Nephrotic Syndrome Secondary to Podocytopathy in SARS-COV2 Infection

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by pulmonary involvement. However, there are reports on patients also suffering from concomitant renal involvement, with clinical manifestations such as hematuria, proteinuria, elevated nitrogen lev...

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Autores:: Aroca-Martínez, Gustavo
Cadena-Bonfanti, Andrés
Avendaño-Echavez, Lil
Conde-Manotas, Juan C.
Pérez, Rafael
García, Raúl
Orozco, Carlos
Musso, Carlos G.

Tipo de recurso:

Fecha de publicación:: 2023

Institución:: Universidad Simón Bolívar

Repositorio:: Repositorio Digital USB

Idioma:: spa

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dc.title.eng.fl_str_mv	Nephrotic Syndrome Secondary to Podocytopathy in SARS-COV2 Infection
dc.title.translated.spa.fl_str_mv	Síndrome nefrótico secundario a podocitopatía en infección por SARS-COV2
title	Nephrotic Syndrome Secondary to Podocytopathy in SARS-COV2 Infection
spellingShingle	Nephrotic Syndrome Secondary to Podocytopathy in SARS-COV2 Infection Podocytopathy Nephrotic syndrome SARS-CoV-2 Podocitopatía Síndrome nefrótico
title_short	Nephrotic Syndrome Secondary to Podocytopathy in SARS-COV2 Infection
title_full	Nephrotic Syndrome Secondary to Podocytopathy in SARS-COV2 Infection
title_fullStr	Nephrotic Syndrome Secondary to Podocytopathy in SARS-COV2 Infection
title_full_unstemmed	Nephrotic Syndrome Secondary to Podocytopathy in SARS-COV2 Infection
title_sort	Nephrotic Syndrome Secondary to Podocytopathy in SARS-COV2 Infection
dc.creator.fl_str_mv	Aroca-Martínez, Gustavo Cadena-Bonfanti, Andrés Avendaño-Echavez, Lil Conde-Manotas, Juan C. Pérez, Rafael García, Raúl Orozco, Carlos Musso, Carlos G.
dc.contributor.author.none.fl_str_mv	Aroca-Martínez, Gustavo Cadena-Bonfanti, Andrés Avendaño-Echavez, Lil Conde-Manotas, Juan C. Pérez, Rafael García, Raúl Orozco, Carlos Musso, Carlos G.
dc.subject.eng.fl_str_mv	Podocytopathy Nephrotic syndrome
topic	Podocytopathy Nephrotic syndrome SARS-CoV-2 Podocitopatía Síndrome nefrótico
dc.subject.spa.fl_str_mv	SARS-CoV-2 Podocitopatía Síndrome nefrótico
description	Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by pulmonary involvement. However, there are reports on patients also suffering from concomitant renal involvement, with clinical manifestations such as hematuria, proteinuria, elevated nitrogen levels and acute kidney injury. Objective: The present study reports two clinical cases of nephrotic syndrome associated with coronavirus disease (COVID-19). Clinical case presentation: Histological imaging by electron microscopy showed, in one case, evidence of minimal changes and fusion of podocytes pedicels, and in the other one, podocytopathy with pedicels loss (70 %) and focal sclerosis of capillary loops. Discussion: Proteinuria in COVID-19 can be secondary to glomerular and acute tubular lesions, with a multifactorial origin: Hemodynamic factors, cytokine storms, secondary infections, druginduced nephrotoxicity and direct viral infection (proximal tubule cells and podocytes). The latter mechanisms could be explained by SARS-CoV2 renal tropism. Conclusion: The present report presents two cases of nephrotic syndrome secondary to podocytopathy in patients suffering from acute COVID-19 infection.
publishDate	2023
dc.date.accessioned.none.fl_str_mv	2023-03-29T19:56:12Z
dc.date.available.none.fl_str_mv	2023-03-29T19:56:12Z
dc.date.issued.none.fl_str_mv	2023
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dc.identifier.citation.eng.fl_str_mv	Musso CG, Aroca-Martínez G, Cadena-Bonfanti A, Avendaño-Echavez L, Conde-Manotas JC, Perez R, et al. Nephrotic Syndrome Secondary to Podocythopathy in SARS-COV2 Infection. Rev. Colomb. Nefrol. 2023; 10(2), e628. https://doi.org/10.22265/acnef.10. 2.628
dc.identifier.issn.none.fl_str_mv	25005006
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dc.identifier.doi.none.fl_str_mv	https://doi.org/10.22265/acnef.10.2.628
