Utility of a Short Neuropsychological Protocol for Detecting HIV-Associated Neurocognitive Disorders in Patients with Asymptomatic HIV-1 Infection

Human Immunodeficiency Virus type 1 (HIV-1) infection is a chronic disease that affects ~40 million people worldwide. HIV-associated neurocognitive disorders (HAND) are common in individuals with HIV-1 Infection, and represent a recent public health problem. Here we evaluate the performance of a rec...

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Autores:: Martinez-Banf, Martha
Vélez, Jorge I.
Mebarak Chams, Moisés R.
Arcos-Holzinger, Mauricio
Acosta-López, Johan E.
García, Ricardo
Perea, María Victoria
Arcos-Burgos, Mauricio
Ladera, Valentina

Tipo de recurso:

Fecha de publicación:: 2021

Institución:: Universidad Simón Bolívar

Repositorio:: Repositorio Digital USB

Idioma:: eng

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dc.title.eng.fl_str_mv	Utility of a Short Neuropsychological Protocol for Detecting HIV-Associated Neurocognitive Disorders in Patients with Asymptomatic HIV-1 Infection
title	Utility of a Short Neuropsychological Protocol for Detecting HIV-Associated Neurocognitive Disorders in Patients with Asymptomatic HIV-1 Infection
spellingShingle	Utility of a Short Neuropsychological Protocol for Detecting HIV-Associated Neurocognitive Disorders in Patients with Asymptomatic HIV-1 Infection HIV AIDS HAND Neurocognitive disorder Predictive models Neuropsychological screening Machine learning
title_short	Utility of a Short Neuropsychological Protocol for Detecting HIV-Associated Neurocognitive Disorders in Patients with Asymptomatic HIV-1 Infection
title_full	Utility of a Short Neuropsychological Protocol for Detecting HIV-Associated Neurocognitive Disorders in Patients with Asymptomatic HIV-1 Infection
title_fullStr	Utility of a Short Neuropsychological Protocol for Detecting HIV-Associated Neurocognitive Disorders in Patients with Asymptomatic HIV-1 Infection
title_full_unstemmed	Utility of a Short Neuropsychological Protocol for Detecting HIV-Associated Neurocognitive Disorders in Patients with Asymptomatic HIV-1 Infection
title_sort	Utility of a Short Neuropsychological Protocol for Detecting HIV-Associated Neurocognitive Disorders in Patients with Asymptomatic HIV-1 Infection
dc.creator.fl_str_mv	Martinez-Banf, Martha Vélez, Jorge I. Mebarak Chams, Moisés R. Arcos-Holzinger, Mauricio Acosta-López, Johan E. García, Ricardo Perea, María Victoria Arcos-Burgos, Mauricio Ladera, Valentina
dc.contributor.author.none.fl_str_mv	Martinez-Banf, Martha Vélez, Jorge I. Mebarak Chams, Moisés R. Arcos-Holzinger, Mauricio Acosta-López, Johan E. García, Ricardo Perea, María Victoria Arcos-Burgos, Mauricio Ladera, Valentina
dc.subject.eng.fl_str_mv	HIV AIDS HAND Neurocognitive disorder Predictive models Neuropsychological screening Machine learning
topic	HIV AIDS HAND Neurocognitive disorder Predictive models Neuropsychological screening Machine learning
