Stevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome
Purpose of Review. Stevia rebaudiana Bertoni is a perennial shrub with zero calorie content that has been increasing in popularity for its potential use as an adjuvant in the treatment of obesity. The level of evidence supporting general benefits to human health is insufficient. We conducted a revie...
- Autores:
-
Rojas, Edward
Bermúdez, Valmore
Fidilio, Enzamaria
Faria, Judith
Rojas, Joselyn
Cabrera de Bravo, Mayela
Contreras, Julio
Mantilla, Linda Pamela
Angarita, Lissé
Sepúlveda, Paola Amar
Kuzmar, Isaac
Motlaghzadeh, Yasaman
Mathew, Justin
- Tipo de recurso:
- Fecha de publicación:
- 2018
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/3585
- Acceso en línea:
- https://hdl.handle.net/20.500.12442/3585
- Palabra clave:
- Stevia rebaudiana Bertoni
Obesity
Type 2 diabetes
Hypertension
- Rights
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Stevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome |
| title |
Stevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome |
| spellingShingle |
Stevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome Stevia rebaudiana Bertoni Obesity Type 2 diabetes Hypertension |
| title_short |
Stevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome |
| title_full |
Stevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome |
| title_fullStr |
Stevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome |
| title_full_unstemmed |
Stevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome |
| title_sort |
Stevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome |
| dc.creator.fl_str_mv |
Rojas, Edward Bermúdez, Valmore Fidilio, Enzamaria Faria, Judith Rojas, Joselyn Cabrera de Bravo, Mayela Contreras, Julio Mantilla, Linda Pamela Angarita, Lissé Sepúlveda, Paola Amar Kuzmar, Isaac Motlaghzadeh, Yasaman Mathew, Justin |
| dc.contributor.author.spa.fl_str_mv |
Rojas, Edward Bermúdez, Valmore Fidilio, Enzamaria Faria, Judith Rojas, Joselyn Cabrera de Bravo, Mayela Contreras, Julio Mantilla, Linda Pamela Angarita, Lissé Sepúlveda, Paola Amar Kuzmar, Isaac |
| dc.contributor.author.eng.fl_str_mv |
Motlaghzadeh, Yasaman Mathew, Justin |
| dc.subject.eng.fl_str_mv |
Stevia rebaudiana Bertoni Obesity Type 2 diabetes Hypertension |
| topic |
Stevia rebaudiana Bertoni Obesity Type 2 diabetes Hypertension |
| description |
Purpose of Review. Stevia rebaudiana Bertoni is a perennial shrub with zero calorie content that has been increasing in popularity for its potential use as an adjuvant in the treatment of obesity. The level of evidence supporting general benefits to human health is insufficient. We conducted a review of the literature summarizing the current knowledge and role in human disease. Recent Findings. Despite stevia’s minimal systemic absorption, studies have been promising regarding its potential benefits against inflammation, carcinogenesis, atherosclerosis glucose control, and hypertension. On the other hand, the growing popularity of artificial sweeteners does not correlate with improved trends in obesity. An increased intake of artificial non-caloric sweeteners may not be associated with decreased intake of traditional sugar-sweetened beverages and foods. The effects of Stevia on weight change have been linked to bacteria in the intestinal microbiome, mainly by affecting Clostridium and Bacteroides sp. populations. A growing body of evidence indicates that Stevia rebaudiana Bertoni is protective against malignant conversion by inhibition of DNA replication in human cancer cell growth in vitro. Summary. Consumption of Stevia has demonstrated to be generally safe in most reports. Further clinical studies are warranted to determine if regular consumption brings sustained benefits for human health. |
