Prediabetes and CKD: does a causal relationship exist?

The relationship between diabetes and the development of kidney complications is well known, but the understanding of prediabetes and insulin resistance with impaired kidney function has been scarcely assessed. Various factors could explain this phenomenon, from the lack of standardization in the de...

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Autores:: Rico Fontalvo, Jorge
Soler, María José
Daza Arnedo, Rodrigo
Navarro-Blackaller, Guillermo
Medina-González, Ramón
Rodríguez Yánez, Tomas
Cardona-Blanco, Maria
Cabrales-Juan, Jose
Uparrela-Gulfo, Isabella
Chávez-Iñiguez, Jonathan S.

Tipo de recurso:

Fecha de publicación:: 2024

Institución:: Universidad Simón Bolívar

Repositorio:: Repositorio Digital USB

Idioma:: spa

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dc.title.eng.fl_str_mv	Prediabetes and CKD: does a causal relationship exist?
title	Prediabetes and CKD: does a causal relationship exist?
spellingShingle	Prediabetes and CKD: does a causal relationship exist? Prediabetes Chronic kidney disease Albuminuria Hyperglycemia
title_short	Prediabetes and CKD: does a causal relationship exist?
title_full	Prediabetes and CKD: does a causal relationship exist?
title_fullStr	Prediabetes and CKD: does a causal relationship exist?
title_full_unstemmed	Prediabetes and CKD: does a causal relationship exist?
title_sort	Prediabetes and CKD: does a causal relationship exist?
dc.creator.fl_str_mv	Rico Fontalvo, Jorge Soler, María José Daza Arnedo, Rodrigo Navarro-Blackaller, Guillermo Medina-González, Ramón Rodríguez Yánez, Tomas Cardona-Blanco, Maria Cabrales-Juan, Jose Uparrela-Gulfo, Isabella Chávez-Iñiguez, Jonathan S.
dc.contributor.author.none.fl_str_mv	Rico Fontalvo, Jorge Soler, María José Daza Arnedo, Rodrigo Navarro-Blackaller, Guillermo Medina-González, Ramón Rodríguez Yánez, Tomas Cardona-Blanco, Maria Cabrales-Juan, Jose Uparrela-Gulfo, Isabella Chávez-Iñiguez, Jonathan S.
dc.subject.keywords.eng.fl_str_mv	Prediabetes Chronic kidney disease Albuminuria Hyperglycemia
topic	Prediabetes Chronic kidney disease Albuminuria Hyperglycemia
description	The relationship between diabetes and the development of kidney complications is well known, but the understanding of prediabetes and insulin resistance with impaired kidney function has been scarcely assessed. Various factors could explain this phenomenon, from the lack of standardization in the definitions of prediabetes, to the erratic and inconsistent evidence in large-scale epidemiological and cohort studies. It seems that the pathophysiological pathway of prediabetes could be related to inflammation and neurohormonal hyperactivation, factors present even before the onset of diabetes, which might be the main drivers of glomerular hyperfiltration, albuminuria, and impaired glomerular filtration rate. It is possible that existing treatments for the management of diabetes, as metformin or SGLT2 inhibitors may also be useful in patients with prediabetes with evidence of functional and structural kidney damage. The purpose of this review is to summarize the evidence regarding the relationship between prediabetes(preDM) and the development of CKD.
publishDate	2024
dc.date.accessioned.none.fl_str_mv	2024-06-24T14:44:11Z
dc.date.available.none.fl_str_mv	2024-06-24T14:44:11Z
dc.date.issued.none.fl_str_mv	2024
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dc.type.spa.none.fl_str_mv	Artículo científico
dc.identifier.citation.eng.fl_str_mv	Fontalvo JR, Soler MJ, Arnedo RD, Navarro-Blackaller G, Medina-González R, Yánez TR, Cardona-Blanco M, Cabrales-Juan J, Uparrela-Gulfo I, Chávez-Iñiguez JS, Prediabetes and CKD: does a causal relationship exist? (2024), doi: https://doi.org/10.1016/j.nefro.2024.06.008
dc.identifier.issn.none.fl_str_mv	19892284 (Online) 02116995 (Print)
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12442/14763
dc.identifier.doi.none.fl_str_mv	https://doi.org/doi:10.1016/j.nefro.2024.06.008
dc.identifier.url.none.fl_str_mv	https://www.sciencedirect.com/science/article/pii/S0211699524000626?via%3Dihub
