Explorando el poder de los abordajes transcriptómicos para identificar biomarcadores asociados a daño renal en pacientes con lupus eritematoso sistémico

El lupus eritematoso sistémico (LES) es una enfermedad compleja y altamente heterogénea que afecta múltiples órganos, incluyendo articulaciones, corazón, sistema hematopoyético, sistema nervioso y riñón, siendo este último el de peor pronóstico y el que conlleva a nefritis lúpica (NL). Aunque la eti...

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Autores:: Arrieta Bravo, Valentina
Rangel Gómez, Tiffany
Pacheco Lugo, Lisandro

Tipo de recurso:

Fecha de publicación:: 2021

Institución:: Universidad Simón Bolívar

Repositorio:: Repositorio Digital USB

Idioma:: spa

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dc.title.spa.fl_str_mv	Explorando el poder de los abordajes transcriptómicos para identificar biomarcadores asociados a daño renal en pacientes con lupus eritematoso sistémico
dc.title.translated.eng.fl_str_mv	Exploring the power of transcriptomic approaches to identify biomarkers associated to renal damage in Systemic Lupus Erythematosus patients
title	Explorando el poder de los abordajes transcriptómicos para identificar biomarcadores asociados a daño renal en pacientes con lupus eritematoso sistémico
spellingShingle	Explorando el poder de los abordajes transcriptómicos para identificar biomarcadores asociados a daño renal en pacientes con lupus eritematoso sistémico Lupus eritematoso sistémico Nefritis lúpica Biomarcadores MicroARNs Systemic lupus erythematosus Lupus nephritis Biomarkers MicroRNAs
title_short	Explorando el poder de los abordajes transcriptómicos para identificar biomarcadores asociados a daño renal en pacientes con lupus eritematoso sistémico
title_full	Explorando el poder de los abordajes transcriptómicos para identificar biomarcadores asociados a daño renal en pacientes con lupus eritematoso sistémico
title_fullStr	Explorando el poder de los abordajes transcriptómicos para identificar biomarcadores asociados a daño renal en pacientes con lupus eritematoso sistémico
title_full_unstemmed	Explorando el poder de los abordajes transcriptómicos para identificar biomarcadores asociados a daño renal en pacientes con lupus eritematoso sistémico
title_sort	Explorando el poder de los abordajes transcriptómicos para identificar biomarcadores asociados a daño renal en pacientes con lupus eritematoso sistémico
dc.creator.fl_str_mv	Arrieta Bravo, Valentina Rangel Gómez, Tiffany Pacheco Lugo, Lisandro
dc.contributor.author.none.fl_str_mv	Arrieta Bravo, Valentina Rangel Gómez, Tiffany Pacheco Lugo, Lisandro
dc.subject.spa.fl_str_mv	Lupus eritematoso sistémico Nefritis lúpica Biomarcadores MicroARNs
topic	Lupus eritematoso sistémico Nefritis lúpica Biomarcadores MicroARNs Systemic lupus erythematosus Lupus nephritis Biomarkers MicroRNAs
dc.subject.eng.fl_str_mv	Systemic lupus erythematosus Lupus nephritis Biomarkers MicroRNAs
description	El lupus eritematoso sistémico (LES) es una enfermedad compleja y altamente heterogénea que afecta múltiples órganos, incluyendo articulaciones, corazón, sistema hematopoyético, sistema nervioso y riñón, siendo este último el de peor pronóstico y el que conlleva a nefritis lúpica (NL). Aunque la etiopatogénesis del LES aún no se conoce con claridad, se cree que la susceptibilidad genética y las modificaciones epigenéticas aberrantes favorecen su desenlace. Para establecer una terapia precisa es necesario evaluar de manera eficiente y objetiva el compromiso de órganos y la actividad de la enfermedad, lo cual es muy difícil por las pocas pruebas de laboratorio clínico disponibles en la actualidad. En las últimas décadas la búsqueda de nuevos biomarcadores de LES ha sido una tendencia y se han identificado varios promisorios a nivel de genómica, metabolómica, proteómica y transcriptómica. En esta revisión se resume el estado del arte relacionado con estudios transcriptómicos que han identificado diversos transcritos potencialmente útiles como biomarcadores del LES y la NL
