Inflammatory and lipotoxicity mechanisms in obesity related CKD

Obesity has been a systemic disease that has been underrecognized for years. Obesity-related chronic kidney disease (Ob-CKD) is a multifaceted disorder that affects patients with CKD to varying degrees. Among the structural changes associated with obesity, obesity-related glomerulopathy (ORG) stands...

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Autores:: Rico Fontalvo, Jorge
Raad Sarabia, Maria
Montejo Hernández, Juan
Rodríguez Yanez, Tomas
Caparroso Ramos, Lacides Rafael
Parra Sánchez, Paula
Ovalle Gomez, Ana Alejandra
Jiménez Quintero, Javier
Daza Ornedo, Rodríguez

Tipo de recurso:

Fecha de publicación:: 2026

Institución:: Universidad Simón Bolívar

Repositorio:: Repositorio Digital USB

Idioma:: eng

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dc.title.eng.fl_str_mv	Inflammatory and lipotoxicity mechanisms in obesity related CKD
title	Inflammatory and lipotoxicity mechanisms in obesity related CKD
spellingShingle	Inflammatory and lipotoxicity mechanisms in obesity related CKD Inflammation Lipotoxicity Cytokines Obesity Chronic kidney disease
title_short	Inflammatory and lipotoxicity mechanisms in obesity related CKD
title_full	Inflammatory and lipotoxicity mechanisms in obesity related CKD
title_fullStr	Inflammatory and lipotoxicity mechanisms in obesity related CKD
title_full_unstemmed	Inflammatory and lipotoxicity mechanisms in obesity related CKD
title_sort	Inflammatory and lipotoxicity mechanisms in obesity related CKD
dc.creator.fl_str_mv	Rico Fontalvo, Jorge Raad Sarabia, Maria Montejo Hernández, Juan Rodríguez Yanez, Tomas Caparroso Ramos, Lacides Rafael Parra Sánchez, Paula Ovalle Gomez, Ana Alejandra Jiménez Quintero, Javier Daza Ornedo, Rodríguez
dc.contributor.author.none.fl_str_mv	Rico Fontalvo, Jorge Raad Sarabia, Maria Montejo Hernández, Juan Rodríguez Yanez, Tomas Caparroso Ramos, Lacides Rafael Parra Sánchez, Paula Ovalle Gomez, Ana Alejandra Jiménez Quintero, Javier Daza Ornedo, Rodríguez
dc.subject.keywords.eng.fl_str_mv	Inflammation Lipotoxicity Cytokines Obesity Chronic kidney disease
topic	Inflammation Lipotoxicity Cytokines Obesity Chronic kidney disease
description	Obesity has been a systemic disease that has been underrecognized for years. Obesity-related chronic kidney disease (Ob-CKD) is a multifaceted disorder that affects patients with CKD to varying degrees. Among the structural changes associated with obesity, obesity-related glomerulopathy (ORG) stands out (glomerular hypertrophy, podocytopathy, mesangial matrix expansion, focal segmental glomerulosclerosis, tubulointerstitial fibrosis, vascular lesions, and tubular atrophy) associated with other kidney diseases. There are direct and indirect mechanisms that affect the kidneys of obese patients. Among the direct mechanisms, several effects may occur: hyperfiltration, activation of the reninangiotensin- aldosterone system (RAAS), inflammation, lipotoxicity, and neurohormonal activation. This is a narrative review that will detail the inflammatory and lipotoxicity mechanisms involved in the genesis of Ob-CKD.
publishDate	2026
dc.date.accessioned.none.fl_str_mv	2026-01-19T19:22:14Z
dc.date.available.none.fl_str_mv	2026-01-19T19:22:14Z
dc.date.issued.none.fl_str_mv	2026
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dc.type.spa.none.fl_str_mv	Artículo científico
dc.identifier.citation.none.fl_str_mv	Rico-Fontalvo J, Raad-Sarabia M, Montejo Hernández J, Rodríguez Yánez T, Caparroso Ramos LR, Parra Sánchez P, Ovalle Gomez AA, Quintero JJ and Daza-Arnedo R (2026) Inflammatory and lipotoxicity mechanisms in obesity related CKD. Front. Nephrol. 5:1684004. doi: 10.3389/fneph.2025.1684004
dc.identifier.issn.none.fl_str_mv	28130626 (Impreso)
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12442/17292
dc.identifier.doi.none.fl_str_mv	10.3389/fneph.2025.1684004
dc.identifier.url.none.fl_str_mv	https://www.frontiersin.org/journals/nephrology/articles/10.3389/fneph.2025.1684004/full
