Neprilysin: A Potential Therapeutic Target of Arterial Hypertension?

Arterial hypertension is the most prevalent chronic disease in the adult population of developed countries and it constitutes a significant risk factor in the development of cardiovascular disease, contributing to the emergence of many comorbidities, among which heart failure excels, a clinical synd...

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Autores:: Salazar, Juan
Rojas-Quintero, Joselyn
Cano, Clímaco
Pérez, José L.
Ramírez, Paola
Carrasquero, Rubén
Torres, Wheeler
Espinoza, Cristobal
Chacín-González, Maricarmen
Bermúdez, Valmore

Tipo de recurso:

Fecha de publicación:: 2020

Institución:: Universidad Simón Bolívar

Repositorio:: Repositorio Digital USB

Idioma:: eng

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dc.title.eng.fl_str_mv	Neprilysin: A Potential Therapeutic Target of Arterial Hypertension?
title	Neprilysin: A Potential Therapeutic Target of Arterial Hypertension?
spellingShingle	Neprilysin: A Potential Therapeutic Target of Arterial Hypertension? Arterial hypertension Heart failure Neprilysin Natriuretic peptides Sacubitril Pharmacology
title_short	Neprilysin: A Potential Therapeutic Target of Arterial Hypertension?
title_full	Neprilysin: A Potential Therapeutic Target of Arterial Hypertension?
title_fullStr	Neprilysin: A Potential Therapeutic Target of Arterial Hypertension?
title_full_unstemmed	Neprilysin: A Potential Therapeutic Target of Arterial Hypertension?
title_sort	Neprilysin: A Potential Therapeutic Target of Arterial Hypertension?
dc.creator.fl_str_mv	Salazar, Juan Rojas-Quintero, Joselyn Cano, Clímaco Pérez, José L. Ramírez, Paola Carrasquero, Rubén Torres, Wheeler Espinoza, Cristobal Chacín-González, Maricarmen Bermúdez, Valmore
dc.contributor.author.none.fl_str_mv	Salazar, Juan Rojas-Quintero, Joselyn Cano, Clímaco Pérez, José L. Ramírez, Paola Carrasquero, Rubén Torres, Wheeler Espinoza, Cristobal Chacín-González, Maricarmen Bermúdez, Valmore
dc.subject.eng.fl_str_mv	Arterial hypertension Heart failure Neprilysin Natriuretic peptides Sacubitril Pharmacology
topic	Arterial hypertension Heart failure Neprilysin Natriuretic peptides Sacubitril Pharmacology
description	Arterial hypertension is the most prevalent chronic disease in the adult population of developed countries and it constitutes a significant risk factor in the development of cardiovascular disease, contributing to the emergence of many comorbidities, among which heart failure excels, a clinical syndrome that nowadays represents a major health problem with uncountable hospitalizations and the indolent course of which progressively worsens until quality of life decreases and lastly death occurs prematurely. In the light of this growing menace, each day more efforts are invested in the field of cardiovascular pharmacology, searching for new therapeutic options that allow us to modulate the physiological systems that appear among these pathologies. Therefore, in the later years, the study of natriuretic peptides has become so relevant, which mediate beneficial effects at the cardiovascular level such as diuresis, natriuresis, and decreasing cardiac remodeling; their metabolism is mediated by neprilysin, a metalloproteinase, widely expressed in the human and capable of catalyzing many substrates. The modulation of these functions has been studied by decades, giving room to Sacubitril, the first neprilysin inhibitor, which in conjunction with an angiotensin receptor blocker has provided a high efficacy and tolerability among patients with heart failure, for whom it has already been approved and recommended. Nonetheless, in the matter of arterial hypertension, significant findings have arisen that demonstrate the potential role that it will play among the pharmacological alternatives in the upcoming years.
publishDate	2020
dc.date.issued.none.fl_str_mv	2020
dc.date.accessioned.none.fl_str_mv	2021-10-25T22:46:34Z
dc.date.available.none.fl_str_mv	2021-10-25T22:46:34Z
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dc.type.spa.spa.fl_str_mv	Artículo científico
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dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12442/8783
dc.identifier.doi.none.fl_str_mv	http://doi.org/10.2174/1573403X15666190625160352
identifier_str_mv	18756557
url	https://hdl.handle.net/20.500.12442/8783 http://doi.org/10.2174/1573403X15666190625160352
dc.language.iso.eng.fl_str_mv	eng
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dc.publisher.eng.fl_str_mv	Bentham Science Publishers
dc.source.eng.fl_str_mv	Current Cardiology Reviews
dc.source.none.fl_str_mv	Vol. 16, Issue 1 (2020)
institution	Universidad Simón Bolívar