dc.identifier.url.none.fl_str_mv	https://revistanefrologia.org/index.php/rcn/article/view/628
identifier_str_mv	Musso CG, Aroca-Martínez G, Cadena-Bonfanti A, Avendaño-Echavez L, Conde-Manotas JC, Perez R, et al. Nephrotic Syndrome Secondary to Podocythopathy in SARS-COV2 Infection. Rev. Colomb. Nefrol. 2023; 10(2), e628. https://doi.org/10.22265/acnef.10. 2.628 25005006
url	https://hdl.handle.net/20.500.12442/12108 https://doi.org/10.22265/acnef.10.2.628 https://revistanefrologia.org/index.php/rcn/article/view/628
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dc.format.mimetype.eng.fl_str_mv	pdf
dc.publisher.spa.fl_str_mv	Asociación Colombiana de Nefrología e Hipertensión Arterial
dc.source.spa.fl_str_mv	Revista Colombiana de Nefrología
dc.source.none.fl_str_mv	Vol. 10 No. 2 (2023)
institution	Universidad Simón Bolívar
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spelling	Aroca-Martínez, Gustavoef65933f-3af8-4323-9a75-9d00de17e70aCadena-Bonfanti, Andrésef1cb12d-618e-46bd-aafd-4064f44fdcbfAvendaño-Echavez, Lile39b3329-5341-44a3-af85-be734dee7edeConde-Manotas, Juan C.7cddcac0-7cfd-486b-aa8c-9e4c37294d8aPérez, Rafaelc6510cbe-7e70-40a0-be51-4226d9859e77García, Raúla64e79bf-ef09-4c8f-9287-a161acb4b8e4Orozco, Carlos22dea520-7e9a-4a6f-9b4f-e86e3242e0daMusso, Carlos G.e1f82fb4-05f8-40b4-8f34-3bd432a0baf42023-03-29T19:56:12Z2023-03-29T19:56:12Z2023Musso CG, Aroca-Martínez G, Cadena-Bonfanti A, Avendaño-Echavez L, Conde-Manotas JC, Perez R, et al. Nephrotic Syndrome Secondary to Podocythopathy in SARS-COV2 Infection. Rev. Colomb. Nefrol. 2023; 10(2), e628. https://doi.org/10.22265/acnef.10. 2.62825005006https://hdl.handle.net/20.500.12442/12108https://doi.org/10.22265/acnef.10.2.628https://revistanefrologia.org/index.php/rcn/article/view/628Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by pulmonary involvement. However, there are reports on patients also suffering from concomitant renal involvement, with clinical manifestations such as hematuria, proteinuria, elevated nitrogen levels and acute kidney injury. Objective: The present study reports two clinical cases of nephrotic syndrome associated with coronavirus disease (COVID-19). Clinical case presentation: Histological imaging by electron microscopy showed, in one case, evidence of minimal changes and fusion of podocytes pedicels, and in the other one, podocytopathy with pedicels loss (70 %) and focal sclerosis of capillary loops. Discussion: Proteinuria in COVID-19 can be secondary to glomerular and acute tubular lesions, with a multifactorial origin: Hemodynamic factors, cytokine storms, secondary infections, druginduced nephrotoxicity and direct viral infection (proximal tubule cells and podocytes). The latter mechanisms could be explained by SARS-CoV2 renal tropism. Conclusion: The present report presents two cases of nephrotic syndrome secondary to podocytopathy in patients suffering from acute COVID-19 infection.Introducción: el síndrome respiratorio agudo severo inducido por coronavirus-2 (SARS-CoV-2) se caracteriza por la instalación de una afectación pulmonar. Sin embargo, existen reportes de afectación renal concomitante, con manifestaciones clínicas como hematuria, proteinuria y daño renal agudo. Objetivo: presentamos dos casos clínicos de síndrome nefrótico asociado a enfermedad por coronavirus (COVID-19). Presentación del caso: un paciente presentó evidencia histológica de cambios mínimos y fusión de pedicelos de podocitos en muestras histológicas evaluadas por microscopía electrónica. Discusión: la proteinuria en COVID-19 puede ser secundaria a lesiones glomerulares y tubulares agudas, con un origen multifactorial: factores hemodinámicos, tormentas de citocinas, infecciones secundarias, nefrotoxicidad inducida por fármacos e infección viral directa de las células del túbulo proximal y podocitos. Esta última podría deberse a una infección directa por el virus debido al mayor tropismo renal de este. Conclusión: el presente informe presenta dos casos de síndrome nefrótico secundario a podocitopatía en pacientes con infección aguda por COVID-19.pdfspaAsociación Colombiana de Nefrología e Hipertensión ArterialAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Revista Colombiana de NefrologíaVol. 