identifier_str_mv	Rico-Fontalvo J, Raad-Sarabia M, Montejo Hernández J, Rodríguez Yánez T, Caparroso Ramos LR, Parra Sánchez P, Ovalle Gomez AA, Quintero JJ and Daza-Arnedo R (2026) Inflammatory and lipotoxicity mechanisms in obesity related CKD. Front. Nephrol. 5:1684004. doi: 10.3389/fneph.2025.1684004 28130626 (Impreso) 10.3389/fneph.2025.1684004
url	https://hdl.handle.net/20.500.12442/17292 https://www.frontiersin.org/journals/nephrology/articles/10.3389/fneph.2025.1684004/full
dc.language.iso.none.fl_str_mv	eng
language	eng
dc.rights.eng.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International
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eu_rights_str_mv	openAccess
dc.format.mimetype.none.fl_str_mv	pdf
dc.publisher.spa.fl_str_mv	Frontiers Media
dc.source.eng.fl_str_mv	Frontiers in Nephrology Front. Nephrol.
dc.source.spa.fl_str_mv	Vol. 5 No. Año 2026
institution	Universidad Simón Bolívar
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spelling	Rico Fontalvo, Jorge1dc43f99-dec8-4bf0-9a62-f33a0011143e-1Raad Sarabia, Maria0c1e194c-596d-4b6c-a523-ee8d88775852-1Montejo Hernández, Juan492f4950-b1cc-4937-9784-8b809eb591e8Rodríguez Yanez, Tomas75df7995-4db4-4f42-8ca0-6a3016b54e68Caparroso Ramos, Lacides Rafael65342235-e3ff-4904-aff4-4de4156603c9-1Parra Sánchez, Paula1b7953a9-79df-43c1-88a6-b230d884156b-1Ovalle Gomez, Ana Alejandradd8fcbd8-fc6f-4828-b3d7-0d462f5d6824-1Jiménez Quintero, Javiera455d519-bdce-415f-879d-84d92696ba6c-1Daza Ornedo, Rodríguezcd0e0afd-859f-4fb4-a8c7-68a5852440f4-12026-01-19T19:22:14Z2026-01-19T19:22:14Z2026Rico-Fontalvo J, Raad-Sarabia M, Montejo Hernández J, Rodríguez Yánez T, Caparroso Ramos LR, Parra Sánchez P, Ovalle Gomez AA, Quintero JJ and Daza-Arnedo R (2026) Inflammatory and lipotoxicity mechanisms in obesity related CKD. Front. Nephrol. 5:1684004. doi: 10.3389/fneph.2025.168400428130626 (Impreso)https://hdl.handle.net/20.500.12442/1729210.3389/fneph.2025.1684004https://www.frontiersin.org/journals/nephrology/articles/10.3389/fneph.2025.1684004/fullObesity has been a systemic disease that has been underrecognized for years. Obesity-related chronic kidney disease (Ob-CKD) is a multifaceted disorder that affects patients with CKD to varying degrees. Among the structural changes associated with obesity, obesity-related glomerulopathy (ORG) stands out (glomerular hypertrophy, podocytopathy, mesangial matrix expansion, focal segmental glomerulosclerosis, tubulointerstitial fibrosis, vascular lesions, and tubular atrophy) associated with other kidney diseases. There are direct and indirect mechanisms that affect the kidneys of obese patients. Among the direct mechanisms, several effects may occur: hyperfiltration, activation of the reninangiotensin- aldosterone system (RAAS), inflammation, lipotoxicity, and neurohormonal activation. This is a narrative review that will detail the inflammatory and lipotoxicity mechanisms involved in the genesis of Ob-CKD.pdfengFrontiers MediaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Frontiers in NephrologyFront. Nephrol.Vol. 5 No. Año 2026Inflammatory and lipotoxicity mechanisms in obesity related CKDinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1InflammationLipotoxicityCytokinesObesityChronic kidney diseaseNawaz S, Chinnadurai R, Al-Chalabi S, Evans P, Kalra PA, Syed AA, et al. Obesity and chronic kidney disease: A current review. Obes Sci Pract. (2022) 9:61–74. doi: 10.1002/osp4.629Rico-Fontalvo J, Ciudin A, Correa-Rotter R, Dı́az-Crespo FJ, Bonanno C, Lecube A, et al. SEN, SLANH, andSEEDOConsensus report on Obesity related kidney disease. Proposal for a new classification. Kidney Int. (2025) 108:572–83. doi: 10.1016/j.kint.2025.06.013Lu JL, Kalantar-Zadeh K, Ma JZ, Quarles LD, Kovesdy CP. Association of body mass index with outcomes in patients with CKD. J Am Soc Nephrol JASN. (2014) 25:2088–96. doi: 10.1681/ASN.2013070754Bello AK, Alrukhaimi M, Ashuntantang GE, Basnet S, Rotter