The A54T polymorphism in the FABP2 gene and its relationship with obesity

Introduction: Obesity is a complex, multifactorial, and mostly preventable disease affecting, along with overweight, more than a third of today’s world population. Variations in the nucleotide sequence of both metabolic and appetite control genes have been counted among these non-modifiable factors...

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Autores:: Torres, Maritza
Prieto, Carem
Ortiz, Rina
Siguencia, Wilson
Durán, Pablo
Pérez, José
Díaz, María P.
Rojas, Milagros
Chacín, Maricarmen
Cano, Clímaco
Bermúdez, Valmore

Tipo de recurso:

Fecha de publicación:: 2020

Institución:: Universidad Simón Bolívar

Repositorio:: Repositorio Digital USB

Idioma:: eng

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dc.title.eng.fl_str_mv	The A54T polymorphism in the FABP2 gene and its relationship with obesity
title	The A54T polymorphism in the FABP2 gene and its relationship with obesity
spellingShingle	The A54T polymorphism in the FABP2 gene and its relationship with obesity Obesity Polymorphism Mutations Cardiovascular diseases Type 2 Diabetes mellitus FABP2 Obesidad Polimorfismo Enfermedades cardiovasculares Diabetes mellitus de tipo 2
title_short	The A54T polymorphism in the FABP2 gene and its relationship with obesity
title_full	The A54T polymorphism in the FABP2 gene and its relationship with obesity
title_fullStr	The A54T polymorphism in the FABP2 gene and its relationship with obesity
title_full_unstemmed	The A54T polymorphism in the FABP2 gene and its relationship with obesity
title_sort	The A54T polymorphism in the FABP2 gene and its relationship with obesity
dc.creator.fl_str_mv	Torres, Maritza Prieto, Carem Ortiz, Rina Siguencia, Wilson Durán, Pablo Pérez, José Díaz, María P. Rojas, Milagros Chacín, Maricarmen Cano, Clímaco Bermúdez, Valmore
dc.contributor.author.none.fl_str_mv	Torres, Maritza Prieto, Carem Ortiz, Rina Siguencia, Wilson Durán, Pablo Pérez, José Díaz, María P. Rojas, Milagros Chacín, Maricarmen Cano, Clímaco Bermúdez, Valmore
dc.subject.eng.fl_str_mv	Obesity Polymorphism Mutations Cardiovascular diseases Type 2 Diabetes mellitus FABP2
topic	Obesity Polymorphism Mutations Cardiovascular diseases Type 2 Diabetes mellitus FABP2 Obesidad Polimorfismo Enfermedades cardiovasculares Diabetes mellitus de tipo 2
dc.subject.spa.fl_str_mv	Obesidad Polimorfismo Enfermedades cardiovasculares Diabetes mellitus de tipo 2
description	Introduction: Obesity is a complex, multifactorial, and mostly preventable disease affecting, along with overweight, more than a third of today’s world population. Variations in the nucleotide sequence of both metabolic and appetite control genes have been counted among these non-modifiable factors and are associated with BMI, lipidic profile, and abdominal circumference alterations. Methods: An analytical, non-experimental, and transversal research was done with the purpose to assess the presence of A54T polymorphism in the FABP gene in a sub-sample from the Maracaibo City Metabolic Syndrome Prevalence Study. Results: 154 individuals eight subjects were carriers of the A54Tpolymorphism, namely, a genotypic frequency of 5.19 %, with a sex distribution of 50 % for women (n=4) and 50 % (n=4) for men. In respect of alleles similarity degree, 75 % (n=6) were homozygous, and 25 % (n=2) were heterozygous. Obesity diagnosis throughout BMI was only present in 12.50 % (n=1) of the A54T carriers. Conversely, 25 % (n=2) of the carriers were overweighed; 50 % (n=4) were presented as normal-weight people; and only 12.50 % (n=1), in one underweighted person. Conclusion: As in many other studies, we do not find an association between Ala54Thr polymorphism and obesity. This result reinforces the fact of the multifactorial character of these diseases and a carrier state of this polymorphism is not necessarily to experience a higher obesity risk, at least, in our environment.
