Prepotent response inhibition and reaction times in children with attention deficit/hyperactivity disorder from a Caribbean community

Abstract Impairment in inhibitory control has been postulated as an underlying hallmark of attention deficit/hyperactivity disorder (ADHD), which can be utilized as a quantitative trait for genetic studies. Here, we evaluate whether inhibitory control, measured by simple automatized prepotent respon...

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Autores:
Jiménez-Figueroa, Giomar
Ardila-Duarte, Carlos
Pineda, David A.
Acosta-López, Johan E.
Cervantes-Henríquez, Martha L.
Pineda-Alhucema, Wilmar
Cervantes-Gutiérrez, Jeimys
Quintero-Ibarra, Marisol
Sáchez-Rojas, Manuel
Vélez, Jorge I.
Puentes-Rozo, Pedro J.
Tipo de recurso:
Fecha de publicación:
2017
Institución:
Universidad Simón Bolívar
Repositorio:
Repositorio Digital USB
Idioma:
eng
OAI Identifier:
oai:bonga.unisimon.edu.co:20.500.12442/1927
Acceso en línea:
http://hdl.handle.net/20.500.12442/1927
Palabra clave:
Inhibitory control
Prepotent response inhibition
Reaction time
ADHD
Endophenotypes
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Licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional
id USIMONBOL2_9145a50efa1851fff16015c93a92af6d
oai_identifier_str oai:bonga.unisimon.edu.co:20.500.12442/1927
network_acronym_str USIMONBOL2
network_name_str Repositorio Digital USB
repository_id_str
dc.title.eng.fl_str_mv Prepotent response inhibition and reaction times in children with attention deficit/hyperactivity disorder from a Caribbean community
title Prepotent response inhibition and reaction times in children with attention deficit/hyperactivity disorder from a Caribbean community
spellingShingle Prepotent response inhibition and reaction times in children with attention deficit/hyperactivity disorder from a Caribbean community
Inhibitory control
Prepotent response inhibition
Reaction time
ADHD
Endophenotypes
title_short Prepotent response inhibition and reaction times in children with attention deficit/hyperactivity disorder from a Caribbean community
title_full Prepotent response inhibition and reaction times in children with attention deficit/hyperactivity disorder from a Caribbean community
title_fullStr Prepotent response inhibition and reaction times in children with attention deficit/hyperactivity disorder from a Caribbean community
title_full_unstemmed Prepotent response inhibition and reaction times in children with attention deficit/hyperactivity disorder from a Caribbean community
title_sort Prepotent response inhibition and reaction times in children with attention deficit/hyperactivity disorder from a Caribbean community
dc.creator.fl_str_mv Jiménez-Figueroa, Giomar
Ardila-Duarte, Carlos
Pineda, David A.
Acosta-López, Johan E.
Cervantes-Henríquez, Martha L.
Pineda-Alhucema, Wilmar
Cervantes-Gutiérrez, Jeimys
Quintero-Ibarra, Marisol
Sáchez-Rojas, Manuel
Vélez, Jorge I.
Puentes-Rozo, Pedro J.
dc.contributor.author.none.fl_str_mv Jiménez-Figueroa, Giomar
Ardila-Duarte, Carlos
Pineda, David A.
Acosta-López, Johan E.
Cervantes-Henríquez, Martha L.
Pineda-Alhucema, Wilmar
Cervantes-Gutiérrez, Jeimys
Quintero-Ibarra, Marisol
Sáchez-Rojas, Manuel
Vélez, Jorge I.
Puentes-Rozo, Pedro J.
