Epigenetic mechanisms and posttranslational modifications in systemic Lupus Erythematosus

The complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their su...

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Autores:
Navarro Quiroz, Elkin
Chavez-Estrada, Valeria
Macias-Ochoa, Karime
Ayala-Navarro, María Fernanda
Flores-Aguilar, Aniyensy Sarai
Morales-Navarrete, Francisco
De la Cruz Lopez, Fernando
Gomez Escorcia, Lorena
G. Musso, Carlos
Aroca Martinez, Gustavo
Gonzales Torres, Henry
Diaz Perez, Anderson
Cadena Bonfanti, Andres
Sarmiento Gutierrez, Joany
Meza, Jainy
Diaz Arroyo, Esperanza
Bello Lemus, Yesit
Ahmad, Mostapha
Navarro Quiroz, Roberto
Tipo de recurso:
Fecha de publicación:
2019
Institución:
Universidad Simón Bolívar
Repositorio:
Repositorio Digital USB
Idioma:
eng
OAI Identifier:
oai:bonga.unisimon.edu.co:20.500.12442/4335
Acceso en línea:
https://hdl.handle.net/20.500.12442/4335
Palabra clave:
Posttranslational modifications
Epigenetic mechanisms
Systemic lupus erythematosus
Ubiquitination
SUMOylation
Glycosylation
Hydroxylation
Phosphorylation
Sulfation
Acetylation
Rights
License
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
id USIMONBOL2_b8aeec2f16f6204ad32d2ed225e4d777
oai_identifier_str oai:bonga.unisimon.edu.co:20.500.12442/4335
network_acronym_str USIMONBOL2
network_name_str Repositorio Digital USB
repository_id_str
dc.title.eng.fl_str_mv Epigenetic mechanisms and posttranslational modifications in systemic Lupus Erythematosus
title Epigenetic mechanisms and posttranslational modifications in systemic Lupus Erythematosus
spellingShingle Epigenetic mechanisms and posttranslational modifications in systemic Lupus Erythematosus
Posttranslational modifications
Epigenetic mechanisms
Systemic lupus erythematosus
Ubiquitination
SUMOylation
Glycosylation
Hydroxylation
Phosphorylation
Sulfation
Acetylation
title_short Epigenetic mechanisms and posttranslational modifications in systemic Lupus Erythematosus
title_full Epigenetic mechanisms and posttranslational modifications in systemic Lupus Erythematosus
title_fullStr Epigenetic mechanisms and posttranslational modifications in systemic Lupus Erythematosus
title_full_unstemmed Epigenetic mechanisms and posttranslational modifications in systemic Lupus Erythematosus
title_sort Epigenetic mechanisms and posttranslational modifications in systemic Lupus Erythematosus
dc.creator.fl_str_mv Navarro Quiroz, Elkin
Chavez-Estrada, Valeria
Macias-Ochoa, Karime
Ayala-Navarro, María Fernanda
Flores-Aguilar, Aniyensy Sarai
Morales-Navarrete, Francisco
De la Cruz Lopez, Fernando
Gomez Escorcia, Lorena
G. Musso, Carlos
Aroca Martinez, Gustavo
Gonzales Torres, Henry
Diaz Perez, Anderson
Cadena Bonfanti, Andres
Sarmiento Gutierrez, Joany
Meza, Jainy
Diaz Arroyo, Esperanza
Bello Lemus, Yesit
Ahmad, Mostapha
Navarro Quiroz, Roberto
dc.contributor.author.none.fl_str_mv Navarro Quiroz, Elkin
Chavez-Estrada, Valeria
Macias-Ochoa, Karime
Ayala-Navarro, María Fernanda
Flores-Aguilar, Aniyensy Sarai
Morales-Navarrete, Francisco
De la Cruz Lopez, Fernando
Gomez Escorcia, Lorena
G. Musso, Carlos
Aroca Martinez, Gustavo
Gonzales Torres, Henry
Diaz Perez, Anderson
Cadena Bonfanti, Andres
Sarmiento Gutierrez, Joany
Meza, Jainy
Diaz Arroyo, Esperanza
Bello Lemus, Yesit
Ahmad, Mostapha
Navarro Quiroz, Roberto
dc.subject.eng.fl_str_mv Posttranslational modifications
Epigenetic mechanisms
Systemic lupus erythematosus
Ubiquitination
SUMOylation
Glycosylation
Hydroxylation
Phosphorylation
Sulfation
Acetylation
topic Posttranslational modifications
Epigenetic mechanisms
Systemic lupus erythematosus
Ubiquitination
SUMOylation
Glycosylation
Hydroxylation
Phosphorylation
Sulfation
Acetylation
description The complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their subcellular localization as well as modulation of the di erential expression of genes in response to external and internal stimuli that allow an organism to respond or adapt to accordingly. However, alterations in these mechanisms have been evidenced in several autoimmune diseases, including systemic lupus erythematosus (SLE). The present review aims to provide an approach to the current knowledge of the implications of these mechanisms in SLE pathophysiology.
