The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium
Adipose tissue (AT) biology is linked to cardiovascular health since obesity is associated with cardiovascular disease (CVD) and positively correlated with excessive visceral fat accumulation. AT signaling to myocardial cells through soluble factors known as adipokines, cardiokines, branched-chain a...
- Autores:
-
Bermúdez, Valmore
Durán, Pablo
Rojas, Edward
Díaz, María P.
Rivas, José
Nava, Manuel
Chací, Maricarmen
Cabrera de Bravo, Mayela
Carrasquero, Rubén
Cano Ponce, Clímaco
Górriz, José Luis
D'Marco, Luis
- Tipo de recurso:
- Fecha de publicación:
- 2021
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/8657
- Palabra clave:
- Adipose tissue
Myocardiocytes
Microbiota
Obesity
Inflammation
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium |
| title |
The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium |
| spellingShingle |
The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium Adipose tissue Myocardiocytes Microbiota Obesity Inflammation |
| title_short |
The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium |
| title_full |
The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium |
| title_fullStr |
The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium |
| title_full_unstemmed |
The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium |
| title_sort |
The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium |
| dc.creator.fl_str_mv |
Bermúdez, Valmore Durán, Pablo Rojas, Edward Díaz, María P. Rivas, José Nava, Manuel Chací, Maricarmen Cabrera de Bravo, Mayela Carrasquero, Rubén Cano Ponce, Clímaco Górriz, José Luis D'Marco, Luis |
| dc.contributor.author.none.fl_str_mv |
Bermúdez, Valmore Durán, Pablo Rojas, Edward Díaz, María P. Rivas, José Nava, Manuel Chací, Maricarmen Cabrera de Bravo, Mayela Carrasquero, Rubén Cano Ponce, Clímaco Górriz, José Luis D'Marco, Luis |
| dc.subject.eng.fl_str_mv |
Adipose tissue Myocardiocytes Microbiota Obesity Inflammation |
| topic |
Adipose tissue Myocardiocytes Microbiota Obesity Inflammation |
| description |
Adipose tissue (AT) biology is linked to cardiovascular health since obesity is associated with cardiovascular disease (CVD) and positively correlated with excessive visceral fat accumulation. AT signaling to myocardial cells through soluble factors known as adipokines, cardiokines, branched-chain amino acids and small molecules like microRNAs, undoubtedly influence myocardial cells and AT function via the endocrine-paracrine mechanisms of action. Unfortunately, abnormal total and visceral adiposity can alter this harmonious signaling network, resulting in tissue hypoxia and monocyte/macrophage adipose infiltration occurring alongside expanded intra-abdominal and epicardial fat depots seen in the human obese phenotype. These processes promote an abnormal adipocyte proteomic reprogramming, whereby these cells become a source of abnormal signals, affecting vascular and myocardial tissues, leading to meta-inflammation, atrial fibrillation, coronary artery disease, heart hypertrophy, heart failure and myocardial infarction. This review first discusses the pathophysiology and consequences of adipose tissue expansion, particularly their association with meta-inflammation and microbiota dysbiosis. We also explore the precise mechanisms involved in metabolic reprogramming in AT that represent plausible causative factors for CVD. Finally, we clarify how lifestyle changes could promote improvement in myocardiocyte function in the context of changes in AT proteomics and a better gut microbiome profile to develop effective, non-pharmacologic approaches to CVD. |
| publishDate |
2021 |
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2021-10-06T15:17:08Z |
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2021-10-06T15:17:08Z |
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2021 |
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info:eu-repo/semantics/article |
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Artículo científico |
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Bermúdez V, Durán P, Rojas E, Díaz MP, Rivas J, Nava M, Chacín M, Cabrera de Bravo M, Carrasquero R, Ponce CC, Górriz JL and D´Marco L (2021) The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium. Front. Endocrinol. 12:735070. doi: 10.3389/fendo.2021.735070 |
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16642392 |
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https://hdl.handle.net/20.500.12442/8657 |
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https://doi.org/10.3389/fendo.2021.735070 |
| identifier_str_mv |
Bermúdez V, Durán P, Rojas E, Díaz MP, Rivas J, Nava M, Chacín M, Cabrera de Bravo M, Carrasquero R, Ponce CC, Górriz JL and D´Marco L (2021) The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium. Front. Endocrinol. 12:735070. doi: 10.3389/fendo.2021.735070 16642392 |
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https://hdl.handle.net/20.500.12442/8657 https://doi.org/10.3389/fendo.2021.735070 |
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eng |
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eng |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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Frontiers in Endocrinology |
