Metabolic Syndrome: Is It Time to Add the Central Nervous System?
Metabolic syndrome (MS) is a set of cardio-metabolic risk factors that includes central obesity, hyperglycemia, hypertension, and dyslipidemias. The syndrome affects 25% of adults worldwide. The definition of MS has evolved over the last 80 years, with various classification systems and criteria, wh...
- Autores:
-
Rojas, Milagros
Chávez-Castillo, Mervin
Pirela, Daniela
Parra, Heliana
Nava, Manuel
Chacín, Maricarmen
Angarita, Lissé
Añez, Roberto
Salazar, Juan
Ortiz, Rina
Durán Agüero, Samuel
Gravini-Donado, Marbel
Bermúdez, Valmore
Díaz-Camargo, Edgar
- Tipo de recurso:
- Fecha de publicación:
- 2021
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/8318
- Palabra clave:
- metabolic syndrome
insulin resistance
diabetes mellitus type 2
mild cognitive impairment
Alzheimer’s disease
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Metabolic Syndrome: Is It Time to Add the Central Nervous System? |
| title |
Metabolic Syndrome: Is It Time to Add the Central Nervous System? |
| spellingShingle |
Metabolic Syndrome: Is It Time to Add the Central Nervous System? metabolic syndrome insulin resistance diabetes mellitus type 2 mild cognitive impairment Alzheimer’s disease |
| title_short |
Metabolic Syndrome: Is It Time to Add the Central Nervous System? |
| title_full |
Metabolic Syndrome: Is It Time to Add the Central Nervous System? |
| title_fullStr |
Metabolic Syndrome: Is It Time to Add the Central Nervous System? |
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Metabolic Syndrome: Is It Time to Add the Central Nervous System? |
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Metabolic Syndrome: Is It Time to Add the Central Nervous System? |
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Rojas, Milagros Chávez-Castillo, Mervin Pirela, Daniela Parra, Heliana Nava, Manuel Chacín, Maricarmen Angarita, Lissé Añez, Roberto Salazar, Juan Ortiz, Rina Durán Agüero, Samuel Gravini-Donado, Marbel Bermúdez, Valmore Díaz-Camargo, Edgar |
| dc.contributor.author.none.fl_str_mv |
Rojas, Milagros Chávez-Castillo, Mervin Pirela, Daniela Parra, Heliana Nava, Manuel Chacín, Maricarmen Angarita, Lissé Añez, Roberto Salazar, Juan Ortiz, Rina Durán Agüero, Samuel Gravini-Donado, Marbel Bermúdez, Valmore Díaz-Camargo, Edgar |
| dc.subject.eng.fl_str_mv |
metabolic syndrome insulin resistance diabetes mellitus type 2 mild cognitive impairment Alzheimer’s disease |
| topic |
metabolic syndrome insulin resistance diabetes mellitus type 2 mild cognitive impairment Alzheimer’s disease |
| description |
Metabolic syndrome (MS) is a set of cardio-metabolic risk factors that includes central obesity, hyperglycemia, hypertension, and dyslipidemias. The syndrome affects 25% of adults worldwide. The definition of MS has evolved over the last 80 years, with various classification systems and criteria, whose limitations and benefits are currently the subject of some controversy. Likewise, hypotheses regarding the etiology of MS add more confusion from clinical and epidemiological points of view. The leading suggestion for the pathophysiology of MS is insulin resistance (IR). IR can affect multiple tissues and organs, from the classic “triumvirate” (myocyte, adipocyte, and hepatocyte) to possible effects on organs considered more recently, such as the central nervous system (CNS). Mild cognitive impairment (MCI) and Alzheimer’s disease (AD) may be clinical expressions of CNS involvement. However, the association between MCI and MS is not understood. The bidirectional relationship that seems to exist between these factors raises the questions of which phenomenon occurs first and whether MCI can be a precursor of MS. This review explores shared pathophysiological mechanisms between MCI and MS and establishes a hypothesis of a possible MCI role in the development of IR and the appearance of MS. |
| publishDate |
2021 |
| dc.date.accessioned.none.fl_str_mv |
2021-09-09T21:32:18Z |
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2021-09-09T21:32:18Z |