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spelling	Salazar, Juanfbd053e7-5aea-424c-812f-92153ecb9181Rojas-Quintero, Joselyn1fcd6ac1-186e-465c-a5fd-3c25563275abCano, Clímacob7d55d6b-f1bf-4136-9b90-54a80ab90ab2Pérez, José L.8cd3b0aa-9887-4ba3-84f8-9abec29a23acRamírez, Paolaf186f789-08a7-460b-bca5-3a56fa7973f2Carrasquero, Rubén87b1437e-aa54-4ca0-ba7e-ccec38847d59Torres, Wheelera82c8c05-2160-44dc-b397-ffc2ac51becaEspinoza, Cristobal9431d6c1-8553-4395-9301-476c5f3ebc9aChacín-González, Maricarmenf2de0f64-ef1d-446f-97f7-509c45051d35Bermúdez, Valmore29f9aa18-16a4-4fd3-8ce5-ed94a0b8663a2021-10-25T22:46:34Z2021-10-25T22:46:34Z202018756557https://hdl.handle.net/20.500.12442/8783http://doi.org/10.2174/1573403X15666190625160352Arterial hypertension is the most prevalent chronic disease in the adult population of developed countries and it constitutes a significant risk factor in the development of cardiovascular disease, contributing to the emergence of many comorbidities, among which heart failure excels, a clinical syndrome that nowadays represents a major health problem with uncountable hospitalizations and the indolent course of which progressively worsens until quality of life decreases and lastly death occurs prematurely. In the light of this growing menace, each day more efforts are invested in the field of cardiovascular pharmacology, searching for new therapeutic options that allow us to modulate the physiological systems that appear among these pathologies. Therefore, in the later years, the study of natriuretic peptides has become so relevant, which mediate beneficial effects at the cardiovascular level such as diuresis, natriuresis, and decreasing cardiac remodeling; their metabolism is mediated by neprilysin, a metalloproteinase, widely expressed in the human and capable of catalyzing many substrates. The modulation of these functions has been studied by decades, giving room to Sacubitril, the first neprilysin inhibitor, which in conjunction with an angiotensin receptor blocker has provided a high efficacy and tolerability among patients with heart failure, for whom it has already been approved and recommended. Nonetheless, in the matter of arterial hypertension, significant findings have arisen that demonstrate the potential role that it will play among the pharmacological alternatives in the upcoming years.pdfengBentham Science PublishersAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Current Cardiology ReviewsVol. 16, Issue 1 (2020)Arterial hypertensionHeart failureNeprilysinNatriuretic peptidesSacubitrilPharmacologyNeprilysin: A Potential Therapeutic Target of Arterial Hypertension?info:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Paulis L, Steckelings UM, Unger T. Key advances in antihypertensive treatment. Nat Rev Cardiol 2012; 9(5): 276-85. [http://dx.doi.org/10.1038/nrcardio.2012.33] [PMID: 22430830]Chor D, Pinho Ribeiro AL, Sá Carvalho M, et al. Prevalence, awareness, treatment and influence of socioeconomic variables on control of high blood pressure: Results of the ELSA-Brasil study. PLoS One 2015; 10(6)e0127382 [http://dx.doi.org/10.1371/journal.pone.0127382] [PMID: 26102079]Singh JS, Lang CC. Angiotensin receptor-neprilysin inhibitors: clinical potential in heart failure and beyond. Vasc Health Risk Manag 2015; 11: 283-95. [PMID: 26082640]Kemp CD, Conte JV. The pathophysiology of heart failure. Cardiovasc Pathol 2012; 21(5): 365-71. [http://dx.doi.org/10.1016/j.carpath.2011.11.007] [PMID: 22227365]Lobato NS, Filgueira FP, Akamine EH, Tostes RC, Carvalho MHC, Fortes ZB. Mechanisms of endothelial dysfunction in obesity-associated hypertension. Braz J Med Biol Res 2012; 45(5): 392-400. [http://dx.doi.org/10.1590/S0100-879X2012007500058] [PMID: 22488221]de Oliveira C, Marmot MG, Demakakos P, Vaz de Melo Mambrini J, Peixoto SV, Lima-Costa MF. 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[http://dx.doi.org/10.1002/cpdd.183] [PMID: 27137712]ORIGINALPDF.pdfPDF.pdfPDFapplication/pdf1517161https://bonga.unisimon.edu.co/bitstreams/40b4b972-930e-454b-a321-2fcd204cc620/download2955c396f6ffe1549ab038ad5bef647dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-8381https://bonga.unisimon.edu.co/bitstreams/60269ef5-e41a-4353-96c8-88663e58cb7e/download733bec43a0bf5ade4d97db708e29b185MD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://bonga.unisimon.edu.co/bitstreams/896db10e-7c21-4c59-abca-9a3ac0bb822a/download4460e5956bc1d1639be9ae6146a50347MD52TEXT2020_Neprilisyn_A-potential-Therapeutic.pdf.txt2020_Neprilisyn_A-potential-Therapeutic.pdf.txtExtracted texttext/plain65468https://bonga.unisimon.edu.co/bitstreams/195eeeff-59f0-41d6-aa41-c5fb2db3f714/downloaddbdfe57723e51d2cff4d6dc77fd3f303MD54PDF.pdf.txtPDF.pdf.txtExtracted texttext/plain71979https://bonga.unisimon.edu.co/bitstreams/758f869a-1a29-4e26-92f5-a92dd242e0af/download8ad8a46da6784d525984356cd58199f6MD56THUMBNAIL2020_Neprilisyn_A-potential-Therapeutic.pdf.jpg2020_Neprilisyn_A-potential-Therapeutic.pdf.jpgGenerated Thumbnailimage/jpeg6023https://bonga.unisimon.edu.co/bitstreams/6075d88b-36e3-4fc1-bd14-3fc4a9554d4e/download505e895226b47932ffe9ad9e80ae4d78MD55PDF.pdf.jpgPDF.pdf.jpgGenerated Thumbnailimage/jpeg2916https://bonga.unisimon.edu.co/bitstreams/e188d3ca-e68d-48e3-89bb-777d3cf294ed/downloadda8c7bae02c60d29b8c8db48f48ddc90MD5720.500.12442/8783oai:bonga.unisimon.edu.co:20.500.12442/87832024-08-14 21:53:55.702http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internacionalopen.accesshttps://bonga.unisimon.edu.coRepositorio Digital Universidad Simón Bolívarrepositorio.digital@unisimon.edu.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

Neprilysin: A Potential Therapeutic Target of Arterial Hypertension?

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