Chronic joint pain 3 years after chikungunya virus infection largely characterized by relapsing-remitting symptoms
Objective. To determine the frequency of chronic joint pain and stiffness 3 years after infection with chikungunya virus in a Latin American cohort. Methods. A cross-sectional follow-up of 120 patients from an initial cohort of 500 patients who reported joint pain 2 years after infection from the At...
- Autores:
-
Tritsch, Sarah R.
Encinales, Liliana
Pacheco, Nelly
Cadena, Andres
Cure, Carlos
McMahon, Elizabeth
Watson, Hugh
Porras Ramirez, Alexandra
Rico Mendoza, Alejandro
Li, Guangzhao
Khurana, Kunal
Jaller-Radd, Juan Jose
Mejia Castillo, Stella
Barrios Taborda, Onaldo
Jaller Char, Alejandro
Jaller-Char, Juan Jose
Avendaño Echavez, Lil
Jiménez, Dennys
Gonzalez Coba, Andres
Alarcon Gomez, Magda
Ariza Orozco, Dores
Bravo, Eyda
Martinez, Victor
Guerra, Brenda
Simon, Gary
Firestein, Gary S.
Chang, Aileen Y.
- Tipo de recurso:
- Fecha de publicación:
- 2019
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/4460
- Acceso en línea:
- https://hdl.handle.net/20.500.12442/4460
- Palabra clave:
- Rights
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Chronic joint pain 3 years after chikungunya virus infection largely characterized by relapsing-remitting symptoms |
| title |
Chronic joint pain 3 years after chikungunya virus infection largely characterized by relapsing-remitting symptoms |
| spellingShingle |
Chronic joint pain 3 years after chikungunya virus infection largely characterized by relapsing-remitting symptoms |
| title_short |
Chronic joint pain 3 years after chikungunya virus infection largely characterized by relapsing-remitting symptoms |
| title_full |
Chronic joint pain 3 years after chikungunya virus infection largely characterized by relapsing-remitting symptoms |
| title_fullStr |
Chronic joint pain 3 years after chikungunya virus infection largely characterized by relapsing-remitting symptoms |
| title_full_unstemmed |
Chronic joint pain 3 years after chikungunya virus infection largely characterized by relapsing-remitting symptoms |
| title_sort |
Chronic joint pain 3 years after chikungunya virus infection largely characterized by relapsing-remitting symptoms |
| dc.creator.fl_str_mv |
Tritsch, Sarah R. Encinales, Liliana Pacheco, Nelly Cadena, Andres Cure, Carlos McMahon, Elizabeth Watson, Hugh Porras Ramirez, Alexandra Rico Mendoza, Alejandro Li, Guangzhao Khurana, Kunal Jaller-Radd, Juan Jose Mejia Castillo, Stella Barrios Taborda, Onaldo Jaller Char, Alejandro Jaller-Char, Juan Jose Avendaño Echavez, Lil Jiménez, Dennys Gonzalez Coba, Andres Alarcon Gomez, Magda Ariza Orozco, Dores Bravo, Eyda Martinez, Victor Guerra, Brenda Simon, Gary Firestein, Gary S. Chang, Aileen Y. |
| dc.contributor.author.none.fl_str_mv |
Tritsch, Sarah R. Encinales, Liliana Pacheco, Nelly Cadena, Andres Cure, Carlos McMahon, Elizabeth Watson, Hugh Porras Ramirez, Alexandra Rico Mendoza, Alejandro Li, Guangzhao Khurana, Kunal Jaller-Radd, Juan Jose Mejia Castillo, Stella Barrios Taborda, Onaldo Jaller Char, Alejandro Jaller-Char, Juan Jose Avendaño Echavez, Lil Jiménez, Dennys Gonzalez Coba, Andres Alarcon Gomez, Magda Ariza Orozco, Dores Bravo, Eyda Martinez, Victor Guerra, Brenda Simon, Gary Firestein, Gary S. Chang, Aileen Y. |
| description |