| publishDate |
2018 |
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2018 |
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2019-07-18T23:41:43Z |
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2019-07-18T23:41:43Z |
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article |
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http://purl.org/coar/resource_type/c_6501 |
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21613311 |
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https://hdl.handle.net/20.500.12442/3585 |
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21613311 |
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https://hdl.handle.net/20.500.12442/3585 |
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eng |
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eng |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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http://purl.org/coar/access_right/c_f1cf |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_f1cf |
| dc.publisher.spa.fl_str_mv |
Springer |
| dc.source.eng.fl_str_mv |
Current Nutrition Reports September 2018, Volume 7, Issue 3 |
| institution |
Universidad Simón Bolívar |
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https://doi.org/10.1007/s13668-018-0228-z |
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Rojas, Edward94d56218-0c78-40f2-a501-74feeca9191cBermúdez, Valmore29f9aa18-16a4-4fd3-8ce5-ed94a0b8663aFidilio, Enzamaria223576a1-fb46-4a85-80e7-6e837face8e8Faria, Judith15076ad9-a5ca-4db8-a7d6-129d5e0da72fRojas, Joselyn2aa91570-0516-424d-8f76-25cd7b39be6eCabrera de Bravo, Mayelad984e281-e460-420f-9c2a-4af12b674973Contreras, Julioee6833d4-08fc-4f10-8638-cd5206d5aeddMantilla, Linda Pamelac981972f-55ac-440e-93c6-18c440325363Angarita, Lissécd37d36e-0d41-457f-9dc8-1ed5b9201b16Sepúlveda, Paola Amar3f0aa8ae-9307-41c8-b05a-c4d6730ae8dcKuzmar, Isaac532c55ce-6c8d-4a73-b7b6-77619a586ed1Motlaghzadeh, Yasaman3d42a2bd-cfad-4b33-b817-1db901d01841Mathew, Justincb243274-cf1d-4689-b2ec-3b2006dd41f22019-07-18T23:41:43Z2019-07-18T23:41:43Z201821613311https://hdl.handle.net/20.500.12442/3585Purpose of Review. Stevia rebaudiana Bertoni is a perennial shrub with zero calorie content that has been increasing in popularity for its potential use as an adjuvant in the treatment of obesity. The level of evidence supporting general benefits to human health is insufficient. We conducted a review of the literature summarizing the current knowledge and role in human disease. Recent Findings. Despite stevia’s minimal systemic absorption, studies have been promising regarding its potential benefits against inflammation, carcinogenesis, atherosclerosis glucose control, and hypertension. On the other hand, the growing popularity of artificial sweeteners does not correlate with improved trends in obesity. An increased intake of artificial non-caloric sweeteners may not be associated with decreased intake of traditional sugar-sweetened beverages and foods. The effects of Stevia on weight change have been linked to bacteria in the intestinal microbiome, mainly by affecting Clostridium and Bacteroides sp. populations. A growing body of evidence indicates that Stevia rebaudiana Bertoni is protective against malignant conversion by inhibition of DNA replication in human cancer cell growth in vitro. Summary. Consumption of Stevia has demonstrated to be generally safe in most reports. Further clinical studies are warranted to determine if regular consumption brings sustained benefits for human health.engSpringerAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_f1cfCurrent Nutrition ReportsSeptember 2018, Volume 7, Issue 3https://doi.org/10.1007/s13668-018-0228-zStevia rebaudiana BertoniObesityType 2 diabetesHypertensionStevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndromearticlehttp://purl.org/coar/resource_type/c_6501Ogden CL, Carroll MD, Fryar CD, Flegal KM. Prevalence of obesity among adults and youth: United States, 2011–2014. NCHS data brief 2015. Num 219. Hyattsville: National Center for Health Statistics.Obesity and overweight. World health organization fact sheet. 