Exploring the relationship between the Gut Microbiota and Ageing: A possible age modulator
The gut microbiota (GM) has been the subject of intense research in recent years. Therefore, numerous factors affecting its composition have been thoroughly examined, and with them, their function and role in the individual’s systems. The gut microbiota’s taxonomical composition dramatically impacts...
- Autores:
-
Salazar, Juan
Durán, Pablo
Díaz, María P.
Chacín, Maricarmen
Santeliz, Raquel
Mengual, Edgardo
Gutiérrez, Emma
León, Xavier
Díaz, Andrea
Bernal, Marycarlota
Escalona, Daniel
Parra Hernández, Luis Alberto
Bermúdez, Valmore
- Tipo de recurso:
- Fecha de publicación:
- 2023
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/13165
- Palabra clave:
- Gut microbiota
Ageing
Longevity
Immune system
Centenarian
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Exploring the relationship between the Gut Microbiota and Ageing: A possible age modulator |
| title |
Exploring the relationship between the Gut Microbiota and Ageing: A possible age modulator |
| spellingShingle |
Exploring the relationship between the Gut Microbiota and Ageing: A possible age modulator Gut microbiota Ageing Longevity Immune system Centenarian |
| title_short |
Exploring the relationship between the Gut Microbiota and Ageing: A possible age modulator |
| title_full |
Exploring the relationship between the Gut Microbiota and Ageing: A possible age modulator |
| title_fullStr |
Exploring the relationship between the Gut Microbiota and Ageing: A possible age modulator |
| title_full_unstemmed |
Exploring the relationship between the Gut Microbiota and Ageing: A possible age modulator |
| title_sort |
Exploring the relationship between the Gut Microbiota and Ageing: A possible age modulator |
| dc.creator.fl_str_mv |
Salazar, Juan Durán, Pablo Díaz, María P. Chacín, Maricarmen Santeliz, Raquel Mengual, Edgardo Gutiérrez, Emma León, Xavier Díaz, Andrea Bernal, Marycarlota Escalona, Daniel Parra Hernández, Luis Alberto Bermúdez, Valmore |
| dc.contributor.author.none.fl_str_mv |
Salazar, Juan Durán, Pablo Díaz, María P. Chacín, Maricarmen Santeliz, Raquel Mengual, Edgardo Gutiérrez, Emma León, Xavier Díaz, Andrea Bernal, Marycarlota Escalona, Daniel Parra Hernández, Luis Alberto Bermúdez, Valmore |
| dc.subject.eng.fl_str_mv |
Gut microbiota Ageing Longevity Immune system Centenarian |
| topic |
Gut microbiota Ageing Longevity Immune system Centenarian |
| description |
The gut microbiota (GM) has been the subject of intense research in recent years. Therefore, numerous factors affecting its composition have been thoroughly examined, and with them, their function and role in the individual’s systems. The gut microbiota’s taxonomical composition dramatically impacts older adults’ health status. In this regard, it could either extend their life expectancy via the modulation of metabolic processes and the immune system or, in the case of dysbiosis, predispose them to age-related diseases, including bowel inflammatory and musculoskeletal diseases and metabolic and neurological disorders. In general, the microbiome of the elderly tends to present taxonomic and functional changes, which can function as a target to modulate the microbiota and improve the health of this population. The GM of centenarians is unique, with the faculty-promoting metabolic pathways capable of preventing and counteracting the different processes associated with age-related diseases. The molecular mechanisms by which the microbiota can exhibit anti-ageing properties are mainly based on anti-inflammatory and antioxidant actions. This review focuses on analysing the current knowledge of gut microbiota characteristics and modifiers, its relationship with ageing, and the GM-modulating approaches to increase life expectancy. |
| publishDate |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2023-08-19T19:45:14Z |
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2023-08-19T19:45:14Z |
| dc.date.issued.none.fl_str_mv |
2023 |
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info:eu-repo/semantics/article |
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Artículo científico |
| dc.identifier.citation.eng.fl_str_mv |
Salazar, J.; Durán, P.; Díaz, M.P.; Chacín, M.; Santeliz, R.; Mengual, E.; Gutiérrez, E.; León, X.; Díaz, A.; Bernal, M.; et al. Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator. Int. J. Environ. Res. Public Health 2023, 20, 5845. https://doi.org/10.3390/ijerph20105845 |
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16604601 |
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https://hdl.handle.net/20.500.12442/13165 |
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https://doi.org/10.3390/ijerph20105845 |
| identifier_str_mv |
Salazar, J.; Durán, P.; Díaz, M.P.; Chacín, M.; Santeliz, R.; Mengual, E.; Gutiérrez, E.; León, X.; Díaz, A.; Bernal, M.; et al. Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator. Int. J. Environ. Res. Public Health 2023, 20, 5845. https://doi.org/10.3390/ijerph20105845 16604601 |
| url |
https://hdl.handle.net/20.500.12442/13165 https://doi.org/10.3390/ijerph20105845 |