Objective. To determine the frequency of chronic joint pain and stiffness 3 years after infection with chikungunya virus in a Latin American cohort. Methods. A cross-sectional follow-up of 120 patients from an initial cohort of 500 patients who reported joint pain 2 years after infection from the Atlántico Department, Colombia. Patients were clinically diagnosed as having chikungunya virus during the 2014–2015 epidemic, and baseline and follow-up symptoms at 40 months were evaluated in serologically confirmed cases. Results. Of the initial 500 patients enrolled in the study, 482 had serologically confirmed chikungunya infection. From this group, 123 patients reported joint pain 20 months after infection, and 54% of those patients reported continued joint pain 40 months after infection. Therefore, 1 out of every 8 people who tested serologically positive for chikungunya infection had persistent joint pain 3 years after infection. Participants that followed up in-person were predominantly adult (mean ± SD age 51 ± 14 years) and female (86%). The most common type of pain reported in these patients at 40 months post-infection was pain with periods of relief and subsequent reoccurrence, and over 75% reported stiffness after immobility, with 39% experiencing morning stiffness. Conclusion. This is the first report to describe persistent joint pain and stiffness 40 months after viral infection. The high frequency of chronic disease highlights the need to develop prevention and treatment methods. Further studies should be conducted to understand the similarities between post-chikungunya joint pain and rheumatoid arthritis. |
| publishDate |
2019 |
| dc.date.accessioned.none.fl_str_mv |
2019-12-13T16:08:20Z |
| dc.date.available.none.fl_str_mv |
2019-12-13T16:08:20Z |
| dc.date.issued.none.fl_str_mv |
2019 |
| dc.type.eng.fl_str_mv |
article |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
| dc.identifier.issn.none.fl_str_mv |
14992752 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12442/4460 |
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14992752 |
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https://hdl.handle.net/20.500.12442/4460 |
| dc.language.iso.eng.fl_str_mv |
eng |
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eng |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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http://purl.org/coar/access_right/c_f1cf |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_f1cf |
| dc.publisher.eng.fl_str_mv |
The Journal of Rheumatology Publishing |
| dc.source.eng.fl_str_mv |
The Journal of Rheumatology |
| dc.source.spa.fl_str_mv |
Vol. 46, No. 12 (2019) |
| institution |
Universidad Simón Bolívar |
| dc.source.uri.eng.fl_str_mv |
http://www.jrheum.org/content/early/2019/06/24/jrheum.190162 |
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Tritsch, Sarah R.3f7396b2-0131-49a2-8113-cb229089c0a8Encinales, Lilianaa4a0678c-5ae7-4693-a621-761891eaa340Pacheco, Nellyd20275f3-a5f0-4665-b432-5d6fe7b22a85Cadena, Andres3c5d440a-d418-4baf-b090-bc2257fd0228Cure, Carlosc26dc240-6075-4860-8cef-a3c83482e8daMcMahon, Elizabeth02cd4402-bc82-4375-80d0-abfcb1f3f896Watson, Hugh26d0cc33-afd2-469e-8652-3edc449cc6e4Porras Ramirez, Alexandra12a27024-0639-4212-8649-a7fdce33be4bRico Mendoza, Alejandrod0b79785-2836-4cd1-b003-caee39c5f099Li, Guangzhaobd9ee064-66e9-4eaa-b1c6-60fc02fe2aa2Khurana, Kunale9b3374b-d436-4494-a5b5-f8c9568342e3Jaller-Radd, Juan Jose51132682-3edd-4582-aa10-f42d3631c860Mejia Castillo, Stellabe7bc1e7-9b48-439a-89aa-7d240ca3e8bbBarrios Taborda, Onaldo12b46164-74fb-4b82-800f-3da892f316a4Jaller Char, Alejandro253e44b3-5b50-40c4-b520-6808d2c11981Jaller-Char, Juan Jose91aec912-31f0-4618-af3e-fd8692219d95Avendaño Echavez, Lile05f8221-bdea-4814-82c4-5df7f07f0fbfJiménez, Dennys32df3388-fc07-49d3-be12-3fad969c1458Gonzalez Coba, Andresa117641d-1fea-47a8-ae6d-f0df5903dbc9Alarcon Gomez, Magda522e1bf0-dc71-4d1a-9fbf-50e803ca6721Ariza Orozco, Dores4a5f484a-dd26-40cb-ab9d-0d201567bd25Bravo, Eyda9803b17e-836c-482e-8bb2-db88a142ac2dMartinez, Victord3f20c35-5471-40d6-ba35-1cadde260a18Guerra, Brenda92be1cf4-07f1-4635-8528-9af0665da22fSimon, Garyfc02dd01-b195-4f95-b13e-cdaf94a73982Firestein, Gary