publishDate	2021
dc.date.issued.none.fl_str_mv	2021
dc.date.accessioned.none.fl_str_mv	2022-01-26T16:26:23Z
dc.date.available.none.fl_str_mv	2022-01-26T16:26:23Z
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dc.type.spa.spa.fl_str_mv	Artículo científico
dc.identifier.issn.none.fl_str_mv	25005006
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12442/9307
dc.identifier.doi.none.fl_str_mv	https://doi.org/10.22265/acnef.8.1.492
identifier_str_mv	25005006
url	https://hdl.handle.net/20.500.12442/9307 https://doi.org/10.22265/acnef.8.1.492
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dc.publisher.spa.fl_str_mv	Asociación Colombiana de Nefrología e hipertensión Arterial Facultad de Ciencias de la Salud
dc.source.spa.fl_str_mv	Vol. 8, Num. 1 (2021) Revista Colombiana de Nefrología. Rev. Colomb. Nefrol.
institution	Universidad Simón Bolívar
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spelling	Arrieta Bravo, Valentinac77f6fb8-d969-46a9-a6d5-a26a7f050fbeRangel Gómez, Tiffanyfbe112e7-c62e-41ee-9387-b92daa8fd9aaPacheco Lugo, Lisandro51b70dab-9baa-4f8f-afc1-f2b44b87c3462022-01-26T16:26:23Z2022-01-26T16:26:23Z202125005006https://hdl.handle.net/20.500.12442/9307https://doi.org/10.22265/acnef.8.1.492El lupus eritematoso sistémico (LES) es una enfermedad compleja y altamente heterogénea que afecta múltiples órganos, incluyendo articulaciones, corazón, sistema hematopoyético, sistema nervioso y riñón, siendo este último el de peor pronóstico y el que conlleva a nefritis lúpica (NL). Aunque la etiopatogénesis del LES aún no se conoce con claridad, se cree que la susceptibilidad genética y las modificaciones epigenéticas aberrantes favorecen su desenlace. Para establecer una terapia precisa es necesario evaluar de manera eficiente y objetiva el compromiso de órganos y la actividad de la enfermedad, lo cual es muy difícil por las pocas pruebas de laboratorio clínico disponibles en la actualidad. En las últimas décadas la búsqueda de nuevos biomarcadores de LES ha sido una tendencia y se han identificado varios promisorios a nivel de genómica, metabolómica, proteómica y transcriptómica. En esta revisión se resume el estado del arte relacionado con estudios transcriptómicos que han identificado diversos transcritos potencialmente útiles como biomarcadores del LES y la NLSystemic Lupus Erythematosus is a complex and highly heterogeneous disease affecting multiple organs such as joints, heart, hematopoietic system, nervous system and kidney, the latter being the worst prognosis and leading to lupus nephritis (LN). While the etiopathogenesis of SLE is still not completely clear, is believed that genetic susceptibility and aberrant epigenetic modifications favor the outcome of the disease. In order to establish an accurate therapy, it is necessary to efficiently and objectively assess organ involvement and disease activity, which is very dificult due to the clinical laboratory tests currently available. In recent decades, the search for new SLE biomarkers has been a trend and many promising biomarkers have been identified at the genomic, metabolomic, proteomic and transcriptomic levels. In this review we summarize the state of the art related to transcriptomic studies that have identified various potentially useful transcripts as biomarkers of SLE and NL.Systemic Lupus Erythematosus is a complex and highly heterogeneous disease affecting multiple organs such as joints, heart, hematopoietic system, nervous system and kidney, the latter being the worst prognosis and leading to lupus nephritis (LN). While the etiopathogenesis of SLE is still not completely clear, is believed that genetic susceptibility and aberrant epigenetic modifications favor the outcome of the disease. In order to establish an accurate therapy, it is necessary to efficiently and objectively assess organ involvement and disease activity, which is very dificult due to the clinical laboratory tests currently available. In recent decades, the search for new SLE