dc.subject.eng.fl_str_mv Inhibitory control
Prepotent response inhibition
Reaction time
ADHD
Endophenotypes
topic Inhibitory control
Prepotent response inhibition
Reaction time
ADHD
Endophenotypes
description Abstract Impairment in inhibitory control has been postulated as an underlying hallmark of attention deficit/hyperactivity disorder (ADHD), which can be utilized as a quantitative trait for genetic studies. Here, we evaluate whether inhibitory control, measured by simple automatized prepotent response (PR) inhibition variables, is a robust discriminant function for the diagnosis of ADHD in children and can be used as an endophenotype for future genetic studies. One hundred fifty-two school children (30.9% female, 67.8% with ADHD) were recruited. The ADHD checklist was used as the screening tool, whilst the DSM-IV Mini International Neuropsychiatry Interview, neurologic interview and neurologic examination, and the WISC III FSIQ test were administered as the gold standard procedure to assert ADHD diagnosis. A Go/No-Go task using a naturalistic and automatized visual signal was administered. A linear multifactor model (MANOVA) was fitted to compare groups including ADHD status, age, and gender as multiple independent factors. Linear discriminant analysis and the receiver operating characteristic curve were used to assess the predictive performance of PR inhibition variables for ADHD diagnosis. We found that four variables of prepotent response reaction time- and prepotent response inhibition established statistically significant differences between children with and without ADHD. Furthermore, these variables generated a strong discriminant function with a total classification capability of 73, 84% specificity, 68% sensitivity, and 90% positive predictive value for ADHD diagnosis, which support reaction times as a candidate endophenotype that could potentially be used in future ADHD genetic research.
publishDate 2017
dc.date.issued.none.fl_str_mv 2017-12
dc.date.accessioned.none.fl_str_mv 2018-04-02T15:20:16Z
dc.date.available.none.fl_str_mv 2018-04-02T15:20:16Z
dc.type.eng.fl_str_mv article
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.identifier.issn.none.fl_str_mv 18666647
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12442/1927
identifier_str_mv 18666647
url http://hdl.handle.net/20.500.12442/1927
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.license.spa.fl_str_mv Licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional
rights_invalid_str_mv Licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional
http://purl.org/coar/access_right/c_abf2
dc.publisher.spa.fl_str_mv Springer Vienna
dc.source.eng.fl_str_mv ADHD Attenton Deficit and Hyperactivity Disorders
Vol. 9, No.4 (2017)
institution Universidad Simón Bolívar
dc.source.uri.none.fl_str_mv https://link.springer.com/article/10.1007/s12402-017-0223-z
bitstream.url.fl_str_mv https://bonga.unisimon.edu.co/bitstreams/9cf2ccee-d68f-4999-9182-cf006ffede2c/download
bitstream.checksum.fl_str_mv 3fdc7b41651299350522650338f5754d
bitstream.checksumAlgorithm.fl_str_mv MD5
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repository.mail.fl_str_mv bibliotecas@biteca.com
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spelling Licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacionalhttp://purl.org/coar/access_right/c_abf2Jiménez-Figueroa, Giomar4e32c178-3e25-4f6d-a185-70fa49c95a41-1Ardila-Duarte, Carlosbc4881d2-0f8f-48b2-811f-808c5332a817-1Pineda, David A.7fa7af6f-d0cb-4f00-b3bf-d0b4188e1ffa-1Acosta-López, Johan E.b7a16ff4-ce8a-419c-a6ba-597013d207ed-1Cervantes-Henríquez, Martha L.fb444be3-6d82-40aa-8a3c-75f422f8ec66-1Pineda-Alhucema, Wilmar7b128890-2199-49dd-bf91-98f5d747142e-1Cervantes-Gutiérrez, Jeimysac0a1277-6eaa-4581-aad3-28a878e6e71f-1Quintero-Ibarra, Marisol4de3f087-888b-4ce8-822d-054c5075b93d-1Sáchez-Rojas, Manuel665e35ef-843e-4ce7-a390-d8c8855878bd-1Vélez, Jorge I.83044e45-79cc-4eec-a9cc-72bf4514e76b-1Puentes-Rozo, Pedro J.f5776586-b6b2-4086-8bed-3e4972516196-12018-04-02T15:20:16Z2018-04-02T15:20:16Z2017-1218666647http://hdl.handle.net/20.500.12442/1927Abstract Impairment in inhibitory control has been postulated as an underlying hallmark of attention