Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?

Chronic pain (CP) is a severe clinical entity with devastating physical and emotional consequences for patients, which can occur in a myriad of diseases. Often, conventional treatment approaches appear to be insufficient for its management. Moreover, considering the adverse effects of traditional analgesic treatments, specialized pro-resolving lipid mediators (SPMs) have emerged as a promising alternative for CP. These include various bioactive molecules such as resolvins, maresins, and protectins, derived from ω-3 polyunsaturated fatty acids (PUFAs); and lipoxins, produced from ω-6 PUFAs. Indeed, SPMs have been demonstrated to play a central role in the regulation and resolution of the inflammation associated with CP. Furthermore, these molecules can modulate neuroinflammation and thus inhibit central and peripheral sensitizations, as well as long-term potentiation, via immunomodulation and regulation of nociceptor activity and neuronal pathways. In this context, preclinical and clinical studies have evidenced that the use of SPMs is beneficial in CP-related disorders, including rheumatic diseases, migraine, neuropathies, and others. This review integrates current preclinical and clinical knowledge on the role of SPMs as a potential therapeutic tool for the management of patients with CP.

• Autores: Chávez-Castillo, Mervin; Ortega, Ángel; Cudris-Torres, Lorena; Duran, Pablo; Rojas, Milagros; Manzano, Alexander; Garrido, Bermary; Salazar, Juan; Silva, Aljadis; Rojas-Gomez, Diana Marcela; De Sanctis, Juan B.; Bermúdez, Valmore
• Fecha de publicación: 2021
• Institución: Universidad Simón Bolívar
• Repositorio: Repositorio Digital USB
• Idioma: eng
• OAI Identifier: oai:bonga.unisimon.edu.co:20.500.12442/8636
• Acceso en línea: https://hdl.handle.net/20.500.12442/8636; https:// doi.org/10.3390/ijms221910370; https://www.mdpi.com/1422-0067/22/19/10370/htm
• Palabra clave: Chronic pain; Specialized pro-resolving lipid mediators; Inflammation; Long-term potentiation; Central nervous system sensitization; Polyunsaturated fatty acids; Eicosanoids; Nociception; Omega 3 fatty acids; Pain management
• Rights: openAccess
• License: Attribution-NonCommercial-NoDerivatives 4.0 Internacional