Obesity and glomerular filtration rate

Obesity has received considerable attention in general medicine and nephrology over the last few years. This condition increases the risk of metabolic syndrome, diabetes mellitus, hypertension, and dyslipidemia, which are the main risk factors for developing chronic kidney disease (CKD). Kidney dama...

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Autores:
Schwartz, Paula
Capotondo, Maria M.
Quaintenne, Miranda
Musso‑Enz, Guido M.
Aroca‑Martinez, Gustavo
Musso, Carlos G.
Tipo de recurso:
Fecha de publicación:
2023
Institución:
Universidad Simón Bolívar
Repositorio:
Repositorio Digital USB
Idioma:
eng
OAI Identifier:
oai:bonga.unisimon.edu.co:20.500.12442/13426
Acceso en línea:
https://hdl.handle.net/20.500.12442/13426
https://doi.org/10.1007/s11255-023-03862-0
https://link.springer.com/article/10.1007/s11255-023-03862-0
Palabra clave:
Obesity
Glomerular filtration rate
Bariatric surgery
Rights
openAccess
License
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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dc.title.eng.fl_str_mv Obesity and glomerular filtration rate
title Obesity and glomerular filtration rate
spellingShingle Obesity and glomerular filtration rate
Obesity
Glomerular filtration rate
Bariatric surgery
title_short Obesity and glomerular filtration rate
title_full Obesity and glomerular filtration rate
title_fullStr Obesity and glomerular filtration rate
title_full_unstemmed Obesity and glomerular filtration rate
title_sort Obesity and glomerular filtration rate
dc.creator.fl_str_mv Schwartz, Paula
Capotondo, Maria M.
Quaintenne, Miranda
Musso‑Enz, Guido M.
Aroca‑Martinez, Gustavo
Musso, Carlos G.
dc.contributor.author.none.fl_str_mv Schwartz, Paula
Capotondo, Maria M.
Quaintenne, Miranda
Musso‑Enz, Guido M.
Aroca‑Martinez, Gustavo
Musso, Carlos G.
dc.subject.eng.fl_str_mv Obesity
Glomerular filtration rate
Bariatric surgery
topic Obesity
Glomerular filtration rate
Bariatric surgery
description Obesity has received considerable attention in general medicine and nephrology over the last few years. This condition increases the risk of metabolic syndrome, diabetes mellitus, hypertension, and dyslipidemia, which are the main risk factors for developing chronic kidney disease (CKD). Kidney damage caused by obesity can be explained by many mechanisms, such as sympathetic nervous and renin-angiotensin-aldosterone systems activation, mechanical stress, hormonal unbalance, as well as inflammatory cytokines production. Even though creatinine-based glomerular filtration rate (GFR) equations in obese individuals have been validated (Salazar-Corcoran and CKD-MCQ), changes in body weight after bariatric surgery (BS) leads to changes in creatininemia, affecting its reliability. Thus, an average between creatine and cystatin-based GFR equations would be more appropriate in this setting. Bariatric surgery can reverse diabetes mellitus and improve hypertension, which are the main causes of CKD. Conclusion: GFR can be affected by obesity and BS, and its value should be cautiously evaluated in this setting.
publishDate 2023
dc.date.accessioned.none.fl_str_mv 2023-11-10T20:42:26Z
dc.date.available.none.fl_str_mv 2023-11-10T20:42:26Z
dc.date.issued.none.fl_str_mv 2023
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dc.identifier.issn.none.fl_str_mv 03011623
E-ISSN 15732584
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12442/13426
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1007/s11255-023-03862-0
dc.identifier.url.none.fl_str_mv https://link.springer.com/article/10.1007/s11255-023-03862-0
identifier_str_mv 03011623
E-ISSN 15732584
url https://hdl.handle.net/20.500.12442/13426
https://doi.org/10.1007/s11255-023-03862-0
https://link.springer.com/article/10.1007/s11255-023-03862-0
dc.language.iso.eng.fl_str_mv eng
language eng
dc.rights.*.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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eu_rights_str_mv openAccess
dc.format.mimetype.spa.fl_str_mv pdf
dc.publisher.eng.fl_str_mv Springer Nature
dc.source.eng.fl_str_mv International Urology and Nephrology
Int Urol Nephrol
institution Universidad Simón Bolívar
