Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties

Tellurium is a rare element that has been regarded as a toxic, nonessential element, and its biological role is not clearly established. In addition, the biological effects of elemental tellurium and some of its organic and inorganic derivatives have been studied, leading to a set of interesting and...

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Autores:
Trindade, Cristiano
Mendes Juchem, André Luiz
Guecheva, Temenouga N.
Oliveira, Iuri M. de
dos Santos Silveira, Priscila
Vargas, José Eduardo
Puga, Renato
Pessoa, Claudia Ó.
Henriques, João A. P.
Tipo de recurso:
Fecha de publicación:
2019
Institución:
Universidad Simón Bolívar
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Repositorio Digital USB
Idioma:
eng
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oai:bonga.unisimon.edu.co:20.500.12442/4383
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https://hdl.handle.net/20.500.12442/4383
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dc.title.eng.fl_str_mv Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties
title Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties
spellingShingle Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties
title_short Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties
title_full Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties
title_fullStr Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties
title_full_unstemmed Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties
title_sort Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties
dc.creator.fl_str_mv Trindade, Cristiano
Mendes Juchem, André Luiz
Guecheva, Temenouga N.
Oliveira, Iuri M. de
dos Santos Silveira, Priscila
Vargas, José Eduardo
Puga, Renato
Pessoa, Claudia Ó.
Henriques, João A. P.
dc.contributor.author.none.fl_str_mv Trindade, Cristiano
Mendes Juchem, André Luiz
Guecheva, Temenouga N.
Oliveira, Iuri M. de
dos Santos Silveira, Priscila
Vargas, José Eduardo
Puga, Renato
Pessoa, Claudia Ó.
Henriques, João A. P.
description Tellurium is a rare element that has been regarded as a toxic, nonessential element, and its biological role is not clearly established. In addition, the biological effects of elemental tellurium and some of its organic and inorganic derivatives have been studied, leading to a set of interesting and promising applications. Diphenyl ditelluride (DPDT), an organic tellurium derivate, showed antioxidant, antigenotoxic, antimutagenic, and anticancer properties. The antioxidant and prooxidant properties of DPDT are complex and depend on experimental conditions, which may explain the contradictory reports of these properties. In addition, DPDT may exert its effects through different pathways, including distinct ones to those responsible for chemotherapy resistance phenotypes: transcription factors, membrane receptors, adhesion, structural molecules, cell cycle regulatory components, and apoptosis pathways. This review aims to present recent advances in our understanding of the biological effects, therapeutic potential, and safety of DPDT treatment. Moreover, original results demonstrating the cytotoxic effects of DPDT in different mammalian cell lines and systems biology analysis are included, and emerging approaches for possible future applications are inferred.
publishDate 2019
dc.date.accessioned.none.fl_str_mv 2019-11-26T21:59:10Z
dc.date.available.none.fl_str_mv 2019-11-26T21:59:10Z
dc.date.issued.none.fl_str_mv 2019
dc.type.eng.fl_str_mv article
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.identifier.issn.none.fl_str_mv 19420900
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12442/4383
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url https://hdl.handle.net/20.500.12442/4383
dc.language.iso.eng.fl_str_mv eng
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dc.publisher.eng.fl_str_mv Hindawi
dc.source.eng.fl_str_mv Oxidative Medicine and Cellular Longevity
dc.source.spa.fl_str_mv Volume 2019
institution Universidad Simón Bolívar
dc.source.uri.spa.fl_str_mv https://doi.org/10.1155/2019/2510936
