenotype. A single-center observational study. REV SEN 2024;12(2):121-130.
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12442/14855
dc.identifier.doi.none.fl_str_mv	29536448 (En linea) http://doi.org/10.56867/78 https://rev-sen.ec/index.php/revista/article/view/78
identifier_str_mv	Salas Carmona YH, Serpa Diaz D, Salas Carmona YC, Ramos Clason E, Raad Sarabia M, Daza Arnedo R, Cardona Blanco M, Parra Sánchez P, Rico Fontalvo J. Characterization of patients with diabetic kidney disease nonalbuminuric phenotype. A single-center observational study. REV SEN 2024;12(2):121-130. 29536448 (En linea)
url	https://hdl.handle.net/20.500.12442/14855 http://doi.org/10.56867/78 https://rev-sen.ec/index.php/revista/article/view/78
dc.language.iso.none.fl_str_mv	eng
language	eng
dc.rights.eng.fl_str_mv	Attribution-NonCommercial-NoDerivs 3.0 United States
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dc.rights.uri.none.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/3.0/us/
dc.rights.accessrights.none.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivs 3.0 United States http://creativecommons.org/licenses/by-nc-nd/3.0/us/ http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.mimetype.none.fl_str_mv	pdf
dc.publisher.spa.fl_str_mv	Sociedad Ecuatoriana de Nefrología, Diálisis y Trasplantes
dc.source.eng.fl_str_mv	REV SEN
dc.source.none.fl_str_mv	Vol. 12 No.2 (2024)
institution	Universidad Simón Bolívar
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spelling	Salas Carmona, Yerina Hortensia5a5486c8-4f65-4f46-a94a-1a43bb23af3d-1Serpa Diaz, Dagobertoaf24a526-adde-42a1-a45d-9ed91c9a3cbb-1Salas Carmona, Yuris C60804af7-6a6b-404a-8533-43a9c9da60dc-1Ramos Clason, Enrique C33b3cb69-f9fd-43ae-9c3e-6528af08c3a7-1Raad Sarabia, María56ed5233-3bd0-4370-8bea-3bdd0978d090-1Daza Arnedo, Rodrigo82ba690f-f5de-45bc-bc67-5d2f7ca76c9f-1Cardona Blanco, María Ximenab3a0768a-8b4e-4fe5-9630-aca491e6096d-1Parra Sánchez, Paula1b7953a9-79df-43c1-88a6-b230d884156b-1Rico Fontalvo, Jorgea156782c-eb0d-4540-a7cb-92742ffaee75-12024-07-18T15:14:35Z2024-07-18T15:14:35Z2024Salas Carmona YH, Serpa Diaz D, Salas Carmona YC, Ramos Clason E, Raad Sarabia M, Daza Arnedo R, Cardona Blanco M, Parra Sánchez P, Rico Fontalvo J. Characterization of patients with diabetic kidney disease nonalbuminuric phenotype. A single-center observational study. REV SEN 2024;12(2):121-130.https://hdl.handle.net/20.500.12442/1485529536448 (En linea)http://doi.org/10.56867/78https://rev-sen.ec/index.php/revista/article/view/78Introduction: The phenotypes with albuminuria and the nonalbuminuric phenotype in diabetic kidney disease (DKD) are known. The nonalbuminuric phenotype is defined with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 associated with km il.;p.albuminuria- creatinuria ratio (ACR) less than 30 mg/gr. The objective of the present study was to describe the clinical characteristics of patients with DKD nonalbuminuric phenotype (nADKD). Methods: This is an observational, descriptive study of patients treated at an IPS in Cartagena, Colombia, from 2021 to 2022. Results: Of a total of 7698 patients with DKD criteria, 1714 patients (22.3%) had nA-DKD criteria, with a median age of 69 years (IQR 62-76), and women (75.73%). A total of 85% had hypertension, (22.3%) dyslipidemia, and the average BMI was in the overweight range. 