Oral analogues of GLP-1: perspectives on glycemic control and cardiorenal risk in patients with type 2 diabetes mellitus

At present, type 2 diabetes mellitus (T2DM) is the leading cause of end-stage kidney disease. The management of T2DM in recent years has moved from a glucocentric approach to a global approach with the priority of introducing treatments that offer renal and cardiovascular protection. In this article...

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Autores:: Rico-Fontalvo, Jorge
daza arnedo, rodrigo andres
Vázquez Jiménez, Lourdes Carolina
Rodríguez-Yánez, Tomas
Raad Sarabia, Maria Isabel
TOAPANTA, NÉSTOR
Pérez, Rafael V.
Montejo-Hernández, Juan
Soler, María J.

Tipo de recurso:

Fecha de publicación:: 2024

Institución:: Universidad Simón Bolívar

Repositorio:: Repositorio Digital USB

Idioma:: eng

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dc.title.eng.fl_str_mv	Oral analogues of GLP-1: perspectives on glycemic control and cardiorenal risk in patients with type 2 diabetes mellitus
dc.title.translated.spa.fl_str_mv	Análogos orales del GLP-1: perspectivas en el control glicémico y riesgo cardiorenal en pacientes con diabetes mellitus tipo 2
title	Oral analogues of GLP-1: perspectives on glycemic control and cardiorenal risk in patients with type 2 diabetes mellitus
spellingShingle	Oral analogues of GLP-1: perspectives on glycemic control and cardiorenal risk in patients with type 2 diabetes mellitus Diabetes mellitus Glucagon-like peptide 1 receptor analogs Semaglutide Diabetes Mellitus Análogos del receptor del péptido similar al glucagón tipo 1 Semaglutida
title_short	Oral analogues of GLP-1: perspectives on glycemic control and cardiorenal risk in patients with type 2 diabetes mellitus
title_full	Oral analogues of GLP-1: perspectives on glycemic control and cardiorenal risk in patients with type 2 diabetes mellitus
title_fullStr	Oral analogues of GLP-1: perspectives on glycemic control and cardiorenal risk in patients with type 2 diabetes mellitus
title_full_unstemmed	Oral analogues of GLP-1: perspectives on glycemic control and cardiorenal risk in patients with type 2 diabetes mellitus
title_sort	Oral analogues of GLP-1: perspectives on glycemic control and cardiorenal risk in patients with type 2 diabetes mellitus
dc.creator.fl_str_mv	Rico-Fontalvo, Jorge daza arnedo, rodrigo andres Vázquez Jiménez, Lourdes Carolina Rodríguez-Yánez, Tomas Raad Sarabia, Maria Isabel TOAPANTA, NÉSTOR Pérez, Rafael V. Montejo-Hernández, Juan Soler, María J.
dc.contributor.author.none.fl_str_mv	Rico-Fontalvo, Jorge daza arnedo, rodrigo andres Vázquez Jiménez, Lourdes Carolina Rodríguez-Yánez, Tomas Raad Sarabia, Maria Isabel TOAPANTA, NÉSTOR Pérez, Rafael V. Montejo-Hernández, Juan Soler, María J.
dc.subject.spa.fl_str_mv	Diabetes mellitus Glucagon-like peptide 1 receptor analogs Semaglutide
topic	Diabetes mellitus Glucagon-like peptide 1 receptor analogs Semaglutide Diabetes Mellitus Análogos del receptor del péptido similar al glucagón tipo 1 Semaglutida
dc.subject.keywords.eng.fl_str_mv	Diabetes Mellitus Análogos del receptor del péptido similar al glucagón tipo 1 Semaglutida
description	At present, type 2 diabetes mellitus (T2DM) is the leading cause of end-stage kidney disease. The management of T2DM in recent years has moved from a glucocentric approach to a global approach with the priority of introducing treatments that offer renal and cardiovascular protection. In this article, we review in depth the pharmacokinetics and pharmacodynamics of the first oral analog of glucagon-like peptide-1 (oral semaglutide) in comparison with its subcutaneous formulation. The knowledge and implementation of these drugs will be very useful in daily clinical practice
publishDate	2024
dc.date.issued.none.fl_str_mv	2024
dc.date.accessioned.none.fl_str_mv	2025-06-10T20:13:22Z
dc.date.available.none.fl_str_mv	2025-06-10T20:13:22Z