publishDate	2020
dc.date.accessioned.none.fl_str_mv	2020-12-16T03:25:27Z
dc.date.available.none.fl_str_mv	2020-12-16T03:25:27Z
dc.date.issued.none.fl_str_mv	2020
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dc.type.spa.spa.fl_str_mv	Artículo científico
dc.identifier.issn.none.fl_str_mv	03674762
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12442/6915
dc.identifier.url.none.fl_str_mv	http://saber.ucv.ve/ojs/index.php/rev_gmc/article/view/19367
identifier_str_mv	03674762
url	https://hdl.handle.net/20.500.12442/6915 http://saber.ucv.ve/ojs/index.php/rev_gmc/article/view/19367
dc.language.iso.eng.fl_str_mv	eng
language	eng
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rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.mimetype.spa.fl_str_mv	pdf
dc.publisher.spa.fl_str_mv	Saber UCV, Universidad Central de Venezuela
dc.source.spa.fl_str_mv	Gaceta Médica de Caracas
dc.source.none.fl_str_mv	Vol. 128, No. 3 (2020)
institution	Universidad Simón Bolívar
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spelling	Torres, Maritza4a2fb4bf-1dad-4c34-9d52-0b205b381716Prieto, Carem63062c43-96c0-48f4-a739-bea7bec417bbOrtiz, Rinab50c3253-2c29-426f-b91b-165deb110151Siguencia, Wilsonbc8fa02d-f37f-4171-a0e1-6be351429d2dDurán, Pablo6bb3ca43-d725-4ff0-ae00-4eda6cdbeea4Pérez, Joséf0034820-9a7a-4179-b03a-40d6dea23fbaDíaz, María P.e5017bb2-15b8-412f-a151-05cba49ffa99Rojas, Milagrosd07a9d4d-cce2-438c-b4a0-fc5ed4af1a67Chacín, Maricarmen5c3b3d7c-4444-47e2-b2be-11f08df10409Cano, Clímacob7d55d6b-f1bf-4136-9b90-54a80ab90ab2Bermúdez, Valmore29f9aa18-16a4-4fd3-8ce5-ed94a0b8663a2020-12-16T03:25:27Z2020-12-16T03:25:27Z202003674762https://hdl.handle.net/20.500.12442/6915http://saber.ucv.ve/ojs/index.php/rev_gmc/article/view/19367Introduction: Obesity is a complex, multifactorial, and mostly preventable disease affecting, along with overweight, more than a third of today’s world population. Variations in the nucleotide sequence of both metabolic and appetite control genes have been counted among these non-modifiable factors and are associated with BMI, lipidic profile, and abdominal circumference alterations. Methods: An analytical, non-experimental, and transversal research was done with the purpose to assess the presence of A54T polymorphism in the FABP gene in a sub-sample from the Maracaibo City Metabolic Syndrome Prevalence Study. Results: 154 individuals eight subjects were carriers of the A54Tpolymorphism, namely, a genotypic frequency of 5.19 %, with a sex distribution of 50 % for women (n=4) and 50 % (n=4) for men. In respect of alleles similarity degree, 75 % (n=6) were homozygous, and 25 % (n=2) were heterozygous. Obesity diagnosis throughout BMI was only present in 12.50 % (n=1) of the A54T carriers. Conversely, 25 % (n=2) of the carriers were overweighed; 50 % (n=4) were presented as normal-weight people; and only 12.50 % (n=1), in one underweighted person. Conclusion: As in many other studies, we do not find an association between Ala54Thr polymorphism and obesity. This result reinforces the fact of the multifactorial character of these diseases and a carrier state of this polymorphism is not necessarily to experience a higher obesity risk, at least, in our environment.La obesidad es una enfermedad compleja, multifactorial y en su mayor parte prevenible que afecta, a más de un tercio de la población mundial actual. Las variaciones en la secuencia de nucleótidos de los genes de control del metabolismo y del apetito se consideran hasta ahora como factores no modificables y se asocian con alteraciones del IMC, del perfil lipídico y de la circunferencia abdominal. Métodos: Se realizó una investigación analítica, no experimental y transversal con el