identifier_str_mv	Fontalvo JR, Soler MJ, Arnedo RD, Navarro-Blackaller G, Medina-González R, Yánez TR, Cardona-Blanco M, Cabrales-Juan J, Uparrela-Gulfo I, Chávez-Iñiguez JS, Prediabetes and CKD: does a causal relationship exist? (2024), doi: https://doi.org/10.1016/j.nefro.2024.06.008 19892284 (Online) 02116995 (Print)
url	https://hdl.handle.net/20.500.12442/14763 https://doi.org/doi:10.1016/j.nefro.2024.06.008 https://www.sciencedirect.com/science/article/pii/S0211699524000626?via%3Dihub
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dc.format.mimetype.none.fl_str_mv	pdf
dc.publisher.spa.fl_str_mv	Sociedad Española de Nefrología
dc.source.spa.fl_str_mv	Revista Nefrología
institution	Universidad Simón Bolívar
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spelling	Rico Fontalvo, Jorgea156782c-eb0d-4540-a7cb-92742ffaee75-1Soler, María José5cd4b83e-a3e6-41df-a0dd-23f304e3daab-1Daza Arnedo, Rodrigo82ba690f-f5de-45bc-bc67-5d2f7ca76c9f-1Navarro-Blackaller, Guillermo5fecde20-a2eb-43eb-89f6-c801d89d9477-1Medina-González, Ramón6291eb4b-a74d-4b1e-aab5-730001468c7d-1Rodríguez Yánez, Tomas00e89aa4-b3ac-45aa-b6fc-a2fbee3797fe-1Cardona-Blanco, Maria0a18b5cd-012b-427b-b3f3-f6812b02ba90-1Cabrales-Juan, Jose74a87125-92c7-48d1-9dfd-3598637a3a82-1Uparrela-Gulfo, Isabella2fa76e82-d0ed-4523-a91a-9492a31f4976-1Chávez-Iñiguez, Jonathan S.66d4e176-c039-4119-86bf-c916b9334705-12024-06-24T14:44:11Z2024-06-24T14:44:11Z2024Fontalvo JR, Soler MJ, Arnedo RD, Navarro-Blackaller G, Medina-González R, Yánez TR, Cardona-Blanco M, Cabrales-Juan J, Uparrela-Gulfo I, Chávez-Iñiguez JS, Prediabetes and CKD: does a causal relationship exist? (2024), doi: https://doi.org/10.1016/j.nefro.2024.06.00819892284 (Online)02116995 (Print)https://hdl.handle.net/20.500.12442/14763https://doi.org/doi:10.1016/j.nefro.2024.06.008https://www.sciencedirect.com/science/article/pii/S0211699524000626?via%3DihubThe relationship between diabetes and the development of kidney complications is well known, but the understanding of prediabetes and insulin resistance with impaired kidney function has been scarcely assessed. Various factors could explain this phenomenon, from the lack of standardization in the definitions of prediabetes, to the erratic and inconsistent evidence in large-scale epidemiological and cohort studies. It seems that the pathophysiological pathway of prediabetes could be related to inflammation and neurohormonal hyperactivation, factors present even before the onset of diabetes, which might be the main drivers of glomerular hyperfiltration, albuminuria, and impaired glomerular filtration rate. It is possible that existing treatments for the management of diabetes, as metformin or SGLT2 inhibitors may also be useful in patients with prediabetes with evidence of functional and structural kidney damage. The purpose of this review is to summarize the evidence regarding the relationship between prediabetes(preDM) and the development of CKD.pdfspaSociedad Española de NefrologíaAttribution-NonCommercial-NoDerivs 3.0 United Stateshttp://creativecommons.org/licenses/by-nc-nd/3.0/us/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Revista NefrologíaPrediabetes and CKD: does a causal relationship exist?info:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/resource_type/c_2df8fbb1PrediabetesChronic kidney diseaseAlbuminuriaHyperglycemiaEchouffo-Tcheugui JB, Selvin E. Prediabetes and What It Means: The Epidemiological Evidence. Annu Rev Public Health. 2021 Apr 1;42:59–77.Echouffo-Tcheugui JB, Narayan KM, Weisman D, Golden SH, Jaar BG. Association between prediabetes and risk of chronic kidney disease: a systematic review and meta-analysis. Diabet Med J Br Diabet Assoc. 2016 Dec;33(12):1615–24.Cosic V, Jakab J, Pravecek MK, Miskic B. The Importance of Prediabetes Screening in the Prevention of Cardiovascular Disease. Med Arch Sarajevo Bosnia Herzeg. 2023 Apr;77(2):97–104.Kim SH. A Nuanced Relationship Between Prediabetes and Chronic Kidney Disease. J Clin Endocrinol Metab. 