description	Human Immunodeficiency Virus type 1 (HIV-1) infection is a chronic disease that affects ~40 million people worldwide. HIV-associated neurocognitive disorders (HAND) are common in individuals with HIV-1 Infection, and represent a recent public health problem. Here we evaluate the performance of a recently proposed short protocol for detecting HAND by studying 60 individuals with HIV-1-Infection and 60 seronegative controls from a Caribbean community in Barranquilla, Colombia. The short evaluation protocol used significant neuropsychological tests from a previous study of asymptomatic HIV-1 infected patients and a group of seronegative controls. Brief screening instruments, i.e., the Mini-mental State Examination (MMSE) and the International HIV Dementia Scale (IHDS), were also applied. Using machine-learning techniques, we derived predictive models of HAND status, and evaluated their performance with the ROC curves. The proposed short protocol performs exceptionally well yielding sensitivity, specificity, and overall prediction values >90%, and better predictive capacity than that of the MMSE and IHDS. Community-specific cut-off values for HAND diagnosis, based on the MMSE and IHDS, make this protocol suitable for HAND screening in individuals from this Caribbean community. This study shows the effectivity of a recently proposed short protocol to detect HAND in individuals with asymptomatic HIV-1-Infection. The application of community-specific cut-off values for HAND diagnosis in the clinical setting may improve HAND screening accuracy and facilitate patients’ treatment and follow-up. Further studies are needed to assess the performance of this protocol in other Latin American populations.
publishDate	2021
dc.date.accessioned.none.fl_str_mv	2021-08-05T14:43:46Z
dc.date.available.none.fl_str_mv	2021-08-05T14:43:46Z
dc.date.issued.none.fl_str_mv	2021
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dc.type.spa.spa.fl_str_mv	Artículo científico
dc.identifier.citation.spa.fl_str_mv	Martinez-Banfi, M.; Vélez, J.I.; Mebarak Chams, M.R.; Arcos-Holzinger, M.; Acosta-López, J.E.; García, R.; Perea, M.V.; Arcos-Burgos, M.; Ladera, V. Utility of a Short Neuropsychological Protocol for Detecting HIV-Associated Neurocognitive Disorders in Patients with Asymptomatic HIV-1 Infection. Brain Sci. 2021, 11, 1037. https:// doi.org/10.3390/brainsci11081037
dc.identifier.issn.none.fl_str_mv	20763425
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12442/8110
dc.identifier.doi.none.fl_str_mv	https://doi.org/10.3390/brainsci11081037
dc.identifier.url.none.fl_str_mv	https://www.mdpi.com/2076-3425/11/8/1037
identifier_str_mv	Martinez-Banfi, M.; Vélez, J.I.; Mebarak Chams, M.R.; Arcos-Holzinger, M.; Acosta-López, J.E.; García, R.; Perea, M.V.; Arcos-Burgos, M.; Ladera, V. Utility of a Short Neuropsychological Protocol for Detecting HIV-Associated Neurocognitive Disorders in Patients with Asymptomatic HIV-1 Infection. Brain Sci. 2021, 11, 1037. https:// doi.org/10.3390/brainsci11081037 20763425
url	https://hdl.handle.net/20.500.12442/8110 https://doi.org/10.3390/brainsci11081037 https://www.mdpi.com/2076-3425/11/8/1037
dc.language.iso.eng.fl_str_mv	eng
language	eng
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dc.format.mimetype.eng.fl_str_mv	pdf
dc.publisher.eng.fl_str_mv	MDPI
dc.source.eng.fl_str_mv	Brain sciences
dc.source.none.fl_str_mv	Vol. 11, No. 8 (2021)
institution	Universidad Simón Bolívar
