Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy
The placebo effect can be defined as the improvement of symptoms in a patient after the administration of an innocuous substance in a context that induces expectations regarding its effects. During recent years, it has been discovered that the placebo response not only has neurobiological functions...
- Autores:
-
Ortega, Ángel
Salazar, Juan
Galban, Néstor
Rojas, Milagros
Ariza, Daniela
Chávez-Castillo, Mervin
Nava, Manuel
Riaño-Garzón, Manuel E.
Díaz-Camargo, Edgar Alexis
Medina-Ortiz, Oscar
Bermúdez, Valmore
- Tipo de recurso:
- Fecha de publicación:
- 2022
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/11295
- Palabra clave:
- placebo effect
Psychoneuroimmunology
Conditioning
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy |
| title |
Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy |
| spellingShingle |
Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy placebo effect Psychoneuroimmunology Conditioning |
| title_short |
Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy |
| title_full |
Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy |
| title_fullStr |
Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy |
| title_full_unstemmed |
Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy |
| title_sort |
Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy |
| dc.creator.fl_str_mv |
Ortega, Ángel Salazar, Juan Galban, Néstor Rojas, Milagros Ariza, Daniela Chávez-Castillo, Mervin Nava, Manuel Riaño-Garzón, Manuel E. Díaz-Camargo, Edgar Alexis Medina-Ortiz, Oscar Bermúdez, Valmore |
| dc.contributor.author.none.fl_str_mv |
Ortega, Ángel Salazar, Juan Galban, Néstor Rojas, Milagros Ariza, Daniela Chávez-Castillo, Mervin Nava, Manuel Riaño-Garzón, Manuel E. Díaz-Camargo, Edgar Alexis Medina-Ortiz, Oscar Bermúdez, Valmore |
| dc.subject.eng.fl_str_mv |
placebo effect Psychoneuroimmunology Conditioning |
| topic |
placebo effect Psychoneuroimmunology Conditioning |
| description |
The placebo effect can be defined as the improvement of symptoms in a patient after the administration of an innocuous substance in a context that induces expectations regarding its effects. During recent years, it has been discovered that the placebo response not only has neurobiological functions on analgesia, but that it is also capable of generating effects on the immune and endocrine systems. The possible integration of changes in different systems of the organism could favor the well-being of the individuals and go hand in hand with conventional treatment for multiple diseases. In this sense, classic conditioning and setting expectations stand out as psychological mechanisms implicated in the placebo effect. Recent advances in neuroimaging studies suggest a relationship between the placebo response and the opioid, cannabinoid, and monoaminergic systems. Likewise, a possible immune response conditioned by the placebo effect has been reported. There is evidence of immune suppression conditioned through the insular cortex and the amygdala, with noradrenalin as the responsible neurotransmitter. Finally, a conditioned response in the secretion of different hormones has been determined in different studies; however, the molecular mechanisms involved are not entirely known. Beyond studies about its mechanism of action, the placebo effect has proved to be useful in the clinical setting with promising results in the management of neurological, psychiatric, and immunologic disorders. However, more research is needed to better characterize its potential use. This review integrates current knowledge about the psycho-neuro-endocrine-immune basis of the placebo effect and its possible clinical applications. |
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2022 |
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2022-11-11T17:41:55Z |
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2022-11-11T17:41:55Z |
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2022 |
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info:eu-repo/semantics/article |
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Artículo científico |
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Ortega, Á., Salazar, J., Galban, N., Rojas, M., Ariza, D., Chávez-Castillo, M., Nava, M., Riaño-Garzón, M. E., Díaz-Camargo, E. A., Medina-Ortiz, O., & Bermúdez, V. (2022). Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy. International Journal of Molecular Sciences, 23(8), 4196. https://doi.org/10.3390/ijms23084196 |
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14220067 |
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https://hdl.handle.net/20.500.12442/11295 |
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https://doi.org/10.3390/ijms23084196 |
| identifier_str_mv |
