Diseño y evaluación de un prototipo de test para detección de nefropatía hipertensiva
La hipertensión arterial (HA) y la enfermedad renal crónica (ERC) presentan una carga sanitaria global considerable, con la HA actuando como un factor de riesgo silente pero potente para la ERC. El seguimiento de la progresión de la ERC en pacientes con HA es fundamental para prevenir el avance haci...
- Autores:
-
Espinosa Garavito, Alberto Carlos
- Tipo de recurso:
- Fecha de publicación:
- 2024
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- spa
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/14644
- Acceso en línea:
- https://hdl.handle.net/20.500.12442/14644
- Palabra clave:
- Hipertensión
Daño renal
Espectroscopia Raman de superficie mejorada
Nanopartículas de oro
Anticuerpos
Orina
Quimiometría
Hypertension
Renal damage
Surface-enhanced Raman spectroscopy
Gold nanoparticles
Antibodies
Urine
Chemometrics
- Rights
- restrictedAccess
- License
- http://purl.org/coar/access_right/c_16ec
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Diseño y evaluación de un prototipo de test para detección de nefropatía hipertensiva |
| title |
Diseño y evaluación de un prototipo de test para detección de nefropatía hipertensiva |
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Diseño y evaluación de un prototipo de test para detección de nefropatía hipertensiva Hipertensión Daño renal Espectroscopia Raman de superficie mejorada Nanopartículas de oro Anticuerpos Orina Quimiometría Hypertension Renal damage Surface-enhanced Raman spectroscopy Gold nanoparticles Antibodies Urine Chemometrics |
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Diseño y evaluación de un prototipo de test para detección de nefropatía hipertensiva |
| title_full |
Diseño y evaluación de un prototipo de test para detección de nefropatía hipertensiva |
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Diseño y evaluación de un prototipo de test para detección de nefropatía hipertensiva |
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Diseño y evaluación de un prototipo de test para detección de nefropatía hipertensiva |
| title_sort |
Diseño y evaluación de un prototipo de test para detección de nefropatía hipertensiva |
| dc.creator.fl_str_mv |
Espinosa Garavito, Alberto Carlos |
| dc.contributor.advisor.none.fl_str_mv |
Navarro Quiroz , Elkin Villa Medina , Joe Luis Pacheco Londoño, Leonardo Carlos |
| dc.contributor.author.none.fl_str_mv |
Espinosa Garavito, Alberto Carlos |
| dc.subject.spa.fl_str_mv |
Hipertensión Daño renal Espectroscopia Raman de superficie mejorada Nanopartículas de oro Anticuerpos Orina Quimiometría Hypertension |
| topic |
Hipertensión Daño renal Espectroscopia Raman de superficie mejorada Nanopartículas de oro Anticuerpos Orina Quimiometría Hypertension Renal damage Surface-enhanced Raman spectroscopy Gold nanoparticles Antibodies Urine Chemometrics |
| dc.subject.eng.fl_str_mv |
Renal damage Surface-enhanced Raman spectroscopy Gold nanoparticles Antibodies Urine Chemometrics |
| description |
La hipertensión arterial (HA) y la enfermedad renal crónica (ERC) presentan una carga sanitaria global considerable, con la HA actuando como un factor de riesgo silente pero potente para la ERC. El seguimiento de la progresión de la ERC en pacientes con HA es fundamental para prevenir el avance hacia la insuficiencia renal y las comorbilidades asociadas. Sin embargo, los métodos convencionales de detección, basados en la medición de la presión arterial y en biomarcadores como la proteinuria y la creatinina sérica, a menudo fallan en identificar las etapas tempranas del daño renal. |
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2024 |
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2024-05-15T14:19:48Z |
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2024-05-15T14:19:48Z |
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2024 |
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http://purl.org/coar/resource_type/c_db06 |
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info:eu-repo/semantics/doctoralThesis |
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Tesis de doctorado |
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https://hdl.handle.net/20.500.12442/14644 |
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https://hdl.handle.net/20.500.12442/14644 |
