A narrative review and expert panel recommendations on dyslipidaemia management after acute coronary syndrome in countries outside western Europe and North America

Patients who have experienced an acute coronary syndrome (ACS) are at very high risk of recurrent atherosclerotic cardiovascular disease (CVD) events. Dyslipidaemia, a major risk factor for CVD, is poorly controlled post ACS in countries outside Western Europe and North America, despite the availabi...

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Autores:: Reda, Ashraf
Almahmeed, Wael
Idit, Dobrecky-Mery
Po-Hsun, Huang
Juarez-Herrera, Ursulo
Ranjith, Naresh
Sayre, Tobias
Urina-Triana, Miguel

Tipo de recurso:

Fecha de publicación:: 2020

Institución:: Universidad Simón Bolívar

Repositorio:: Repositorio Digital USB

Idioma:: eng

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dc.title.eng.fl_str_mv	A narrative review and expert panel recommendations on dyslipidaemia management after acute coronary syndrome in countries outside western Europe and North America
title	A narrative review and expert panel recommendations on dyslipidaemia management after acute coronary syndrome in countries outside western Europe and North America
spellingShingle	A narrative review and expert panel recommendations on dyslipidaemia management after acute coronary syndrome in countries outside western Europe and North America Atherosclerosis Acute coronary syndrome Dyslipidaemia LDL-C PCSK9 inhibitor Statin
title_short	A narrative review and expert panel recommendations on dyslipidaemia management after acute coronary syndrome in countries outside western Europe and North America
title_full	A narrative review and expert panel recommendations on dyslipidaemia management after acute coronary syndrome in countries outside western Europe and North America
title_fullStr	A narrative review and expert panel recommendations on dyslipidaemia management after acute coronary syndrome in countries outside western Europe and North America
title_full_unstemmed	A narrative review and expert panel recommendations on dyslipidaemia management after acute coronary syndrome in countries outside western Europe and North America
title_sort	A narrative review and expert panel recommendations on dyslipidaemia management after acute coronary syndrome in countries outside western Europe and North America
dc.creator.fl_str_mv	Reda, Ashraf Almahmeed, Wael Idit, Dobrecky-Mery Po-Hsun, Huang Juarez-Herrera, Ursulo Ranjith, Naresh Sayre, Tobias Urina-Triana, Miguel
dc.contributor.author.none.fl_str_mv	Reda, Ashraf Almahmeed, Wael Idit, Dobrecky-Mery Po-Hsun, Huang Juarez-Herrera, Ursulo Ranjith, Naresh Sayre, Tobias Urina-Triana, Miguel
dc.subject.eng.fl_str_mv	Atherosclerosis Acute coronary syndrome Dyslipidaemia LDL-C PCSK9 inhibitor Statin
topic	Atherosclerosis Acute coronary syndrome Dyslipidaemia LDL-C PCSK9 inhibitor Statin
description	Patients who have experienced an acute coronary syndrome (ACS) are at very high risk of recurrent atherosclerotic cardiovascular disease (CVD) events. Dyslipidaemia, a major risk factor for CVD, is poorly controlled post ACS in countries outside Western Europe and North America, despite the availability of effective lipid-modifying therapies (LMTs) and guidelines governing their use. Recent guideline updates recommend that low-density lipoprotein cholesterol (LDL-C), the primary target for dyslipidaemia therapy, be reduced by C 50% and to \1.4 mmol/L (55 mg/dL) in patients at very high risk of CVD, including those with ACS. The high prevalence of CVD risk factors in some regions outside Western Europe and North America confers a higher risk of CVD on patients in these countries. ACS onset is often earlier in these patients, and they may be more challenging to treat. Other barriers to effective dyslipidaemia control include low awareness of the value of intensive lipid lowering in patients with ACS, physician non-adherence to guideline recommendations, and lack of efficacy of currently used LMTs. Lack of appropriate pathways to guide follow-up of patients with ACS post discharge and poor access to intensive medications are important factors limiting dyslipidaemia therapy in many countries. Opportunities exist to improve attainment of LDL-C targets by the use of country-specific treatment algorithms to promote adherence to guideline recommendations, medical education and greater prioritisation by healthcare systems of dyslipidaemia management in very high risk patients.
publishDate	2020
dc.date.accessioned.none.fl_str_mv	2020-04-02T21:15:06Z
dc.date.available.none.fl_str_mv	2020-04-02T21:15:06Z
dc.date.issued.none.fl_str_mv	2020-02-12
dc.type.eng.fl_str_mv	article
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dc.type.driver.eng.fl_str_mv	article
dc.identifier.issn.none.fl_str_mv	0741238X
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12442/5084
dc.identifier.doi.none.fl_str_mv	https://doi.org/10.1007/s12325-020-01302-4
identifier_str_mv	0741238X
url	https://hdl.handle.net/20.500.12442/5084 https://doi.org/10.1007/s12325-020-01302-4
dc.language.iso.eng.fl_str_mv	eng
language	eng
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_14cb
dc.format.mimetype.spa.fl_str_mv	pdf
dc.publisher.eng.fl_str_mv	Springer
dc.source.eng.fl_str_mv	Advances in Therapy
dc.source.spa.fl_str_mv	Vol. 37, N° 2 Año (2020)
institution	Universidad Simón Bolívar