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spelling Schwartz, Paula08be340e-7aa2-4723-ba7c-4da5005fdf0dCapotondo, Maria M.af538927-1ae8-4dd7-8a03-6312220c0352Quaintenne, Miranda3f6719f3-8de2-4871-8e4f-eeef1d51d73bMusso‑Enz, Guido M.a00b6fde-0fef-4db5-9d78-68ba38304161Aroca‑Martinez, Gustavo8af8cd86-1c1c-4521-a728-2cd6e7b33274Musso, Carlos G.e1f82fb4-05f8-40b4-8f34-3bd432a0baf42023-11-10T20:42:26Z2023-11-10T20:42:26Z202303011623E-ISSN 15732584https://hdl.handle.net/20.500.12442/13426https://doi.org/10.1007/s11255-023-03862-0https://link.springer.com/article/10.1007/s11255-023-03862-0Obesity has received considerable attention in general medicine and nephrology over the last few years. This condition increases the risk of metabolic syndrome, diabetes mellitus, hypertension, and dyslipidemia, which are the main risk factors for developing chronic kidney disease (CKD). Kidney damage caused by obesity can be explained by many mechanisms, such as sympathetic nervous and renin-angiotensin-aldosterone systems activation, mechanical stress, hormonal unbalance, as well as inflammatory cytokines production. Even though creatinine-based glomerular filtration rate (GFR) equations in obese individuals have been validated (Salazar-Corcoran and CKD-MCQ), changes in body weight after bariatric surgery (BS) leads to changes in creatininemia, affecting its reliability. Thus, an average between creatine and cystatin-based GFR equations would be more appropriate in this setting. Bariatric surgery can reverse diabetes mellitus and improve hypertension, which are the main causes of CKD. Conclusion: GFR can be affected by obesity and BS, and its value should be cautiously evaluated in this setting.pdfengSpringer NatureAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2International Urology and NephrologyInt Urol NephrolObesityGlomerular filtration rateBariatric surgeryObesity and glomerular filtration rateinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Chang AR, George J, Levey AS, Coresh J, Grams ME, Inker LA (2020) Performance of glomerular filtration rate estimating equations before and after bariatric surgery. Kidney Med 2(6):699-706. e1KDIGO (2012) Clinical Practice Guideline for the Evaluation andManagement of Chronic Kidney Disease. Kidney Int Suppl 3(1):1–163Li K, Zou J, Ye Z, Di J, Han X, Zhang H et al (2016) Effects of bariatric surgery on renal function in obese patients: a systematic review and meta analysis. PLoS ONE 11(10):e0163907Billeter AT, Kopf S, Zeier M, Scheurlen K, Fischer L, Schulte TM et al (2016) Renal function in Type 2 diabetes following gastric bypass. Dtsch Arzteblatt Int 113(49):827–833Provenzano M, Jongs N, Vart P, Stefánsson B, Chertow G, Langkilde AM, McMurray J, Correa-Rotter R, Rossing P, Sjöström D, Toto R, Wheeler D, Heerspink H, DAPA-CKD Trial Committees and Investigators (2022) The kidney protective effects of the sodium-glucose cotransporter-2 inhibitor dapagliflozin, are present in patients with CKD treated with mineralocorticoid receptor antagonists. Kidney Int Rep 7(3):436–443. https:// doi. org/ 10. 1016/j. ekir. 2021. 12. 013Ramspek C, Evans M, Wanner C, Drechsler C, Chesnaye N, Szymczak M, Krajewska M, Torino C, Porto G, Hayward S, Caskey F, Dekker F, Jager K, van Diepen M, EQUAL Study Investigators (2021) Kidney failure prediction models: a comprehensive external validation study in patients with advanced CKD. J Am Soc Nephrol 32(5):1174–1186. https:// doi. org/ 10. 1681/ ASN. 20200 71077Comai G, Corradetti V, Bini C, Tondolo F, Hu L, Valente S, Pasquinelli G, Malvi D, Vasuri F, Ravaioli M, Provenzano M, La Manna G (2023) Histological findings of diabetic kidneys transplanted in non-diabetic recipients: a case series. Int Urol Nephrol. https:// doi. org/ 10. 1007/ s11255- 023- 03552-xGarcía-Carro C, Vergara A, Bermejo S, Azancot MA, Sellarés J, Soler MJ (2021) A Nephrologist perspective on obesity: from kidney injury to clinical management. Front Med 8:1–11. https:// doi. org/ 10. 3389/ fmed. 2021. 655871Silva da Junior GB, Bentes ACSN, Daher EDF, de Matos SMA (2017) Obesity and kidney disease. J Bras Nefrol Orgao Of Soc Bras E Lat-Am Nefrol 39(1):65–69Sharma I, Liao Y, Zheng X, Ys K (2021) New pandemic: obesity and associated nephropathy. Front Med. https:// doi. org/ 10. 3389/ fmed. 2021. 673556Chagnac A, Zingerman B, Rozen-Zvi B, Herman-Edelstein M (2019) Consequences of glomerular hyperfiltration: the role of physical forces in the pathogenesis of chronic kidney disease in diabetes and obesity. Nephron 143(1):38–42. https:// doi. org/ 10. 