Advanced Glycation End Products: New Clinical and Molecular Perspectives
Diabetes mellitus (DM) is considered one of the most massive epidemics of the twenty-first century due to its high mortality rates caused mainly due to its complications; therefore, the early identification of such complications becomes a race against time to establish a prompt diagnosis. The resear...
- Autores:
-
Salazar, Juan
Navarro, Carla
Ortega, Ángel
Nava, Manuel
Morillo, Daniela
Torres, Wheeler
Hernández, Marlon
Cabrera, Mayela
Angarita, Lissé
Ortiz, Rina
Chacín, Maricarmen
D'Marco, Luis
Bermúdez, Valmore
- Tipo de recurso:
- Fecha de publicación:
- 2021
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/8360
- Palabra clave:
- advanced glycation end products
diabetes mellitus
chronic complications
skin fluorescence
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Advanced Glycation End Products: New Clinical and Molecular Perspectives |
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Advanced Glycation End Products: New Clinical and Molecular Perspectives |
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Advanced Glycation End Products: New Clinical and Molecular Perspectives advanced glycation end products diabetes mellitus chronic complications skin fluorescence |
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Advanced Glycation End Products: New Clinical and Molecular Perspectives |
| title_full |
Advanced Glycation End Products: New Clinical and Molecular Perspectives |
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Advanced Glycation End Products: New Clinical and Molecular Perspectives |
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Advanced Glycation End Products: New Clinical and Molecular Perspectives |
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Advanced Glycation End Products: New Clinical and Molecular Perspectives |
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Salazar, Juan Navarro, Carla Ortega, Ángel Nava, Manuel Morillo, Daniela Torres, Wheeler Hernández, Marlon Cabrera, Mayela Angarita, Lissé Ortiz, Rina Chacín, Maricarmen D'Marco, Luis Bermúdez, Valmore |
| dc.contributor.author.none.fl_str_mv |
Salazar, Juan Navarro, Carla Ortega, Ángel Nava, Manuel Morillo, Daniela Torres, Wheeler Hernández, Marlon Cabrera, Mayela Angarita, Lissé Ortiz, Rina Chacín, Maricarmen D'Marco, Luis Bermúdez, Valmore |
| dc.subject.eng.fl_str_mv |
advanced glycation end products diabetes mellitus chronic complications skin fluorescence |
| topic |
advanced glycation end products diabetes mellitus chronic complications skin fluorescence |
| description |
Diabetes mellitus (DM) is considered one of the most massive epidemics of the twenty-first century due to its high mortality rates caused mainly due to its complications; therefore, the early identification of such complications becomes a race against time to establish a prompt diagnosis. The research of complications of DM over the years has allowed the development of numerous alternatives for diagnosis. Among these emerge the quantification of advanced glycation end products (AGEs) given their increased levels due to chronic hyperglycemia, while also being related to the induction of different stress-associated cellular responses and proinflammatory mechanisms involved in the progression of chronic complications of DM. Additionally, the investigation for more valuable and safe techniques has led to developing a newer, noninvasive, and effective tool, termed skin fluorescence (SAF). Hence, this study aimed to establish an update about the molecular mechanisms induced by AGEs during the evolution of chronic complications of DM and describe the newer measurement techniques available, highlighting SAF as a possible tool to measure the risk of developing DM chronic complications. |
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2021 |
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2021-09-13T23:13:59Z |
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2021-09-13T23:13:59Z |
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2021 |
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Artículo científico |
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16604601 |
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https://hdl.handle.net/20.500.12442/8360 |
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https://doi.org/10.3390/ijerph18147236 |
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16604601 |
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https://hdl.handle.net/20.500.12442/8360 https://doi.org/10.3390/ijerph18147236 |
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eng |
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eng |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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openAccess |