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spelling	Reda, Ashraf1e71d322-8c76-4611-825b-4e8ce2a55f0eAlmahmeed, Wael4c7f9862-85a0-47dd-8a55-45cac7bc7616Idit, Dobrecky-Mery009d986d-4760-445b-beb1-93d9bbaceb3bPo-Hsun, Huang7e49d9c3-c15e-47ec-85cb-5bfcb1b51eccJuarez-Herrera, Ursulocd113a60-2fcc-4d44-97d5-d64dd730c192Ranjith, Naresh9359403c-a501-40fb-aa40-56f48a674d63Sayre, Tobias7227af58-cbed-42b7-a0c8-ed3915684579Urina-Triana, Migueld749d19c-0dae-4d0b-8e9a-6d623d682f9e2020-04-02T21:15:06Z2020-04-02T21:15:06Z2020-02-120741238Xhttps://hdl.handle.net/20.500.12442/5084https://doi.org/10.1007/s12325-020-01302-4Patients who have experienced an acute coronary syndrome (ACS) are at very high risk of recurrent atherosclerotic cardiovascular disease (CVD) events. Dyslipidaemia, a major risk factor for CVD, is poorly controlled post ACS in countries outside Western Europe and North America, despite the availability of effective lipid-modifying therapies (LMTs) and guidelines governing their use. Recent guideline updates recommend that low-density lipoprotein cholesterol (LDL-C), the primary target for dyslipidaemia therapy, be reduced by C 50% and to \1.4 mmol/L (55 mg/dL) in patients at very high risk of CVD, including those with ACS. The high prevalence of CVD risk factors in some regions outside Western Europe and North America confers a higher risk of CVD on patients in these countries. ACS onset is often earlier in these patients, and they may be more challenging to treat. Other barriers to effective dyslipidaemia control include low awareness of the value of intensive lipid lowering in patients with ACS, physician non-adherence to guideline recommendations, and lack of efficacy of currently used LMTs. Lack of appropriate pathways to guide follow-up of patients with ACS post discharge and poor access to intensive medications are important factors limiting dyslipidaemia therapy in many countries. Opportunities exist to improve attainment of LDL-C targets by the use of country-specific treatment algorithms to promote adherence to guideline recommendations, medical education and greater prioritisation by healthcare systems of dyslipidaemia management in very high risk patients.pdfengSpringerAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_14cbAdvances in TherapyVol. 37, N° 2 Año (2020)AtherosclerosisAcute coronary syndromeDyslipidaemiaLDL-CPCSK9 inhibitorStatinA narrative review and expert panel recommendations on dyslipidaemia management after acute coronary syndrome in countries outside western Europe and North Americaarticlearticlehttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ ASPC/NLA/PCNA guideline on the management of blood cholesterol: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2019;73:3168–209.Mach F, Baigent C, Catapano AL, et al. 2019 ESC/ EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020;41:111–88.Pearson TA, Laurora I, Chu H, Kafonek S. The lipid treatment assessment project (L-TAP): a multicenter survey to evaluate the percentages of dyslipidemic patients receiving lipid-lowering therapy andachieving low-density lipoprotein cholesterol goals. Arch Intern Med. 2000;160:459–67.Waters DD, Brotons C, Chiang CW, et al. Lipid treatment assessment project 2: a multinational survey to evaluate the proportion of patients achieving low-density lipoprotein cholesterol goals. Circulation. 2009;120:28–34.Reiner Z, De Backer G, Fras Z, et al. Lipid lowering drug therapy in patients with coronary heart disease from 24 European countries—findings from the EUROASPIRE IV survey. Atherosclerosis. 2016;246: 243–50.Kotseva K, De Bacquer D, Jennings C, et al. 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Impact of prior use of four preventive medications on outcomes in patients hospitalized for acute coronary syndrome—results from CPACS-2 Study. PLoS One. 2016;11:e0163068.Sun YJ, Li YZ, Jiang DM, et al. Relationship between low-density lipoprotein levels on admission and 1-year outcome in patients with acute ST-segmentelevation myocardial infarction. Kaohsiung J Med Sci. 2013;29:206–13.Tian L, Yang Y, Zhu J, et al. Impact of previous stroke on short-term myocardial reinfarction in patients with acute ST segment elevation myocardial infarction: an observational multicenter study. Medicine. 2016;95:e2742.Wang Y, Cong H, Lu C, Liu J, Wu J. Use of secondary prevention medications among patients with acute coronary syndromes in Tianjin, China. Value Health. 2017;20:A276–7.Poh KK, Ambegaonkar B, Baxter CA, et al. 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J Clin Exp Cardiol. 2011;2:1000163.CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://bonga.unisimon.edu.co/bitstreams/62cd6268-4a38-4006-b6f4-5d8540a73834/download4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8381https://bonga.unisimon.edu.co/bitstreams/2cbfc728-ba6e-4235-8f41-5979534e7ba9/download733bec43a0bf5ade4d97db708e29b185MD5320.500.12442/5084oai:bonga.unisimon.edu.co:20.500.12442/50842024-08-14 21:53:50.759http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internacionalmetadata.onlyhttps://bonga.unisimon.edu.coRepositorio Digital Universidad Simón Bolívarrepositorio.digital@unisimon.edu.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

A narrative review and expert panel recommendations on dyslipidaemia management after acute coronary syndrome in countries outside western Europe and North America

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