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spelling	Martinez-Banf, Martha5d801b9f-7115-4f70-93b5-36934d811496Vélez, Jorge I.83044e45-79cc-4eec-a9cc-72bf4514e76bMebarak Chams, Moisés R.dbd6e858-b87b-4262-a8cd-248a228ee921Arcos-Holzinger, Mauricio7238c0fe-3118-4a98-8904-f598cb43fd53Acosta-López, Johan E.b7a16ff4-ce8a-419c-a6ba-597013d207edGarcía, Ricardofb12fb60-9e6a-4bd4-9642-e75c6fc2aa08Perea, María Victoriac6709389-9b9f-4aed-b112-f22e4d9783c9Arcos-Burgos, Mauriciob0eeb625-a6f6-4508-8925-309b5f765a14Ladera, Valentinabf8d447e-dc7d-4cff-80c5-a6c3667811062021-08-05T14:43:46Z2021-08-05T14:43:46Z2021Martinez-Banfi, M.; Vélez, J.I.; Mebarak Chams, M.R.; Arcos-Holzinger, M.; Acosta-López, J.E.; García, R.; Perea, M.V.; Arcos-Burgos, M.; Ladera, V. Utility of a Short Neuropsychological Protocol for Detecting HIV-Associated Neurocognitive Disorders in Patients with Asymptomatic HIV-1 Infection. Brain Sci. 2021, 11, 1037. https:// doi.org/10.3390/brainsci1108103720763425https://hdl.handle.net/20.500.12442/8110https://doi.org/10.3390/brainsci11081037https://www.mdpi.com/2076-3425/11/8/1037Human Immunodeficiency Virus type 1 (HIV-1) infection is a chronic disease that affects ~40 million people worldwide. HIV-associated neurocognitive disorders (HAND) are common in individuals with HIV-1 Infection, and represent a recent public health problem. Here we evaluate the performance of a recently proposed short protocol for detecting HAND by studying 60 individuals with HIV-1-Infection and 60 seronegative controls from a Caribbean community in Barranquilla, Colombia. The short evaluation protocol used significant neuropsychological tests from a previous study of asymptomatic HIV-1 infected patients and a group of seronegative controls. Brief screening instruments, i.e., the Mini-mental State Examination (MMSE) and the International HIV Dementia Scale (IHDS), were also applied. Using machine-learning techniques, we derived predictive models of HAND status, and evaluated their performance with the ROC curves. The proposed short protocol performs exceptionally well yielding sensitivity, specificity, and overall prediction values >90%, and better predictive capacity than that of the MMSE and IHDS. Community-specific cut-off values for HAND diagnosis, based on the MMSE and IHDS, make this protocol suitable for HAND screening in individuals from this Caribbean community. This study shows the effectivity of a recently proposed short protocol to detect HAND in individuals with asymptomatic HIV-1-Infection. The application of community-specific cut-off values for HAND diagnosis in the clinical setting may improve HAND screening accuracy and facilitate patients’ treatment and follow-up. Further studies are needed to assess the performance of this protocol in other Latin American populations.pdfengMDPIAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Brain sciencesVol. 11, No. 8 (2021)HIVAIDSHANDNeurocognitive disorderPredictive modelsNeuropsychological screeningMachine learningUtility of a Short Neuropsychological Protocol for Detecting HIV-Associated Neurocognitive Disorders in Patients with Asymptomatic HIV-1 Infectioninfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Moral De La Rubia, J.; Segovia Chavez, M. Discrimination Against Women Infected with Human Immunodeficiency Virus (HIV) By Members of Their Own Family. Psicogente 2015, 18, 89–103.Marin-Webb, V.; Jessen, H.; Kopp, U.; Jessen, A.B.; Hahn, K. Validation of the International HIV Dementia Scale as a Screening Tool for HIV-Associated Neurocognitive Disorders in a German-Speaking HIV Outpatient Clinic. PLoS ONE 2016, 11, e0168225.Heaton, R.K.; Franklin, D.R.; Ellis, R.J.; McCutchan, J.A.; Letendre, S.L.; Leblanc, S.; Corkran, S.H.; Duarte, N.A.; Clifford, D.B.; Woods, S.P.; et al. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: Differences in rates, nature, and predictors. J. Neurovirol. 