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2021-06 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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Artículo científico |
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20726643 |
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https://hdl.handle.net/20.500.12442/8318 |
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https://doi.org/10.3390/nu13072254 |
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20726643 |
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https://hdl.handle.net/20.500.12442/8318 https://doi.org/10.3390/nu13072254 |
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eng |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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pdf |
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MDPI |
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Nutrients |
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Vol. 13, No. 7, 2021 |
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Universidad Simón Bolívar |
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Rojas, Milagrosd07a9d4d-cce2-438c-b4a0-fc5ed4af1a67Chávez-Castillo, Mervin912e1d3d-18fb-43af-8edb-826137f74a5aPirela, Danielaf7d00476-6884-4e9b-b972-aa1b154fcf02Parra, Heliana13603b25-99ce-42ac-a469-5b65a89ce794Nava, Manuelcf0ca570-5fc3-4ec7-9913-90be952261e2Chacín, Maricarmen5c3b3d7c-4444-47e2-b2be-11f08df10409Angarita, Lissécd37d36e-0d41-457f-9dc8-1ed5b9201b16Añez, Roberto0a8ecfdc-a89a-4435-9859-b66bba8947faSalazar, Juanfbd053e7-5aea-424c-812f-92153ecb9181Ortiz, Rinab50c3253-2c29-426f-b91b-165deb110151Durán Agüero, Samuel1ec96ecd-37dc-4900-9d2c-11f00f2c2d7dGravini-Donado, Marbelf5216d16-f0e2-4742-a70b-587021000208Bermúdez, Valmore29f9aa18-16a4-4fd3-8ce5-ed94a0b8663aDíaz-Camargo, Edgare056554f-7c70-4102-b9c6-bad4ba6afb392021-09-09T21:32:18Z2021-09-09T21:32:18Z2021-0620726643https://hdl.handle.net/20.500.12442/8318https://doi.org/10.3390/nu13072254Metabolic syndrome (MS) is a set of cardio-metabolic risk factors that includes central obesity, hyperglycemia, hypertension, and dyslipidemias. The syndrome affects 25% of adults worldwide. The definition of MS has evolved over the last 80 years, with various classification systems and criteria, whose limitations and benefits are currently the subject of some controversy. Likewise, hypotheses regarding the etiology of MS add more confusion from clinical and epidemiological points of view. The leading suggestion for the pathophysiology of MS is insulin resistance (IR). IR can affect multiple tissues and organs, from the classic “triumvirate” (myocyte, adipocyte, and hepatocyte) to possible effects on organs considered more recently, such as the central nervous system (CNS). Mild cognitive impairment (MCI) and Alzheimer’s disease (AD) may be clinical expressions of CNS involvement. However, the association between MCI and MS is not understood. The bidirectional relationship that seems to exist between these factors raises the questions of which phenomenon occurs first and whether MCI can be a precursor of MS. This review explores shared pathophysiological mechanisms between MCI and MS and establishes a hypothesis of a possible MCI role in the development of IR and the appearance of MS.pdfengMDPIAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2NutrientsVol. 13, No. 7, 2021metabolic syndromeinsulin resistancediabetes mellitus type 2mild cognitive impairmentAlzheimer’s diseaseMetabolic Syndrome: Is It Time to Add the Central Nervous System?info:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Hennekens, C.H.; Andreotti, F. Leading Avoidable Cause of Premature Deaths Worldwide: Case for Obesity. Am. J. Med. 2013, 126, 97–98. [CrossRef] [PubMedAlberti, K.G.M.M.; Eckel, R.H.; Grundy, S.M.; Zimmet, P.Z.; Cleeman, J.I.; Donato, K.A.; Smith, S.C., Jr. Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009, 120, 1640–1645.Mente, A.; Yusuf, S.; Islam, S.; McQueen, M.J.; Tanomsup, S.; Onen, C.L.; Rangarajan, S.; Gerstein, H.C.; Anand, S.S. Metabolic syndrome and risk of acute myocardial infarction a case-control study of 26,903 subjects from 52 countries. J. Am. Coll. Cardiol. 