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Bermúdez, Valmore29f9aa18-16a4-4fd3-8ce5-ed94a0b8663aDurán, Pablo6bb3ca43-d725-4ff0-ae00-4eda6cdbeea4Rojas, Edward94d56218-0c78-40f2-a501-74feeca9191cDíaz, María P.e5017bb2-15b8-412f-a151-05cba49ffa99Rivas, Josée04c76cc-1f79-43a1-b7ad-ea11db9b8e23Nava, Manuelf9865b69-841a-4eea-b7da-6a174b033d10Chací, Maricarmend0dfd276-7638-450e-bee4-f11a5b30b2b8Cabrera de Bravo, Mayelad984e281-e460-420f-9c2a-4af12b674973Carrasquero, Rubén87b1437e-aa54-4ca0-ba7e-ccec38847d59Cano Ponce, Clímaco48f3cf35-b24c-4071-80c6-85776c27c0acGórriz, José Luis3bfbeb8b-bff2-4c54-92a6-8b35f29dccc6D'Marco, Luis4f289143-892b-43a3-ac1f-6f462224f3142021-10-06T15:17:08Z2021-10-06T15:17:08Z2021Bermúdez V, Durán P, Rojas E, Díaz MP, Rivas J, Nava M, Chacín M, Cabrera de Bravo M, Carrasquero R, Ponce CC, Górriz JL and D´Marco L (2021) The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium. Front. Endocrinol. 12:735070. doi: 10.3389/fendo.2021.73507016642392https://hdl.handle.net/20.500.12442/8657https://doi.org/10.3389/fendo.2021.735070Adipose tissue (AT) biology is linked to cardiovascular health since obesity is associated with cardiovascular disease (CVD) and positively correlated with excessive visceral fat accumulation. AT signaling to myocardial cells through soluble factors known as adipokines, cardiokines, branched-chain amino acids and small molecules like microRNAs, undoubtedly influence myocardial cells and AT function via the endocrine-paracrine mechanisms of action. Unfortunately, abnormal total and visceral adiposity can alter this harmonious signaling network, resulting in tissue hypoxia and monocyte/macrophage adipose infiltration occurring alongside expanded intra-abdominal and epicardial fat depots seen in the human obese phenotype. These processes promote an abnormal adipocyte proteomic reprogramming, whereby these cells become a source of abnormal signals, affecting vascular and myocardial tissues, leading to meta-inflammation, atrial fibrillation, coronary artery disease, heart hypertrophy, heart failure and myocardial infarction. This review first discusses the pathophysiology and consequences of adipose tissue expansion, particularly their association with meta-inflammation and microbiota dysbiosis. We also explore the precise mechanisms involved in metabolic reprogramming in AT that represent plausible causative factors for CVD. Finally, we clarify how lifestyle changes could promote improvement in myocardiocyte function in the context of changes in AT proteomics and a better gut microbiome profile to develop effective, non-pharmacologic approaches to CVD.pdfengFrontiers MediaAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Frontiers in EndocrinologyVol. 12 (2021)Adipose tissueMyocardiocytesMicrobiotaObesityInflammationThe Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardiuminfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1World Health Organization. Obesity and Overweight. Available at: https:// www.who.int/news-room/fact-sheets/detail/obesity-and-overweight (Accessed cited 2021 May 6).Cawley J, Meyerhoefer C. The Medical Care Costs of Obesity: An Instrumental Variables Approach. J Health Econ (2012) 31(1):219–30. doi: 10.1016/j.jhealeco.2011.10.003. Fruh SM. Obesity: Risk Factors, Complications, and Strategies for Sustainable Long-Term Weight Management. J Am Assoc Nurse Pract (2017) 29(S1):S3–14. doi: 10.1002/2327-6924.12510World Health Organization. Cardiovascular Diseases (CVDs). Available at: https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases- (cvds) (Accessed cited 2021 May 6).Oikonomou EK, Antoniades C. The Role of Adipose Tissue in Cardiovascular Health and Disease. Nat Rev Cardiol (2019) 16(2):83–99. doi: 10.1038/s41569-018-0097-6Antoniades C. “Dysfunctional” Adipose Tissue in Cardiovascular Disease: A Reprogrammable Target or an Innocent Bystander? Cardiovasc Res (2017) 113(9):997–8. doi: 10.1093/cvr/cvx116Rodrıguez A, Becerril S, Ezquerro S, Me ́ ́ndez-Giménez L, Frühbeck G. Crosstalk Between Adipokines and Myokines in Fat Browning. Acta Physiol (Oxf) (2017) 219(2):362–81. doi: 10.1111/apha.12686Arner P, Kulyté A. MicroRNA Regulatory Networks in Human Adipose Tissue and Obesity. Nat Rev Endocrinol (2015) 11(5):276–88. doi: 10.1038/ nrendo.2015.25Ahima RS, Lazar MA. Adipokines and the Peripheral and Neural Control of Energy Balance. Mol Endocrinol (2008) 22(5):1023–31. doi: 10.1210/ me.2007-0529Bohan R, Tianyu X, Tiantian Z, Ruonan F, Hongtao H, Qiong W, et al. Gut Microbiota: A Potential Manipulator for Host Adipose Tissue and Energy Metabolism. J Nutr Biochem (2019) 64:206–17. doi: 10.1016/ j.jnutbio.2018.10.020. Matsuzawa Y, Shimomura I, Nakamura T, Keno Y, Kotani K, Tokunaga K. Pathophysiology and Pathogenesis of Visceral Fat Obesity. Obes Res (1995) 3(Suppl 2):187S–94S. doi: 10.1002/j.1550-8528.1995.tb00462.xVacca M, Di Eusanio M, Cariello M, Graziano G, D’Amore S, Petridis FD, et al. Integrative miRNA and Whole-Genome Analyses of Epicardial Adipose Tissue in Patients With Coronary Atherosclerosis. 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Adipose Tissue Hypoxia in Obesity and Its Impact on Preadipocytes and Macrophages: Hypoxia Hypothesis. Adv Exp Med Biol (2017) 960:305–26. doi: 10.1007/978-3-319-48382-5_13Cildir G, Akıncılar SC, Tergaonkar V. Chronic Adipose Tissue Inflammation: All Immune Cells on the Stage. Trends Mol Med (2013) 19 (8):487–500. doi: 10.1016/j.molmed.2013.05.001Guzik TJ, Skiba DS, Touyz RM, Harrison DG. The Role of Infiltrating Immune Cells in Dysfunctional Adipose Tissue. Cardiovasc Res (2017) 113 (9):1009–23. doi: 10.1093/cvr/cvx108Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW. Obesity Is Associated With Macrophage Accumulation in Adipose Tissue. J Clin Invest (2003) 112(12):1796–808. doi: 10.1172/JCI200319246Amano SU, Cohen JL, Vangala P, Tencerova M, Nicoloro SM, Yawe JC, et al. Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation. 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