Treatment adherence and quality of life in colombian patients with lupus nephritis
Background: As with many other chronic diseases, systemic lupus erythematosus (SLE) and lupus nephritis (LN) have significant impacts on the health-related quality of life (HRQoL). Medication non-adherence is a significant challenge in the management of SLE, with consistently up to 75% of patients b...
- Autores:
-
Domínguez-Vargas, Alex
González-Torres, Henry Joseth
Martínez-Bayona, Álvaro
Sanguino Jaramillo, Maria Gabriela
Vélez-Verbel, María
Cadena Bonfanti, Andres Angélo
Musso, Carlos
Depine, Santos
egea, eduardo
Aroca-Martinez, Gustavo
- Tipo de recurso:
- Fecha de publicación:
- 2024
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/15721
- Acceso en línea:
- https://hdl.handle.net/20.500.12442/15721
https://doi.org/10.1177/09612033241280548
https://journals.sagepub.com/doi/10.1177/09612033241280548
- Palabra clave:
- Lupus nephritis
Treatment adherence
Quality of life
Patient-reported outcomes
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivs 3.0 United States
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Treatment adherence and quality of life in colombian patients with lupus nephritis |
| title |
Treatment adherence and quality of life in colombian patients with lupus nephritis |
| spellingShingle |
Treatment adherence and quality of life in colombian patients with lupus nephritis Lupus nephritis Treatment adherence Quality of life Patient-reported outcomes |
| title_short |
Treatment adherence and quality of life in colombian patients with lupus nephritis |
| title_full |
Treatment adherence and quality of life in colombian patients with lupus nephritis |
| title_fullStr |
Treatment adherence and quality of life in colombian patients with lupus nephritis |
| title_full_unstemmed |
Treatment adherence and quality of life in colombian patients with lupus nephritis |
| title_sort |
Treatment adherence and quality of life in colombian patients with lupus nephritis |
| dc.creator.fl_str_mv |
Domínguez-Vargas, Alex González-Torres, Henry Joseth Martínez-Bayona, Álvaro Sanguino Jaramillo, Maria Gabriela Vélez-Verbel, María Cadena Bonfanti, Andres Angélo Musso, Carlos Depine, Santos egea, eduardo Aroca-Martinez, Gustavo |
| dc.contributor.author.none.fl_str_mv |
Domínguez-Vargas, Alex González-Torres, Henry Joseth Martínez-Bayona, Álvaro Sanguino Jaramillo, Maria Gabriela Vélez-Verbel, María Cadena Bonfanti, Andres Angélo Musso, Carlos Depine, Santos egea, eduardo Aroca-Martinez, Gustavo |
| dc.subject.keywords.eng.fl_str_mv |
Lupus nephritis Treatment adherence Quality of life Patient-reported outcomes |
| topic |
Lupus nephritis Treatment adherence Quality of life Patient-reported outcomes |
| description |
Background: As with many other chronic diseases, systemic lupus erythematosus (SLE) and lupus nephritis (LN) have significant impacts on the health-related quality of life (HRQoL). Medication non-adherence is a significant challenge in the management of SLE, with consistently up to 75% of patients being non-adherent with their SLE medications. There is a need to assess the patient’s perspective using patient-reported outcomes (PROs) to better understand the current impact of LN on HRQoL and treatment adherence in our region. The aim of this study was to explore the relationship between HRQoL and treatment adherence in patients with LN from the Colombian Caribbean. Methods: A cross-sectional study was conducted from June to December 2022, including patients with biopsy-proven LN. HRQoL and treatment adherence were assessed using the Lupus Quality of Life (LupusQoL) and the Compliance Questionnaire in Rheumatology 19 (CQR19) instruments, respectively. Patients were categorized as adherent or nonadherent based on medication intake (defined as >80% correct dosage). Principal component analysis (PCA) was employed to identify principal components between adherent and non-adherent patients. Results: A total of 42 patients with LN were included. Of these, 38 (90%) were female, and the mean age was 31 ± 10 years. Proliferative class IV was the predominant histopathological profile (90%). Twenty-five (60%) patients were categorized as non-adherent. Across all LupusQoL domains, a comprehensive range of responses was observed. Pain, planning, and intimate relationships domains remained unaffected, while burden to others domain had the lowest score. Poorer planning score correlated with older age (r = 0.72; p < .05) and longer disease duration (r = 0.74; p < .05). SLEDAI-2 K correlated with the pain domain (r = 0.78; p < .05). Non-adherent patients exhibited significantly worse pain domain scores compared to adherent counterparts (p < .05). PCA showed strong interactions between planning and pain, as well as between physical health and body image domains. Conclusions: LupusQoL pain domain scores were significantly worse in non-adherent patients compared to adherent patients. Effective pain management could be a determinant in HRQoL and treatment adherence rates in our population. |