Ortega, Á., Salazar, J., Galban, N., Rojas, M., Ariza, D., Chávez-Castillo, M., Nava, M., Riaño-Garzón, M. E., Díaz-Camargo, E. A., Medina-Ortiz, O., & Bermúdez, V. (2022). Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy. International Journal of Molecular Sciences, 23(8), 4196. https://doi.org/10.3390/ijms23084196 14220067 |
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https://hdl.handle.net/20.500.12442/11295 https://doi.org/10.3390/ijms23084196 |
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Ortega, Ángelb6a809bb-4d26-4e53-9419-e4eb9fb40a9bSalazar, Juanfbd053e7-5aea-424c-812f-92153ecb9181Galban, Néstordce44827-2bbc-421d-a1dd-15201c3cf3c5Rojas, Milagrosd07a9d4d-cce2-438c-b4a0-fc5ed4af1a67Ariza, Danielad25a8393-79fc-472e-8dd8-79dbbf383c79Chávez-Castillo, Mervin912e1d3d-18fb-43af-8edb-826137f74a5aNava, Manuelcf0ca570-5fc3-4ec7-9913-90be952261e2Riaño-Garzón, Manuel E.40d363d1-1c0d-4cbf-a685-c8ab2ca9caa2Díaz-Camargo, Edgar Alexis9b364e11-4795-4929-bae5-d7fa459903e9Medina-Ortiz, Oscar7c447a42-58e2-4ad4-be32-82d6e7b6a6c5Bermúdez, Valmore29f9aa18-16a4-4fd3-8ce5-ed94a0b8663a2022-11-11T17:41:55Z2022-11-11T17:41:55Z2022Ortega, Á., Salazar, J., Galban, N., Rojas, M., Ariza, D., Chávez-Castillo, M., Nava, M., Riaño-Garzón, M. E., Díaz-Camargo, E. A., Medina-Ortiz, O., & Bermúdez, V. (2022). Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy. International Journal of Molecular Sciences, 23(8), 4196. https://doi.org/10.3390/ijms2308419614220067https://hdl.handle.net/20.500.12442/11295https://doi.org/10.3390/ijms23084196The placebo effect can be defined as the improvement of symptoms in a patient after the administration of an innocuous substance in a context that induces expectations regarding its effects. During recent years, it has been discovered that the placebo response not only has neurobiological functions on analgesia, but that it is also capable of generating effects on the immune and endocrine systems. The possible integration of changes in different systems of the organism could favor the well-being of the individuals and go hand in hand with conventional treatment for multiple diseases. In this sense, classic conditioning and setting expectations stand out as psychological mechanisms implicated in the placebo effect. Recent advances in neuroimaging studies suggest a relationship between the placebo response and the opioid, cannabinoid, and monoaminergic systems. Likewise, a possible immune response conditioned by the placebo effect has been reported. There is evidence of immune suppression conditioned through the insular cortex and the amygdala, with noradrenalin as the responsible neurotransmitter. Finally, a conditioned response in the secretion of different hormones has been determined in different studies; however, the molecular mechanisms involved are not entirely known. Beyond studies about its mechanism of action, the placebo effect has proved to be useful in the clinical setting with promising results in the management of neurological, psychiatric, and immunologic disorders. However, more research is needed to better characterize its potential use. This review integrates current knowledge about the psycho-neuro-endocrine-immune basis of the placebo effect and its possible clinical applications.pdfengMDPIAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2International Journal of Molecular SciencesVol. 23, Isuue 8 (2022)placebo effectPsychoneuroimmunologyConditioningPsycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapyinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Jütte, R. The Early History of the Placebo. Complement. Ther. Med. 2013, 21, 94–97.Kerr, C.E.; Milne, I.; Kaptchuk, T.J. William Cullen and a Missing Mind-Body Link in the Early History of Placebos. J. R. Soc. Med. 2008, 101, 89–92.Tavel, M.E. The Placebo Effect: The Good, the Bad, and the Ugly. Am. J. Med. 2014, 127, 484–488.Colagiuri, B.; Schenk, L.A.; Kessler, M.D.; Dorsey, S.G.; Colloca, L. The Placebo Effect: From Concepts to Genes. Neuroscience 2015, 307, 171–190.Colagiuri, B.; Schenk, L.A.; Kessler, M.D.; Dorsey, S.G.; Colloca, L. The Placebo Effect: From Concepts to Genes. Neuroscience 2015, 307, 171–190.Wager, T.D.; Atlas, L.Y. The Neuroscience of Placebo Effects: Connecting Context, Learning and Health. Nat. Rev. Neurosci. 2015, 16, 403–418.Klinger, R.; Colloca, L.; Bingel, U.; Flor, H. Placebo Analgesia: Clinical Applications. Pain 2014, 155, 1055–1058.Meyer, B.; Yuen, K.S.L.; Ertl, M.; Polomac, N.; Mulert, C.; Büchel, C.; Kalisch, R. Neural Mechanisms of Placebo Anxiolysis. J. Neurosci. 2015, 35, 7365–7373.Frisaldi, E.; Carlino, E.; Zibetti, M.; Barbiani, D.; Dematteis, F.; Lanotte, M.; Lopiano, L.; Benedetti, F. The Placebo Effect on Bradykinesia in Parkinson’s Disease with and without Prior Drug Conditioning. Mov. 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