S.88081310-ddb8-475d-bc89-020e95bacc54Chang, Aileen Y.aba8d024-0745-4f4c-857d-d8d995d118422019-12-13T16:08:20Z2019-12-13T16:08:20Z201914992752https://hdl.handle.net/20.500.12442/4460Objective. To determine the frequency of chronic joint pain and stiffness 3 years after infection with chikungunya virus in a Latin American cohort. Methods. A cross-sectional follow-up of 120 patients from an initial cohort of 500 patients who reported joint pain 2 years after infection from the Atlántico Department, Colombia. Patients were clinically diagnosed as having chikungunya virus during the 2014–2015 epidemic, and baseline and follow-up symptoms at 40 months were evaluated in serologically confirmed cases. Results. Of the initial 500 patients enrolled in the study, 482 had serologically confirmed chikungunya infection. From this group, 123 patients reported joint pain 20 months after infection, and 54% of those patients reported continued joint pain 40 months after infection. Therefore, 1 out of every 8 people who tested serologically positive for chikungunya infection had persistent joint pain 3 years after infection. Participants that followed up in-person were predominantly adult (mean ± SD age 51 ± 14 years) and female (86%). The most common type of pain reported in these patients at 40 months post-infection was pain with periods of relief and subsequent reoccurrence, and over 75% reported stiffness after immobility, with 39% experiencing morning stiffness. Conclusion. This is the first report to describe persistent joint pain and stiffness 40 months after viral infection. The high frequency of chronic disease highlights the need to develop prevention and treatment methods. Further studies should be conducted to understand the similarities between post-chikungunya joint pain and rheumatoid arthritis.engThe Journal of Rheumatology PublishingAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_f1cfThe Journal of RheumatologyVol. 46, No. 12 (2019)http://www.jrheum.org/content/early/2019/06/24/jrheum.190162Chronic joint pain 3 years after chikungunya virus infection largely characterized by relapsing-remitting symptomsarticlehttp://purl.org/coar/resource_type/c_6501Robinson MC. An epidemic of virus disease in southern province, tanganyika territory, in 1952-53. I. Clinical features. Trans R Soc Trop Med Hyg 1955;49:28-32.Paul BJ, Sadanand S. Chikungunya infection: A re-emerging epidemic. Rheumatol Ther 2018;5:317-26.Centers for Disease Control and Prevention. Chikungunya virus: Resources for healthcare providers. [Internet. Accessed December 10, 2018.]; Available from: https://www.cdc.gov/chikungunya/hc/resources.html.Borgherini G, Poubeau P, Jossaume A, Gouix A, Cotte L, Michault A, et al. Persistent arthralgia associated with chikungunya virus: A study of 88 adult patients on Réunion Island. Clin Infect Dis 2008;47:469-75.Chang AY, Encinales L, Porras A, Pacheco N, Reid SP, Martins KAO, et al. Frequency of chronic joint pain following chikungunya virus infection: A Colombian cohort study. Arthritis Rheumatol 2018;70:578-84.Hoarau J-J, Jaffar Bandjee M-C, Krejbich Trotot P, Das T, Li-Pat-Yuen G, Dassa B, et al. Persistent chronic inflammation and infection by chikungunya arthritogenic alphavirus in spite of a robust host immune response. J Immunol 2010;184:5914.Soumahoro M-K, Gérardin P, Boëlle P-Y, Perrau J, Fianu A, Pouchot J, et al. Impact of chikungunya virus infection on health status and quality of life: A retrospective cohort study. Plos One 2009;4:e7800.Rahim AA, Thekkekara RJ, Bina T, Paul BJ. Disability with persistent pain following an epidemic of chikungunya in rural south India. J Rheumatol 2016;43:440-4.Brighton SW, Prozesky OW, de la Harpe