biomarkers has been a trend and many promising biomarkers have been identified at the genomic, metabolomic, proteomic and transcriptomic levels. In this review we summarize the state of the art related to transcriptomic studies that have identified various potentially useful transcripts as biomarkers of SLE and NL.pdfspaAsociación Colombiana de Nefrología e hipertensión ArterialFacultad de Ciencias de la SaludAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Vol. 8, Num. 1 (2021)Revista Colombiana de Nefrología. Rev. Colomb. Nefrol.Lupus eritematoso sistémicoNefritis lúpicaBiomarcadoresMicroARNsSystemic lupus erythematosusLupus nephritisBiomarkersMicroRNAsExplorando el poder de los abordajes transcriptómicos para identificar biomarcadores asociados a daño renal en pacientes con lupus eritematoso sistémicoExploring the power of transcriptomic approaches to identify biomarkers associated to renal damage in Systemic Lupus Erythematosus patientsinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Honarpisheh M, Köhler P, von Rauchhaupt E, Lech M. The Involvement of MicroRNAs in Modulation of Innate and Adaptive Immunity in Systemic Lupus Erythematosus and Lupus Nephritis. J Immunol Res. 2018;2018:4123106. https://dx.doi.org/10.1155/2018/4126106Zhu H, Mi W, Luo H, Chen T, Liu S, Raman I, et al. 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Rev Colomb Nefrol. 2014;1(2):57-64. https://dx.doi.org/10.22265/ acnef.1.2.176Pacheco-Lugo L, Díaz-Olmos Y, Aroca-Martínez G. Biomarcadores en fuídos biológicos y su potencial uso como indicadores de nefritis lúpica en individuos con lupus eritematoso sistémico. Rev Colomb Nefrol. 2014;1(1):39-47. https://dx.doi.org/10.22265/acnef.1.1.171Sede BarranquillaMedicinahttps://revistanefrologia.org/index.php/rcn/article/view/492ORIGINALPDF.pdfPDF.pdfapplication/pdf493597https://bonga.unisimon.edu.co/bitstreams/6b10361b-0cf9-4053-a767-ca5415ed0d92/download9336a0facdc85d3c959b48ed806bf1deMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-83000https://bonga.unisimon.edu.co/bitstreams/27278814-5d96-4a75-804c-ae72ce8aaff8/download2a1661e5960a7bab4fd8dda692fb677cMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://bonga.unisimon.edu.co/bitstreams/ea28d38a-064d-4d53-8045-641ddc72b517/download4460e5956bc1d1639be9ae6146a50347MD52TEXTExplorando_Poder_Abordajes_Transcriptómicos_Artículo.pdf.txtExplorando_Poder_Abordajes_Transcriptómicos_Artículo.pdf.txtExtracted texttext/plain40521https://bonga.unisimon.edu.co/bitstreams/64b48f3d-e7ce-447c-b1ce-4a281439d639/downloadfeef25d087571a890739401958e4b1deMD54PDF.txtPDF.txtExtracted texttext/plain44722https://bonga.unisimon.edu.co/bitstreams/65e321d8-c6cd-4d06-a203-df6e5eab6d18/download94cfd6bfdf2556c2f28cab430c25fea7MD56PDF.pdf.txtPDF.pdf.txtExtracted texttext/plain44722https://bonga.unisimon.edu.co/bitstreams/b60f621d-1f8f-4eaa-9b5a-e3269af3ef7d/download94cfd6bfdf2556c2f28cab430c25fea7MD58THUMBNAILExplorando_Poder_Abordajes_Transcriptómicos_Artículo.pdf.jpgExplorando_Poder_Abordajes_Transcriptómicos_Artículo.pdf.jpgGenerated Thumbnailimage/jpeg17796https://bonga.unisimon.edu.co/bitstreams/056a0047-0510-48e3-b3c3-65d75c116781/download1b3241cab82dc83f378bab1ece5f0547MD55PDF.jpgPDF.jpgGenerated Thumbnailimage/jpeg5761https://bonga.unisimon.edu.co/bitstreams/c1791b4f-8573-49b1-9b4c-e73f41c2e2c6/download69c19370ec49bf35073173556f4eb58bMD57PDF.pdf.jpgPDF.pdf.jpgGenerated Thumbnailimage/jpeg5761https://bonga.unisimon.edu.co/bitstreams/df189b25-1b34-4aae-b12d-97a0a08c9ccb/download69c19370ec49bf35073173556f4eb58bMD5920.500.12442/9307oai:bonga.unisimon.edu.co:20.500.12442/93072024-08-14 21:54:25.673http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internacionalrestrictedhttps://bonga.unisimon.edu.coRepositorio Digital Universidad Simón Bolívarrepositorio.digital@unisimon.edu.co

Explorando el poder de los abordajes transcriptómicos para identificar biomarcadores asociados a daño renal en pacientes con lupus eritematoso sistémico

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