publishDate 2019
dc.date.accessioned.none.fl_str_mv 2019-11-13T22:11:08Z
dc.date.available.none.fl_str_mv 2019-11-13T22:11:08Z
dc.date.issued.none.fl_str_mv 2019
dc.type.eng.fl_str_mv article
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.identifier.issn.none.fl_str_mv 14220067
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12442/4335
identifier_str_mv 14220067
url https://hdl.handle.net/20.500.12442/4335
dc.language.iso.eng.fl_str_mv eng
language eng
dc.rights.*.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
http://purl.org/coar/access_right/c_abf2
dc.publisher.eng.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.eng.fl_str_mv International Journal of Molecular Sciences
dc.source.spa.fl_str_mv Vol. 20, No. 22 (2019)
institution Universidad Simón Bolívar
dc.source.uri.spa.fl_str_mv https://doi.org/10.3390/ijms20225679
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spelling Navarro Quiroz, Elkind586f4e1-e86b-4364-8aa2-1b1dc7c1bb5eChavez-Estrada, Valeria0fa20917-3656-4d39-b764-e230b87c3f23Macias-Ochoa, Karimecfd0ffb7-7c26-46f9-b536-3afafde819c8Ayala-Navarro, María Fernandaa5323b93-52fa-4bea-a175-a5ae36002623Flores-Aguilar, Aniyensy Saraia7951ecd-0231-4c61-8f86-fe62bfd6aa6eMorales-Navarrete, Franciscob9998165-74aa-447b-bffb-2a25e94b0dfaDe la Cruz Lopez, Fernandocb80443d-3239-4256-a8ce-56a20aa1f910Gomez Escorcia, Lorena0eda4380-18c9-49b2-b09c-a02809a7d505G. Musso, Carlos1558dfd1-c0d4-4a2e-bf43-38a3a1d8ce11Aroca Martinez, Gustavo85796035-bace-4923-8931-ac7730cbd5e7Gonzales Torres, Henryae3fef95-8048-4806-866b-e710bb79524aDiaz Perez, Anderson0bf078d9-6f60-46ea-a589-3bf4f2263adeCadena Bonfanti, Andres72c24732-5739-4168-87d9-1ab282d7aefeSarmiento Gutierrez, Joany6d46181b-18dc-43b8-9e71-2924cd829789Meza, Jainyc049ac0c-0fa3-4751-ade8-bf5e19119d0fDiaz Arroyo, Esperanza4a7166a2-c17a-40ce-8d95-f47693864d9eBello Lemus, Yesit8e7f3dac-a463-4db6-81e5-6d7249682c3bAhmad, Mostaphab2d96cdf-1f82-497f-8a5a-d0351e1b527fNavarro Quiroz, Roberto1246844f-5707-438a-808b-1f8c2761977e2019-11-13T22:11:08Z2019-11-13T22:11:08Z201914220067https://hdl.handle.net/20.500.12442/4335The complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their subcellular localization as well as modulation of the di erential expression of genes in response to external and internal stimuli that allow an organism to respond or adapt to accordingly. However, alterations in these mechanisms have been evidenced in several autoimmune diseases, including systemic lupus erythematosus (SLE). The present review aims to provide an approach to the current knowledge of the implications of these mechanisms in SLE pathophysiology.engMultidisciplinary Digital Publishing Institute (MDPI)Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2International Journal of Molecular SciencesVol. 20, No. 22 (2019)https://doi.org/10.3390/ijms20225679Wu, H.; Zhao, M.; Tan, L.; Lu, Q. 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Ph.D. Thesis, Universidad de Sevilla, Seville, Spain, December 2013.Posttranslational modificationsEpigenetic mechanismsSystemic lupus erythematosusUbiquitinationSUMOylationGlycosylationHydroxylationPhosphorylationSulfationAcetylationEpigenetic mechanisms and posttranslational modifications in systemic Lupus Erythematosusarticlehttp://purl.org/coar/resource_type/c_6501ORIGINALPDF.pdfPDF.pdfPDFapplication/pdf642813https://bonga.unisimon.edu.co/bitstreams/1f288d5d-aad5-4e3e-ab7c-e5d3c41e1d6d/downloadd207a5378fdd70f6ff0a09245ecdc836MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://bonga.unisimon.edu.co/bitstreams/8b9e3a13-10d3-4273-bac8-906552e71cf3/download4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8381https://bonga.unisimon.edu.co/bitstreams/17ab5806-07c2-412c-9ab5-e72f32c1190c/download733bec43a0bf5ade4d97db708e29b185MD53TEXTEpigenetic_Mechanisms.pdf.txtEpigenetic_Mechanisms.pdf.txtExtracted texttext/plain83296https://bonga.unisimon.edu.co/bitstreams/cf91c0b8-8fcf-43bd-bbb6-5956bd4b7877/downloada9c4cfbf65154cb84f653719b3f77019MD54PDF.pdf.txtPDF.pdf.txtExtracted texttext/plain88973https://bonga.unisimon.edu.co/bitstreams/c843a9dd-5231-482e-93df-0facbb883e14/download17d1be2dd3819b0a71ab9cf851468a38MD56THUMBNAILEpigenetic_Mechanisms.pdf.jpgEpigenetic_Mechanisms.pdf.jpgGenerated Thumbnailimage/jpeg19618https://bonga.unisimon.edu.co/bitstreams/63945e09-4f95-4797-9bb5-dad4403d1811/download57cb4df2687556962872a053d0a97cbcMD55PDF.pdf.jpgPDF.pdf.jpgGenerated Thumbnailimage/jpeg5103https://bonga.unisimon.edu.co/bitstreams/83ac15e1-1714-4167-af6d-f3079116caa4/downloadaf44fad428bc2988d2f21d43d521ff36MD5720.500.12442/4335oai:bonga.unisimon.edu.co:20.500.12442/43352024-08-14 21:53:21.399http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internacionalopen.accesshttps://bonga.unisimon.edu.coRepositorio Digital Universidad Simón Bolívarrepositorio.digital@unisimon.edu.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