2011, 17, 3–16.Woods, S.P.; Moore, D.J.; Weber, E.; Grant, I. Cognitive Neuropsychology of HIV-Associated Neurocognitive Disorders. Neuropsychol. Rev. 2009, 19, 152–168.Eggers, C.; Arendt, G.; Hahn, K.; Husstedt, I.W.; Maschke, M.; Neuen-Jacob, E.; Obermann, M.; Rosenkranz, T.; Schielke, E.; Straube, E.; et al. HIV-1-associated neurocognitive disorder: Epidemiology, pathogenesis, diagnosis, and treatment. J. Neurol. 2017, 264, 1715–1727.Antinori, A.; Arendt, G.; Becker, J.T.; Brew, B.; Byrd, D.A.; Cherner, M.; Clifford, D.B.; Cinque, P.; Epstein, L.; Goodkin, K.; et al. Updated research nosology for HIV-associated neurocognitive disorders. Neurology 2007, 69.Joska, J.A.; Witten, J.; Thomas, K.G.; Robertson, C.; Casson-Crook, M.; Roosa, H.; Creighton, J.; Lyons, J.; McArthur, J.; Sacktor, N.C. A Comparison of Five Brief Screening Tools for HIV-Associated Neurocognitive Disorders in the USA and South Africa. AIDS Behav. 2016, 20, 1621–1631.Heaton, R.K.; Clifford, D.B.; Franklin, D.R.; Woods, S.P.; Ake, C.; Vaida, F.; Ellis, R.J.; Letendre, S.L.; Marcotte, T.D.; Atkinson, J.H.; et al. HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology 2010, 75, 2087–2096Oshinaike, O.O.; Akinbami, A.A.; Ojo, O.O.; Ojini, I.F.; Okubadejo, N.; Danesi, A.M. Comparison of the Minimental State Examination Scale and the International HIV Dementia Scale in Assessing Cognitive Function in Nigerian HIV Patients on Antiretroviral Therapy. AIDS Res. Treat. 2012, 2012, 581531.Kabuba, N.; Menon, J.A.; Franklin, D.R.; Heaton, R.K.; Hestad, K.A. Use of Western Neuropsychological Test Battery in Detecting HIV-Associated Neurocognitive Disorders (HAND) in Zambia. AIDS Behav. 2017, 21, 1717–1727.Butters, N.; Grant, I.; Haxby, J.; Judd, L.L.; Martin, A.; McClelland, J.; Pequegnat, W.; Schacter, D.; Stover, E. Assessment of Aids-related cognitive changes: Recommendations of the NIMH workshop on neuropsychological assessment approaches. J. Clin. Exp. Neuropsychol. 1990, 12, 963–978.Maj, M.; Starace, F.; Sartourius, N. Neuropsychiatric aspects of HIV-1 infection: Data collection instrument for a WHO crosscultural study. Organ 1991, 69, 243–245.Grant, I.; Martin, A. Neuropsychology of HIV Infection; Oxford University Press: Oxford, UK, 1994.Pugh, K.; Riccio, M.; Jadresic, D.; Burgess, A.P.; Baldeweg, T.; Catalan, J.; Lovett, E.; Hawkins, D.A.; Gruzelier, J.; Thompson, C. A longitudinal study of the neuropsychiatric consequences of HIV-1 infection in gay men. II. Psychological and health status at baseline and at 12-month follow-up. Psychol. Med. 1994, 24, 897–904Ardila-Ardila, A.; Goodkin, K.; Concha-Bartolini, M.; Lecusay-Ruiz, R.; Mellan-Fajardo, S.O.; Suárez-Bustamante, P.; MolinaVásquez, R.; Lee, D.; Chayeb, G.; Wilkie, F.L. HUMANS: A neuropsychological battery for evaluating HIV 1 infected patients. Rev. Neurol. 2003, 36, 756–762.De Almeida, M.; Kamat, R.; Cherner, M.; Umlauf, A.; Ribeiro, C.E.; de Pereira, A.P.; Franklin, D.; Heaton, R.K.; Ellis, R. Improving Detection of HIV-Associated Cognitive Impairment: Comparison of the International HIV Dementia Scale and a Brief Screening Battery. J. Acquir. Immune Defic. 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Utility of a Short Neuropsychological Protocol for Detecting HIV-Associated Neurocognitive Disorders in Patients with Asymptomatic HIV-1 Infection

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