2017. Available at: https://www.who.int/mediacentre/factsheets/fs311/en/ (Accessed 12/31/2017).Garvey WT, Mechanick JI, Brett EM, Garber AJ, Hurley DL, Jastreboff AM, et al. American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity. Endocr Pract. 2016;22(Supp3):1–205.Goyal SK, Samsher, Goyal RK. Stevia (Stevia rebaudiana) a bio-sweetener: a review. Int J Food Sci Nutr. 2010;61(1):1–10. https://doi.org/10.3109/09637480903193049.Atteh J, Onagbesan O, Tona K, Decuypere E, Geuns J, Buyse J. Evaluation of supplementary Stevia (Stevia rebaudiana Bertoni) leaves and stevioside in broiler diets: effects on feed intake, nutrient metabolism, blood parameters and growth performance. J Anim Physiol Anim Nutr. 2008;92(6):640–9.Kroyer G. Stevioside and Stevia-sweetener in food: application, stability and interaction with food ingredients. J. Verbr. Lebensm. 2010;5:225–9. https://doi.org/10.1007/s00003-010-0557-3.Seema T. Stevia rebaudiana: a medicinal and nutraceutical plant and sweet gold for diabetic patients. Int. J. of Pharm. Life Sci. 2010;1(8):451–7.Chattopadhyay S, Raychaudhuri U, Chakraborty R. Artificial sweeteners—a review. J Food Sci Technol. 2014;51(4):611–21. https://doi.org/10.1007/s13197-011-0571-1.International Stevia Council. Available online at: https://www.internationalsteviacouncil.org/fileadmin/media/About_Stevia/stevia_6pp__1_.pdf. Accessed 01/02/2018.Le Bertoni M. Kaà He-é Sa nature et ses proprietes. Anales Científicos Paraguayos. 1905;5:1–14.Kinghorn AD. Stevia: the genus Stevia, vol. 224. Boca Raton: CRC Press; 2003.Chatsudthipong V, Muanprasat C. Stevioside and related compounds: therapeutic benefits beyond sweetness. Pharmacol Ther. 2009;121:41–54.Aminha S, Soumya AN, Raju VG, Goud BM, Irfath M, Quadri SAP. Isolation and extraction of artificial sweetener (Stevia). World J Pharm Res. 2014;3:481–6.Kinghorn AD, Soejarto DD. Current status of stevioside as a sweetening agent for human use. Progress in medicinal and Economic Plan research, vol. 1. London: Academic Press; 1985. p. 1–51.Crammer B, Ikan R. Progress in the chemistry and properties of the rebaudiosides. In: Grenby, editor. Developments in Sweeteners 1987. London: Elsevier Applied Science; 1987. p. 45–64.Phillips KC. Stevia: steps in developing a new sweetener. In: Grenby TH, editor. Developments in sweeteners. Vol 3. London: Elsevier Applied Science; 1987. p. 1–43.Bridel M, Lavieille R. Le principe a saveur sucree du Kaa-he-e (Stevia Rebaudiana) Bertoni. Bull Soc Chim Biol. 1931;13:636–55.Khoda H, Kaisai R, Yamasaki K, Tanaka O. New sweet diterpene glucose from Stevia rebaudiana. Phytochemistry. 1976;15:981–3.Kinghorn D, Soejarto DD, Nanyakkare NPD, Compadre CM, Makapugay HC, Hovanec-Brown JM, et al. A phytochemical screening procedure for sweet ent-Kaurene glycosides in the genus Stevia. Nat Prod. 1984;47:439–44.Savita S, Sheela K, Sunanda S, Shankar A, Ramakrishna P. Stevia rebaudiana—a functional component for food industry. J Hum Ecol. 2004;15:261–4.Mauri P, Catalano G, Gardana C, Pietta P. Analysis of Stevia glyosides by capillary electrophoresis. Electrophoresis. 1997;17:376–1.Madan S, Ahmad S, Singh GN, Kohli K, Kumar Y, Singh R, et al. Stevia rebaudiana (Bert.) Bertoni—a review. Indian J Nat Prod Resour. 