10 No. 2 (2023)PodocytopathyNephrotic syndromeSARS-CoV-2PodocitopatíaSíndrome nefróticoNephrotic Syndrome Secondary to Podocytopathy in SARS-COV2 InfectionSíndrome nefrótico secundario a podocitopatía en infección por SARS-COV2info:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Aroca-Martínez G, Musso CG, Avendaño-Echavez L, Vélez-Verbel M, Chartouni-Narvaez S, Hernandez S, et al. Differences between COVID-19-induced acute kidney injury and chronic kidney disease patients. J Bras Nefrol 2022 Apr-Jun;44(2):155-163. https://doi.org/10.1590/ 2175-8239-jbn-2021-0161Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. 2020;97(5):829-838. https:// doi.org/10.1016/j.kint.2020.03.005Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-513. https://doi.org/10.1016/S0140-6736(20)30211-7Avendaño-Echávez LG, Palmera-Hernández JL, Riascos-Palacios WB. Chronic kidney disease and covid-19: the importance of hydration. Rev Colomb Nefrol. 2020;7(Supl 2):273-279. http://dx.doi.org/10.22265/acnef.7.Supl.2.4Aroca-Martínez G, Musso CG, Avendaño-Echavez L, González-Torres H, Vélez-Verbel M, Chartouni-Narvaez S, et al. Impact of frailty and viral load on acute kidney injury evolution in patients affected by coronavirus disease. Saudi J Kidney Dis Transpl. 2021;32(5):1356- 1364. https://doi.org/10.4103/1319-2442.344755Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. 2020;97(5):829–838. https:// doi.org/10.1016/j.kint.2020.03.005Su H, Yang M, Wan C, Yi LX, Tang F, Zhu HY, et al. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int. 2020;98(1):219–227. https://doi.org/10.1016/j.kint.2020.04.003Kudose S, Batal I, Santoriello D, Xu K, Barasch J, Peleg Y, et al. Kidney Biopsy Findings in Patients with COVID-19. JASN. 2020;31(9):1959–1968. https://doi.org/10.1681/ASN. 2020060802Gupta R , Bhargava R, Shaukat A, Albert E, Leggat J. Spectrum of podocytopathies in newonset nephrotic syndrome following COVID-19 disease: a report of 2 cases. BMC Nephrol. 2020 Aug;21:326. https://doi.org/10.1186/s12882-020-01970-yBraun F, Huber T, Puelles V.. Proximal tubular dysfunction in patients with COVID-19: what have we learnt so far? Kidney Int. 2020:98(5):1092-1094. https://doi.org/10.1016/j.kint. 2020.09.002Risso M, Sallustio S, Sueiro V, Bertoni V, Gonzalez-Torres H, Musso CG. The Importance of Tubular Function in Chronic Kidney Disease. Int J Nephrol Renovasc Dis. 2019;12: 257–262. https://doi.org/10.2147/IJNRD.S216673Khan S, Chen L, Yang CR, Raghuram V, Khundmiri SJ, Knepper M. Does SARS-CoV- 2 Infect the Kidney? JASN. 2020;31(12):2746-2748. https://doi.org/10.1681/ASN.2020081229Doevelaar A, Hölzer B, Seibert FS, Bauer F, Stervbo U, Rohn BJ, et al. Lessons for the clinical nephrologist: recurrence of nephrotic syndrome induced by SARS-CoV-2. J Nephrol. 2020;33:1369-1372. https://doi.org/10.1007/s40620-020-00855-5Wang J, Jiang M, Chen X, Montaner L. Cytokine storm and leukocyte changes in mild versus severe SARS-CoV2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts. J Leukoc Biol. 2020;108(1):17–41. https://doi.org/ 10.1002/JLB.3COVR0520-272RKopp JB, Anders HJ, Susztak K, Podesta MA, Remuzzi G, Hildebrandt F, et al. Podocytopathies. Nat Rev Dis Primers. 2020;68(6):1-24. https://doi.org/10.1038/s41572-020-0196-7Aroca-Martínez G, Avendaño-Echavez L, Garcia C, Ripoll D, Dianda D, Cadena-Bonfanti A, et al. Renal tubular dysfunction in COVID-19 patients. 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Nephrotic Syndrome Secondary to Podocytopathy in SARS-COV2 Infection

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