2020 Apr 1;105(4):dgaa079.Rett K, Gottwald-Hostalek U. Understanding prediabetes: definition, prevalence, burden and treatment options for an emerging disease. Curr Med Res Opin. 2019 Sep;35(9):1529–34.American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014 Jan;37 Suppl 1:S81-90.World Health Organization, Federation ID. Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia : report of a WHO/IDF consultation [Internet]. World Health Organization; 2006 [cited 2023 Mar 6]. Available from: https://apps.who.int/iris/handle/10665/43588Tabák AG, Herder C, Rathmann W, Brunner EJ, Kivimäki M. Prediabetes: a highrisk state for diabetes development. Lancet Lond Engl. 2012 Jun 16;379(9833):2279–90.Zheng R, Xu Y, Li M, Gao Z, Wang G, Hou X, et al. Data-driven subgroups of prediabetes and the associations with outcomes in Chinese adults. Cell Rep Med. 2023 Mar 21;4(3):100958.James C, Bullard KM, Rolka DB, Geiss LS, Williams DE, Cowie CC, et al. Implications of alternative definitions of prediabetes for prevalence in U.S. adults. Diabetes Care. 2011 Feb;34(2):387–91.Gujral UP, Jagannathan R, He S, Huang M, Staimez LR, Wei J, et al. Association between varying cut-points of intermediate hyperglycemia and risk of mortality, cardiovascular events and chronic kidney disease: a systematic review and meta-analysis. BMJ Open Diabetes Res Care. 2021 Apr;9(1):e001776.Cai X, Liu X, Sun L, He Y, Zheng S, Zhang Y, et al. Prediabetes and the risk of heart failure: A meta-analysis. Diabetes Obes Metab. 2021 Aug;23(8):1746–53.Mai L, Wen W, Qiu M, Liu X, Sun L, Zheng H, et al. Association between prediabetes and adverse outcomes in heart failure. Diabetes Obes Metab. 2021 Nov;23(11):2476–83Jin J, Lu P. Association Between Prediabetes and Retinopathy: A Meta-Analysis. Horm Metab Res Horm Stoffwechselforschung Horm Metab. 2021 Dec;53(12):801–9.Jin M, Yuan S, Wang B, Yi L, Wang C. Association Between Prediabetes and Erectile Dysfunction: A Meta-Analysis. Front Endocrinol. 2021;12:733434.Cobo Marcos M, de la Espriella R, Gayán Ordás J, Llàcer P, Pomares A, Fort A, et al. Prevalence and clinical profile of kidney disease in patients with chronic heart failure. Insights from the Spanish cardiorenal registry. Rev Espanola Cardiol Engl Ed. 2023 May 20;S1885-5857(23)00140-8.Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group. KDIGO 2020 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease. Kidney Int. 2020 Oct;98(4S):S1–115.de Boer IH, Khunti K, Sadusky T, Tuttle KR, Neumiller JJ, Rhee CM, et al. Diabetes Management in Chronic Kidney Disease: A Consensus Report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO). Diabetes Care. 2022 Dec 1;45(12):3075–90.Ali MK, Bullard KM, Saydah S, Imperatore G, Gregg EW. Cardiovascular and renal burdens of prediabetes in the USA: analysis of data from serial cross-sectional surveys, 1988-2014. Lancet Diabetes Endocrinol. 2018 May;6(5):392–403.Huang Y, Cai X, Mai W, Li M, Hu Y. Association between prediabetes and risk of cardiovascular disease and all cause mortality: systematic review and meta-analysis. BMJ. 2016 Nov 23;355:i5953.Tang O, Matsushita K, Coresh J, Sharrett AR, McEvoy JW, Windham BG, et al. Mortality Implications of Prediabetes and Diabetes in Older Adults. Diabetes Care. 2020 Feb;43(2):382–8.Shilpasree AS, Patil VS, Revanasiddappa M, Patil VP, Ireshnavar D. Renal Dysfunction in Prediabetes: Confirmed by Glomerular Hyperfiltration and Albuminuria. J Lab Physicians. 2021 Sep;13(3):257–62.Koye DN, Magliano DJ, Nelson RG, Pavkov ME. The Global Epidemiology of Diabetes and Kidney Disease. Adv Chronic Kidney Dis. 2018 Mar;25(2):121–32.Lamprou S, Koletsos N, Mintziori G, Anyfanti P, Trakatelli C, Kotsis V, et al. Microvascular and Endothelial Dysfunction in Prediabetes. Life Basel Switz. 2023 Feb 25;13(3):644.Daza-Arnedo R, Rico-Fontalvo JE, Pájaro-Galvis N, Leal-Martínez V, Abuabara- Franco E, Raad-Sarabia M, et al. Dipeptidyl Peptidase-4 Inhibitors and Diabetic Kidney Disease: A Narrative Review. Kidney Med. 2021 Dec;3(6):1065–73.Neves JS, Correa S, Baeta Baptista R, Bigotte Vieira M, Waikar SS, Mc Causland FR. Association of Prediabetes With CKD Progression and Adverse Cardiovascular Outcomes: An Analysis of the CRIC Study. 