9.5% had a history of smoking. Little presence of diabetic retinopathy was found. Conclusion: Nonalbuminuric phenotype diabetic kidney disease is not uncommon in our environment. In general, the characteristics of our patients are very similar to those reported in other series.pdfengSociedad Ecuatoriana de Nefrología, Diálisis y TrasplantesAttribution-NonCommercial-NoDerivs 3.0 United Stateshttp://creativecommons.org/licenses/by-nc-nd/3.0/us/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2REV SENVol. 12 No.2 (2024)Characterization of patients with diabetic kidney disease nonalbuminuric phenotype. A single-center observational studyinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Chronic kidney diseaseDiabetic kidney diseaseMellitus diabetesAlbuminuriaCreatinuriaGlomerular filtration rateTsai JL, Chen CH, Wu MJ, Tsai SF. New Approaches to Diabetic Nephropathy from Bed to Bench. Biomedicines. 2022 Apr 9;10(4):876. doi: 10.3390/biomedicines10040876. PMID: 35453626; PMCID: PMC9031931.Lameire NH, Levin A, Kellum JA, Cheung M, Jadoul M, Winkelmayer WC, Stevens PE; Conference Participants. Harmonizing acute and chronic kidney disease definition and classification: report of a Kidney Disease: Improving Global Outcomes (KDIGO) Consensus Conference. Kidney Int. 2021 Sep;100(3):516-526. doi: 10.1016/j.kint.2021.06.028. Epub 2021 Jul 9. PMID: 34252450.Chen C, Wang C, Hu C, Han Y, Zhao L, Zhu X, Xiao L, Sun L. Normoalbuminuric diabetic kidney disease. Front Med. 2017 Sep;11(3):310-318. doi: 10.1007/s11684-017- 0542-7. Epub 2017 Jul 18. PMID: 28721497.Watanabe H, Anezaki H, Kazawa K, Tamaki Y, Hashimoto H, Moriyama M. Long-term effectiveness of a disease management program to prevent diabetic nephropathy: a propensity score matching analysis using administrative data in Japan. BMC Endocr Disord. 2022 May 20;22(1):135. doi: 10.1186/s12902-022-01040-4. PMID: 35596152; PMCID: PMC9123750.Umanath K, Lewis JB. Update on Diabetic Nephropathy: Core Curriculum 2018. Am J Kidney Dis. 2018 Jun;71(6):884-895. doi: 10.1053/j.ajkd.2017.10.026. Epub 2018 Feb 3. PMID: 29398179.Dai Q, Chen N, Zeng L, Lin XJ, Jiang FX, Zhuang XJ, Lu ZY. Clinical features of and risk factors for normoalbuminuric diabetic kidney disease in hospitalized patients with type 2 diabetes mellitus: a retrospective crosssectional study. BMC Endocr Disord. 2021 May 22;21(1):104. doi: 10.1186/s12902-021-00769-8. PMID: 34022855; PMCID: PMC8141213.de Sá JR, Rangel EB, Canani LH, Bauer AC, Escott GM, Zelmanovitz T, Bertoluci MC, Silveiro SP. The 2021-2022 position of Brazilian Diabetes Society on diabetic kidney disease (DKD) management: an evidence-based guideline to clinical practice. Screening and treatment of hyperglycemia, arterial hypertension, and dyslipidemia in the patient with DKD. Diabetol Metab Syndr. 2022 Jun 11;14(1):81. doi: 10.1186/s13098-022-00843-8. PMID: 35690830; PMCID: PMC9188192.Mogensen CE, Christensen CK, Vittinghus E. The stages in diabetic renal disease. With emphasis on the stage of incipient diabetic nephropathy. Diabetes. 