1159/ 00049 9486Tsuboi N, Okabayashi Y, Shimizu A, Yokoo T (2017) The renal pathology of obesity. Kidney Int Rep 2(2):251–260. https:// doi. org/ 10. 1016/j. ekir. 2017. 01. 007Aiello F, Dueñas EP, Musso CG (2017) Senescent nephropathy: the new renal síndrome. Healthcare (Basel). https:// doi. org/ 10. 3390/ healt hcare 50400 81Chuah LL, Miras AD, Perry LM, Frankel AH, Towey DJ, Al- Mayahi Z et al (2018) Measurement of glomerular filtration rate in patients undergoing obesity surgery. BMC Nephrol 19(1):383D’Agati VD, Chagnac A, de Vries APJ, Levi M, Porrini E, Herman- Edelstein M et al (2016) Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis. Nat Rev Nephrol 12(8):453–471von Scholten BJ, Persson F, Svane MS, Hansen TW, Madsbad S, Rossing P (2017) Effect of large weight reductions on measured and estimated kidney function. BMC Nephrol 18(1):52Kittiskulnam P, Tiskajornsiri K, Katavetin P, Chaiwatanarat T, Eiam-Ong S, Praditpornsilpa K (2020) The failure of glomerular filtration rate estimating equations among obese population. PLoS ONE 15(11):1–13Musso CG, González-Torres H (2019) How to evaluate glomerular filtration rate in the obese patient. Rev Colomb Nefrol. 6(2):84–86Koch V (2021) Obesity facts and their influence on renal function across the life span. Front Med 8:1–10. https:// doi. org/ 10. 3389/ fmed. 2021. 704409Rothberg AE, McEwen LN, Herman WH (2020) Severe obesity and the impact of medical weight loss on estimated glomerular filtration rate. PLoS ONE 15(2):e0228984Musso CG, Álvarez-Gregori J, Jauregui J, Macías-Núñez JF (2016) Glomerular filtration rate equations: a comprehensive review. Int Urol Nephrol 48:1105–1110Delanaye P, Cavalier E, Pottel H, Stehlé T (2023) New and old GFR equations: a European perspective. Clin Kidney J 16(9):1375–1383. https:// doi. org/ 10. 1093/ ckj/ sfad0 39Nawaz S, Chinnadurai R, Al-Chalabi S, Evans P, Kalra PA, Syed AA, Sinha S (2023) Obesity and chronic kidney disease: a current review. Obes Sci Pract 9:61–74Grangeon-Chapon C, Laurain A, Esnault VLM, Cruzel C, Iannelli A, Favre GA (2021) Extracellular fluid volume: a suitable indexation variable to assess impact of bariatric surgery on glomerular filtration rate in patients with chronic kidney disease. PLoS ONE 16(8):e0256234GalleT M, Drouet C, Berriolo-Riedinger A, Nicolas A, Cochet A, Riedinger JM (2021) Effect of obesity, age and gender on glomerular filtration rate measured in normal adults. Ann Biol Clin (Paris). https:// doi. org/ 10. 1684/ abc. 2021. 1615Erstad BL (2021) Nix DE Assessment of kidney function in patients with extreme obesity: a narrative review. Ann Pharmacother 55(1):80–88Negrín-Mena N, Folgueras T, Escamilla B, Estupiñán S, Delgado- Mallén P, Marrero-Miranda D, González-Rinne A, Miquel- Rodríguez RM, Cobo-Caso MA, Díaz-Martín L, Jiménez-Sosa A, González-Rinne F, Torres A, Porrini E (2020) The estimation of GFR and the adjustment for BSA in overweight and obesity: a dreadful combination of two errors. Int J Obes 44(5):1129–1140Capotondo MM, Aroca-Martinez G, Specterman SR, Musso CG (2023) Acute kidney injury in oncology. Interdisciplanary Cancer Research. Springer, ChamFriedman AN, Moe S, Fadel WF, Inman M, Mattar SG, Shihabi Z et al (2014) Predicting the glomerular filtration rate in bariatric surgery patients. Am J Nephrol 39(1):8–15Rosenstock JL, Pommier M, Stoffels G, Patel S, Michelis MF (2018) Prevalence of proteinuria and albuminuria in an obese population and associated risk factors. Front Med 5:122Gheith O, Al-Otaibi T, Halim MA, Mahmoud T, Mosaad A, Yagan J et al (2017) Bariatric surgery in renal transplant patients. Exp Clin Transplant Off J Middle East Soc Organ Transplant 15(Suppl 1):164–169Chang AR, Grams ME, Navaneethan SD (2017) Bariatric surgery and kidney-related outcomes. Kidney Int Rep 2(2):261–270Ritz E (2013) Bariatric surgery and the kidney—much benefit, but also potential harm. Clin Kidney J 6(4):368–372Pommer W (2018) Preventive nephrology: the role of obesity in different stages of chronic kidney disease. Kidney Dis Basel Switz 4(4):199–204Dias RSC, Calado IL, de Alencar JD, Hortegal EV, Santos EJF, de Brito DJ, A, et al (2018) Abdominal obesity and reduction of glomerular filtration. 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