Epigenetic mechanisms and posttranslational modifications in systemic Lupus Erythematosus

The complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their subcellular localization as well as modulation of the di erential expression of genes in response to external and internal stimuli that allow an organism to respond or adapt to accordingly. However, alterations in these mechanisms have been evidenced in several autoimmune diseases, including systemic lupus erythematosus (SLE). The present review aims to provide an approach to the current knowledge of the implications of these mechanisms in SLE pathophysiology.

• Autores: Navarro Quiroz, Elkin; Chavez-Estrada, Valeria; Macias-Ochoa, Karime; Ayala-Navarro, María Fernanda; Flores-Aguilar, Aniyensy Sarai; Morales-Navarrete, Francisco; De la Cruz Lopez, Fernando; Gomez Escorcia, Lorena; G. Musso, Carlos; Aroca Martinez, Gustavo; Gonzales Torres, Henry; Diaz Perez, Anderson; Cadena Bonfanti, Andres; Sarmiento Gutierrez, Joany; Meza, Jainy; Diaz Arroyo, Esperanza; Bello Lemus, Yesit; Ahmad, Mostapha; Navarro Quiroz, Roberto
• Fecha de publicación: 2019
• Institución: Universidad Simón Bolívar
• Repositorio: Repositorio Digital USB
• Idioma: eng
• OAI Identifier: oai:bonga.unisimon.edu.co:20.500.12442/4335
• Acceso en línea: https://hdl.handle.net/20.500.12442/4335
• Palabra clave: Posttranslational modifications; Epigenetic mechanisms; Systemic lupus erythematosus; Ubiquitination; SUMOylation; Glycosylation; Hydroxylation; Phosphorylation; Sulfation; Acetylation
• License: Attribution-NonCommercial-NoDerivatives 4.0 Internacional