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JAMA Netw Open. 2021 Mar 1;4(3):e212612.Kawata I, Koshi T, Hirabayashi K, Koike H, Sato Y, Yamashita K, et al. Prediabetes defined by the International Expert Committee as a risk for development of glomerular hyperfiltration. Acta Diabetol. 2019 May;56(5):525–9.Lay AC, Coward RJM. The Evolving Importance of Insulin Signaling in Podocyte Health and Disease. Front Endocrinol. 2018;9:693.Pina AF, Borges DO, Meneses MJ, Branco P, Birne R, Vilasi A, et al. Insulin: Trigger and Target of Renal Functions. Front Cell Dev Biol. 2020;8:519.Melsom T, Schei J, Stefansson VTN, Solbu MD, Jenssen TG, Mathisen UD, et al. Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study. Am J Kidney Dis Off J Natl Kidney Found. 2016 Jun;67(6):841–50.Okada R, Wakai K, Naito M, Morita E, Kawai S, Yin G, et al. Renal hyperfiltration in prediabetes confirmed by fasting plasma glucose and hemoglobin A1c. 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J Diabetes Res. 2022;2022:2971382.Zhou Y, Huang Y, Ji X, Wang X, Shen L, Wang Y. Pioglitazone for the Primary and Secondary Prevention of Cardiovascular and Renal Outcomes in Patients with or at High Risk of Type 2 Diabetes Mellitus: A Meta-Analysis. J Clin Endocrinol Metab. 2020 May 1;105(5):dgz252.Galaviz KI, Weber MB, Suvada K, Gujral UP, Wei J, Merchant R, et al. Interventions for Reversing Prediabetes: A Systematic Review and Meta-Analysis. Am J Prev Med. 2022 Apr;62(4):614–25.American Diabetes Association. 5. Prevention or Delay of Type 2 Diabetes: Standards of Medical Care in Diabetes-2018. Diabetes Care. 2018 Jan;41(Suppl 1):S51–4.Diabetes Prevention Program Research Group, Knowler WC, Fowler SE, Hamman RF, Christophi CA, Hoffman HJ, et al. 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet Lond Engl. 2009 Nov 14;374(9702):1677–86.Heerspink HJL, Stefánsson BV, Correa-Rotter R, Chertow GM, Greene T, Hou FF, et al. Dapagliflozin in Patients with Chronic Kidney Disease. N Engl J Med. 2020 Oct 8;383(15):1436–46.Empagliflozin in Patients with Chronic Kidney Disease. N Engl J Med. 2023 Jan 12;388(2):117–27.Prandi FR, Barone L, Lecis D, Belli M, Sergi D, Milite M, et al. Biomolecular Mechanisms of Cardiorenal Protection with Sodium-Glucose Co-Transporter 2 Inhibitors. Biomolecules. 2022 Sep 22;12(10):1349.Jaikumkao K, Pongchaidecha A, Chueakula N, Thongnak LO, Wanchai K, Chatsudthipong V, et al. Dapagliflozin, a sodium-glucose co-transporter-2 inhibitor, slows the progression of renal complications through the suppression of renal inflammation, endoplasmic reticulum stress and apoptosis in prediabetic rats. Diabetes Obes Metab. 2018 Nov;20(11):2617–26.PERSSON F, ROSSING P, VART P, CHERTOW GM, HOU FF, MCMURRAY JJ, et al. 317-OR: Efficacy and Safety of Dapagliflozin by Glycemic Status in the DAPA-CKD Trial. Diabetes. 2021 Jun 1;70(Supplement_1):317-OR.Persson F, Rossing P, Vart P, Chertow GM, Hou FF, Jongs N, et al. Efficacy and Safety of Dapagliflozin by Baseline Glycemic Status: A Prespecified Analysis From the DAPA-CKD Trial. Diabetes Care. 2021 Aug;44(8): 1894-7Y, Duru OK, Tuttle KR, Fukuma S, Taura D, Harada N, et al. Sodium- Glucose Cotransporter 2 Inhibitors and New-onset Type 2 Diabetes in Adults With Prediabetes: Systematic Review and Meta-analysis of Randomized Controlled Trials. J Clin Endocrinol Metab. 2022 Dec 17;108(1):87-104Merovci A, Solis-Herrera C, Daniele G, Eldor R, Fiorentino TV, Tripathy D, et al. Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production. J Clin Invest. 2014 Feb;124(2):509–14.Al Jorobi H, Daniele G, Adams J, Cersosimo E, Solis-Herrera C, Triplitt C, et al. Empagliflozin Treatment Is Associated With Improved β-Cell Function in Type 2 Diabetes Mellitus. 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Prediabetes and CKD: does a causal relationship exist?

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