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eng |
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eng |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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pdf |
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MDPI |
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International Journal of Environmental Research and Public Health Vol. 20 Issue 10 (2023) |
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Salazar, Juanfbd053e7-5aea-424c-812f-92153ecb9181Durán, Pablo6bb3ca43-d725-4ff0-ae00-4eda6cdbeea4Díaz, María P.e5017bb2-15b8-412f-a151-05cba49ffa99Chacín, Maricarmen5c3b3d7c-4444-47e2-b2be-11f08df10409Santeliz, Raquel5e2f7a44-1208-4164-83cb-743abf6a557dMengual, Edgardo5edba640-de3b-4a53-9282-38702933c2a8Gutiérrez, Emma7705ea22-6dbe-425b-b05b-a5dacd11dcc9León, Xavierbf70c08a-cf3c-4ce3-b3e2-823dee88d835Díaz, Andreab0824160-4dec-47a7-96c6-b7f49a750f1aBernal, Marycarlota846bfea5-30c4-4f35-b961-e31bf79aee9bEscalona, Daniel0d731e82-c39a-40b3-b682-16c02e731a2aParra Hernández, Luis Alberto276479aa-68fc-403e-bbfa-8bf2df858fbcBermúdez, Valmore29f9aa18-16a4-4fd3-8ce5-ed94a0b8663a2023-08-19T19:45:14Z2023-08-19T19:45:14Z2023Salazar, J.; Durán, P.; Díaz, M.P.; Chacín, M.; Santeliz, R.; Mengual, E.; Gutiérrez, E.; León, X.; Díaz, A.; Bernal, M.; et al. Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator. Int. J. Environ. Res. Public Health 2023, 20, 5845. https://doi.org/10.3390/ijerph2010584516604601https://hdl.handle.net/20.500.12442/13165https://doi.org/10.3390/ijerph20105845The gut microbiota (GM) has been the subject of intense research in recent years. Therefore, numerous factors affecting its composition have been thoroughly examined, and with them, their function and role in the individual’s systems. The gut microbiota’s taxonomical composition dramatically impacts older adults’ health status. In this regard, it could either extend their life expectancy via the modulation of metabolic processes and the immune system or, in the case of dysbiosis, predispose them to age-related diseases, including bowel inflammatory and musculoskeletal diseases and metabolic and neurological disorders. In general, the microbiome of the elderly tends to present taxonomic and functional changes, which can function as a target to modulate the microbiota and improve the health of this population. The GM of centenarians is unique, with the faculty-promoting metabolic pathways capable of preventing and counteracting the different processes associated with age-related diseases. The molecular mechanisms by which the microbiota can exhibit anti-ageing properties are mainly based on anti-inflammatory and antioxidant actions. This review focuses on analysing the current knowledge of gut microbiota characteristics and modifiers, its relationship with ageing, and the GM-modulating approaches to increase life expectancy.pdfengMDPIAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2International Journal of Environmental Research and Public HealthVol. 20 Issue 10 (2023)Gut microbiotaAgeingLongevityImmune systemCentenarianExploring the relationship between the Gut Microbiota and Ageing: A possible age modulatorinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Han, S.; Van Treuren, W.; Fischer, C.R.; Merrill, B.D.; DeFelice, B.C.; Sanchez, J.M.; Higginbottom, S.K.; Guthrie, L.; Fall, L.A.; Dodd, D.; et al. A metabolomics pipeline for the mechanistic interrogation of the gut microbiome. Nature 2021, 595, 415–420.Sankar, S.A.; Lagier, J.C.; Pontarotti, P.; Raoult, D.; Fournier, P.E. The human gut microbiome, a taxonomic conundrum. Syst. Appl. Microbiol. 2015, 38, 276–286.Fan, Y.; Pedersen, O. Gut microbiota in human metabolic health and disease. Nat. Rev. Microbiol. 2021, 19, 55–71Thursby, E.; Juge, N. Introduction to the human gut microbiota. Biochem. J. 2017, 474, 1823–183.Schluter, J.; Peled, J.; Taylor, B.P.; Markey, K.A.; Smith, J.A.; Taur, Y.; Niehus, R.; Staffas, A.; Dai, A.; Fontana, E.; et al. The gut microbiota is associated with immune cell dynamics in humans. Nature 2020, 588, 303–307The Integrative HMP (iHMP) Research Network Consortium. The Integrative Human Microbiome Project. Nature 2019, 569, 641–648.Ma, Q.; Xing, C.; Long, W.; Wang, H.Y.; Liu, Q.; Wang, R.F. Impact of microbiota on central nervous system and neurological diseases: The gut-brain axis. J. Neuroinflamm. 2019, 16, 53.The Milieu Intérieur Consortium; Scepanovic, P.; Hodel, F.; Mondot, S.; Partula, V.; Byrd, A.; Hammer, C.; Alanio, C.; Bergstedt, J.; Patin, E.; et al. A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals. Microbiome 2019, 7, 130Redondo-Useros, N.; Nova, E.; González-Zancada, N.; Díaz, L.E.; Gómez-Martínez, S.; Marcos, A. Microbiota and Lifestyle: A Special Focus on Diet. Nutrients 2020, 12, 1776.Bermúdez, V.; Durán, P.; Rojas, E.; Díaz, M.P.; Rivas, J.; Nava, M.; Chacín, M.; Cabrera de Bravo, M.; Carrasquero, R.; Ponce, C.C.; et al. The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium. Front. Endocrinol. 2021, 12, 735070.De Luca, F.; Shoenfeld, Y. The microbiome in autoimmune diseases. Clin. Exp. 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