AL. Chikungunya virus infection. A retrospective study of 107 cases. S Afr Med J 1983;63:313-5.Sissoko D, Malvy D, Ezzedine K, Renault P, Moscetti F, Ledrans M, et al. Post-epidemic chikungunya disease on Réunion Island: Course of rheumatic manifestations and associated factors over a 15-month period. PLoS Negl Trop Dis 2009;3:e389.Couturier E, Guillemin F, Mura M, Léon L, Virion J-M, Letort M-J, et al. Impaired quality of life after chikungunya virus infection: A 2-year follow-up study. Rheumatology 2012;51:1315-22.Ravindran V, Alias G. Efficacy of combination DMARD therapy vs. Hydroxychloroquine monotherapy in chronic persistent chikungunya arthritis: A 24-week randomized controlled open label study. Clin Rheumatol 2017;36:1335-40.Zaid A, Gérardin P, Taylor A, Mostafavi H, Malvy D, Mahalingam S. Review: Chikungunya arthritis: Implications of acute and chronic inflammation mechanisms on disease management. Arthritis Rheumatol 2017;70:484-95.Nasci RS. Movement of chikungunya virus into the western hemisphere. Emerg Infect Diseases 2014;20:1394-5.Leparc-Goffart I, Nougairede A, Cassadou S, Prat C, de Lamballerie X. Chikungunya in the Americas. Lancet 2014;383:514.Lanciotti RS, Valadere AM. Transcontinental movement of asian genotype chikungunya virus. Emerg Infect Diseases 2014;20:1400-2.Lanciotti RS, Lambert AJ. Phylogenetic analysis of chikungunya virus strains circulating in the western hemisphere. Am J Trop Med Hyg 2016;94:800-3.Costa-da-Silva AL, Ioshino RS, Petersen V, Lima AF, Cunha MdP, Wiley MR, et al. First report of naturally infected aedes aegypti with chikungunya virus genotype ecsa in the Americas. PLoS Negl Trop Dis 2017;11:e0005630.Schilte C, Staikowsky F, Couderc T, Madec Y, Carpentier F, Kassab S, et al. Chikungunya virus-associated long-term arthralgia: A 36-month prospective longitudinal study. PLoS Negl Trop Dis 2013;7:e2137.Mathew AJ, Goyal V, George E, Thekkemuriyil DV, Jayakumar B, Chopra A. Rheumatic-musculoskeletal pain and disorders in a naive group of individuals 15 months following a chikungunya viral epidemic in south India: A population based observational study. Int J Clin Pract 2011;65:1306-12.Chopra A, Anuradha V, Ghorpade R, Saluja M. Acute chikungunya and persistent musculoskeletal pain following the 2006 Indian epidemic: A 2-year prospective rural community study. Epidemiol Infect 2012;140:842-50.Chang AY, Martins KAO, Encinales L, Reid SP, Acuna M, Encinales C, et al. Chikungunya arthritis mechanisms in the Americas: A cross-sectional analysis of chikungunya arthritis patients twenty-two months after infection demonstrating no detectable viral persistence in synovial fluid. Arthritis Rheumatol 2018;70:585-93.Chang AY, Tritsch S, Reid SP, Martins K, Encinales L, Pacheco N, et al. The cytokine profile in acute chikungunya infection is predictive of chronic arthritis 20 months post infection. Diseases 2018;6.Staikowsky F, Le Roux K, Schuffenecker I, Laurent P, Grivard P, Develay A, et al. Retrospective survey of chikungunya disease in Réunion Island hospital staff. Epidemiol Infect 2008;136:196-206.Heise MT, Simpson DA, Johnston RE. Sindbis-group alphavirus replication in periosteum and endosteum of long bones in adult mice. J Virol 2000;74:9294-9.Soden M, Vasudevan H, Roberts B, Coelen R, Hamlin G, Vasudevan S, et al. Detection of viral ribonucleic acid and histologic analysis of inflamed synovium in ross river virus infection. Arthritis Rheum 2000;43:365-9.Rulli NE, Suhrbier A, Hueston L, Heise MT, Tupanceska D, Zaid A, et al. Ross river virus: Molecular and cellular aspects of disease pathogenesis. Pharmacol Ther 2005;107:329-42.Labadie K, Larcher T, Joubert C, Mannioui A, Delache B, Brochard P, et al. Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages. J Clin Invest 2010;120:894-906.Pan American Health Organization. Number of reported cases of chikungunya fever in the Americas, by country or territory: 2016, culminative cases. [Internet. Accessed November 22, 2018.]; Available from: https://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=3 7867&lang=en.World Health Organization. Chikungunya. [Internet. Accessed November 22, 2018.]; Available from: http://www.who.int/news-room/fact-sheets/detail/chikungunya.Prevoo MLL, Van'T Hof MA, Kuper HH, Van Leeuwen MA, Van De Putte LBA, Van Riel PLCM. Modified disease activity scores that include twenty-eight-joint counts development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995;38:44-8.Halls S, Dures E, Kirwan J, Pollock J, Baker G, Edmunds A, et al. Ab1128-hpr developing a new rheumatoid arthritis (RA) stiffness patient reported outcome measure (PROM). Ann Rheum Dis 2016;75:1317.Guo Q, Wang Y, Xu D, Nossent J, Pavlos NJ, Xu J. Rheumatoid arthritis: Pathological mechanisms and modern pharmacologic therapies. Bone Res 2018;6:15.Nakaya HI, Gardner J, Poo Y-S, Major L, Pulendran B, Suhrbier A. Gene profiling of chikungunya virus arthritis in a mouse model reveals significant overlap with rheumatoid arthritis. Arthritis Rheum 2012;64:3553-63.Assunção-Miranda I, Cruz-Oliveira C, Da Poian AT. Molecular mechanisms involved in the pathogenesis of alphavirus-induced arthritis. Biomed Res Int 2013;2013:973516.Chen W, Foo S-S, Sims NA, Herrero LJ, Walsh NC, Mahalingam S. Arthritogenic alphaviruses: New insights into arthritis and bone pathology. Trends Microbiol 2015;23:35-43.Miner JJ, Aw-Yeang H-X, Fox JM, Taffner S, Malkova ON, Oh ST, et al. Brief report: Chikungunya viral arthritis in the united states: A mimic of seronegative rheumatoid arthritis. Arthritis Rheumatol 2015;67:1214-20.Manimunda SP, Vijayachari P, Uppoor R, Sugunan AP, Singh SS, Rai SK, et al. Clinical progression of chikungunya fever during acute and chronic arthritic stages and the changes in joint morphology as revealed by imaging. Trans R Soc Trop Med Hyg 2010;104:392-9.Bouquillard E, Fianu A, Bangil M, Charlette N, Ribera A, Michault A, et al. Rheumatic manifestations associated with chikungunya virus infection: A study of 307 patients with 32- month follow-up (RHUMATOCHIK study). Joint Bone Spine 2018;85:207-10.Simon F, Javelle E, Cabie A, Bouquillard E, Troisgros O, Gentile G, et al. French guidelines for the management of chikungunya (acute and persistent presentations). November 2014. Med Mal Infect 2015;45:243-63.Wolfe F, Michaud K, Pincus T. Development and validation of the health assessment questionnaire ii: A revised version of the health assessment questionnaire. Arthritis Rheum 2004;50:3296-305.Groot H, Morales A, Vidales H. Virus isolations from forest mosquitoes in San Vicente de Chucuri, Colombia. Am J Trop Med Hyg 1961;10:397-402.Ospina ML MDM, Pacheco García OE, Quijada Bonilla H. Protocolo de vigilancia en salud pública: Chikunguña. Instituto Nacional de Salud Vigilancia y Analysis del Riesgo en Salud Pública 2016;2:1-3.Sede BarranquillaEspecialización en Medicina InternaCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://bonga.unisimon.edu.co/bitstreams/8750ef48-61c4-40db-8f63-68bb8ba8ab86/download4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8381https://bonga.unisimon.edu.co/bitstreams/0241d8da-63a7-4a0a-9c81-573a13ae7a83/download733bec43a0bf5ade4d97db708e29b185MD5320.500.12442/4460oai:bonga.unisimon.edu.co:20.500.12442/44602024-08-14 21:53:25.566http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internacionalmetadata.onlyhttps://bonga.unisimon.edu.coRepositorio Digital Universidad Simón Bolívarrepositorio.digital@unisimon.edu.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 |