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dc.type.spa.none.fl_str_mv	Artículo científico
dc.identifier.issn.none.fl_str_mv	24449032 (Electrónico)
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12442/16665
dc.identifier.doi.none.fl_str_mv	http://dx.doi.org/10.24875/NEFRO.M24000021
dc.identifier.url.none.fl_str_mv	https://www.nefrologialatinoamericana.com/frame_eng.php?id=120
identifier_str_mv	24449032 (Electrónico)
url	https://hdl.handle.net/20.500.12442/16665 http://dx.doi.org/10.24875/NEFRO.M24000021 https://www.nefrologialatinoamericana.com/frame_eng.php?id=120
dc.language.iso.none.fl_str_mv	eng
language	eng
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dc.format.mimetype.none.fl_str_mv	pdf
dc.publisher.spa.fl_str_mv	Sociedad Latinoamericana de Nefrología e Hipertensión
dc.source.spa.fl_str_mv	Nefrología Latinoamericana Vol. 21 No. 1, (2024)
dc.source.eng.fl_str_mv	Nefro Latinoam.
institution	Universidad Simón Bolívar
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spelling	Rico-Fontalvo, Jorge31340a30-7424-40ed-9cb2-e504948263de600daza arnedo, rodrigo andresc449be2b-1fb7-45f0-a742-1e418dbbb99b600Vázquez Jiménez, Lourdes Carolinae86e28a6-ad7f-4d84-9868-948a5e96cc2d600Rodríguez-Yánez, Tomas00e89aa4-b3ac-45aa-b6fc-a2fbee3797fe-1Raad Sarabia, Maria Isabel16aeb3f9-6400-416d-a053-d1da65ab4573600TOAPANTA, NÉSTORc0a5ea92-b5b9-426f-881c-16c3e964ca5d600Pérez, Rafael V.207e2612-3b9c-427d-aad5-49461ecfb316-1Montejo-Hernández, Juand43e9eda-cbd3-4cf7-bdfa-8da1dcc3731e-1Soler, María J.69f21324-645b-420d-a7d5-788fb2357ada-12025-06-10T20:13:22Z2025-06-10T20:13:22Z202424449032 (Electrónico)https://hdl.handle.net/20.500.12442/16665http://dx.doi.org/10.24875/NEFRO.M24000021https://www.nefrologialatinoamericana.com/frame_eng.php?id=120At present, type 2 diabetes mellitus (T2DM) is the leading cause of end-stage kidney disease. The management of T2DM in recent years has moved from a glucocentric approach to a global approach with the priority of introducing treatments that offer renal and cardiovascular protection. In this article, we review in depth the pharmacokinetics and pharmacodynamics of the first oral analog of glucagon-like peptide-1 (oral semaglutide) in comparison with its subcutaneous formulation. The knowledge and implementation of these drugs will be very useful in daily clinical practiceLa diabetes mellitus tipo 2 (DM2) es la primera causa de inicio de terapia renal sustitutiva en la actualidad. El manejo de la DM2 en los últimos años ha pasado de un enfoque glucocéntrico a un enfoque global con la prioridad de la introducción de los tratamientos que ofrecen protección renal y cardiovascular. En este artículo revisamos en profundidad la farmacoci nética y farmacodinamia del primer análogo oral del péptido similar al glucagón-1 (semaglutide oral) en comparación con su formulación subcutánea. El conocimiento e implementación de dichos fármacos nos serán de gran utilidad en la práctica clínica habitualpdfengSociedad Latinoamericana de Nefrología e HipertensiónAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Nefrología LatinoamericanaVol. 21 No. 1, (2024)Nefro Latinoam.Diabetes mellitusGlucagon-like peptide 1 receptor analogsSemaglutideDiabetes MellitusAnálogos del receptor del péptido similar al glucagón tipo 1SemaglutidaOral analogues of GLP-1: perspectives on glycemic control and cardiorenal risk in patients with type 2 diabetes mellitusAnálogos orales del GLP-1: perspectivas en el control glicémico y riesgo cardiorenal en pacientes con diabetes mellitus tipo 2info:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Mahapatra MK, Karuppasamy M, Sahoo BM. Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes. Vol. 23, Reviews in Endocrine and Metabolic Disorders. 2022Aroda VR, Ahmann A, Cariou B, Chow F, Davies MJ, Jódar E, et al. Comparative efficacy, safety, and cardiovascular outcomes with once-weekly subcutaneous semaglutide in the treatment of type 2 diabetes: Insights from the SUSTAIN 1–7 trials. Vol. 45, Diabetes and Metabolism. 