1983 May;32 Suppl 2:64-78. doi: 10.2337/diab.32.2.s64. PMID: 6400670.Chen Y, Lee K, Ni Z, He JC. Diabetic Kidney Disease: Challenges, Advances, and Opportunities. Kidney Dis (Basel). 2020 Jul;6(4):215-225. doi: 10.1159/000506634. Epub 2020 Mar 31. PMID: 32903946; PMCID: PMC7445658.Zoccali C, Mallamaci F. Nonproteinuric progressive diabetic kidney disease. Curr Opin Nephrol Hypertens. 2019 May;28(3):227-232. doi: 10.1097/MNH.0000000000000489. PMID: 30672815.Weldegiorgis M, de Zeeuw D, Li L, Parving HH, Hou FF, Remuzzi G, Greene T, Heerspink HJL. Longitudinal Estimated GFR Trajectories in Patients With and Without Type 2 Diabetes and Nephropathy. Am J Kidney Dis. 2018 Jan;71(1):91-101. doi: 10.1053/j.ajkd.2017.08.010. Epub 2017 Nov 16. PMID: 29153995.Pugliese G, Penno G, Natali A, Barutta F, Di Paolo S, Reboldi G, Gesualdo L, De Nicola L; Italian Diabetes Society and the Italian Society of Nephrology. Diabetic kidney disease: new clinical and therapeutic issues. Joint position statement of the Italian Diabetes Society and the Italian Society of Nephrology on "The natural history of diabetic kidney disease and treatment of hyperglycemia in patients with type 2 diabetes and impaired renal function". J Nephrol. 2020 Feb;33(1):9-35. doi: 10.1007/s40620-019- 00650-x. PMID: 31576500; PMCID: PMC7007429.Klisic A, Kavaric N, Ninic A. Retinol-binding protein 4 versus albuminuria as predictors of estimated glomerular filtration rate decline in patients with type 2 diabetes. J Res Med Sci. 2018 May 30;23:44. doi: 10.4103/jrms.JRMS_893_17. PMID: 29937906; PMCID: PMC5996567.Bae J, Won YJ, Lee BW. Non-Albumin Proteinuria (NAP) as a Complementary Marker for Diabetic Kidney Disease (DKD). Life (Basel). 2021 Mar 10;11(3):224. doi: 10.3390/life11030224. PMID: 33802211; PMCID: PMC7998887.Shi S, Ni L, Gao L, Wu X. Comparison of Nonalbuminuric and Albuminuric Diabetic Kidney Disease Among Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis. Front Endocrinol (Lausanne). 2022 Jun 3;13:871272. doi: 10.3389/fendo.2022.871272. PMID: 35721745; PMCID: PMC9203723.Jayakumari S, Gomez R, Dipin S, Jayakumar RV, Vijayakumar K, Sreenath R, Ajeesh T, Jabbar PK, Das DV, Gopi GV, Seena TP, Nair A. 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Epub 2019 Feb 24. PMID: 30799525; PMCID: PMC6597612.Hong CY, Hughes K, Chia KS, Ng V, Ling SL. Urinary alpha1-microglobulin as a marker of nephropathy in type 2 diabetic Asian subjects in Singapore. Diabetes Care. 2003 Feb;26(2):338-42. doi: 10.2337/diacare.26.2.338. PMID: 12547859.Selby NM, Taal MW. An updated overview of diabetic nephropathy: Diagnosis, prognosis, treatment goals and latest guidelines. Diabetes Obes Metab. 2020 Apr;22 Suppl 1:3-15. doi: 10.1111/dom.14007. PMID: 32267079.Chen HM, Shen WW, Ge YC, Zhang YD, Xie HL, Liu ZH. The relationship between obesity and diabetic nephropathy in China. BMC Nephrol. 2013 Mar 25;14:69. doi: 10.1186/1471-2369-14-69. PMID: 23521842; PMCID: PMC3614546.Liao D, Ma L, Liu J, Fu P. Cigarette smoking as a risk factor for diabetic nephropathy: A systematic review and metaanalysis of prospective cohort studies. PLoS One. 2019 Feb 4;14(2):e0210213. doi: 10.1371/journal.pone.0210213. PMID: 30716100; PMCID: PMC6361430.Adler AI, Stevens RJ, Manley SE, Bilous RW, Cull CA, Holman RR; UKPDS GROUP. Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64). Kidney Int. 2003 Jan;63(1):225-32. doi: 10.1046/j.1523- 1755.2003.00712.x. PMID: 12472787.Penno G, Solini A, Orsi E, Bonora E, Fondelli C, Trevisan R, Vedovato M, Cavalot F, Lamacchia O, Scardapane M, Nicolucci A, Pugliese G; Renal Insufficiency And Cardiovascular Events (RIACE) Study Group. Nonalbuminuric renal impairment is a strong predictor of mortality in individuals with type 2 diabetes: the Renal Insufficiency And Cardiovascular Events (RIACE) Italian multicenter study. Diabetologia. 2018 Nov;61(11):2277- 2289. doi: 10.1007/s00125-018-4691-2. Epub 2018 Jul 21. PMID: 30032426.Yamamoto Y, Hanai K, Mori T, Yokoyama Y, Yoshida N, Murata H, Shinozaki T, Babazono T. Kidney outcomes and all-cause mortality in people with type 2 diabetes exhibiting nonalbuminuric kidney insufficiency. Diabetologia. 2022 Jan;65(1):234-245. doi: 10.1007/s00125-021-05590-5. Epub 2021 Nov 5. PMID: 34739552.Rico-Fontalvo J, Yama-Mosquera E, Robayo-García A, Aroca-Martínez G, Arango-Álvarez JJ, Barros-Camargo L, et al. Situación de la enfermedad renal crónica en Colombia. Nefrología Latinoamericana. 2022 Dec 20;19(2). DOAJ: 10.24875Cuenta de Alto Costo. Situación de la enfermedad renal crónica, la hipertensión arterial y la diabetes mellitus en Colombia 2022 - Cuenta de Alto Costo. 2023.García-Carro C, Vergara A, Bermejo S, Azancot MA, Sánchez-Fructuoso AI, Sánchez de la Nieta MD, Agraz I, Soler MJ. How to Assess Diabetic Kidney Disease Progression? From Albuminuria to GFR. J Clin Med. 2021 Jun 5;10(11):2505. doi: 10.3390/jcm10112505. PMID: 34198818; PMCID: PMC8201333.Rico Fontalvo J, Vázquez Jiménez L. Enfermedad renal diabética: pilares en el tratamiento. ANALES. 2023 Apr. 28;56(1):133-6. Anales: 3365Rico Fontalvo J, Aroca-Martínez G, Daza-Arnedo R, Raad- Sarabia M, Torres JL, Pajaro-Galvis N, Uparella-Gulfo I, Porto-Corbacho D, Sarabia-Cannepa S, Ramos-Clason E. Enfermedad renal diabética no proteinúrica: Estado del arte. Rev Nefrol Dial Traspl. 19 de diciembre de 2022 ;42(04):330-9. OJS: 860Rico Fontalvo Jorge, Daza Arnedo Rodrigo, Raad Sarabia María, Pájaro Galvis Nehomar, Bello Espinosa Ariel, Uparella Gulfo Isabella et al . Proteoma urinario en la enfermedad renal diabética. Estado del arte. Rev. colom. nefrol. 2021 Dec; 8(3): e304. doi: 10.22265/acnef.8.3.546.Espinosa Fuentes Guillermo Austreberto, Julián Hernández Yazmín Jocelyn, López Lievanos Miguel Ángel, Berumen Lechuga María Guadalupe. Screening de enfermedad renal crónica en pacientes diabéticos de larga evolución de la UMF (unidad de medicina familiar) 222. Rev. colom. nefrol. 2022 Apr; 9(1): 203. Doi: 10.22265/acnef.9.1.543.Rico-Fontalvo J, Aroca-Martínez G, Daza-Arnedo R, Cabrales J, Rodríguez-Yanez T, Cardona-Blanco M, Montejo-Hernández J, Rodelo Barrios D, Patiño-Patiño J, Osorio Rodríguez E. Novel Biomarkers of Diabetic Kidney Disease. Biomolecules. 2023 Mar 31;13(4):633. doi:10.3390/biom13040633. 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Characterization of patients with diabetic kidney disease nonalbuminuric phenotype. A single-center observational study

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