RC, Douthat WG, et al. Complications of chronic kidney disease: current state, knowledge gaps, and strategy for action. Kidney Int Suppl. (2017) 7:122–9. doi: 10.1016/j.kisu.2017.07.007Aristizábal-Colorado D, Corredor-Rengifo D, Sierra-Castillo S, López-Corredor C, Vernaza-Trujillo DA, Weir-Restrepo D, et al. A decade of progress in type 2 diabetes and cardiovascular disease: advances in SGLT2 inhibitors and GLP-1 receptor agonists – a comprehensive review. Front Endocrinol. (2025) 16:1605746. doi: 10.3389/ fendo.2025.1605746Hojs R, Ekart R, Bevc S, Vodošek Hojs N. Chronic kidney disease and obesity. Nephron. (2023) 147:660–4. doi: 10.1159/000531379Hall JE. The kidney, hypertension, and obesity. Hypertens Dallas Tex 1979. (2003) 41:625–33. doi: 10.1161/01.HYP.0000052314.95497.78Haruhara K, Okabayashi Y, Sasaki T, Kubo E, D’Agati VD, Bertram JF, et al. Podocyte density as a predictor of long-term kidney outcome in obesity-related glomerulopathy. Kidney Int. (2024) 106:496–507. doi: 10.1016/j.kint.2024.05.025Hall JE, Mouton AJ, da Silva AA, Omoto ACM, Wang Z, Li X, et al. Obesity, kidney dysfunction, and inflammation: interactions in hypertension. Cardiovasc Res. (2021) 117:1859–76. doi: 10.1093/cvr/cvaa336Ellington AA, Malik AR, Klee GG, Turner ST, Rule AD, Mosley TH, et al. 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Obesity-related kidney disease: A growing threat to renal health. Int J Mol Sci. (2025) 26:6641. doi: 10.3390/ijms26146641D’Agati VD, Chagnac A, de Vries APJ, Levi M, Porrini E, Herman-Edelstein M, et al. Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis. Nat Rev Nephrol. (2016) 12:453–71. doi: 10.1038/nrneph.2016.75Yang S, Cao C, Deng T, Zhou Z. Obesity-related glomerulopathy: A latent change in obesity requiring more attention. Kidney Blood Press Res. (2020) 45:510–22. doi: 10.1159/000507784Daza-Arnedo R, Rico-Fontalvo J, Aroca-Martı́nez G, Rodrı́guez-Yanez T, Martı́nez-Ávila MC, Almanza-Hurtado A, et al. Insulin and the kidneys: a contemporary view on the molecular basis. Front Nephrol. (2023) 3:1133352. doi: 10.3389/fneph.2023.1133352Kambham N, Markowitz GS, Valeri AM, Lin J, D’Agati VD. Obesity-related glomerulopathy: an emerging epidemic. Kidney Int. 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SGLT2 inhibitors and how they work beyond the glucosuric effect. State of the art. Am J Cardiovasc Drugs Drugs Devices Interv. (2024) 24:707–18. doi: 10.1007/s40256-024-00673-1Rico-Fontalvo J, Daza-Arnedo R, Rodrı́guez-Yanez T, Osorio W, Suarez- Romero B, Soto O, et al. Obesidad y enfermedad renal crónica. Una mirada desde los mecanismos fisiopatológicos.: Revisión narrativa. Rev Soc Ecuat Nefrol Diálisis Traspl. (2022) 10:97–107. doi: 10.56867/32Rico-Fontalvo J, Daza-Arnedo R, Montejo-Hernandez J, Cardona-Blanco M, Rodrı́guez-Yanez T. Reflexiones de la enfermedad renal crónica asociada a obesidad: de una vieja relación causal hasta un enfoque basado en la fenotipificación. Rev Soc Ecuat Nefrol Diálisis Traspl. (2022) 10:137–9. doi: 10.56867/37ORIGINALpdf.pdfpdf.pdfapplication/pdf2488832https://bonga.unisimon.edu.co/bitstreams/b734e8fc-fdbb-456a-97ec-40db87611ad6/download5929bef2527f3373276d418cda5d33a3MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8899https://bonga.unisimon.edu.co/bitstreams/a4aef916-f475-4368-bcec-41ef111d9767/download3b6ce8e9e36c89875e8cf39962fe8920MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8381https://bonga.unisimon.edu.co/bitstreams/446e33a5-a467-4f43-8718-5b1a49858ce8/download733bec43a0bf5ade4d97db708e29b185MD5320.500.12442/17292oai:bonga.unisimon.edu.co:20.500.12442/172922026-01-19 14:39:44.773http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internationalopen.accesshttps://bonga.unisimon.edu.coRepositorio Digital Universidad Simón Bolívarrepositorio.digital@unisimon.edu.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

Inflammatory and lipotoxicity mechanisms in obesity related CKD

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