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pdf |
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MDPI |
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International Journal of Enviromental Research and Public Health |
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Vol. 18 N° 14 (2021) |
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Salazar, Juanfbd053e7-5aea-424c-812f-92153ecb9181Navarro, Carla9892bf34-10a9-479a-8b3a-6769d4804207Ortega, Ángelb6a809bb-4d26-4e53-9419-e4eb9fb40a9bNava, Manuelcf0ca570-5fc3-4ec7-9913-90be952261e2Morillo, Daniela77703376-f18e-4e23-8a70-807d63f9f78aTorres, Wheelera82c8c05-2160-44dc-b397-ffc2ac51becaHernández, Marlonc706ac0a-7de4-41dc-8c44-9face12fbc6fCabrera, Mayelad08d7973-5581-4736-b7b4-4d47da8b412cAngarita, Lissécd37d36e-0d41-457f-9dc8-1ed5b9201b16Ortiz, Rinab50c3253-2c29-426f-b91b-165deb110151Chacín, Maricarmen5c3b3d7c-4444-47e2-b2be-11f08df10409D'Marco, Luis4f289143-892b-43a3-ac1f-6f462224f314Bermúdez, Valmore29f9aa18-16a4-4fd3-8ce5-ed94a0b8663a2021-09-13T23:13:59Z2021-09-13T23:13:59Z202116604601https://hdl.handle.net/20.500.12442/8360https://doi.org/10.3390/ijerph18147236Diabetes mellitus (DM) is considered one of the most massive epidemics of the twenty-first century due to its high mortality rates caused mainly due to its complications; therefore, the early identification of such complications becomes a race against time to establish a prompt diagnosis. The research of complications of DM over the years has allowed the development of numerous alternatives for diagnosis. Among these emerge the quantification of advanced glycation end products (AGEs) given their increased levels due to chronic hyperglycemia, while also being related to the induction of different stress-associated cellular responses and proinflammatory mechanisms involved in the progression of chronic complications of DM. Additionally, the investigation for more valuable and safe techniques has led to developing a newer, noninvasive, and effective tool, termed skin fluorescence (SAF). Hence, this study aimed to establish an update about the molecular mechanisms induced by AGEs during the evolution of chronic complications of DM and describe the newer measurement techniques available, highlighting SAF as a possible tool to measure the risk of developing DM chronic complications.pdfengMDPIAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2International Journal of Enviromental Research and Public HealthVol. 18 N° 14 (2021)advanced glycation end productsdiabetes mellituschronic complicationsskin fluorescenceAdvanced Glycation End Products: New Clinical and Molecular Perspectivesinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Kerner, W.; Brückel, J. German Diabetes Association Definition, Classification and Diagnosis of Diabetes Mellitus. Exp. Clin. Endocrinol. Diabetes 2014, 122, 384–386.Zimmet, P.; Alberti, K.G.; Magliano, D.J.; Bennett, P.H. Diabetes Mellitus Statistics on Prevalence and Mortality: Facts and Fallacies. Nat. Rev. Endocrinol. 2016, 12, 616–622.International Diabetes Federation (IDF). IDF Diabetes Atlas, 7th ed.; International Diabetes Federation: Brussels, Belgium, 2015; Available online: https://www.desang.net/2017/11/idf-diabetes-atlas-7th-edition/ (accessed on 7 May 2021).Singh, V.P.; Bali, A.; Singh, N.; Jaggi, A.S. Advanced Glycation End Products and Diabetic Complications. Korean J. Physiol. Pharm. 2014, 18, 1–14.Butalia, S.; Patel, A.B.; Johnson, J.A.; Ghali, W.A.; Rabi, D.M. Geographic Clustering of Acute Complications and Sociodemographic Factors in Adults with Type 1 Diabetes. Can. J. Diabetes 2017, 41, 132–137.Elgart, J.F.; Caporale, J.E.; Asteazarán, S.; De La Fuente, J.L.; Camilluci, C.; Brown, J.B.; González, C.D.; Gagliardino, J.J. Association between Socioeconomic Status, Type 2 Diabetes and Its Chronic Complications in Argentina. Diabetes Res. Clin. Pract. 2014, 104, 241–247.Shi, Y.; Vanhoutte, P.M. Macro- and Microvascular Endothelial Dysfunction in Diabetes. J. Diabetes 2017, 9, 434–449.Loomis, S.J.; Chen, Y.; Sacks, D.B.; Christenson, E.S.; Christenson, R.H.; Rebholz, C.M.; Selvin, E. Cross-Sectional Analysis of AGE-CML, SRAGE, and EsRAGE with Diabetes and Cardiometabolic Risk Factors in a Community-Based Cohort. Clin. Chem. 2017, 63, 980–989.Vélayoudom-Céphise, F.-L.; Rajaobelina, K.; Helmer, C.; Nov, S.; Pupier, E.; Blanco, L.; Hugo, M.; Farges, B.; Astrugue, C.; Gin, H.; et al. Skin Autofluorescence Predicts Cardio-Renal Outcome in Type 1 Diabetes: A Longitudinal Study. Cardiovasc. Diabetol. 2016, 15, 127.Thomas, M.C.; Woodward, M.; Neal, B.; Li, Q.; Pickering, R.; Marre, M.; Williams, B.; Perkovic, V.; Cooper, M.E.; Zoungas, S.; et al. 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