deficit/hyperactivity disorder (ADHD), which can be utilized as a quantitative trait for genetic studies. Here, we evaluate whether inhibitory control, measured by simple automatized prepotent response (PR) inhibition variables, is a robust discriminant function for the diagnosis of ADHD in children and can be used as an endophenotype for future genetic studies. One hundred fifty-two school children (30.9% female, 67.8% with ADHD) were recruited. The ADHD checklist was used as the screening tool, whilst the DSM-IV Mini International Neuropsychiatry Interview, neurologic interview and neurologic examination, and the WISC III FSIQ test were administered as the gold standard procedure to assert ADHD diagnosis. A Go/No-Go task using a naturalistic and automatized visual signal was administered. A linear multifactor model (MANOVA) was fitted to compare groups including ADHD status, age, and gender as multiple independent factors. Linear discriminant analysis and the receiver operating characteristic curve were used to assess the predictive performance of PR inhibition variables for ADHD diagnosis. We found that four variables of prepotent response reaction time- and prepotent response inhibition established statistically significant differences between children with and without ADHD. Furthermore, these variables generated a strong discriminant function with a total classification capability of 73, 84% specificity, 68% sensitivity, and 90% positive predictive value for ADHD diagnosis, which support reaction times as a candidate endophenotype that could potentially be used in future ADHD genetic research.engSpringer ViennaADHD Attenton Deficit and Hyperactivity DisordersVol. 9, No.4 (2017)https://link.springer.com/article/10.1007/s12402-017-0223-zInhibitory controlPrepotent response inhibitionReaction timeADHDEndophenotypesPrepotent response inhibition and reaction times in children with attention deficit/hyperactivity disorder from a Caribbean communityarticlehttp://purl.org/coar/resource_type/c_6501Acosta J, Cervantes ML, Jime´nez G, Nu´n˜ez M, Sa´nchez M, Puentes P (2013) Uso de una escala comportamental Wender Utah para evaluaren retrospectiva trastorno de atencio´n-hiperactividad en adultos de la ciudad de Barranquilla. Revista Universidad y Salud 15(1):45–61Ferrando L, Bobes J, Gibert J, Lecrubier Y (1997) Mini international neuropsychiatric interview. In: Bobes J, Bouson˜o M, Gonza´lez MP (eds) Manejo de los trastornos mentales y del comportamiento en Atencio´n Primaria, 2nd edn. Gofer, OviedoPineda D, Henao G, Puerta IC, Mejı´a S, Go´mez LF, Miranda ML et al (1999b) Uso de un cuestionario breve para el diagnóstico de deficiencia atencional. Rev Neurol 28:344–351Puentes-Rozo P, Jiménez-Figueroa G, Pineda-Alhucema W, Pimienta-Montoya D, Acosta-López J, Cervantes-Henrı´quez ML et al (2014) Déficit en habilidades sociales en niños con Trastorno por De´ficit de Atencio´n-Hiperactividad, evaluados con la escala BASC. Revista Colombiana de Psicología 23(1):95–106. doi:10.15446/rcp.v23n1.34332Villalón J (2008) Colonias extranjeras en Barranquilla. Barranquilla, Colombia. http://barranquillaenelmundo.blogspot.com.co/2011/ 07/colonias-extranjeras-en-barranquilla.html. 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Clin Neuropsychol 22(5):826–841. doi:10.1080/13854040701563583LICENSElicense.txtlicense.txttext/plain; charset=utf-8368https://bonga.unisimon.edu.co/bitstreams/9cf2ccee-d68f-4999-9182-cf006ffede2c/download3fdc7b41651299350522650338f5754dMD5220.500.12442/1927oai:bonga.unisimon.edu.co:20.500.12442/19272019-04-11 21:51:34.297metadata.onlyhttps://bonga.unisimon.edu.coDSpace UniSimonbibliotecas@biteca.comPGEgcmVsPSJsaWNlbnNlIiBocmVmPSJodHRwOi8vY3JlYXRpdmVjb21tb25zLm9yZy9saWNlbnNlcy9ieS1uYy80LjAvIj48aW1nIGFsdD0iTGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyIgc3R5bGU9ImJvcmRlci13aWR0aDowIiBzcmM9Imh0dHBzOi8vaS5jcmVhdGl2ZWNvbW1vbnMub3JnL2wvYnktbmMvNC4wLzg4eDMxLnBuZyIgLz48L2E+PGJyLz5Fc3RhIG9icmEgZXN0w6EgYmFqbyB1bmEgPGEgcmVsPSJsaWNlbnNlIiBocmVmPSJodHRwOi8vY3JlYXRpdmVjb21tb25zLm9yZy9saWNlbnNlcy9ieS1uYy80LjAvIj5MaWNlbmNpYSBDcmVhdGl2ZSBDb21tb25zIEF0cmlidWNpw7NuLU5vQ29tZXJjaWFsIDQuMCBJbnRlcm5hY2lvbmFsPC9hPi4=

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