Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?

Chronic pain (CP) is a severe clinical entity with devastating physical and emotional consequences for patients, which can occur in a myriad of diseases. Often, conventional treatment approaches appear to be insufficient for its management. Moreover, considering the adverse effects of traditional an...

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Autores:: Chávez-Castillo, Mervin
Ortega, Ángel
Cudris-Torres, Lorena
Duran, Pablo
Rojas, Milagros
Manzano, Alexander
Garrido, Bermary
Salazar, Juan
Silva, Aljadis
Rojas-Gomez, Diana Marcela
De Sanctis, Juan B.
Bermúdez, Valmore

Tipo de recurso:

Fecha de publicación:: 2021

Institución:: Universidad Simón Bolívar

Repositorio:: Repositorio Digital USB

Idioma:: eng

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dc.title.eng.fl_str_mv	Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?
title	Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?
spellingShingle	Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy? Chronic pain Specialized pro-resolving lipid mediators Inflammation Long-term potentiation Central nervous system sensitization Polyunsaturated fatty acids Eicosanoids Nociception Omega 3 fatty acids Pain management
title_short	Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?
title_full	Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?
title_fullStr	Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?
title_full_unstemmed	Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?
title_sort	Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?
dc.creator.fl_str_mv	Chávez-Castillo, Mervin Ortega, Ángel Cudris-Torres, Lorena Duran, Pablo Rojas, Milagros Manzano, Alexander Garrido, Bermary Salazar, Juan Silva, Aljadis Rojas-Gomez, Diana Marcela De Sanctis, Juan B. Bermúdez, Valmore
dc.contributor.author.none.fl_str_mv	Chávez-Castillo, Mervin Ortega, Ángel Cudris-Torres, Lorena Duran, Pablo Rojas, Milagros Manzano, Alexander Garrido, Bermary Salazar, Juan Silva, Aljadis Rojas-Gomez, Diana Marcela De Sanctis, Juan B. Bermúdez, Valmore
dc.subject.eng.fl_str_mv	Chronic pain Specialized pro-resolving lipid mediators Inflammation Long-term potentiation Central nervous system sensitization Polyunsaturated fatty acids Eicosanoids Nociception Omega 3 fatty acids Pain management
topic	Chronic pain Specialized pro-resolving lipid mediators Inflammation Long-term potentiation Central nervous system sensitization Polyunsaturated fatty acids Eicosanoids Nociception Omega 3 fatty acids Pain management
description	Chronic pain (CP) is a severe clinical entity with devastating physical and emotional consequences for patients, which can occur in a myriad of diseases. Often, conventional treatment approaches appear to be insufficient for its management. Moreover, considering the adverse effects of traditional analgesic treatments, specialized pro-resolving lipid mediators (SPMs) have emerged as a promising alternative for CP. These include various bioactive molecules such as resolvins, maresins, and protectins, derived from ω-3 polyunsaturated fatty acids (PUFAs); and lipoxins, produced from ω-6 PUFAs. Indeed, SPMs have been demonstrated to play a central role in the regulation and resolution of the inflammation associated with CP. Furthermore, these molecules can modulate neuroinflammation and thus inhibit central and peripheral sensitizations, as well as long-term potentiation, via immunomodulation and regulation of nociceptor activity and neuronal pathways. In this context, preclinical and clinical studies have evidenced that the use of SPMs is beneficial in CP-related disorders, including rheumatic diseases, migraine, neuropathies, and others. This review integrates current preclinical and clinical knowledge on the role of SPMs as a potential therapeutic tool for the management of patients with CP.
publishDate	2021
dc.date.accessioned.none.fl_str_mv	2021-10-05T14:51:18Z
dc.date.available.none.fl_str_mv	2021-10-05T14:51:18Z
dc.date.issued.none.fl_str_mv	2021
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dc.type.spa.spa.fl_str_mv	Artículo científico
dc.identifier.citation.eng.fl_str_mv	Chávez-Castillo, M.; Ortega, Á.; Cudris-Torres, L.; Duran, P.; Rojas, M.; Manzano, A.; Garrido, B.; Salazar, J.; Silva, A.; Rojas-Gomez, D.M.; et al. Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?. Int. J. Mol. Sci. 2021, 22, 10370. https:// doi.org/10.3390/ijms221910370
dc.identifier.issn.none.fl_str_mv	14220067
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12442/8636
dc.identifier.doi.none.fl_str_mv	https:// doi.org/10.3390/ijms221910370
dc.identifier.url.none.fl_str_mv	https://www.mdpi.com/1422-0067/22/19/10370/htm
identifier_str_mv	Chávez-Castillo, M.; Ortega, Á.; Cudris-Torres, L.; Duran, P.; Rojas, M.; Manzano, A.; Garrido, B.; Salazar, J.; Silva, A.; Rojas-Gomez, D.M.; et al. Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?. Int. J. Mol. Sci. 2021, 22, 10370. https:// doi.org/10.3390/ijms221910370 14220067
url	https://hdl.handle.net/20.500.12442/8636 https:// doi.org/10.3390/ijms221910370 https://www.mdpi.com/1422-0067/22/19/10370/htm
dc.language.iso.eng.fl_str_mv	eng
language	eng