2019.Cho YM, Fujita Y, Kieffer TJ. Glucagon-like peptide-1: Glucose homeostasis and beyond. Annual Review of Physiology. 2014.Medicina A DE, Rico-Fontalvo J, Daza-Arnedo R, Raad-Sarabia M, Pájaro-Galvis N, Correa-Guerrero J, et al. Agonistas Del Receptor Glp-1: Desde su Efecto Fisiologico en el Sistema Incretina Hasta du Rol en Enfermedad Renal DiabeticaGlp-1 Receptor Agonists: From their Physio logical Effect on the Incretine System to their Role in Diabetic Kidney Disease. 17(2). Available from: www.archivosdemedicina.comNadkarni P, Chepurny OG, Holz GG. Regulation of glucose homeostasis by GLP-1. In: Progress in Molecular Biology and Translational Science. 2014Meier JJ. GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus. Nature Reviews Endocrinology. 2012Tran KL, Park YI, Pandya S, Muliyil NJ, Jensen BD, Huynh K, et al. Overview of glucagon-like peptide-1 receptor agonists for the treatment of patients with type 2 diabetes. Am Health Drug Benefits. 2017;Anderson SL, Beutel TR, Trujillo JM. Oral semaglutide in type 2 diabetes. Vol. 34, Journal of Diabetes and its Complications. Elsevier Inc.; 2020.Mahapatra MK, Karuppasamy M, Sahoo BM. Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes. Vol. 23, Reviews in Endocrine and Metabolic Disorders. 2022.Daza-Arnedo R, Rico-Fontalvo J, Raad-Sarabia M, Ramos-Clason E, Bohórquez-Rivero J, Montejo-Hernández J, et al. Semaglutida en enfermedad renal diabética: Experiencia en dos programas de salud renal en Colombia. Revista Colombiana de Endocrinología, Diabetes & Metabolismo. 2022 Sep 21;9(3).Bucheit JD, Pamulapati LG, Carter N, Malloy K, Dixon DL, Sisson EM. Oral Semaglutide: A Review of the First Oral Glucagon-Like Peptide 1 Receptor Agonist. Vol. 22, Diabetes Technology and Therapeutics. 2020.Buckley ST, Bækdal TA, Vegge A, Maarbjerg SJ, Pyke C, Ahnfelt-Rønne J, et al. Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist. Sci Transl Med. 2018;10(468)Jensen L, Helleberg H, Roffel A, van Lier JJ, Bjørnsdottir I, Pedersen PJ, et al. Absorption, metabolism and excretion of the GLP-1 analogue se maglutide in humans and nonclinical species. European Journal of Phar maceutical Sciences. 2017Davies M, Pieber TR, Hartoft-Nielsen ML, Hansen OKH, Jabbour S, Rosenstock J. Effect of oral semaglutide compared with placebo and subcutaneous semaglutide on glycemic control in patients with type 2 diabetes a randomized clinical trial. JAMA - Journal of the American Medical Association. 2017;318(15).Rodbard HW, Rosenstock J, Canani LH, Deerochanawong C, Gumprecht J, Lindberg SØ, et al. Oral semaglutide versus empagliflozin in patients with type 2 diabetes uncontrolled on metformin: The PIONEER 2 trial. Diabetes Care. 2019;42(12).Rosenstock J, Allison D, Birkenfeld AL, Blicher TM, Deenadayalan S, Jacobsen JB, et al. Effect of Additional Oral Semaglutide vs Sitagliptin on Glycated Hemoglobin in Adults with Type 2 Diabetes Uncontrolled with Metformin Alone or with Sulfonylurea: The PIONEER 3 Randomized Clini cal Trial. JAMA - Journal of the American Medical Association. 2019;32Avgerinos I, Michailidis T, Liakos A, Karagiannis T, Matthews DR, Tsapas A, et al. Oral semaglutide for type 2 diabetes: A systematic review and meta-analysis. Diabetes Obes Metab. 2020;22(3).Marso SP, Daniels GH, Frandsen KB, Kristensen P, Mann JFE, Nauck MA, et al. Liraglutide and cardiovascular outcomes in type 2 diabetes. New England Journal of Medicine. 2016;Hernandez AF, Green JB, Janmohamed S, D’Agostino RB, Granger CB, Jones NP, et al. Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial. The Lancet. 2018;Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, Pais P, et al. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial. The Lancet. 2019;Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jódar E, Leiter LA, et al. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. New England Journal of Medicine.Husain M, Birkenfeld AL, Donsmark M, Dungan K, Eliaschewitz FG, Franco DR, et al. Oral semaglutide and cardiovascular outcomes in patients with type 2 diabetes. New England Journal of Medicine. 2McGuire DK, Busui RP, Deanfield J, Inzucchi SE, Mann JFE, Marx N, et al. Effects of oral semaglutide on cardiovascular outcomes in individuals with type 2 diabetes and established atherosclerotic cardiovascular disease and/or chronic kidney disease: Design and baseline characteristics of SOUL, a randomized trial. Diabetes Obes Metab. 2023;25(7)Rico-Fontalvo J, Aroca G, Cabrales J, Daza-Arnedo R, Yánez-Rodríguez T, Martínez-Ávila MC, et al. Molecular Mechanisms of Diabetic Kidney Disease. Vol. 23, International Journal of Molecular Sciences. MDPRico-Fontalvo J, Aroca-Martínez G, Daza-Arnedo R, Cabrales J, Rodríguez-Yanez T, Cardona-Blanco M, et al. Novel Biomarkers of Diabetic Kidney Disease. Vol. 13, Biomolecules. 2Granhall C, Søndergaard FL, Thomsen M, Anderson TW. Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects with Renal Impairment. Clin Pharmacokinet. 2018;57(12).Mosenzon O, Blicher TM, Rosenlund S, Eriksson JW, Heller S, Hels OH, et al. Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial. Lancet Diabetes Endocrinol. 2Aroda VR, Rosenstock J, Terauchi Y, Altuntas Y, Lalic NM, Villegas ECM, et al. PIONEER 1: Randomized clinical trial of the efficacy and safety of oral semaglutide monotherapy in comparison with placebo in patients with type 2 diabetes. Diabetes Care. 2019;42(9).Pratley R, Amod A, Hoff ST, Kadowaki T, Lingvay I, Nauck M, et al. Oral semaglutide versus subcutaneous liraglutide and placebo in type 2 diabetes (PIONEER 4): a randomised, double-blind, phase 3a trial. The Lancet. 2019;394(10192)Pieber TR, Bode B, Mertens A, Cho YM, Christiansen E, Hertz CL, et al. Efficacy and safety of oral semaglutide with flexible dose adjustment versus sitagliptin in type 2 diabetes (PIONEER 7): a multicentre, open-label, randomised, phase 3a trial. Lancet DiaZinman B, Aroda VR, Buse JB, Cariou B, Harris SB, Hoff ST, et al. Efficacy, safety, and tolerability of oral semaglutide versus placebo added to insulin with or without metformin in patients with type 2 diabetes: The PioNEER 8 trial. Diabetes Care. 2019;42(12).Yamada Y, Katagiri H, Hamamoto Y, Deenadayalan S, Navarria A, Nishijima K, et al. Dose-response, efficacy, and safety of oral semaglutide monotherapy in Japanese patients with type 2 diabetes (PIONEER 9): a 52-week, phase 2/3a, randomised, controlled trial. Lancet Diabetes Endocrinol. 2020;8(5).Yabe D, Nakamura J, Kaneto H, Deenadayalan S, Navarria A, Gislum M, et al. Safety and efficacy of oral semaglutide versus dulaglutide in Japanese patients with type 2 diabetes (PIONEER 10): an open-label, randomised, active-controlled, phase 3a trial. Lancet Diabetes Endocrinol. 2020;8(5)Rico Fontalvo JE. Guía de práctica clínica para la enfermedad renal diabética. Revista Colombiana de Nefrología. 2021;8(2).Rico Fontalvo JE, Daza Arnedo R, Raad M, Pájaro N, Correa Guerrero J, Villacob Oviedo A, et al. Agonistas del receptor Glp-1: Desde su efecto fisiológico en el sistema incretina hasta du rol en enfermedad renal diabetica. Archivos de medicina, ISSN-e 1698-9465, Vol 17, No 2, 2021. 2021;Lopera Vargas JM, Rico Fontalvo JE, Melgarejo R. E, Castillo Barrios GA, Ramírez Rincón A, Gomez AM, et al. Efecto de terapias farmacológicas para el control glucémico en pacientes con diabetes mellitus tipo 2 en los desenlaces vasculares. Revista Colombiana de Nefrología. 2020 Apr 13;7(1):44–59.CHMP. 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Oral analogues of GLP-1: perspectives on glycemic control and cardiorenal risk in patients with type 2 diabetes mellitus

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