Hormona paratiroidea, aldosterona e hipertensión arterial ¿una amenaza infravalorada?

El Hiperparatiroidismo primario (HPTP) es un trastorno endocrino frecuente caracterizado por una secreción autónoma de hormona paratiroidea (PTH). Si bien, su variante asintomática es la más frecuentemente encontrada en la práctica clínica (la cual se diagnostica incidentalmente), las complicaciones...

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Autores:
Rojas, Joselyn
Olivar, Luis Carlos
Chávez Castillo, Mervin
Martínez, María Sofia
Wilches-Durán, Sandra
Tipo de recurso:
Fecha de publicación:
2017
Institución:
Universidad Simón Bolívar
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Repositorio Digital USB
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spa
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oai:bonga.unisimon.edu.co:20.500.12442/1850
Acceso en línea:
http://hdl.handle.net/20.500.12442/1850
Palabra clave:
Hiperparatirodismo primario
Aldosterona
Hormona paratiroidea
Hipertensión arterial
Riesgo cardiovascular
Mortalidad cardiovascular
Primary Hiperparathyroidism
Aldosterone
Parathyroid hormone
Hypertension
Cardiovascular risk
Cardiovascular mortality
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dc.title.spa.fl_str_mv Hormona paratiroidea, aldosterona e hipertensión arterial ¿una amenaza infravalorada?
title Hormona paratiroidea, aldosterona e hipertensión arterial ¿una amenaza infravalorada?
spellingShingle Hormona paratiroidea, aldosterona e hipertensión arterial ¿una amenaza infravalorada?
Hiperparatirodismo primario
Aldosterona
Hormona paratiroidea
Hipertensión arterial
Riesgo cardiovascular
Mortalidad cardiovascular
Primary Hiperparathyroidism
Aldosterone
Parathyroid hormone
Hypertension
Cardiovascular risk
Cardiovascular mortality
title_short Hormona paratiroidea, aldosterona e hipertensión arterial ¿una amenaza infravalorada?
title_full Hormona paratiroidea, aldosterona e hipertensión arterial ¿una amenaza infravalorada?
title_fullStr Hormona paratiroidea, aldosterona e hipertensión arterial ¿una amenaza infravalorada?
title_full_unstemmed Hormona paratiroidea, aldosterona e hipertensión arterial ¿una amenaza infravalorada?
title_sort Hormona paratiroidea, aldosterona e hipertensión arterial ¿una amenaza infravalorada?
dc.creator.fl_str_mv Rojas, Joselyn
Olivar, Luis Carlos
Chávez Castillo, Mervin
Martínez, María Sofia
Wilches-Durán, Sandra
dc.contributor.author.none.fl_str_mv Rojas, Joselyn
Olivar, Luis Carlos
Chávez Castillo, Mervin
Martínez, María Sofia
Wilches-Durán, Sandra
dc.subject.spa.fl_str_mv Hiperparatirodismo primario
Aldosterona
Hormona paratiroidea
Hipertensión arterial
Riesgo cardiovascular
Mortalidad cardiovascular
topic Hiperparatirodismo primario
Aldosterona
Hormona paratiroidea
Hipertensión arterial
Riesgo cardiovascular
Mortalidad cardiovascular
Primary Hiperparathyroidism
Aldosterone
Parathyroid hormone
Hypertension
Cardiovascular risk
Cardiovascular mortality
dc.subject.eng.fl_str_mv Primary Hiperparathyroidism
Aldosterone
Parathyroid hormone
Hypertension
Cardiovascular risk
Cardiovascular mortality
description El Hiperparatiroidismo primario (HPTP) es un trastorno endocrino frecuente caracterizado por una secreción autónoma de hormona paratiroidea (PTH). Si bien, su variante asintomática es la más frecuentemente encontrada en la práctica clínica (la cual se diagnostica incidentalmente), las complicaciones óseas y renales afectan de forma importante la calidad de vida del paciente. Sin embargo, el espectro de manifestaciones de este trastorno no se limita al metabolismo mineral, puesto que las concentraciones elevadas de PTH se asocian a un mayor riesgo de alteraciones metabólicas como el síndrome metabólico, diabetes mellitus 2 y enfermedades cardiovasculares. En este ámbito, la hipertensión arterial (HTA), relacionada con aproximadamente 9,4 millones de muerte al año, ha sido considerada una manifestación no clásica del HPTP. La interacción PTH-Aldosterona ha surgido como un importante eslabón para tratar de explicar esta relación, planteándose diversos mecanismos teóricos que posicionan a la PTH como estimulador directo de la síntesis de aldosterona en las células de la zona glomerular. Sin embargo, estos mecanismos teóricos han estado rodeados de controversia en su aspecto epidemiológico y clínico, existiendo aún muy pocos estudios poblacionales explorando este vínculo y su relación con la morbimortalidad cardiovascular, por lo que es necesario mayor investigación en el área con el fin de conocer el verdadero impacto de estos mecanismos en la salud de los individuos. Esta revisión resume aspectos del metabolismo del calcio, al igual que los principales mecanismos subyacentes al vínculo HPTP-HTA, y los datos epidemiológicos disponibles sobre el tópico, a fin de brindar un mejor entendimiento sobre este novel planteamiento.