propósito de evaluar la presencia del polimorfismo A54T en el gen FABP en una submuestra del Estudio de Prevalencia del Síndrome Metabólico de la Ciudad de Maracaibo. Resultados: De los 154 individuos de la submuestra ocho sujetos fueron portadores del polimorfismo A54T, es decir, una frecuencia genotípica de 5,19 %, con una distribución por sexo de 50 % para las mujeres (n=4) y 50 % (n=4) para los hombres. Con respecto al grado de similitud de los alelos, el 75 % (n=6) eran homocigotos y el 25 % (n=2) heterocigotos. El diagnóstico de obesidad a lo largo del IMC sólo estuvo presente en el 12,50 % (n=1) de los portadores de A54T. Por el contrario, el 25 % (n=2) de los portadores tenían sobrepeso; el 50 % (n=4) se presentaron como personas de peso normal; y sólo el 12,50 % (n=1) en la categoría de peso insuficiente. Conclusión: No se encontró una asociación entre el polimorfismo de Ala54Thr y la obesidad. Este resultado refuerza el carácter multifactorial de estas enfermedades y que un estado portador de este polimorfismo no es causa necesaria para padecer obesidad, al menos, en nuestro medio.pdfengSaber UCV, Universidad Central de VenezuelaAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Gaceta Médica de CaracasVol. 128, No. 3 (2020)ObesityPolymorphismMutationsCardiovascular diseasesType 2 Diabetes mellitusFABP2ObesidadPolimorfismoEnfermedades cardiovascularesDiabetes mellitus de tipo 2The A54T polymorphism in the FABP2 gene and its relationship with obesityinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Bermúdez Pirela V, Herazo Beltrán Y, Valero P, Souki A, Arráiz Rodríguez NJ, Prieto Fuenmayor C, et al. Aspectos básicos en obesidad. Ediciones Universidad Simón Bolívar; 2018.OMS \| Obesidad y sobrepeso. WHO n.d. http://www. who.int/mediacentre/factsheets/fs311/es/ (accessed March 28, 2017).Albala B C, Jiménez R B, Pérez B F, Liberman G C. Polimorfismo de la proteína ligante de ácidos grasos intestinal (FABP2), obesidad e insulina resistencia. Rev Méd Chile 2006;134. https://doi.org/10.4067/ S0034-98872006000300017.Albala B C, Jiménez R B, Pérez B F, Liberman G C. Polimorfismo de la proteína ligante de ácidos grasos intestinal (FABP2), obesidad e insulina resistencia. Rev Méd Chile 2006;134:372-379. https://doi. org/10.4067/S0034-98872006000300017.Hernandez-Sampieri R. METODOLOGIA DE LA INVESTIGACION. Edición: 6. México, D.F.: McGraw-Hill Interamericana de España S.L.; 2014.Añez R, Morillo J, Rojas M, Torres Y, Apruzzese V, Martínez MS, et al. Punto de corte de homeostasis model assessment (HOMA-IR) para determinar insulinorresistencia en individuos adultos del municipio Maracaibo-Estado Zulia, Venezuela. 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Diabetes Metab. 2017;43:163-166. https://doi.org/10.1016/j. diabet.2016.09.004.Lackey AI, Chen T, Zhou YX, Bottasso Arias NM, Doran JM, Zacharisen SM, et al. Mechanisms underlying reduced weight gain in intestinal fatty acid-binding protein (IFABP) null mice. A J Physiol- Gastrointest. Liver Physiol. 2020;318:G518–30. https://doi.org/10.1152/ajpgi.00120.2019.Ordovas JM. Genetics, postprandial lipemia and obesity. Nutr Metab Cardiovasc Dis. NMCD. 2001;11:118-133.Berthier M-T, Couillard C, Prud’homme D, Nadeau A, Bergeron J, Tremblay A, et al. Effects of the FABP2 A54T Mutation on Triglyceride Metabolism of Viscerally Obese Men. Obes Res. 2001;9:668-675. https://doi.org/10.1038/oby.2001.91.Lewis MR, Tracy RP. The role of the immune system in the insulin resistance syndrome. Curr. Diab. Rep. 2002;2:96–9. https://doi.org/10.1007/s11892-002- 0064-8.Baier LJ, Sacchettini JC, Knowler WC, Eads J, Paolisso G, Tataranni PA, et al. 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The A54T polymorphism in the FABP2 gene and its relationship with obesity

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