Mecanismos patogénicos de infección por SARS-CoV-2 y enfermedad renal: una perspectiva clínico-molecular
La infección por SARS-CoV-2 se ha convertido en un problema mundial de salud pública. Su presentación clínica es variada, desde benigna hasta un síndrome de distrés respiratorio agudo, afectación sistémica y fallo multiorgánico. La severidad del cuadro clínico depende de factores biológicos del viru...
- Autores:
-
Torres, W.
Morillo, V.
Suarez, M.K.
Parra, H.
Lameda, V.
Nava, M.
D'Marco, L.
Puchades, M.J.
Medina, O.
Guerra-Torres, X.E.
Bermúdez, V.
- Tipo de recurso:
- Fecha de publicación:
- 2021
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- spa
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/13225
- Palabra clave:
- SARS-CoV-2
COVID-19
Enzima convertidora de angiotensina 2.
Enfermedad renal crónica
Lesión renal aguda
Angiotensin-converting enzyme 2.
Chronic kidney disease
Acute kidney injury
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Mecanismos patogénicos de infección por SARS-CoV-2 y enfermedad renal: una perspectiva clínico-molecular |
| dc.title.translated.eng.fl_str_mv |
Pathogenic mechanisms of SARS-CoV-2 infection and kidney disease: a clinical and molecular perspective |
| title |
Mecanismos patogénicos de infección por SARS-CoV-2 y enfermedad renal: una perspectiva clínico-molecular |
| spellingShingle |
Mecanismos patogénicos de infección por SARS-CoV-2 y enfermedad renal: una perspectiva clínico-molecular SARS-CoV-2 COVID-19 Enzima convertidora de angiotensina 2. Enfermedad renal crónica Lesión renal aguda Angiotensin-converting enzyme 2. Chronic kidney disease Acute kidney injury |
| title_short |
Mecanismos patogénicos de infección por SARS-CoV-2 y enfermedad renal: una perspectiva clínico-molecular |
| title_full |
Mecanismos patogénicos de infección por SARS-CoV-2 y enfermedad renal: una perspectiva clínico-molecular |
| title_fullStr |
Mecanismos patogénicos de infección por SARS-CoV-2 y enfermedad renal: una perspectiva clínico-molecular |
| title_full_unstemmed |
Mecanismos patogénicos de infección por SARS-CoV-2 y enfermedad renal: una perspectiva clínico-molecular |
| title_sort |
Mecanismos patogénicos de infección por SARS-CoV-2 y enfermedad renal: una perspectiva clínico-molecular |
| dc.creator.fl_str_mv |
Torres, W. Morillo, V. Suarez, M.K. Parra, H. Lameda, V. Nava, M. D'Marco, L. Puchades, M.J. Medina, O. Guerra-Torres, X.E. Bermúdez, V. |
| dc.contributor.author.none.fl_str_mv |
Torres, W. Morillo, V. Suarez, M.K. Parra, H. Lameda, V. Nava, M. D'Marco, L. Puchades, M.J. Medina, O. Guerra-Torres, X.E. Bermúdez, V. |
| dc.subject.spa.fl_str_mv |
SARS-CoV-2 COVID-19 Enzima convertidora de angiotensina 2. Enfermedad renal crónica Lesión renal aguda |
| topic |
SARS-CoV-2 COVID-19 Enzima convertidora de angiotensina 2. Enfermedad renal crónica Lesión renal aguda Angiotensin-converting enzyme 2. Chronic kidney disease Acute kidney injury |
| dc.subject.eng.fl_str_mv |
Angiotensin-converting enzyme 2. Chronic kidney disease Acute kidney injury |
| description |
La infección por SARS-CoV-2 se ha convertido en un problema mundial de salud pública. Su presentación clínica es variada, desde benigna hasta un síndrome de distrés respiratorio agudo, afectación sistémica y fallo multiorgánico. La severidad del cuadro clínico depende de factores biológicos del virus y del huésped y de comorbilidades como la enfermedad renal. Además, la interacción entre el virus, la enzima convertidora de angiotensina 2 y la respuesta inmunológica exacerbada podría conducir al desarrollo de lesión renal aguda. Sin embargo, las implicaciones de la infección por SARSCoV-2 sobre las células renales, las repercusiones pronósticas en los pacientes con enfermedad renal crónica y su efecto a largo plazo sobre la función renal no están del todo claras. El objetivo es revisar el papel del SARSCoV-2 en la enfermedad renal aguda y crónica, y sus posibles mecanismos patogénicos en la afectación renal. |