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Navarro Quiroz , ElkinVilla Medina , Joe LuisPacheco Londoño, Leonardo CarlosEspinosa Garavito, Alberto Carlos11663c0c-f778-49f4-b1c6-a53c00738216-12024-05-15T14:19:48Z2024-05-15T14:19:48Z2024https://hdl.handle.net/20.500.12442/14644La hipertensión arterial (HA) y la enfermedad renal crónica (ERC) presentan una carga sanitaria global considerable, con la HA actuando como un factor de riesgo silente pero potente para la ERC. El seguimiento de la progresión de la ERC en pacientes con HA es fundamental para prevenir el avance hacia la insuficiencia renal y las comorbilidades asociadas. Sin embargo, los métodos convencionales de detección, basados en la medición de la presión arterial y en biomarcadores como la proteinuria y la creatinina sérica, a menudo fallan en identificar las etapas tempranas del daño renal.High blood pressure (AH) and chronic kidney disease (CKD) present a considerable global health burden, with AH acting as a silent but potent risk factor for CKD. Monitoring the progression of CKD in patients with AH is essential to prevent progression to renal failure and associated comorbidities. However, conventional screening methods, based on blood pressure measurement and biomarkers such as proteinuria and serum creatinine, often fail to identify the early stages of kidney damage.pdfspaEdiciones Universidad Simón BolívarHipertensiónDaño renalEspectroscopia Raman de superficie mejoradaNanopartículas de oroAnticuerposOrinaQuimiometríaHypertensionRenal damageSurface-enhanced Raman spectroscopyGold nanoparticlesAntibodiesUrineChemometricsDiseño y evaluación de un prototipo de test para detección de nefropatía hipertensivainfo:eu-repo/semantics/restrictedAccesshttp://purl.org/coar/access_right/c_16ecinfo:eu-repo/semantics/doctoralThesisTesis de doctoradohttp://purl.org/coar/resource_type/c_db06M. M. Lopera-Medina, “La enfermedad renal crónica en Colombia: Necesidades en salud y respuesta del Sistema General de Seguridad Social en Salud,” Revista Gerencia y Politicas de Salud, vol. 15, no. 30, pp. 212–233, Jan. 2016, doi: 10.11144/Javeriana.rgyps15-30.ercc“Día mundial de la hipertensión arterial 2022 | Cuenta de Alto Costo.” Accessed: Oct. 10, 2022. [Online]. Available: https://cuentadealtocosto.org/site/general/diamundial-de-la-hipertension-arterial-2022/“Situación de la enfermedad renal crónica, la hipertensión arterial y diabetes mellitus en Colombia 2020 | Cuenta de Alto Costo.” Accessed: Oct. 11, 2022. [Online]. Available: https://cuentadealtocosto.org/site/publicaciones/situacion-de-laenfermedad-renal-cronica-la-hipertension-arterial-y-diabetes-mellitus-en-colombia2020/?1665593257100Fondo Colombiano de Enfermedades de Alto Costo Cuenta de Alto Costo (CAC), “Situación de la enfermedad renal crónica, la hipertensión arterial y la diabetes mellitus en Colombia 2022,” Bogotá, D.C., 2023.L. Acuña, P. Sánchez, L. A. Soler, and L. F. Alvis, “Enfermedad renal en Colombia: prioridad para la gestión de riesgo Investigación original.”S. e Arango, “Biomarcadores para la evaluación de riesgo en la salud humana,” Rev. Fac. Nac. Salud Pública, vol. 30, pp. 75–82, 2012.M. A. Martín-Gómez et al., “Glomerulonefritis colapsante con marcadores de desdiferenciación podocitaria en síndrome hemofagocítico secundario a linfoma hepatoesplénico de células T,” Biomedica, vol. 38, no. 4, pp. 456–462, 2018, doi: 10.7705/biomedica.v38i4.3893E. Vazquez Martul and M. Praga, “Anatomía patológica y nefrología. La necesidad de un cambio,” Nefrología, vol. 38, no. 3, pp. 247–249, May 2018, doi: 10.1016/j.nefro.2017.11.002.M. Seijas, C. Baccino, N. Nin, and J. A. Lorente, “Definición y biomarcadores de daño renal agudo: Nuevas perspectivas,” Medicina Intensiva, vol. 38, no. 6. Ediciones Doyma, S.L., pp. 376–385, 2014. doi: 10.1016/j.medin.2013.09.001.C. Nacional de Verificación de Maquinaria -María José Quintana San José -Miren Agurtzane Zugasti Macazaga -María del Carmen Uribe Zallo -Begoña Uribe Ortega, C. Nacional de Nuevas Tecnologías -Virginia Gálvez Pérez -María Encarnación Sousa Rodríguez -María Teresa Sánchez Cabo -Mercedes Colorado Soriano -Josefa Aguilar Franco Colaboradores, and -Rosa Méndez Zurutuza - Natividad Montes Beneitez -José Maria Rojo Aparicio -Antonia Hernández Castañeda -Silvia Torres Ruiz, “Elaborado por.” [Online]. Available: http://publicacionesoficiales.boe.eshttp://www.insht.es/catalogopublicaciones/F. De Química and L. 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Lê Cao, “mixOmics: An R package for ‘omics feature selection and multiple data integration,” PLoS Comput Biol, vol. 13, no. 11, Nov. 2017, doi: 10.1371/journal.pcbi.1005752.Sede BarranquillaDoctorado en Genética y Biología MolecularLICENSElicense.txtlicense.txttext/plain; charset=utf-83000https://bonga.unisimon.edu.co/bitstreams/4046014e-e4cb-46bb-ab33-2a2039605adf/download2a1661e5960a7bab4fd8dda692fb677cMD51ORIGINALPDF_Resumen.pdfPDF_Resumen.pdfapplication/pdf423937https://bonga.unisimon.edu.co/bitstreams/cfcf1379-966d-4439-aad3-49b3d2b817eb/download2a7e80ef0d501f23e6f466f92b0c43fcMD52TEXTPDF_RESUMEN.txtPDF_RESUMEN.txtExtracted texttext/plain57716https://bonga.unisimon.edu.co/bitstreams/dc86e027-898e-48dd-a09d-995e99d06e69/download6e7176eb2f1f2e9aafbc93fe2b5dd917MD53PDF_Resumen.pdf.txtPDF_Resumen.pdf.txtExtracted 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