Latin American registry of renal involvement in COVID-19 disease. The relevance of assessing proteinuria throughout the clinical course

The Latin American Society of Nephrology and Hypertension conducted a prospective cohort, multinational registry of Latin American patients with kidney impairment associated to COVID-19 infection with the objective to describe the characteristics of acute kidney disease under these circumstances. Th...

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Autores:
Lombardi, Raúl
Ferreiro, Alejandro
Ponce, Daniela
Claure-Del Granado, Rolando
Aroca, Gustavo
Venegas, Yanissa
Pereira, Mariana
Chavez-Iñiguez, Jonathan
Rojas, Nelson
Villa, Ana
Colombo, Marcos
Carlino, Cristina
Guimaraes, Caio
Younes-Ibrahim, Mauricio
Rizo, Lilia Maria
Guzmán, Gisselle
Varela, Carlos
Rosa-Diez, Guillermo
Janiques, Diego
Ayala, Roger
Coronel, Galo
Roessler, Eric
Amor, Serena
Osorio, Washington
Rivas, Natalia
Pereira, Benedito
de Azevedo, Caroline
Flores, Adriana
Ubillo, José
Raño, Julieta
Yu, Luis
Burdmann, Emmanuel A.
Rodríguez, Luis
Galagarza-Gutiérrez, Gianny
Curitomay-Cruz, Jesús
Tipo de recurso:
Fecha de publicación:
2022
Institución:
Universidad Simón Bolívar
Repositorio:
Repositorio Digital USB
Idioma:
eng
OAI Identifier:
oai:bonga.unisimon.edu.co:20.500.12442/9337
Acceso en línea:
https://hdl.handle.net/20.500.12442/9337
https://doi.org/10.1371/journal.pone.0261764
https://www.researchgate.net/publication/358185376_Latin_American_registry_of_renal_involvement_in_COVID-19_disease_The_relevance_of_assessing_proteinuria_throughout_the_clinical_course
Palabra clave:
Nephrology
Hypertension
COVID-19
Multiorgan dysfunction syndrome
Rights
openAccess
License
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Description
Summary:The Latin American Society of Nephrology and Hypertension conducted a prospective cohort, multinational registry of Latin American patients with kidney impairment associated to COVID-19 infection with the objective to describe the characteristics of acute kidney disease under these circumstances. The study was carried out through open invitation in order to describe the characteristics of the disease in the region. Eight-hundred and seventy patients from 12 countries were included. Median age was 63 years (54–74), most of patients were male (68.4%) and with diverse comorbidities (87.2%). Acute kidney injury (AKI) was hospital-acquired in 64.7% and non-oliguric in 59.9%. Multiorgan dysfunction syndrome (MODS) due to COVID-19 and volume depletion were the main factors contributing to AKI (59.2% and 35.7% respectively). Kidney replacement therapy was started in 46.2%. Non-recovery of renal function was observed in 65.3%. 71.5% of patients were admitted to ICU and 72.2% underwent mechanical ventilation. Proteinuria at admission was present in 62.4% of patients and proteinuria during hospital-stay occurred in 37.5%. Those patients with proteinuria at admission had higher burden of comorbidities, higher baseline sCr, and MODS was severe. On the other hand, patients with de novo proteinuria had lower incidence of comorbidities and near normal sCr at admission, but showed adverse course of disease. COVID-19 MODS was the main cause of AKI in both groups. All-cause mortality of the general population was 57.4%, and it was associated to age, sepsis as cause of AKI, severity of condition at admission, oliguria, mechanical ventilation, non-recovery of renal function, in-hospital complications and hospital stay. In conclusion, our study contributes to a better knowledge of this condition and highlights the relevance of the detection of proteinuria throughout the clinical course.