2010;1(3):267–86.Gupta E, Purwar S, Sundaram S, Rai GK. Nutritional and therapeutic values of Stevia rebaudiana: a review. J Med Plants Res. 2013;7(46):3343–53.Hutapea AM, Toskulkao C, Buddhasukh D, Wilairat P, Glinsukon T. Digestion of stevioside, a natural sweetener, by various digestive enzymes. J Clin Biochem Nutr. 1997;23:177–86.Koyama E, Kitazawa K, Ohori Y, Izawa O, Kakegawa K, Fujino A, et al. In vitro metabolism of the glycosidic sweeteners, Stevia mixture and enzymatically modified Stevia in human intestinal microflora. Food Chem Toxicol. 2003;41:359–74.Simonetti P, Gardana C, Bramati L, Pietta PG. Bioavailability of Stevioside from Stevia rebaudiana in human volunteers: preliminary report. Proceedings of the first symposium on the safety of stevioside, April 16, 2004. Heverlee-Leuven, Belgium: Euprint Editions, pp. 51–62.Magnuson BA, Carakostas MC, Moore NH, Poulos SP, Renwick AG. Biological fate of low-calorie sweeteners. Nutr Rev. 2016;74(11):670–89. https://doi.org/10.1093/nutrit/nuw032.Geuns JMC, Buyse J, Vankeirsbilck A, Temme EHM. Metabolism of stevioside by healthy subjects. Exp Biol Med. 2007;232:164–73.Nikiforov AI, Rihner MO, Eapen AK, Thomas JA. Metabolism and toxicity studies supporting the safety of rebaudioside D. 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Antioxidant, anti-diabetic and renal protective properties of Stevia rebaudiana. J Diabetes Complicat. 2013;27:103–13.Assaei R, Mokarram P, Dastghaib S, Darbandi S, Darbandi M, Zal F, et al. Hypoglycemic effect of aquatic extract of Stevia in pancreas of diabetic rats: PPARγ -dependent regulation or antioxidant potential. Avicenna J Med Biotech. 2016;8(2):65–74.Philippaert K, Pironet A, Mesuere M, Sones W, Vermeiren L, Kerselaers S, et al. Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity. Nat Commun. 2017;8:14733. https://doi.org/10.1038/ncomms14733.Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism. 2004;53(1):73–6. https://doi.org/10.1016/j.metabol.2003.07.013.Ruiz-Ruiz JC, Moguel-Ordoñez YB, Matus-Basto AJ, Segura-Campos MR. Antidiabetic and antioxidant activity of Stevia rebaudiana extracts (Var. Morita) and their incorporation into a potential functional bread. J Food Sci Technol. 2015;52(12):7894–903. https://doi.org/10.1007/s13197-015-1883-3.Sylvetsky AC, Welsh JA, Brown RJ, Vos MB. Low-calorie sweetener consumption is increasing in the United States. Am J Clin Nutr. 2012;96(3):640–6. https://doi.org/10.3945/ajcn.112.034751.Fowler SP, Williams K, Resendez RG, Hunt KJ, Hazuda HP, Stern MP. Fueling the obesity epidemic? Artificially sweetened beverage use and long-term weight gain. Obesity (Silver Spring). 2008;16(8):1894–900. https://doi.org/10.1038/oby.2008.284.Colditz GA, Willett WC, Stampfer MJ, London SJ, Segal MR, Speizer FE. Patterns of weight change and their relation to diet in a cohort of healthy women. Am J Clin Nutr. 1990;51(6):1100–5.de Koning L, Malik VS, Rimm EB, Willett WC, Hu FB. Sugar sweetened and artificially sweetened beverage consumption and risk of type 2 diabetes in men. 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Am J Clin Nutr. 2012;95(4):909–15. https://doi.org/10.3945/ajcn.111.026682.Gardener H, Rundek T, Markert M, Wright CB, Elkind MS, Sacco RL. Diet soft drink consumption is associated with an increased risk of vascular events in the Northern Manhattan study. J Gen Intern Med. 2012;27(9):1120–6. https://doi.org/10.1007/s11606-011-1968-2.Bernstein AM, de Koning L, Flint AJ, Rexrode KM, Willett WC. Soda consumption and the risk of stroke in men and women. Am J Clin Nutr. 2012;95(5):1190–9. https://doi.org/10.3945/ajcn.111.030205.Chia CW, Shardell M, Tanaka T, Liu DD, Gravenstein KS, Simonsick EM, et al. Chronic low-calorie sweetener use and risk of abdominal obesity among older adults: a cohort study. PLoS One. 2016;11(11):e0167241. https://doi.org/10.1371/journal.pone.0167241.Fagherazzi G, et al. Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the etude Epidemiologique aupres des femmes de la Mutuelle Generale de l’Education Nationale-European prospective investigation into Cancer and nutrition cohort. Am J Clin Nutr. 2013;97:517–23.Gardener H, et al. Diet soft drink consumption is associated with an increased risk of vascular events in the Northern Manhattan study. J Gen Intern Med. 2012;27:1120–6.Cohen L, et al. Association of sweetened beverage intake with incident hypertension. J Gen Intern Med. 2012;27:1127–34.Duffey KJ, et al. Dietary patterns matter: diet beverages and cardiometabolic risks in the longitudinal Coronary Artery Risk Development in Young Adults (CARDIA) study. Am J Clin Nutr. 2012;95:909–15.Swithers SE. Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements. 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Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. CMAJ. 2017;189:E929–39. https://doi.org/10.1503/cmaj.161390.Ashwell M. Stevia, nature’s zero-calorie sustainable sweetener a new player in the fight against obesity. Nutr Today. 2015;50(3):129–34. https://doi.org/10.1097/NT.0000000000000099.Pearlman M, Obert J, Casey L. The association between artificial sweeteners and obesity. Curr Gastroenterol Rep. 2017;19:64. https://doi.org/10.1007/s11894-017-0602-9.Qin J, Li Y, Cai Z, Li S, Zhu J, Zhang F, et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature. 2012;490(7418):55–60. https://doi.org/10.1038/nature11450.Karlsson FH, Tremaroli V, Nookaew I, Bergstrom G, Behre CJ, Fagerberg B, et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature. 2013;498(7452):99–103. https://doi.org/10.1038/nature12198.Gardana C, Simonetti P, Canzi E, et al. Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora. J Agric Food Chem. 2003;51:6618–22.Vijay-Kumar M, Aitken JD, Carvalho FA, et al. Metabolic syndrome and altered gut microbiota in mice lacking toll-like receptor 5. Science. 2010;328:228–31.Backhed F, Ding H, Wang T, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci. 2004;101:15718–23.Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Maza O, et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014;514(7521):181–6. https://doi.org/10.1038/nature13793.Renwick AG, Tarka SM. Microbial hydrolysis of steviol glycosides. Food Chem Toxicol. 2008;46(suppl 7):S70–4.Sheiham A, James WPT. 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Available at: https://www.foodstandards.gov.au/code/applications/Pages/A1108-RebaudiosideM-SteviolGlycosideIntenseSweetener.aspx.CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://bonga.unisimon.edu.co/bitstreams/9cc0f0be-491d-4580-86ef-f7750e132738/download4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8368https://bonga.unisimon.edu.co/bitstreams/61b17498-6e92-4e40-a8fa-c1a644d2acfc/download3fdc7b41651299350522650338f5754dMD5320.500.12442/3585oai:bonga.unisimon.edu.co:20.500.12442/35852024-08-14 21:52:51.069http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internacionalmetadata.onlyhttps://bonga.unisimon.edu.coRepositorio Digital Universidad Simón Bolívarrepositorio.digital@unisimon.edu.coPGEgcmVsPSJsaWNlbnNlIiBocmVmPSJodHRwOi8vY3JlYXRpdmVjb21tb25zLm9yZy9saWNlbnNlcy9ieS1uYy80LjAvIj48aW1nIGFsdD0iTGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyIgc3R5bGU9ImJvcmRlci13aWR0aDowIiBzcmM9Imh0dHBzOi8vaS5jcmVhdGl2ZWNvbW1vbnMub3JnL2wvYnktbmMvNC4wLzg4eDMxLnBuZyIgLz48L2E+PGJyLz5Fc3RhIG9icmEgZXN0w6EgYmFqbyB1bmEgPGEgcmVsPSJsaWNlbnNlIiBocmVmPSJodHRwOi8vY3JlYXRpdmVjb21tb25zLm9yZy9saWNlbnNlcy9ieS1uYy80LjAvIj5MaWNlbmNpYSBDcmVhdGl2ZSBDb21tb25zIEF0cmlidWNpw7NuLU5vQ29tZXJjaWFsIDQuMCBJbnRlcm5hY2lvbmFsPC9hPi4= |