2010, 55, 2390–2398. [CrossRef]Kerekes, G.; Nurmohamed, M.T.; González-Gay, M.A.; Seres, I.; Paragh, G.; Kardos, Z.; Baráth, Z.; Tamási, L.; Soltész, P.; Szekanecz, Z. Rheumatoid arthritis and metabolic syndrome. Nat. Rev. Rheumatol. 2014, 10, 691–696. [CrossRef] [PubMed]Uzunlulu, M.; Caklili, O.T.; Oguz, A. Association between Metabolic Syndrome and Cancer. Ann. Nutr. Metab. 2016, 68, 173–179. [CrossRef]Bangen, K.J.; Armstrong, N.M.; Au, R.; Gross, A.L. Metabolic Syndrome and Cognitive Trajectories in the Framingham Offspring Study. J. Alzheimer’s Dis. 2019, 71, 931–943. [CrossRef]Laws, S.M.; Gaskin, S.; Woodfield, A.; Srikanth, V.; Bruce, D.; Fraser, P.E.; Porter, T.; Newsholme, P.; Wijesekara, N.; Burnham, S.; et al. Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults. Sci. Rep. 2017, 7, 1–11. [CrossRef]Petersen, R.C.; Roberts, R.O.; Knopman, D.S.; Boeve, B.F.; Geda, Y.E.; Ivnik, R.J.; Smith, G.E.; Jack, C.R., Jr. Mild cognitive impairment: Ten years later. Arch. Neurol. 2009, 66, 1447–1455. [CrossRef] [PubMed]Sanford, A.M. Mild Cognitive Impairment. Clin. Geriatr. Med. 2017, 33, 325–337. [CrossRef] [PubMed]Biessels, G.J.; Despa, F. Cognitive decline and dementia in diabetes mellitus: Mechanisms and clinical implications. Nat. Rev. Endocrinol. 2018, 14, 591–604. [CrossRef] [PubMed]Arnold, S.E.; Arvanitakis, Z.; Macauley-Rambach, S.L.; Koenig, A.M.; Wang, H.-Y.; Ahima, R.S.; Craft, S.; Gandy, S.; Buettner, C.; Stoeckel, L.E.; et al. Brain insulin resistance in type 2 diabetes and Alzheimer disease: Concepts and conundrums. Nat. Rev. Neurol. 2018, 14, 168–181. [CrossRef]Kylin, E. Hypertonie and Zuckerkrankheit. Zent. Inn. Med. 1921, 42, 873–877Marañon, G. Über Hypertonie and Zuckerkrankheit. Zent. Inn. Med. 1922, 43, 169–176Hanefeld, M.; Leonhardt, W. Das Metabolische Syndrom. Dt Gesundh Wesen. 1981, 36, 545–551. [CrossRef]Reaven, G.M. Banting lecture Role of insulin resistance in human disease. Diabetes 1988, 37, 1595–1607. [CrossRef]Reaven, G.M. Why Syndrome X? From Harold Himsworth to the Insulin Resistance Syndrome. Cell Metab. 2005, 1, 9–14. 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Cortical Neurons Develop Insulin Resistance and Blunted Akt Signaling: A Potential Mechanism Contributing to Enhanced Ischemic Injury in Diabetes. Antioxidants Redox Signal. 2011, 14, 1829–1839. [CrossRef]Zhang, Y.; Huang, N.-Q.; Yan, F.; Jin, H.; Zhou, S.-Y.; Shi, J.-S.; Jin, F. Diabetes mellitus and Alzheimer’s disease: GSK-3β as a potential link. Behav. Brain Res. 2018, 339, 57–65. [CrossRef]Esposito, G.; Scuderi, C.; Lu, J.; Savani, C.; De Filippis, D.; Iuvone, T.; Steardo, L., Jr.; Sheen, V.; Steardo, L. S100B induces tau protein hyperphosphorylation via Dickopff-1 up-regulation and disrupts the Wnt pathway in human neural stem cells. J. Cell. Mol. Med. 2008, 12, 914–927. [CrossRef]van der Harg, J.M.; Eggels, L.; Bangel, F.N.; Ruigrok, S.R.; Zwart, R.; Hoozemans, J.J.M.; la Fleur, S.E.; Scheper, W. Insulin deficiency results in reversible protein kinase A activation and tau phosphorylation. Neurobiol. Dis. 2017, 103, 163–173. [CrossRef]Gratuze, M.; Julien, J.; Petry, F.R.; Morin, F.; Planel, E. Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer’s disease-like tau pathology. Sci. Rep. 2017, 7, srep46359. [CrossRef]Kins, S.; Crameri, A.; Evans, D.R.; Hemmings, B.A.; Nitsch, R.M.; Gotz, J. Reduced protein phosphatase 2A activity induces hyper-phosphorylation and altered compartmentalization of tau in transgenic mice. J. Biol. Chem. 2001, 276, 38193–38200. [CrossRef]Planel, E.; Tatebayashi, Y.; Miyasaka, T.; Liu, L.; Wang, L.; Herman, M.; Yu, W.H.; Luchsinger, J.A.; Wadzinski, B.; Duff, K.E.; et al. Insulin dysfunction induces in vivo tau hyperphos-phorylation through distinct mechanisms. J. Neurosci. Off. J. Soc. Neurosci. 2007, 27, 13635–13648. [CrossRef]Zilka, N.; Filipcik, P.; Koson, P.; Fialova, L.; Skrabana, R.; Zilkova, M.; Rolkova, G.P.; Kontsekova, E.; Novak, M. 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