dc.rights.*.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.mimetype.spa.fl_str_mv	pdf
dc.publisher.eng.fl_str_mv	MDPI
dc.source.eng.fl_str_mv	International Journal of Molecular Sciences
dc.source.none.fl_str_mv	Vol. 22, No.19 (2021)
institution	Universidad Simón Bolívar
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spelling	Chávez-Castillo, Mervin912e1d3d-18fb-43af-8edb-826137f74a5aOrtega, Ángelb6a809bb-4d26-4e53-9419-e4eb9fb40a9bCudris-Torres, Lorenaf795de95-c059-4cdf-9b5e-0f60feec0752Duran, Pablo09ab4429-4e0a-42c4-a4e2-27b3560375bcRojas, Milagrosd07a9d4d-cce2-438c-b4a0-fc5ed4af1a67Manzano, Alexander0dd1f5fe-19cd-42e0-b698-34b17a178629Garrido, Bermary5bac9928-0ee3-4e86-9c28-f6b1bff624e9Salazar, Juanfbd053e7-5aea-424c-812f-92153ecb9181Silva, Aljadis970fb948-70da-438f-95e6-6d0de2c1f9f6Rojas-Gomez, Diana Marcelad58335c1-9d5f-4585-b1a2-faa5cc09780aDe Sanctis, Juan B.ca98a00e-c126-4f97-bdb0-a08c25ad8c59Bermúdez, Valmore29f9aa18-16a4-4fd3-8ce5-ed94a0b8663a2021-10-05T14:51:18Z2021-10-05T14:51:18Z2021Chávez-Castillo, M.; Ortega, Á.; Cudris-Torres, L.; Duran, P.; Rojas, M.; Manzano, A.; Garrido, B.; Salazar, J.; Silva, A.; Rojas-Gomez, D.M.; et al. Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?. Int. J. Mol. Sci. 2021, 22, 10370. https:// doi.org/10.3390/ijms22191037014220067https://hdl.handle.net/20.500.12442/8636https:// doi.org/10.3390/ijms221910370https://www.mdpi.com/1422-0067/22/19/10370/htmChronic pain (CP) is a severe clinical entity with devastating physical and emotional consequences for patients, which can occur in a myriad of diseases. Often, conventional treatment approaches appear to be insufficient for its management. Moreover, considering the adverse effects of traditional analgesic treatments, specialized pro-resolving lipid mediators (SPMs) have emerged as a promising alternative for CP. These include various bioactive molecules such as resolvins, maresins, and protectins, derived from ω-3 polyunsaturated fatty acids (PUFAs); and lipoxins, produced from ω-6 PUFAs. Indeed, SPMs have been demonstrated to play a central role in the regulation and resolution of the inflammation associated with CP. Furthermore, these molecules can modulate neuroinflammation and thus inhibit central and peripheral sensitizations, as well as long-term potentiation, via immunomodulation and regulation of nociceptor activity and neuronal pathways. In this context, preclinical and clinical studies have evidenced that the use of SPMs is beneficial in CP-related disorders, including rheumatic diseases, migraine, neuropathies, and others. This review integrates current preclinical and clinical knowledge on the role of SPMs as a potential therapeutic tool for the management of patients with CP.pdfengMDPIAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2International Journal of Molecular SciencesVol. 22, No.19 (2021)Chronic painSpecialized pro-resolving lipid mediatorsInflammationLong-term potentiationCentral nervous system sensitizationPolyunsaturated fatty acidsEicosanoidsNociceptionOmega 3 fatty acidsPain managementSpecialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?info:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Geurts, J.W.; Willems, P.C.; Lockwood, C.; van Kleef, M.; Kleijnen, J.; Dirksen, C. Patient Expectations for Management of Chronic Non-Cancer Pain: A Systematic Review. Health Expect. 2017, 20, 1201–1217. [CrossRef]GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, Regional, and National Incidence, Prevalence, and Years Lived with Disability for 328 Diseases and Injuries for 195 Countries, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016. Lancet 2017, 390, 1211–1259. [CrossRef]Fayaz, A.; Croft, P.; Langford, R.M.; Donaldson, L.J.; Jones, G.T. Prevalence of Chronic Pain in the UK: A Systematic Review and Meta-Analysis of Population Studies. BMJ Open 2016, 6, e010364. [CrossRef] [PubMed]Kheiry, F.; Rakhshan, M.; Shaygan, M. The prevalence and associated factors of chronic pain in nurses Iran. Latinoam. Hipertens. 2019, 14, 20–25.Dahlhamer, J.; Lucas, J.; Zelaya, C.; Nahin, R.; Mackey, S.; DeBar, L.; Kerns, R.; Von Korff, M.; Porter, L.; Helmick, C. Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults—United States, 2016. MMWR Morb. Mortal. Wkly. Rep. 2018, 67, 1001–1006. [CrossRef] [PubMed]World Health Organization. Opioid Overdose. Available online: https://www.who.int/news-room/fact-sheets/detail/opioidoverdose (accessed on 21 June 2021).Ji, R.-R.; Xu, Z.-Z.; Gao, Y.-J. Emerging Targets in Neuroinflammation-Driven Chronic Pain. Nat. Rev. Drug Discov. 2014, 13, 533–548. [CrossRef]Valdes, A.M.; Ravipati, S.; Menni, C.; Abhishek, A.; Metrustry, S.; Harris, J.; Nessa, A.; Williams, F.M.K.; Spector, T.D.; Doherty, M.; et al. Association of the Resolvin Precursor 17-HDHA, but Not D- or E- Series Resolvins, with Heat Pain Sensitivity and Osteoarthritis Pain in Humans. Sci. Rep. 2017, 7, 10748. [CrossRef]Chiang, N.; Serhan, C.N. Structural Elucidation and Physiologic Functions of Specialized Pro-Resolving Mediators and Their Receptors. Mol. Asp. Med. 2017, 58, 114–129. 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Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?

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