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2021 |
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2021 |
| dc.date.accessioned.none.fl_str_mv |
2023-08-28T16:32:52Z |
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2023-08-28T16:32:52Z |
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info:eu-repo/semantics/article |
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Artículo científico |
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11376627 |
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https://hdl.handle.net/20.500.12442/13225 |
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https://doi.org/10.23938/ASSN.0973 |
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11376627 |
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https://hdl.handle.net/20.500.12442/13225 https://doi.org/10.23938/ASSN.0973 |
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pdf |
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Gobierno de Navarra |
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Anales del Sistema Sanitario de Navarra |
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Vol. 44 No. 3 (2021) |
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Torres, W.7ccb9322-0503-4079-9494-1ea849d1e070Morillo, V.a716d5d5-89b0-46b4-8af7-9d2fbd8ae4ddSuarez, M.K.a66b607a-7481-4420-b7ee-803ca68ec386Parra, H.bf523499-c315-44d1-9f98-d72429198433Lameda, V.f086dd90-9191-4a86-976b-49f520ffbe7cNava, M.32e439a8-ad7e-4ec6-8213-f2a05dd943a7D'Marco, L.cec4b3cc-cdcc-4e6e-bcdc-dc0bea09f1c2Puchades, M.J.9ff94dd8-d57e-4957-825f-22b92276065fMedina, O.88b3dc4c-b278-4902-9eb6-d7489816ff4fGuerra-Torres, X.E.b6335f9b-0fa8-4eaf-ad35-a52191238d84Bermúdez, V.b275e333-8d86-412a-bce9-74bdf69f7ef92023-08-28T16:32:52Z2023-08-28T16:32:52Z202111376627https://hdl.handle.net/20.500.12442/13225https://doi.org/10.23938/ASSN.0973La infección por SARS-CoV-2 se ha convertido en un problema mundial de salud pública. Su presentación clínica es variada, desde benigna hasta un síndrome de distrés respiratorio agudo, afectación sistémica y fallo multiorgánico. La severidad del cuadro clínico depende de factores biológicos del virus y del huésped y de comorbilidades como la enfermedad renal. Además, la interacción entre el virus, la enzima convertidora de angiotensina 2 y la respuesta inmunológica exacerbada podría conducir al desarrollo de lesión renal aguda. Sin embargo, las implicaciones de la infección por SARSCoV-2 sobre las células renales, las repercusiones pronósticas en los pacientes con enfermedad renal crónica y su efecto a largo plazo sobre la función renal no están del todo claras. El objetivo es revisar el papel del SARSCoV-2 en la enfermedad renal aguda y crónica, y sus posibles mecanismos patogénicos en la afectación renal.The SARS-CoV-2 infection has become as a worldwide public health emergency. It exhibits a variety of clinical presentations, ranging from benign to acute respiratory distress syndrome, systemic involvement, and multiorganic failure. The severity of the clinical picture depends on host and virus biological features and the presence of comorbidities such as chronic kidney