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spelling Trindade, Cristiano30b50065-9290-4b8a-837b-01634d3219d7Mendes Juchem, André Luiz8029481b-4296-4efc-8207-511092d279d8Guecheva, Temenouga N.e7e17ca9-1a89-44de-a472-2b528cff409dOliveira, Iuri M. de37b98348-1742-4f8f-93a4-ee998be560b3dos Santos Silveira, Priscila07a9136f-1f41-4346-bddc-fc856628c8edVargas, José Eduardo416f0def-6df6-4f2d-ad69-3c969af5664dPuga, Renato27951978-47c5-484c-a747-a0d418c2eb19Pessoa, Claudia Ó.798fe502-4198-40d6-92c4-8d141c1d0facHenriques, João A. P.1cfc7cec-c3fb-4bcb-ae53-26228c00decb2019-11-26T21:59:10Z2019-11-26T21:59:10Z201919420900https://hdl.handle.net/20.500.12442/4383Tellurium is a rare element that has been regarded as a toxic, nonessential element, and its biological role is not clearly established. In addition, the biological effects of elemental tellurium and some of its organic and inorganic derivatives have been studied, leading to a set of interesting and promising applications. Diphenyl ditelluride (DPDT), an organic tellurium derivate, showed antioxidant, antigenotoxic, antimutagenic, and anticancer properties. The antioxidant and prooxidant properties of DPDT are complex and depend on experimental conditions, which may explain the contradictory reports of these properties. In addition, DPDT may exert its effects through different pathways, including distinct ones to those responsible for chemotherapy resistance phenotypes: transcription factors, membrane receptors, adhesion, structural molecules, cell cycle regulatory components, and apoptosis pathways. This review aims to present recent advances in our understanding of the biological effects, therapeutic potential, and safety of DPDT treatment. Moreover, original results demonstrating the cytotoxic effects of DPDT in different mammalian cell lines and systems biology analysis are included, and emerging approaches for possible future applications are inferred.engHindawiAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Oxidative Medicine and Cellular LongevityVolume 2019https://doi.org/10.1155/2019/2510936Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Propertiesarticlehttp://purl.org/coar/resource_type/c_6501T. G. Chasteen, D. E. Fuentes, J. C. Tantaleán, and C. C. Vásquez, “Tellurite: history, oxidative stress, and molecular mechanisms of resistance,” FEMS Microbiology Reviews, vol. 33, no. 4, pp. 820–832, 2009.Y. Ogra, “Biology and toxicology of tellurium explored by speciation analysis,” Metallomics, vol. 9, no. 5, pp. 435–441, 2017.A. J. Larner, “How does garlic exert its hypocholesterolaemic action? 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Paccanaro, “Detecting overlapping protein complexes in protein-protein interaction networks,” Nature Methods, vol. 9, no. 5, pp. 471-472, 2012.ORIGINALPDF.pdfPDF.pdfPDFapplication/pdf2543853https://bonga.unisimon.edu.co/bitstreams/f90c7b52-3e4e-4dc7-b8e8-7061a89ff257/downloadd340bc8d93de1066e860281cea619fb1MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://bonga.unisimon.edu.co/bitstreams/3d5cccac-5d51-45e9-ad23-4464ad9ef5c4/download4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8381https://bonga.unisimon.edu.co/bitstreams/afef733f-5606-43f8-a7f6-f29f32c34960/download733bec43a0bf5ade4d97db708e29b185MD53TEXTDiphenyl_Ditelluride_Redox-Modulating.pdf.txtDiphenyl_Ditelluride_Redox-Modulating.pdf.txtExtracted texttext/plain68016https://bonga.unisimon.edu.co/bitstreams/9c079ec4-c1a8-4391-a2db-3f7befc189df/download21044aa9303e30e5583b5e47827ead56MD54PDF.pdf.txtPDF.pdf.txtExtracted texttext/plain69726https://bonga.unisimon.edu.co/bitstreams/e00fc21e-69fb-4e6b-b7bd-3ce566f05c26/download2db814293759aaa05f41c3e924973fb5MD56THUMBNAILDiphenyl_Ditelluride_Redox-Modulating.pdf.jpgDiphenyl_Ditelluride_Redox-Modulating.pdf.jpgGenerated Thumbnailimage/jpeg1637https://bonga.unisimon.edu.co/bitstreams/2475b5e3-8e48-4044-b50e-57339696975d/downloadb12fab332216ab09be0cbf4666df647eMD55PDF.pdf.jpgPDF.pdf.jpgGenerated Thumbnailimage/jpeg5560https://bonga.unisimon.edu.co/bitstreams/ca63be44-1b65-4456-b8f4-2aebed620e63/download66e00f30b0b1c82ec73d549a2f2d01eaMD5720.500.12442/4383oai:bonga.unisimon.edu.co:20.500.12442/43832024-08-14 21:52:21.08http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internacionalopen.accesshttps://bonga.unisimon.edu.coRepositorio Digital Universidad Simón Bolívarrepositorio.digital@unisimon.edu.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