publishDate 2017
dc.date.issued.none.fl_str_mv 2017
dc.date.accessioned.none.fl_str_mv 2018-03-12T16:23:30Z
dc.date.available.none.fl_str_mv 2018-03-12T16:23:30Z
dc.type.spa.fl_str_mv article
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.identifier.issn.none.fl_str_mv 18564550
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12442/1850
identifier_str_mv 18564550
url http://hdl.handle.net/20.500.12442/1850
dc.language.iso.spa.fl_str_mv spa
language spa
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dc.rights.license.spa.fl_str_mv Licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional
rights_invalid_str_mv Licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional
http://purl.org/coar/access_right/c_abf2
dc.publisher.spa.fl_str_mv Cooperativa servicios y suministros 212518 RS
dc.source.spa.fl_str_mv Revista Latinoamericana de Hipertensión
Vol. 12, No.1 (2017)
institution Universidad Simón Bolívar
dc.source.uri.none.fl_str_mv https://www.redalyc.org/articulo.oa?id=170250838001
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spelling Licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacionalhttp://purl.org/coar/access_right/c_abf2Rojas, Joselyn2aa91570-0516-424d-8f76-25cd7b39be6e-1Olivar, Luis Carlos212e67d1-e669-4a31-9299-d653994d03a6-1Chávez Castillo, Mervin8f5d4f42-382f-4e4d-b9d1-3b85d6e1fcd2-1Martínez, María Sofiac2c15b32-7287-4e03-a13d-63cc39b1e432-1Wilches-Durán, Sandra57727544-0054-45e6-997c-6d75c266cea0-12018-03-12T16:23:30Z2018-03-12T16:23:30Z201718564550http://hdl.handle.net/20.500.12442/1850El Hiperparatiroidismo primario (HPTP) es un trastorno endocrino frecuente caracterizado por una secreción autónoma de hormona paratiroidea (PTH). Si bien, su variante asintomática es la más frecuentemente encontrada en la práctica clínica (la cual se diagnostica incidentalmente), las complicaciones óseas y renales afectan de forma importante la calidad de vida del paciente. Sin embargo, el espectro de manifestaciones de este trastorno no se limita al metabolismo mineral, puesto que las concentraciones elevadas de PTH se asocian a un mayor riesgo de alteraciones metabólicas como el síndrome metabólico, diabetes mellitus 2 y enfermedades cardiovasculares. En este ámbito, la hipertensión arterial (HTA), relacionada con aproximadamente 9,4 millones de muerte al año, ha sido considerada una manifestación no clásica del HPTP. La interacción PTH-Aldosterona ha surgido como un importante eslabón para tratar de explicar esta relación, planteándose diversos mecanismos teóricos que posicionan a la PTH como estimulador directo de la síntesis de aldosterona en las células de la zona glomerular. Sin embargo, estos mecanismos teóricos han estado rodeados de controversia en su aspecto epidemiológico y clínico, existiendo aún muy pocos estudios poblacionales explorando este vínculo y su relación con la morbimortalidad cardiovascular, por lo que es necesario mayor investigación en el área con el fin de conocer el verdadero impacto de estos mecanismos en la salud de los individuos. Esta revisión resume aspectos del metabolismo del calcio, al igual que los principales mecanismos subyacentes al vínculo HPTP-HTA, y los datos epidemiológicos disponibles sobre el tópico, a fin de brindar un mejor entendimiento sobre este novel planteamiento.Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by autonomic parathyroid hormone secretion (PTH). Although its asymptomatic variant is the most frequently found in clinical practice (which is incidentally diagnosed), bone and kidney complications significantly affect the patient’s quality of life. However, the spectrum of manifestations of this disorder is not limited to mineral metabolism, since elevated concentrations of PTH are associated with an increased risk of metabolic syndrome, type 2 diabetes mellitus and cardiovascular disease. In this area, hypertension (AHT), related to approximately 9.4 million deaths per year, has been considered a non-classical manifestation of PHPT. The interaction PTH-Aldosterone has emerged as an important link to try to explain this relationship, posing various theoretical mechanisms that position PTH as a direct stimulator of aldosterone synthesis in the glomerular zone cells. However, these theoretical mechanisms have been surrounded by controversy in their epidemiological and clinical aspects, and there are still very few population studies exploring this link and its relation with cardiovascular morbimortality, which is why more research is needed in the area in order to know. The true impact of these mechanisms on the health of individuals. This review summarizes aspects of calcium metabolism, as well as the main mechanisms underlying the HPTP-HTA link, and available epidemiological data on the topic, in order to provide a better understanding of this novel approach.spaCooperativa servicios y suministros 212518 RSRevista Latinoamericana de HipertensiónVol. 12, No.1 (2017)https://www.redalyc.org/articulo.oa?id=170250838001Hiperparatirodismo primarioAldosteronaHormona paratiroideaHipertensión arterialRiesgo cardiovascularMortalidad cardiovascularPrimary HiperparathyroidismAldosteroneParathyroid hormoneHypertensionCardiovascular riskCardiovascular mortalityHormona paratiroidea, aldosterona e hipertensión arterial ¿una amenaza infravalorada?articlehttp://purl.org/coar/resource_type/c_6501WHO. The top ten causes of death. Fact sheet No 310 / May 2014 Avalaible at: http://www. who.int/mediacentre/factsheets/fs310/en/.Who. 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Cardiovasc Res. 2012;94(1):10-9.LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bonga.unisimon.edu.co/bitstreams/b8b14705-0e14-44ab-9002-998427063171/download8a4605be74aa9ea9d79846c1fba20a33MD5220.500.12442/1850oai:bonga.unisimon.edu.co:20.500.12442/18502019-04-11 21:51:42.671metadata.onlyhttps://bonga.unisimon.edu.coDSpace UniSimonbibliotecas@biteca.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