| publishDate |
2024 |
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2024-10-01T14:26:35Z |
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2024-10-01T14:26:35Z |
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2024 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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info:eu-repo/semantics/article |
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Artículo científico |
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Domínguez-Vargas A, González-Torres H, Martínez-Bayona Á, et al. Treatment adherence and quality of life in colombian patients with lupus nephritis. Lupus. 2024;33(12):1317-1327. doi:10.1177/09612033241280548 |
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09612033 14770962 (Electrónico) |
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https://hdl.handle.net/20.500.12442/15721 |
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https://doi.org/10.1177/09612033241280548 |
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https://journals.sagepub.com/doi/10.1177/09612033241280548 |
| identifier_str_mv |
Domínguez-Vargas A, González-Torres H, Martínez-Bayona Á, et al. Treatment adherence and quality of life in colombian patients with lupus nephritis. Lupus. 2024;33(12):1317-1327. doi:10.1177/09612033241280548 09612033 14770962 (Electrónico) |
| url |
https://hdl.handle.net/20.500.12442/15721 https://doi.org/10.1177/09612033241280548 https://journals.sagepub.com/doi/10.1177/09612033241280548 |
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eng |
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eng |
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Attribution-NonCommercial-NoDerivs 3.0 United States |
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info:eu-repo/semantics/openAccess |
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openAccess |
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pdf |
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Lupus Vol. 33 No. 12 Año 2024 |
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Universidad Simón Bolívar |
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Domínguez-Vargas, Alex0453d0ab-277b-48a6-8b5c-bfff01ab6b45600González-Torres, Henry Joseth37e25181-47e0-41ee-af16-5e08fb0582c7600Martínez-Bayona, Álvaro5b32ddbe-0f99-4c7f-a8a8-802ac4023729-1Sanguino Jaramillo, Maria Gabriela 980dc345-323d-45c8-846f-d500b475e8a3600Vélez-Verbel, María8cbb1ae1-ca05-406f-81fc-86ff55fb6f20-1Cadena Bonfanti, Andres Angélo3e45a0af-9f1a-46aa-806d-542d9e3fe050600Musso, Carlosaeb50798-b41f-4530-8a9a-a111989e7013600Depine, Santosb82398ed-2fc8-43f7-96e6-ad263761e886600egea, eduardo51ccaede-8cc9-4576-9bb6-e2328fb69ac9600Aroca-Martinez, Gustavo67c32f19-65fe-4ea4-a517-50c788898b546002024-10-01T14:26:35Z2024-10-01T14:26:35Z2024Domínguez-Vargas A, González-Torres H, Martínez-Bayona Á, et al. Treatment adherence and quality of life in colombian patients with lupus nephritis. Lupus. 2024;33(12):1317-1327. doi:10.1177/096120332412805480961203314770962 (Electrónico)https://hdl.handle.net/20.500.12442/15721https://doi.org/10.1177/09612033241280548https://journals.sagepub.com/doi/10.1177/09612033241280548Background: As with many other chronic diseases, systemic lupus erythematosus (SLE) and lupus nephritis (LN) have significant impacts on the health-related quality of life (HRQoL). Medication non-adherence is a significant challenge in the management of SLE, with consistently up to 75% of patients being non-adherent with their SLE medications. There is a need to assess the patient’s perspective using patient-reported outcomes (PROs) to better understand the current impact of LN on HRQoL and treatment adherence in our region. The aim of this study was to explore the relationship between HRQoL and treatment adherence in patients with LN from the Colombian Caribbean. Methods: A cross-sectional study was conducted from June to December 2022, including patients with biopsy-proven LN. HRQoL and treatment adherence were assessed using the Lupus Quality of Life (LupusQoL) and the Compliance Questionnaire in Rheumatology 19 (CQR19) instruments, respectively. Patients were categorized as adherent or nonadherent based on medication intake (defined as >80% correct dosage). Principal component analysis (PCA) was employed to identify principal components between adherent and non-adherent patients. Results: A total of 42 patients with LN were included. Of these, 38 (90%) were female, and the mean age was 31 ± 10 years. Proliferative class IV was the predominant histopathological profile (90%). Twenty-five (60%) patients were categorized as non-adherent. Across all LupusQoL domains, a comprehensive range of responses was observed. Pain, planning, and intimate relationships domains remained unaffected, while burden to others domain had the lowest score. Poorer planning score correlated with older age (r = 0.72; p < .05) and longer disease duration (r = 0.74; p < .05). SLEDAI-2 K correlated with the pain domain (r = 0.78; p < .05). Non-adherent patients exhibited significantly worse pain domain scores compared to adherent counterparts (p < .05). PCA showed strong interactions between planning and pain, as well as between physical health and body image domains. Conclusions: LupusQoL pain domain scores were significantly worse in non-adherent patients compared to adherent patients. Effective pain management could be a determinant in HRQoL and treatment adherence rates in our population.pdfengSAGEAttribution-NonCommercial-NoDerivs 3.0 United Stateshttp://creativecommons.org/licenses/by-nc-nd/3.0/us/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2LupusVol. 33 No. 12 Año 2024Treatment adherence and quality of life in colombian patients with lupus nephritisinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Lupus nephritisTreatment adherenceQuality of lifePatient-reported outcomesCarter EE, Barr SG and Clarke AE. The global burden of SLE: prevalence, health disparities and socioeconomic impact. Nat Rev Rheumatol 2016; 12(10): 605–620. DOI: 10. 1038/nrrheum.2016.137.Davidson A. What is damaging the kidney in lupus nephritis? Nat Rev Rheumatol 2016; 12(3): 143–153. DOI: 10.1038/ nrrheum.2015.159.McElhone K, Castelino M, Abbott J, et al. The LupusQoL and associations with demographics and clinical measurements in patients with systemic lupus erythematosus. J Rheumatol 2010; 37(11): 2273–2279. DOI: 10.3899/jrheum.091277.McElhone K, Abbott J, Shelmerdine J, et al. Development and validation of a disease-specific health-related quality of life measure, the LupusQol, for adults with systemic lupus erythematosus. Arthritis Rheum 2007; 57(6): 972–979. DOI: 10.1002/art.22881.Jinoos Yazdany MDM. Health-related quality of life measurement in systemic lupus erythematosus: the LupusQoL, SLEQoL, and L-QoL. Health-related 2011; 141(4): 520–529. DOI: 10.1002/acr.20636.Radin M, El Hasbani G, Barinotti A, et al. Quality of life measures in Systemic Lupus Erythematosus: a systematic review. Reumatismo 2022; 73(4): 1447. DOI: 10.4081/ reumatismo.2021.1447.Williams-Hall R, Berry P, Williamson N, et al. Generation of evidence supporting the content validity of SF-36, FACIT-F, and LupusQoL, and novel patient-reported symptom items for use in patients with systemic lupus erythematosus (SLE) and SLE with lupus nephritis (LN). Lupus Sci Med 2022; 9(1): e000712. DOI: 10.1136/lupus- 2022-000712.Rinaldi S, Doria A, Salaffi F, et al. Health-related quality of life in Italian patients with systemic lupus erythematosus. I. Relationship between physical and mental dimension and impact of age. Rheumatology 2004; 43(12): 1574–1579. DOI: 10.1093/rheumatology/keh397.Mehat P, Atiquzzaman M, Esdaile JM, et al. Medication nonadherence in systemic lupus erythematosus: a systematic review. Arthritis Care Res 2017; 69(11): 1706–1713. DOI: 10.1002/acr.23191.Liu LH, Fevrier HB, Goldfien R, et al. Understanding nonadherence with hydroxychloroquine therapy in systemic lupus erythematosus. J Rheumatol 2019; 46(10): 1309–1315. DOI: 10.3899/jrheum.180946.Chehab G, Sauer GM, Richter JG, et al. 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Medication adherence of patients with systemic lupus erythematosus and rheumatoid arthritis considering the psychosocial factors, health literacy and current life concerns of patients. Curr Rheumatol Rev 2021; 17(4): 412–420. DOI: 10.2174/ 1573397117666210301144651.Xie X, Yang H, Nie A, et al. Predictors of medication nonadherence in patients with systemic lupus erythematosus in Sichuan: a cross-sectional study. Patient Prefer Adherence 2018; 12: 1505–1511. DOI: 10.2147/PPA.S169776.Sailler L, Puissant B,M´eliani P, et al. Blood concentrations of hydroxychloroquine and its desethyl derivative correlate negatively with the percentage of CD45RO+ cells among CD4+ lymphocytes in hydroxychloroquine-treated lupus patients. Ann N Y Acad Sci 2007; 1108: 41–50. DOI: 10.1196/ annals.1422.005.My lupus log. https://myhealthapps.net/app/details/410/mylupus- logTrack the symptoms of lupus with this symptom tracking app, 2020. https://careclinic.io/lupus-symptom-trackerKhan F, Granville N, Malkani R, et al. Health-related quality of life improvements in systemic lupus erythematosus derived from a digital therapeutic plus tele-health coaching intervention: randomized controlled pilot trial. J Med Internet Res 2020; 22(10): e23868. DOI: 10.2196/23868.Chambers SA, Allen E, Rahman A, et al. Damage and mortality in a group of British patients with systemic lupus erythematosus followed up for over 10 years. Rheumatology 2009; 48(6): 673–675. DOI: 10.1093/rheumatology/ kep062.Elera-Fitzcarrald C, Fuentes A, Gonz´alez LA, et al. Factors affecting quality of life in patients with systemic lupus erythematosus: important considerations and potential interventions. Expert Rev Clin Immunol 2018; 14(11): 915–931. 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