disease. In addition, the interaction between the virus, angiotensin-converting enzyme 2, and the exacerbated immune response could lead to the development of acute kidney injury. However, the implications of SARSCoV-2 infection on renal cells, the prognosis of patients with chronic kidney disease, and the long-term behavior of renal function are not entirely understood. This review aims to explore the role of SARS-CoV-2 in acute and chronic kidney disease and the possible pathogenic mechanisms of renal involvement.pdfspaGobierno de NavarraAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Anales del Sistema Sanitario de NavarraVol. 44 No. 3 (2021)SARS-CoV-2COVID-19Enzima convertidora de angiotensina 2.Enfermedad renal crónicaLesión renal agudaAngiotensin-converting enzyme 2.Chronic kidney diseaseAcute kidney injuryMecanismos patogénicos de infección por SARS-CoV-2 y enfermedad renal: una perspectiva clínico-molecularPathogenic mechanisms of SARS-CoV-2 infection and kidney disease: a clinical and molecular perspectiveinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Guan W-J, ni Z-Y, Hu Y, LianG W-H, Ou C-Q, He J-X et al. Clinical characteristics of coronavi- rus disease 2019 in China. N Engl J Med 2020; 382: 1708-172World Health Organization. Coronavirus di- sease (COVID-19) Weekly Epidemiological Update and Weekly Operational Update. Co- ronavirus Disease (COVID-19) Situation Re- ports 2020 [consultado 07-07-2020Braun F, LütGeHetmann m, PFeFFerLe S, WOnG mn, C arSten a, L indenmeYer mt et al. SARS-CoV-2 renal tropism associates with acute kidney injury. Lancet 2020; 396: 597-59naiCker S, YanG C-W, HWanG S-J, Liu B-C, CHen J-H, JHa V. The novel coronavirus 2019 epide- mic and kidneys. Kidney Int 2020; 97: 824-828HuanG C, W anG Y, L i X, ren L, ZHaO J, H u Y et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet Lond Engl 2020; 395: 497-506WanG d, H u B, H u C, ZHu F, L iu X, ZHanG J et al. Clinical characteristics of 138 hospitali- zed patients with 2019 novel coronavirus- infected pneumonia in Wuhan, China. JAMA 2020; 323: 1061-1069GuO Y-r, C aO Q-d, HOnG Z-S, tan Y-Y, CHen S-d, Jin H-J et al. The origin, transmission and cli- nical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status. Mil Med Res 2020; 7: 1Xu X, CHen P, WanG J, FenG J, ZHOu H, Li X et al. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Sci China Life Sci 2020; 63: 457-460ParaSkeViS d, kOStaki eG, maGiOrkiniS G, PanaYiO- takOPOuLOS G, SOurVinOS G, tSiOdraS S. Full-geno- me evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombi- nation event. Infect Genet Evol J Mol Epide- miol Evol Genet Infect Dis 2020; 79: 104212Liu Z, X iaO X, W ei X, L i J, Y anG J, tan H et al. Composition and divergence of coronavirus spike proteins and host ACE2 receptors pre- dict potential intermediate hosts of SARS- CoV-2. J Med Virol 2020; 92: 595-601FOrSter P, FOrSter L, renFreW C, FOrSter m. Phylo- genetic network analysis of SARS-CoV-2 geno- mes. Proc Natl Acad Sci 2020; 117: 9241-9243Lu r, ZHaO X, L i J, niu P, Y anG B, W u H et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet Lond Engl 2020; 395: 565-574.raBaan aa, aL-aHmed SH, HaQue S, SaH r, tiWari r, maLik YS et al. SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview. Infez Med. 2020; 28: 174-184.maLik YS, S irCar S, BHat S, SHarun k, dHama k, dadar m et al. Emerging novel coronavirus(2019-nCoV)-current scenario, evolutionary perspective based on genome analysis and recent developments. Vet Q 2020; 40: 68-76.tOrtOriCi ma, VeeSLer d. Structural insights into coronavirus entry. Adv Virus Res 2019; 105: 93-11SHereen ma, kHan S, kaZmi a, B aSHir n, S iddiQue r. COVID-19 infection: Origin, transmission, and characteristics of human coronaviru- ses. J Adv Res 2020; 24: 91-98GuPta a, madHaVan mV, S eHGaL k, nair n, maHa- Jan S, S eHraWat tS et al. Extrapulmonary ma- nifestations of COVID-19. Nat Med 2020; 26: 1017-1032.WierSinGa WJ, rHOdeS a, CHenG aC, PeaCOCk SJ, P reSCOtt HC. Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): A review. JAMA 2020; 324: 782-793.CHenG Y, LuO r, WanG k, ZHanG m, WanG Z, dOnG L et al. Kidney disease is associated with in- hospital death of patients with COVID-19. Kidney Int 2020; 97: 829-838.Wang Q, ZHanG Y, Wu L, Niu S, Song C, Zhang Z, et al. Structural and functional basis of SARS-CoV-2 entry by using human ACE2. Cell. 2020;181: 894-904.e9.. WraPP d, W anG n, COrBett kS, GOLdSmitH Ja, HSieH C-L, aBiOna O et al. Cryo-EM Structure of the 2019-nCoV spike in the prefusion confor- mation. Science 2020; 367:WaLLS aC, P ark Y-J, tOrtOriCi ma, W aLL a, mC- Guire at, VeeSLer d. Structure, function, and antigenicity of the SARS-CoV-2 spike glyco- protein. Cell 2020; 181: 281-292FeHr ar, P erLman S. Coronaviruses: an over- view of their replication and pathogenesis. Methods Mol Biol Clifton NJ 2015; 1282: 1-23LunG J, L in Y-S, Y anG Y-H, CHOu Y-L, SHu L-H, CHenG Y-C et al. The potential chemical struc- ture of anti-SARS-CoV-2 RNA-dependent RNApolymerase. J Med Virol 2020; 92: 693-697CHOi HS, kim iJ, kim CS, ma Sk, SCHOLeY JW, kim SW et al. Angiotensin-[1-7] attenuates kidney injury in experimental Alport syndrome. Sci Rep 2020; 10: 4225.VaduGanatHan m, V ardenY O, miCHeL t, mCmu- rraY JJV, PFeFFer ma, SOLOmOn Sd. Renin-An- giotensin-Aldosterone system inhibitors in patients with Covid-19. N Engl J Med 2020; 382: 1653-1659kuBa k, imai Y, raO S, G aO H, G uO F, G uan B et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-indu- ced lung injury. Nat Med 2005; 11: 875-879Lin L, Lu L, C aO W, L i t. Hypothesis for poten- tial pathogenesis of SARS-CoV-2 infection-a review of immune changes in patients with viral pneumonia. Emerg Microbes Infect 2020; 9: 727-732.Fu Y, CHenG Y, W u Y. Understanding SARS- CoV-2-Mediated inflammatory responses: From mechanisms to potential therapeutic tools. Virol Sin 2020; 35: 266-27YanG m. Cell Pyroptosis, a potential pathoge- nic mechanism of 2019-nCoV infection. SSRN 2020 [consultado 07-07-2020].SHi J, ZHaO Y, W anG k, SHi X, W anG Y, H uanG H et al. Cleavage of GSDMD by inflamma- tory caspases determines pyroptotic cell death. Nature 2015; 526: 660-665GuBernatOrOVa eO, GOrSHkOVa ea, POLinOVa ai, drutSkaYa mS. IL-6: Relevance for immuno- pathology of SARS-CoV-2. Cytokine Growth Factor Rev 2020; 53: 13-24.taY mZ, POH Cm, rénia L, maCarY Pa, nG LFP. The trinity of COVID-19: immunity, inflam- mation and intervention. Nat Rev Immunol 2020; 20: 363-374.HaGa S, Y amamOtO n, nakai-murakami C, OSaWa Y, tOkunaGa k, S ata t et al. Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF- alpha production and facilitates viral entry. Proc Natl Acad Sci USA 2008; 105: 7809-7814.GarCía LF. Immune Response, Inflammation, and the Clinical Spectrum of COVID-19.Front Immunol 2020; 11: 144JOHnSOn de, O’keeFe ra, GrandiS Jr. Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat Rev Clin Oncol 2018; 15: 234-248Rubin S, Orieux A, Prevel R, Garric A, Bats M-L, Dabernat S et al. Characterization of acute kidney injury in critically ill patients with severe coronavirus disease 2019. Clin Kidney J 2020; 13: 354-361.Chan L, Chaudhary K, Saha A, Chauhan K, Vaid A, Zhao S et al. AKI in Hospitalized Patients with COVID-19. J Am Soc Nephrol 2021; 32: 151- 160.https://doi.org/ 10.1681Xiao G, Hu H, Wu F, Sha T, Huang Q, Li H et al. Acute kidney injury in patients hospitalized with COVID-19 in Wuhan, China: A single-center retrospective observational study. medRxiv 2020 [consultado 07-07-2020Li Z, Wu M, Yao J, Guo J, Liao X, Song S et al. Caution on kidney dysfunctions of COVID-19 patients. medRxiv 2020 [consultado 07-07-2020Xu S, Fu L, Fei J, Xiang H-X, Xiang Y, Tan Z-X et al. Acute kidney injury at early stage as a negative prognostic indicator of patients with COVID- 19: a hospital-based retrospective analysis. medRxiv 2020 [consultado 07-07-2020]. https://doi.org/10.1101/2020.03.24.20042408Hirsch JS, Ng JH, Ross DW, Sharma P, Shah HH, Barnett RL et al. Acute kidney injury in patients hospitalized with COVID-19. Kidney Int 2020; 98: 209-218. https://doi.org/10.1016/j. kint.2020.05.006Fanelli V, Fiorentino M, Cantaluppi V, Gesualdo L, Stallone G, Ronco C et al. Acute kidney injury in SARS-CoV-2 infected patients. Crit Care Lond Engl 2020; 24: 155.Pan X-W, Xu D, Zhang H, Zhou W, Wang L-H, Cui X-G. Identification of a potential mechanism of acute kidney injury during the COVID- 19 outbreak: a study based on single-cell transcriptome analysis. Intensive Care Med 2020; 46: 1114-1116.Pan X-W, Xu D, Zhang H, Zhou W, Wang L-H, Cui X-G. Identification of a potential mechanism of acute kidney injury during the COVID- 19 outbreak: a study based on single-cell transcriptome analysis. Intensive Care Med 2020; 46: 1114-1116.Ye M, Wysocki J, William J, Soler MJ, Cokic I, Batlle D. Glomerular localization and expression of Angiotensin-converting enzyme 2 and Angiotensin-converting enzyme: implications for albuminuria in diabetes. J Am Soc Nephrol 2006; 17: 3067-3075. https://doi. org/10.1681/asn.2006050423An. Sist. Sanit. Navar. 2021, Vol. 44, Nº 3, septiembre-diciembreDiao B, Wang C, Wang R, Feng Z, Tan Y, Wang H et al. Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. medRxiv 2020 [consultado 07-07-2020]. https://doi. org/10.1101/2020.03.04.20031120Izzedine H, Jhaveri KD. Acute kidney injury in patients with COVID-19: an update on the pathophysiology. Nephrol Dial Transplant 2021; 36: 224-226. https://doi.org/10.1093/ ndt/gfaa184Werion A, Belkhir L, Perrot M, Schmit G, Aydin S, Chen Z et al. SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule. Kidney Int 2020; 98: 1296-1307.https://doi. org/10.1016/j.kint.2020.07.019Werion A, Belkhir L, Perrot M, Schmit G, Aydin S, Chen Z et al. SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule. Kidney Int 2020; 98: 1296-1307.https://doi. org/10.1016/j.kint.2020.07.019Fan C, Li K, Ding Y, Lu WL, Wang J. ACE2 expression in kidney and testis may cause kidney and testis damage after 2019-nCoV infection. medRxiv 2020. [consultado 07-07-2020]. https://doi.org/10.1101/2020.02.12.20022418Tian X, Li C, Huang A, Xia S, Lu S, Shi Z et al. Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody. Emerg Microbes Infect 2020; 9: 382-385. https://doi. org/10.1101/2020.01.28.923011Sturrock BR, Milne K, Chevassut TJ. The reninangiotensin system – a therapeutic target in COVID-19? Clin Med Lond Engl 2020; 20: 1-4. https://doi.org/10.7861/clinmed.2020-0146Sturrock BR, Milne K, Chevassut TJ. The reninangiotensin system – a therapeutic target in COVID-19? Clin Med Lond Engl 2020; 20: 1-4. https://doi.org/10.7861/clinmed.2020-0146de Abajo FJ, Rodríguez-Martín S, Lerma V, Mejía- Abril G, Aguilar M, García-Luque A et al. Use of renin-angiotensin-aldosterone system inhibitors and risk of COVID-19 requiring admission to hospital: a case-population study. Lancet 2020; 395: 1705-1714. httMathew D, Giles JR, Baxter AE, Oldridge DA, Greenplate AR, Wu JE et al. Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications. Science 2020; 369: eabc8511. https://doi. org/10.1126/science.abc8511Liu F, Li L, Xu M, Wu J, Luo D, Zhu Y et al. Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID- 19. J Clin Virol 2020; 127: 104370. https:// doi.org/10.1016/j.jcv.2020.104370Xu C, Chang A, Hack BK, Eadon MT, Alper SL, Cunningham PN. TNF-mediated damage to glomerular endothelium is an important determinant of acute kidney injury in sepsis. Kidney Int 2014; 85: 72-81. https://doi. org/10.1038/ki.2013.286Nechemia-Arbely Y, Barkan D, Pizov G, Shriki A, Rose-John S, Galun E et al. IL-6/IL-6R axis plays a critical role in acute kidney injury. J Am Soc Nephrol 2008; 19: 1106-1115. https://doi. org/10.1681/asn.2007070744Cugno M, Meroni PL, Gualtierotti R, Griffini S, Grovetti E, Torri A et al. Complement activation in patients with COVID-19: A novel therapeutic target. J Allergy Clin Immunol 2020; 146: 215-217. https://doi.org/10.1016/j. jaci.2020.05.006Magro C, Mulv ey JJ, Berlin D, Nuovo G, Salv atore S, Harp J et al. Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases. Transl Res J Lab Clin Med 2020; 220: 1-13. https://doi.org/10.1016/j. trsl.2020.04.007Helms J, Tacquard C, Severac F, Leonard-Lorant I, Ohana M, Delabranche X et al. High risk of thrombosis in patients with severe SARSCoV- 2 infection: a multicenter prospective cohort study. Intensive Care Med 2020; 46: 1089-1098. https://doi.org/10.1007/s00134- 020-06062-xHelms J, Tacquard C, Severac F, Leonard-Lorant I, Ohana M, Delabranche X et al. High risk of thrombosis in patients with severe SARSCoV- 2 infection: a multicenter prospective cohort study. Intensive Care Med 2020; 46: 1089-1098. https://doi.org/10.1007/s00134- 020-06062-xGoshua G, Pine AB, Meizlish ML, Chang C-H, Zhang H, Bahel P et al. Endotheliopathy in COVID- 19-associated coagulopathy: evidence from a single-centre, cross-sectional study. Lancet Haematol 2020; 7: e575-e582. https:// doi.org/10.1016/s2352-3026(20)30216-7Santoriello D, Khairallah P, Bomback AS, Xu K, Kudose S, Batal I et al. Postmortem kidneykidney pathology findings in patients with COVID- 19. J Am Soc Nephrol 2020; 31: 2158-2167. https://doi.org/10.1681/asn.2020050744Jhaveri KD, Meir LR, Flores Chang BS, Parikh R, Wanchoo R, Barilla-LaBarca ML et al. Thrombotic microangiopathy in a patient with COVID- 19. Kidney Int 2020; 98: 509-512. https:// doi.org/10.1016/j.kint.2020.05.025Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet Lond Engl 2020; 395: 1417-1418. https://doi.org/10.1016/s0140- 6736(20)30937-5Chen T, Wu D, Chen H, Yan W, Yang D, Chen G et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ 2020; m1091. https:// doi.org/10.1136/bmj.m1091Carriazo S, Kanbay M, Ortiz A. Kidney disease and electrolytes in COVID-19: more than meets the eye. Clin Kidney J 2020; 13: 274- 280. https://doi.org/10.1093/ckj/sfaa112D’Marco L, Puchades MJ, Romero-Parra M, Gimenez- Civera E, Soler MJ, Ortiz A et al. Coronavirus disease 2019 in chronic kidney disease. Clin Kidney J 2020; 13: 297-306.https://doi. org/10.1093/ckj/sfaa104Meijers B, Hilbrands LB. The clinical characteristics of coronavirus-associated nephropathy. Nephrol Dial Transplant 2020; 35: 1279-1281. https://doi.org/10.1093/ndt/ gfaa197Ma Y, Diao B, Lv X, Zhu J, Liang W, Liu L et al. 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